RAB14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB14
Entrez Gene ID	51552
Full Name	RAB14, member RAS oncogene family
Synonyms	FBP,RAB-14
General protein information	Preferred Names RAB14, member RAS oncogene family Names ras-related protein Rab-14 F protein-binding protein 1 bA165P4.3 (member RAS oncogene family) small GTP binding protein RAB14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q33.2
Summary	RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009].
Disorder MIM:	612673

mRNA and Protein(s)

mRNA	Protein	Name
NM_016322.3	NP_057406.2	ras-related protein Rab-14
NM_016322.4	NP_057406.2	ras-related protein Rab-14

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RAB14	XP_001149341.2
Neurospora crassa	NCU01647	XP_956269.1
Xenopus tropicalis (tropical clawed frog)	rab14	NP_001007505.1
Canis lupus familiaris (dog)	RAB14	XP_532048.2
Bos taurus (cattle)	RAB14	NP_001124226.1
Danio rerio (zebrafish)	rab14l	NP_956977.1
Magnaporthe oryzae (rice blast fungus)	MGG_07191	XP_003715397.1
Homo sapiens (human)	RAB14	NP_057406.2
	RAB14	XP_001093688.1
Gallus gallus (chicken)	RAB14	NP_001012814.1
Mus musculus (house mouse)	Rab14	NP_080973.1
Rattus norvegicus (Norway rat)	Rab14	NP_446041.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-320a serves as a negative regulator in the progression of gastric cancer by targeting RAB14.
Li Y, Liu H, Shao J, Xing G
Molecular medicine reports16(3)2652-2658(2017 Sep)

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, Caswell PT, Campbell AD, Hogeweg A, Sansom OJ, Morton JP, Norman JC
Nature communications814646(2017 Mar)

Rab11 family expression in the human placenta: Localization at the maternal-fetal interface.
Taglauer ES, Artemiuk PA, Hanscom SR, Lindsay AJ, Wuebbolt D, Breathnach FM, Tully EC, Khan AR, McCaffrey MW
PloS one12(9)e0184864(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rab14-specific siRNA-induced downregulation of Rab14 increases the sensitivity to cisplatin, while forced expression of Rab14 lacking 3'-UTR abrogated the pro-apoptotic function of miR-148a in renal cancer cells. miR-148a acts as a tumor suppressor and holds great potential for renal cancer therapy by directly targeting Rab14.
Title: miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells.

acst as oncogene and Induces proliferation of gastric cancer cells via AKT signaling pathway
Title: Rab14 Act as Oncogene and Induce Proliferation of Gastric Cancer Cells via AKT Signaling Pathway.

The results from this analysis indicated that Rab11a, Rab11c(Rab25) and Rab14 were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line.
Title: Rab11 family expression in the human placenta: Localization at the maternal-fetal interface.

We find that Rab14 indeed binds to RCP, albeit with reduced affinity relative to conventional Rab11-FIP and Rab25-FIP complexes. However, in vivo, Rab11 recruits RCP onto biological membranes.
Title: Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP).

PKCiota binds to Rab14 and that PKCiota requires Rab14 for its correct distribution in cells. As with Rab14, PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier.
Title: PKC? interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels.

The following RAB14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12700	NM_016322.4 Latest version!	Homo sapiens RAB14, member RAS oncogene family (RAB14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12700	NM_016322.3	Homo sapiens RAB14, member RAS oncogene family (RAB14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB14 ( NM_016322.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057406.2 Homo sapiens RAB14, member RAS oncogene family (RAB14), mRNA.

