YTHDF2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	YTHDF2
Entrez Gene ID	51441
Full Name	YTH N6-methyladenosine RNA binding protein 2
Synonyms	CAHL,HGRG8,NY-REN-2
General protein information	Preferred Names YTH N6-methyladenosine RNA binding protein 2 Names YTH domain-containing family protein 2 9430020E02Rik CLL-associated antigen KW-14 YTH N(6)-methyladenosine RNA binding protein 2 YTH domain family, member 2 high-glucose-regulated protein 8 renal carcinoma antigen NY-REN-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p35.3
Summary	This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].
Disorder MIM:	610640

mRNA and Protein(s)

mRNA	Protein	Name
NM_016258.2	NP_057342.2	YTH domain-containing family protein 2 isoform 1
NM_016258.3	NP_057342.2	YTH domain-containing family protein 2 isoform 1
NM_001173128.1	NP_001166599.1	YTH domain-containing family protein 2 isoform 1
NM_001172828.2	NP_001166299.1	YTH domain-containing family protein 2 isoform 2
NM_001172828.1	NP_001166299.1	YTH domain-containing family protein 2 isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	yth2	NP_956544.1
Rattus norvegicus (Norway rat)	Ythdf2	NP_001040564.1
Gallus gallus (chicken)	YTHDF2	XP_003642623.2
Homo sapiens (human)	YTHDF2	NP_001166599.1
Pan troglodytes (chimpanzee)	YTHDF2	XP_001154190.1
	YTHDF2	XP_002802315.1
Canis lupus familiaris (dog)	YTHDF2	XP_005617750.1
Bos taurus (cattle)	YTHDF2	NP_001069721.1
Mus musculus (house mouse)	Ythdf2	NP_663368.3
Xenopus tropicalis (tropical clawed frog)	ythdf2	XP_004911607.1

Gene Ontology
Bibliography

Related articles in PubMed

YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells.
Chen J, Sun Y, Xu X, Wang D, He J, Zhou H, Lu Y, Zeng J, Du F, Gong A, Xu M
Cell cycle (Georgetown, Tex.)16(23)2259-2271(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-145 modulates N(6)-methyladenosine levels by targeting the 3'-UTR of YTHDF2 mRNA in hepatocellular carcinoma cells
Title: MicroRNA-145 Modulates

The authors found that the overexpression of YTHDF proteins in cells inhibited HIV-1 infection mainly by decreasing HIV-1 reverse transcription, while knockdown of YTHDF1-3 in cells had the opposite effects. Moreover, silencing the N(6)-methyladenosine writers decreased HIV-1 Gag protein expression in virus-producing cells, while silencing the N(6)-methyladenosine erasers increased Gag expression.
Title: N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

binding affinities of the YTH domains of three human proteins and yeast YTH domain protein Pho92
Title: Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.

The basic residues K416 and R527 on the surface of the YTH domain of YTHDF2 are involved in binding to the RNA backbone, and residues W432 and W486 within the hydrophobic pocket contribute to the specific recognition of N6-methyladenosine.
Title: Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine.

The study presents the structure of YTH-YTHDF2 in complex with an N6-methyladenosine mononucleotide.
Title: Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.

The following YTHDF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YTHDF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08838	NM_016258.3 Latest version!	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08838	NM_001173128.1 Latest version!	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08840	NM_001172828.2 Latest version!	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu08838	NM_016258.2	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08840	NM_001172828.1	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