Price & Availability↑

CloneID	OHu12700
Clone ID Related Accession (Same CDS sequence)	NM_016322.3 , NM_016322.4
Accession Version	NM_016322.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ras-related protein Rab-14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA404780.1, BC006081.1, AL137068.10 and AL162081.1. On Oct 17, 2008 this sequence version replaced NM_016322.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL162081.1, SRR1803614.117979.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCAACTG CACCATACAA CTACTCTTAC ATCTTTAAAT ATATTATTAT TGGGGACATG 
GGAGTAGGAA AATCTTGCTT GCTTCATCAA TTTACAGAAA AAAAATTTAT GGCTGATTGT 
CCTCACACAA TTGGTGTTGA ATTTGGTACA AGAATAATCG AAGTTAGTGG CCAAAAAATA 
AAACTGCAGA TTTGGGATAC GGCAGGACAG GAGCGATTTA GGGCTGTTAC ACGGAGCTAC 
TACAGAGGAG CTGCGGGAGC TCTTATGGTC TATGATATCA CTAGAAGAAG TACATATAAC 
CACTTAAGCA GCTGGTTGAC AGATGCAAGG AATCTCACCA ATCCAAATAC TGTAATAATT 
CTCATAGGAA ATAAAGCAGA TTTGGAGGCA CAGAGAGATG TTACATATGA AGAAGCCAAA 
CAGTTTGCTG AAGAAAATGG CTTATTGTTC CTCGAAGCGA GTGCAAAAAC GGGAGAGAAT 
GTAGAAGATG CCTTCCTTGA GGCTGCCAAG AAAATCTATC AGAACATTCA GGATGGAAGC 
TTGGATCTGA ATGCTGCTGA GTCTGGTGTA CAACACAAAC CTTCAGCCCC GCAGGGAGGC 
CGGCTAACCA GTGAACCCCA ACCCCAGAGA GAAGGCTGTG GCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057406.2
CDS	457..1104
Translation	MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC

Target ORF information:

RefSeq Version	NM_016322.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB14, member RAS oncogene family (RAB14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016322.3

ORF Insert Sequence:

ATGGCAACTG CACCATACAA CTACTCTTAC ATCTTTAAAT ATATTATTAT TGGGGACATG 
GGAGTAGGAA AATCTTGCTT GCTTCATCAA TTTACAGAAA AAAAATTTAT GGCTGATTGT 
CCTCACACAA TTGGTGTTGA ATTTGGTACA AGAATAATCG AAGTTAGTGG CCAAAAAATA 
AAACTGCAGA TTTGGGATAC GGCAGGACAG GAGCGATTTA GGGCTGTTAC ACGGAGCTAC 
TACAGAGGAG CTGCGGGAGC TCTTATGGTC TATGATATCA CTAGAAGAAG TACATATAAC 
CACTTAAGCA GCTGGTTGAC AGATGCAAGG AATCTCACCA ATCCAAATAC TGTAATAATT 
CTCATAGGAA ATAAAGCAGA TTTGGAGGCA CAGAGAGATG TTACATATGA AGAAGCCAAA 
CAGTTTGCTG AAGAAAATGG CTTATTGTTC CTCGAAGCGA GTGCAAAAAC GGGAGAGAAT 
GTAGAAGATG CCTTCCTTGA GGCTGCCAAG AAAATCTATC AGAACATTCA GGATGGAAGC 
TTGGATCTGA ATGCTGCTGA GTCTGGTGTA CAACACAAAC CTTCAGCCCC GCAGGGAGGC 
CGGCTAACCA GTGAACCCCA ACCCCAGAGA GAAGGCTGTG GCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB14 ( NM_016322.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057406.2 Homo sapiens RAB14, member RAS oncogene family (RAB14), mRNA.