YTHDF2 ( NM_016258.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057342.2 Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08838
Clone ID Related Accession (Same CDS sequence)	NM_016258.2 , NM_016258.3 , NM_001173128.1
Accession Version	NM_016258.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	YTH domain-containing family protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA697091.1, BC002559.2, AK074276.1 and BF792382.1. On Oct 28, 2006 this sequence version replaced NM_016258.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF192968.1, SRR1803615.64535.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGCCA GCAGCCTCTT GGAGCAGAGA CCAAAAGGTC AAGGAAACAA AGTACAAAAT 
GGATCTGTAC ATCAAAAGGA TGGATTAAAC GATGATGATT TTGAACCTTA CTTGAGTCCA 
CAGGCAAGGC CCAATAATGC ATATACTGCC ATGTCAGATT CCTACTTACC CAGTTACTAC 
AGTCCCTCCA TTGGCTTCTC CTATTCTTTG GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC 
ACAGCCATGC CCTACTTAAC TTCTTATGGA CAGCTGAGCA ACGGAGAGCC CCACTTCCTA 
CCAGATGCAA TGTTTGGGCA ACCAGGAGCC CTAGGTAGCA CTCCATTTCT TGGTCAGCAT 
GGTTTTAATT TCTTTCCCAG TGGGATTGAC TTCTCAGCAT GGGGAAATAA CAGTTCTCAG 
GGACAGTCTA CTCAGAGCTC TGGATATAGT AGCAATTATG CTTATGCACC TAGCTCCTTA 
GGTGGAGCCA TGATTGATGG ACAGTCAGCT TTTGCCAATG AGACCCTCAA TAAGGCTCCT 
GGCATGAATA CTATAGACCA AGGGATGGCA GCACTGAAGT TGGGTAGCAC AGAAGTTGCA 
AGCAATGTTC CAAAAGTTGT AGGTTCTGCT GTTGGTAGCG GGTCCATTAC TAGTAACATC 
GTGGCTTCCA ATAGTTTGCC TCCAGCCACC ATTGCTCCTC CAAAACCAGC ATCTTGGGCT 
GATATTGCTA GCAAGCCTGC AAAACAGCAA CCTAAACTGA AGACCAAGAA TGGCATTGCA 
GGGTCAAGTC TTCCGCCACC CCCGATAAAG CATAACATGG ATATTGGAAC TTGGGATAAC 
AAGGGTCCCG TTGCAAAAGC CCCCTCACAG GCTTTGGTTC AGAATATAGG TCAGCCAACC 
CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG GCTAACAATA GCCCACCAGT GGCTCAGGCA 
TCAGTAGGGC AACAGACACA GCCATTGCCT CCACCTCCAC CACAGCCTGC CCAGCTTTCA 
GTCCAGCAAC AGGCAGCTCA GCCAACCCGC TGGGTAGCAC CTCGGAACCG TGGCAGTGGG 
TTCGGTCATA ATGGGGTGGA TGGTAATGGA GTAGGACAGT CTCAGGCTGG TTCTGGATCT 
ACTCCTTCAG AACCCCACCC AGTGTTGGAG AAGCTTCGGT CCATTAATAA CTATAACCCC 
AAAGATTTTG ACTGGAATCT GAAACATGGC CGGGTTTTCA TCATTAAGAG CTACTCTGAG 
GACGATATTC ACCGTTCCAT TAAGTATAAT ATTTGGTGCA GCACAGAGCA TGGTAACAAG 
AGACTGGATG CTGCTTATCG TTCCATGAAC GGGAAAGGCC CCGTTTACTT ACTTTTCAGT 
GTCAACGGCA GTGGACACTT CTGTGGCGTG GCAGAAATGA AATCTGCTGT GGACTACAAC 
ACATGTGCAG GTGTGTGGTC CCAGGACAAA TGGAAGGGTC GTTTTGATGT CAGGTGGATT 
TTTGTGAAGG ACGTTCCCAA TAGCCAACTG CGACACATTC GCCTAGAGAA CAACGAGAAT 
AAACCAGTGA CCAACTCTAG GGACACTCAG GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG 
TTGAAAATTA TAGCCAGCTA CAAGCACACC ACTTCCATTT TTGATGACTT CTCACACTAT 
GAGAAACGCC AAGAGGAAGA AGAAAGTGTT AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057342.2
CDS	498..2237
Translation	MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARPNNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQGRGK

Target ORF information:

RefSeq Version	NM_016258.2
Organism	Homo sapiens(human)
Definition	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016258.2

ORF Insert Sequence:

ATGTCGGCCA GCAGCCTCTT GGAGCAGAGA CCAAAAGGTC AAGGAAACAA AGTACAAAAT 
GGATCTGTAC ATCAAAAGGA TGGATTAAAC GATGATGATT TTGAACCTTA CTTGAGTCCA 
CAGGCAAGGC CCAATAATGC ATATACTGCC ATGTCAGATT CCTACTTACC CAGTTACTAC 
AGTCCCTCCA TTGGCTTCTC CTATTCTTTG GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC 
ACAGCCATGC CCTACTTAAC TTCTTATGGA CAGCTGAGCA ACGGAGAGCC CCACTTCCTA 
CCAGATGCAA TGTTTGGGCA ACCAGGAGCC CTAGGTAGCA CTCCATTTCT TGGTCAGCAT 
GGTTTTAATT TCTTTCCCAG TGGGATTGAC TTCTCAGCAT GGGGAAATAA CAGTTCTCAG 
GGACAGTCTA CTCAGAGCTC TGGATATAGT AGCAATTATG CTTATGCACC TAGCTCCTTA 
GGTGGAGCCA TGATTGATGG ACAGTCAGCT TTTGCCAATG AGACCCTCAA TAAGGCTCCT 
GGCATGAATA CTATAGACCA AGGGATGGCA GCACTGAAGT TGGGTAGCAC AGAAGTTGCA 
AGCAATGTTC CAAAAGTTGT AGGTTCTGCT GTTGGTAGCG GGTCCATTAC TAGTAACATC 
GTGGCTTCCA ATAGTTTGCC TCCAGCCACC ATTGCTCCTC CAAAACCAGC ATCTTGGGCT 
GATATTGCTA GCAAGCCTGC AAAACAGCAA CCTAAACTGA AGACCAAGAA TGGCATTGCA 
GGGTCAAGTC TTCCGCCACC CCCGATAAAG CATAACATGG ATATTGGAAC TTGGGATAAC 
AAGGGTCCCG TTGCAAAAGC CCCCTCACAG GCTTTGGTTC AGAATATAGG TCAGCCAACC 
CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG GCTAACAATA GCCCACCAGT GGCTCAGGCA 
TCAGTAGGGC AACAGACACA GCCATTGCCT CCACCTCCAC CACAGCCTGC CCAGCTTTCA 
GTCCAGCAAC AGGCAGCTCA GCCAACCCGC TGGGTAGCAC CTCGGAACCG TGGCAGTGGG 
TTCGGTCATA ATGGGGTGGA TGGTAATGGA GTAGGACAGT CTCAGGCTGG TTCTGGATCT 
ACTCCTTCAG AACCCCACCC AGTGTTGGAG AAGCTTCGGT CCATTAATAA CTATAACCCC 
AAAGATTTTG ACTGGAATCT GAAACATGGC CGGGTTTTCA TCATTAAGAG CTACTCTGAG 
GACGATATTC ACCGTTCCAT TAAGTATAAT ATTTGGTGCA GCACAGAGCA TGGTAACAAG 
AGACTGGATG CTGCTTATCG TTCCATGAAC GGGAAAGGCC CCGTTTACTT ACTTTTCAGT 
GTCAACGGCA GTGGACACTT CTGTGGCGTG GCAGAAATGA AATCTGCTGT GGACTACAAC 
ACATGTGCAG GTGTGTGGTC CCAGGACAAA TGGAAGGGTC GTTTTGATGT CAGGTGGATT 
TTTGTGAAGG ACGTTCCCAA TAGCCAACTG CGACACATTC GCCTAGAGAA CAACGAGAAT 
AAACCAGTGA CCAACTCTAG GGACACTCAG GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG 
TTGAAAATTA TAGCCAGCTA CAAGCACACC ACTTCCATTT TTGATGACTT CTCACACTAT 
GAGAAACGCC AAGAGGAAGA AGAAAGTGTT AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YTHDF2 ( NM_016258.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057342.2 Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08838
Clone ID Related Accession (Same CDS sequence)	NM_016258.2 , NM_016258.3 , NM_001173128.1
Accession Version	NM_016258.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	YTH domain-containing family protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL645729.14 and AL356786.36. On Nov 23, 2018 this sequence version replaced NM_016258.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.6449.1, SRR3476690.1034250.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373812.8/ ENSP00000362918.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGCCA GCAGCCTCTT GGAGCAGAGA CCAAAAGGTC AAGGAAACAA AGTACAAAAT 
GGATCTGTAC ATCAAAAGGA TGGATTAAAC GATGATGATT TTGAACCTTA CTTGAGTCCA 
CAGGCAAGGC CCAATAATGC ATATACTGCC ATGTCAGATT CCTACTTACC CAGTTACTAC 
AGTCCCTCCA TTGGCTTCTC CTATTCTTTG GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC 
ACAGCCATGC CCTACTTAAC TTCTTATGGA CAGCTGAGCA ACGGAGAGCC CCACTTCCTA 
CCAGATGCAA TGTTTGGGCA ACCAGGAGCC CTAGGTAGCA CTCCATTTCT TGGTCAGCAT 
GGTTTTAATT TCTTTCCCAG TGGGATTGAC TTCTCAGCAT GGGGAAATAA CAGTTCTCAG 
GGACAGTCTA CTCAGAGCTC TGGATATAGT AGCAATTATG CTTATGCACC TAGCTCCTTA 
GGTGGAGCCA TGATTGATGG ACAGTCAGCT TTTGCCAATG AGACCCTCAA TAAGGCTCCT 
GGCATGAATA CTATAGACCA AGGGATGGCA GCACTGAAGT TGGGTAGCAC AGAAGTTGCA 
AGCAATGTTC CAAAAGTTGT AGGTTCTGCT GTTGGTAGCG GGTCCATTAC TAGTAACATC 
GTGGCTTCCA ATAGTTTGCC TCCAGCCACC ATTGCTCCTC CAAAACCAGC ATCTTGGGCT 
GATATTGCTA GCAAGCCTGC AAAACAGCAA CCTAAACTGA AGACCAAGAA TGGCATTGCA 
GGGTCAAGTC TTCCGCCACC CCCGATAAAG CATAACATGG ATATTGGAAC TTGGGATAAC 
AAGGGTCCCG TTGCAAAAGC CCCCTCACAG GCTTTGGTTC AGAATATAGG TCAGCCAACC 
CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG GCTAACAATA GCCCACCAGT GGCTCAGGCA 
TCAGTAGGGC AACAGACACA GCCATTGCCT CCACCTCCAC CACAGCCTGC CCAGCTTTCA 
GTCCAGCAAC AGGCAGCTCA GCCAACCCGC TGGGTAGCAC CTCGGAACCG TGGCAGTGGG 
TTCGGTCATA ATGGGGTGGA TGGTAATGGA GTAGGACAGT CTCAGGCTGG TTCTGGATCT 
ACTCCTTCAG AACCCCACCC AGTGTTGGAG AAGCTTCGGT CCATTAATAA CTATAACCCC 
AAAGATTTTG ACTGGAATCT GAAACATGGC CGGGTTTTCA TCATTAAGAG CTACTCTGAG 
GACGATATTC ACCGTTCCAT TAAGTATAAT ATTTGGTGCA GCACAGAGCA TGGTAACAAG 
AGACTGGATG CTGCTTATCG TTCCATGAAC GGGAAAGGCC CCGTTTACTT ACTTTTCAGT 
GTCAACGGCA GTGGACACTT CTGTGGCGTG GCAGAAATGA AATCTGCTGT GGACTACAAC 
ACATGTGCAG GTGTGTGGTC CCAGGACAAA TGGAAGGGTC GTTTTGATGT CAGGTGGATT 
TTTGTGAAGG ACGTTCCCAA TAGCCAACTG CGACACATTC GCCTAGAGAA CAACGAGAAT 
AAACCAGTGA CCAACTCTAG GGACACTCAG GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG 
TTGAAAATTA TAGCCAGCTA CAAGCACACC ACTTCCATTT TTGATGACTT CTCACACTAT 
GAGAAACGCC AAGAGGAAGA AGAAAGTGTT AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057342.2
CDS	182..1921
Translation	MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARPNNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQGRGK

Target ORF information:

RefSeq Version	NM_016258.3
Organism	Homo sapiens(human)
Definition	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016258.3

ORF Insert Sequence:

ATGTCGGCCA GCAGCCTCTT GGAGCAGAGA CCAAAAGGTC AAGGAAACAA AGTACAAAAT 
GGATCTGTAC ATCAAAAGGA TGGATTAAAC GATGATGATT TTGAACCTTA CTTGAGTCCA 
CAGGCAAGGC CCAATAATGC ATATACTGCC ATGTCAGATT CCTACTTACC CAGTTACTAC 
AGTCCCTCCA TTGGCTTCTC CTATTCTTTG GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC 
ACAGCCATGC CCTACTTAAC TTCTTATGGA CAGCTGAGCA ACGGAGAGCC CCACTTCCTA 
CCAGATGCAA TGTTTGGGCA ACCAGGAGCC CTAGGTAGCA CTCCATTTCT TGGTCAGCAT 
GGTTTTAATT TCTTTCCCAG TGGGATTGAC TTCTCAGCAT GGGGAAATAA CAGTTCTCAG 
GGACAGTCTA CTCAGAGCTC TGGATATAGT AGCAATTATG CTTATGCACC TAGCTCCTTA 
GGTGGAGCCA TGATTGATGG ACAGTCAGCT TTTGCCAATG AGACCCTCAA TAAGGCTCCT 
GGCATGAATA CTATAGACCA AGGGATGGCA GCACTGAAGT TGGGTAGCAC AGAAGTTGCA 
AGCAATGTTC CAAAAGTTGT AGGTTCTGCT GTTGGTAGCG GGTCCATTAC TAGTAACATC 
GTGGCTTCCA ATAGTTTGCC TCCAGCCACC ATTGCTCCTC CAAAACCAGC ATCTTGGGCT 
GATATTGCTA GCAAGCCTGC AAAACAGCAA CCTAAACTGA AGACCAAGAA TGGCATTGCA 
GGGTCAAGTC TTCCGCCACC CCCGATAAAG CATAACATGG ATATTGGAAC TTGGGATAAC 
AAGGGTCCCG TTGCAAAAGC CCCCTCACAG GCTTTGGTTC AGAATATAGG TCAGCCAACC 
CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG GCTAACAATA GCCCACCAGT GGCTCAGGCA 
TCAGTAGGGC AACAGACACA GCCATTGCCT CCACCTCCAC CACAGCCTGC CCAGCTTTCA 
GTCCAGCAAC AGGCAGCTCA GCCAACCCGC TGGGTAGCAC CTCGGAACCG TGGCAGTGGG 
TTCGGTCATA ATGGGGTGGA TGGTAATGGA GTAGGACAGT CTCAGGCTGG TTCTGGATCT 
ACTCCTTCAG AACCCCACCC AGTGTTGGAG AAGCTTCGGT CCATTAATAA CTATAACCCC 
AAAGATTTTG ACTGGAATCT GAAACATGGC CGGGTTTTCA TCATTAAGAG CTACTCTGAG 
GACGATATTC ACCGTTCCAT TAAGTATAAT ATTTGGTGCA GCACAGAGCA TGGTAACAAG 
AGACTGGATG CTGCTTATCG TTCCATGAAC GGGAAAGGCC CCGTTTACTT ACTTTTCAGT 
GTCAACGGCA GTGGACACTT CTGTGGCGTG GCAGAAATGA AATCTGCTGT GGACTACAAC 
ACATGTGCAG GTGTGTGGTC CCAGGACAAA TGGAAGGGTC GTTTTGATGT CAGGTGGATT 
TTTGTGAAGG ACGTTCCCAA TAGCCAACTG CGACACATTC GCCTAGAGAA CAACGAGAAT 
AAACCAGTGA CCAACTCTAG GGACACTCAG GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG 
TTGAAAATTA TAGCCAGCTA CAAGCACACC ACTTCCATTT TTGATGACTT CTCACACTAT 
GAGAAACGCC AAGAGGAAGA AGAAAGTGTT AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YTHDF2 ( NM_001173128.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166599.1 Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08838
Clone ID Related Accession (Same CDS sequence)	NM_016258.2 , NM_016258.3 , NM_001173128.1
Accession Version	NM_001173128.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	YTH domain-containing family protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC425394.1, BP320783.1, AK292581.1 and AA603037.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) has a split 5' UTR exon, as compared to variant 1. Both variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1660803.104961.1, SRR1660809.166555.1 [ECO:0000331] ##Evidence-Data-END##