Price & Availability↑

CloneID	OHu12700
Clone ID Related Accession (Same CDS sequence)	NM_016322.3 , NM_016322.4
Accession Version	NM_016322.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	ras-related protein Rab-14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA404780.1, BC006081.1, AL137068.10 and AL162081.1. On Nov 22, 2018 this sequence version replaced NM_016322.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK023524.1, SRR1803614.117979.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373840.9/ ENSP00000362946.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAACTG CACCATACAA CTACTCTTAC ATCTTTAAAT ATATTATTAT TGGGGACATG 
GGAGTAGGAA AATCTTGCTT GCTTCATCAA TTTACAGAAA AAAAATTTAT GGCTGATTGT 
CCTCACACAA TTGGTGTTGA ATTTGGTACA AGAATAATCG AAGTTAGTGG CCAAAAAATA 
AAACTGCAGA TTTGGGATAC GGCAGGACAG GAGCGATTTA GGGCTGTTAC ACGGAGCTAC 
TACAGAGGAG CTGCGGGAGC TCTTATGGTC TATGATATCA CTAGAAGAAG TACATATAAC 
CACTTAAGCA GCTGGTTGAC AGATGCAAGG AATCTCACCA ATCCAAATAC TGTAATAATT 
CTCATAGGAA ATAAAGCAGA TTTGGAGGCA CAGAGAGATG TTACATATGA AGAAGCCAAA 
CAGTTTGCTG AAGAAAATGG CTTATTGTTC CTCGAAGCGA GTGCAAAAAC GGGAGAGAAT 
GTAGAAGATG CCTTCCTTGA GGCTGCCAAG AAAATCTATC AGAACATTCA GGATGGAAGC 
TTGGATCTGA ATGCTGCTGA GTCTGGTGTA CAACACAAAC CTTCAGCCCC GCAGGGAGGC 
CGGCTAACCA GTGAACCCCA ACCCCAGAGA GAAGGCTGTG GCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057406.2
CDS	239..886
Translation	MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC

Target ORF information:

RefSeq Version	NM_016322.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB14, member RAS oncogene family (RAB14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016322.4

ORF Insert Sequence:

ATGGCAACTG CACCATACAA CTACTCTTAC ATCTTTAAAT ATATTATTAT TGGGGACATG 
GGAGTAGGAA AATCTTGCTT GCTTCATCAA TTTACAGAAA AAAAATTTAT GGCTGATTGT 
CCTCACACAA TTGGTGTTGA ATTTGGTACA AGAATAATCG AAGTTAGTGG CCAAAAAATA 
AAACTGCAGA TTTGGGATAC GGCAGGACAG GAGCGATTTA GGGCTGTTAC ACGGAGCTAC 
TACAGAGGAG CTGCGGGAGC TCTTATGGTC TATGATATCA CTAGAAGAAG TACATATAAC 
CACTTAAGCA GCTGGTTGAC AGATGCAAGG AATCTCACCA ATCCAAATAC TGTAATAATT 
CTCATAGGAA ATAAAGCAGA TTTGGAGGCA CAGAGAGATG TTACATATGA AGAAGCCAAA 
CAGTTTGCTG AAGAAAATGG CTTATTGTTC CTCGAAGCGA GTGCAAAAAC GGGAGAGAAT 
GTAGAAGATG CCTTCCTTGA GGCTGCCAAG AAAATCTATC AGAACATTCA GGATGGAAGC 
TTGGATCTGA ATGCTGCTGA GTCTGGTGTA CAACACAAAC CTTCAGCCCC GCAGGGAGGC 
CGGCTAACCA GTGAACCCCA ACCCCAGAGA GAAGGCTGTG GCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-320a serves as a negative regulator in the progression of gastric cancer by targeting RAB14.
Molecular medicine reports16(3)2652-2658(2017 Sep)
Li Y,Liu H,Shao J,Xing G

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Nature communications814646(2017 Mar)
Gundry C,Marco S,Rainero E,Miller B,Dornier E,Mitchell L,Caswell PT,Campbell AD,Hogeweg A,Sansom OJ,Morton JP,Norman JC

Rab11 family expression in the human placenta: Localization at the maternal-fetal interface.
PloS one12(9)e0184864(2017)
Taglauer ES,Artemiuk PA,Hanscom SR,Lindsay AJ,Wuebbolt D,Breathnach FM,Tully EC,Khan AR,McCaffrey MW

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RAB14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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