ATGTCGGCCA GCAGCCTCTT GGAGCAGAGA CCAAAAGGTC AAGGAAACAA AGTACAAAAT 
GGATCTGTAC ATCAAAAGGA TGGATTAAAC GATGATGATT TTGAACCTTA CTTGAGTCCA 
CAGGCAAGGC CCAATAATGC ATATACTGCC ATGTCAGATT CCTACTTACC CAGTTACTAC 
AGTCCCTCCA TTGGCTTCTC CTATTCTTTG GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC 
ACAGCCATGC CCTACTTAAC TTCTTATGGA CAGCTGAGCA ACGGAGAGCC CCACTTCCTA 
CCAGATGCAA TGTTTGGGCA ACCAGGAGCC CTAGGTAGCA CTCCATTTCT TGGTCAGCAT 
GGTTTTAATT TCTTTCCCAG TGGGATTGAC TTCTCAGCAT GGGGAAATAA CAGTTCTCAG 
GGACAGTCTA CTCAGAGCTC TGGATATAGT AGCAATTATG CTTATGCACC TAGCTCCTTA 
GGTGGAGCCA TGATTGATGG ACAGTCAGCT TTTGCCAATG AGACCCTCAA TAAGGCTCCT 
GGCATGAATA CTATAGACCA AGGGATGGCA GCACTGAAGT TGGGTAGCAC AGAAGTTGCA 
AGCAATGTTC CAAAAGTTGT AGGTTCTGCT GTTGGTAGCG GGTCCATTAC TAGTAACATC 
GTGGCTTCCA ATAGTTTGCC TCCAGCCACC ATTGCTCCTC CAAAACCAGC ATCTTGGGCT 
GATATTGCTA GCAAGCCTGC AAAACAGCAA CCTAAACTGA AGACCAAGAA TGGCATTGCA 
GGGTCAAGTC TTCCGCCACC CCCGATAAAG CATAACATGG ATATTGGAAC TTGGGATAAC 
AAGGGTCCCG TTGCAAAAGC CCCCTCACAG GCTTTGGTTC AGAATATAGG TCAGCCAACC 
CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG GCTAACAATA GCCCACCAGT GGCTCAGGCA 
TCAGTAGGGC AACAGACACA GCCATTGCCT CCACCTCCAC CACAGCCTGC CCAGCTTTCA 
GTCCAGCAAC AGGCAGCTCA GCCAACCCGC TGGGTAGCAC CTCGGAACCG TGGCAGTGGG 
TTCGGTCATA ATGGGGTGGA TGGTAATGGA GTAGGACAGT CTCAGGCTGG TTCTGGATCT 
ACTCCTTCAG AACCCCACCC AGTGTTGGAG AAGCTTCGGT CCATTAATAA CTATAACCCC 
AAAGATTTTG ACTGGAATCT GAAACATGGC CGGGTTTTCA TCATTAAGAG CTACTCTGAG 
GACGATATTC ACCGTTCCAT TAAGTATAAT ATTTGGTGCA GCACAGAGCA TGGTAACAAG 
AGACTGGATG CTGCTTATCG TTCCATGAAC GGGAAAGGCC CCGTTTACTT ACTTTTCAGT 
GTCAACGGCA GTGGACACTT CTGTGGCGTG GCAGAAATGA AATCTGCTGT GGACTACAAC 
ACATGTGCAG GTGTGTGGTC CCAGGACAAA TGGAAGGGTC GTTTTGATGT CAGGTGGATT 
TTTGTGAAGG ACGTTCCCAA TAGCCAACTG CGACACATTC GCCTAGAGAA CAACGAGAAT 
AAACCAGTGA CCAACTCTAG GGACACTCAG GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG 
TTGAAAATTA TAGCCAGCTA CAAGCACACC ACTTCCATTT TTGATGACTT CTCACACTAT 
GAGAAACGCC AAGAGGAAGA AGAAAGTGTT AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166599.1
CDS	264..2003
Translation	MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARPNNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQGRGK

Target ORF information:

RefSeq Version	NM_001173128.1
Organism	Homo sapiens(human)
Definition	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173128.1

ORF Insert Sequence:

ATGTCGGCCA GCAGCCTCTT GGAGCAGAGA CCAAAAGGTC AAGGAAACAA AGTACAAAAT 
GGATCTGTAC ATCAAAAGGA TGGATTAAAC GATGATGATT TTGAACCTTA CTTGAGTCCA 
CAGGCAAGGC CCAATAATGC ATATACTGCC ATGTCAGATT CCTACTTACC CAGTTACTAC 
AGTCCCTCCA TTGGCTTCTC CTATTCTTTG GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC 
ACAGCCATGC CCTACTTAAC TTCTTATGGA CAGCTGAGCA ACGGAGAGCC CCACTTCCTA 
CCAGATGCAA TGTTTGGGCA ACCAGGAGCC CTAGGTAGCA CTCCATTTCT TGGTCAGCAT 
GGTTTTAATT TCTTTCCCAG TGGGATTGAC TTCTCAGCAT GGGGAAATAA CAGTTCTCAG 
GGACAGTCTA CTCAGAGCTC TGGATATAGT AGCAATTATG CTTATGCACC TAGCTCCTTA 
GGTGGAGCCA TGATTGATGG ACAGTCAGCT TTTGCCAATG AGACCCTCAA TAAGGCTCCT 
GGCATGAATA CTATAGACCA AGGGATGGCA GCACTGAAGT TGGGTAGCAC AGAAGTTGCA 
AGCAATGTTC CAAAAGTTGT AGGTTCTGCT GTTGGTAGCG GGTCCATTAC TAGTAACATC 
GTGGCTTCCA ATAGTTTGCC TCCAGCCACC ATTGCTCCTC CAAAACCAGC ATCTTGGGCT 
GATATTGCTA GCAAGCCTGC AAAACAGCAA CCTAAACTGA AGACCAAGAA TGGCATTGCA 
GGGTCAAGTC TTCCGCCACC CCCGATAAAG CATAACATGG ATATTGGAAC TTGGGATAAC 
AAGGGTCCCG TTGCAAAAGC CCCCTCACAG GCTTTGGTTC AGAATATAGG TCAGCCAACC 
CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG GCTAACAATA GCCCACCAGT GGCTCAGGCA 
TCAGTAGGGC AACAGACACA GCCATTGCCT CCACCTCCAC CACAGCCTGC CCAGCTTTCA 
GTCCAGCAAC AGGCAGCTCA GCCAACCCGC TGGGTAGCAC CTCGGAACCG TGGCAGTGGG 
TTCGGTCATA ATGGGGTGGA TGGTAATGGA GTAGGACAGT CTCAGGCTGG TTCTGGATCT 
ACTCCTTCAG AACCCCACCC AGTGTTGGAG AAGCTTCGGT CCATTAATAA CTATAACCCC 
AAAGATTTTG ACTGGAATCT GAAACATGGC CGGGTTTTCA TCATTAAGAG CTACTCTGAG 
GACGATATTC ACCGTTCCAT TAAGTATAAT ATTTGGTGCA GCACAGAGCA TGGTAACAAG 
AGACTGGATG CTGCTTATCG TTCCATGAAC GGGAAAGGCC CCGTTTACTT ACTTTTCAGT 
GTCAACGGCA GTGGACACTT CTGTGGCGTG GCAGAAATGA AATCTGCTGT GGACTACAAC 
ACATGTGCAG GTGTGTGGTC CCAGGACAAA TGGAAGGGTC GTTTTGATGT CAGGTGGATT 
TTTGTGAAGG ACGTTCCCAA TAGCCAACTG CGACACATTC GCCTAGAGAA CAACGAGAAT 
AAACCAGTGA CCAACTCTAG GGACACTCAG GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG 
TTGAAAATTA TAGCCAGCTA CAAGCACACC ACTTCCATTT TTGATGACTT CTCACACTAT 
GAGAAACGCC AAGAGGAAGA AGAAAGTGTT AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YTHDF2 ( NM_001172828.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166299.1 Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 3, mRNA.

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CloneID	OHu08840
Clone ID Related Accession (Same CDS sequence)	NM_001172828.2 , NM_001172828.1
Accession Version	NM_001172828.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	YTH domain-containing family protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL645729.14 and AL356786.36. On May 31, 2019 this sequence version replaced NM_001172828.1. Transcript Variant: This variant (3) lacks an exon in the 5' region, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303833.1, SRR6380200.127409.7 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END##

ATGTCAGATT CCTACTTACC CAGTTACTAC AGTCCCTCCA TTGGCTTCTC CTATTCTTTG 
GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC ACAGCCATGC CCTACTTAAC TTCTTATGGA 
CAGCTGAGCA ACGGAGAGCC CCACTTCCTA CCAGATGCAA TGTTTGGGCA ACCAGGAGCC 
CTAGGTAGCA CTCCATTTCT TGGTCAGCAT GGTTTTAATT TCTTTCCCAG TGGGATTGAC 
TTCTCAGCAT GGGGAAATAA CAGTTCTCAG GGACAGTCTA CTCAGAGCTC TGGATATAGT 
AGCAATTATG CTTATGCACC TAGCTCCTTA GGTGGAGCCA TGATTGATGG ACAGTCAGCT 
TTTGCCAATG AGACCCTCAA TAAGGCTCCT GGCATGAATA CTATAGACCA AGGGATGGCA 
GCACTGAAGT TGGGTAGCAC AGAAGTTGCA AGCAATGTTC CAAAAGTTGT AGGTTCTGCT 
GTTGGTAGCG GGTCCATTAC TAGTAACATC GTGGCTTCCA ATAGTTTGCC TCCAGCCACC 
ATTGCTCCTC CAAAACCAGC ATCTTGGGCT GATATTGCTA GCAAGCCTGC AAAACAGCAA 
CCTAAACTGA AGACCAAGAA TGGCATTGCA GGGTCAAGTC TTCCGCCACC CCCGATAAAG 
CATAACATGG ATATTGGAAC TTGGGATAAC AAGGGTCCCG TTGCAAAAGC CCCCTCACAG 
GCTTTGGTTC AGAATATAGG TCAGCCAACC CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG 
GCTAACAATA GCCCACCAGT GGCTCAGGCA TCAGTAGGGC AACAGACACA GCCATTGCCT 
CCACCTCCAC CACAGCCTGC CCAGCTTTCA GTCCAGCAAC AGGCAGCTCA GCCAACCCGC 
TGGGTAGCAC CTCGGAACCG TGGCAGTGGG TTCGGTCATA ATGGGGTGGA TGGTAATGGA 
GTAGGACAGT CTCAGGCTGG TTCTGGATCT ACTCCTTCAG AACCCCACCC AGTGTTGGAG 
AAGCTTCGGT CCATTAATAA CTATAACCCC AAAGATTTTG ACTGGAATCT GAAACATGGC 
CGGGTTTTCA TCATTAAGAG CTACTCTGAG GACGATATTC ACCGTTCCAT TAAGTATAAT 
ATTTGGTGCA GCACAGAGCA TGGTAACAAG AGACTGGATG CTGCTTATCG TTCCATGAAC 
GGGAAAGGCC CCGTTTACTT ACTTTTCAGT GTCAACGGCA GTGGACACTT CTGTGGCGTG 
GCAGAAATGA AATCTGCTGT GGACTACAAC ACATGTGCAG GTGTGTGGTC CCAGGACAAA 
TGGAAGGGTC GTTTTGATGT CAGGTGGATT TTTGTGAAGG ACGTTCCCAA TAGCCAACTG 
CGACACATTC GCCTAGAGAA CAACGAGAAT AAACCAGTGA CCAACTCTAG GGACACTCAG 
GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG TTGAAAATTA TAGCCAGCTA CAAGCACACC 
ACTTCCATTT TTGATGACTT CTCACACTAT GAGAAACGCC AAGAGGAAGA AGAAAGTGTT 
AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166299.1
CDS	307..1896
Translation	MSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQGRGK

Target ORF information:

RefSeq Version	NM_001172828.2
Organism	Homo sapiens(human)
Definition	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172828.2

ORF Insert Sequence:

ATGTCAGATT CCTACTTACC CAGTTACTAC AGTCCCTCCA TTGGCTTCTC CTATTCTTTG 
GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC ACAGCCATGC CCTACTTAAC TTCTTATGGA 
CAGCTGAGCA ACGGAGAGCC CCACTTCCTA CCAGATGCAA TGTTTGGGCA ACCAGGAGCC 
CTAGGTAGCA CTCCATTTCT TGGTCAGCAT GGTTTTAATT TCTTTCCCAG TGGGATTGAC 
TTCTCAGCAT GGGGAAATAA CAGTTCTCAG GGACAGTCTA CTCAGAGCTC TGGATATAGT 
AGCAATTATG CTTATGCACC TAGCTCCTTA GGTGGAGCCA TGATTGATGG ACAGTCAGCT 
TTTGCCAATG AGACCCTCAA TAAGGCTCCT GGCATGAATA CTATAGACCA AGGGATGGCA 
GCACTGAAGT TGGGTAGCAC AGAAGTTGCA AGCAATGTTC CAAAAGTTGT AGGTTCTGCT 
GTTGGTAGCG GGTCCATTAC TAGTAACATC GTGGCTTCCA ATAGTTTGCC TCCAGCCACC 
ATTGCTCCTC CAAAACCAGC ATCTTGGGCT GATATTGCTA GCAAGCCTGC AAAACAGCAA 
CCTAAACTGA AGACCAAGAA TGGCATTGCA GGGTCAAGTC TTCCGCCACC CCCGATAAAG 
CATAACATGG ATATTGGAAC TTGGGATAAC AAGGGTCCCG TTGCAAAAGC CCCCTCACAG 
GCTTTGGTTC AGAATATAGG TCAGCCAACC CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG 
GCTAACAATA GCCCACCAGT GGCTCAGGCA TCAGTAGGGC AACAGACACA GCCATTGCCT 
CCACCTCCAC CACAGCCTGC CCAGCTTTCA GTCCAGCAAC AGGCAGCTCA GCCAACCCGC 
TGGGTAGCAC CTCGGAACCG TGGCAGTGGG TTCGGTCATA ATGGGGTGGA TGGTAATGGA 
GTAGGACAGT CTCAGGCTGG TTCTGGATCT ACTCCTTCAG AACCCCACCC AGTGTTGGAG 
AAGCTTCGGT CCATTAATAA CTATAACCCC AAAGATTTTG ACTGGAATCT GAAACATGGC 
CGGGTTTTCA TCATTAAGAG CTACTCTGAG GACGATATTC ACCGTTCCAT TAAGTATAAT 
ATTTGGTGCA GCACAGAGCA TGGTAACAAG AGACTGGATG CTGCTTATCG TTCCATGAAC 
GGGAAAGGCC CCGTTTACTT ACTTTTCAGT GTCAACGGCA GTGGACACTT CTGTGGCGTG 
GCAGAAATGA AATCTGCTGT GGACTACAAC ACATGTGCAG GTGTGTGGTC CCAGGACAAA 
TGGAAGGGTC GTTTTGATGT CAGGTGGATT TTTGTGAAGG ACGTTCCCAA TAGCCAACTG 
CGACACATTC GCCTAGAGAA CAACGAGAAT AAACCAGTGA CCAACTCTAG GGACACTCAG 
GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG TTGAAAATTA TAGCCAGCTA CAAGCACACC 
ACTTCCATTT TTGATGACTT CTCACACTAT GAGAAACGCC AAGAGGAAGA AGAAAGTGTT 
AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YTHDF2 ( NM_001172828.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166299.1 Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 3, mRNA.

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CloneID	OHu08840
Clone ID Related Accession (Same CDS sequence)	NM_001172828.2 , NM_001172828.1
Accession Version	NM_001172828.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-21
Organism	Homo sapiens(human)
Product	YTH domain-containing family protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303833.1, AK292581.1 and AA603037.1. Transcript Variant: This variant (3) lacks an exon in the 5' region, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END##

ATGTCAGATT CCTACTTACC CAGTTACTAC AGTCCCTCCA TTGGCTTCTC CTATTCTTTG 
GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC ACAGCCATGC CCTACTTAAC TTCTTATGGA 
CAGCTGAGCA ACGGAGAGCC CCACTTCCTA CCAGATGCAA TGTTTGGGCA ACCAGGAGCC 
CTAGGTAGCA CTCCATTTCT TGGTCAGCAT GGTTTTAATT TCTTTCCCAG TGGGATTGAC 
TTCTCAGCAT GGGGAAATAA CAGTTCTCAG GGACAGTCTA CTCAGAGCTC TGGATATAGT 
AGCAATTATG CTTATGCACC TAGCTCCTTA GGTGGAGCCA TGATTGATGG ACAGTCAGCT 
TTTGCCAATG AGACCCTCAA TAAGGCTCCT GGCATGAATA CTATAGACCA AGGGATGGCA 
GCACTGAAGT TGGGTAGCAC AGAAGTTGCA AGCAATGTTC CAAAAGTTGT AGGTTCTGCT 
GTTGGTAGCG GGTCCATTAC TAGTAACATC GTGGCTTCCA ATAGTTTGCC TCCAGCCACC 
ATTGCTCCTC CAAAACCAGC ATCTTGGGCT GATATTGCTA GCAAGCCTGC AAAACAGCAA 
CCTAAACTGA AGACCAAGAA TGGCATTGCA GGGTCAAGTC TTCCGCCACC CCCGATAAAG 
CATAACATGG ATATTGGAAC TTGGGATAAC AAGGGTCCCG TTGCAAAAGC CCCCTCACAG 
GCTTTGGTTC AGAATATAGG TCAGCCAACC CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG 
GCTAACAATA GCCCACCAGT GGCTCAGGCA TCAGTAGGGC AACAGACACA GCCATTGCCT 
CCACCTCCAC CACAGCCTGC CCAGCTTTCA GTCCAGCAAC AGGCAGCTCA GCCAACCCGC 
TGGGTAGCAC CTCGGAACCG TGGCAGTGGG TTCGGTCATA ATGGGGTGGA TGGTAATGGA 
GTAGGACAGT CTCAGGCTGG TTCTGGATCT ACTCCTTCAG AACCCCACCC AGTGTTGGAG 
AAGCTTCGGT CCATTAATAA CTATAACCCC AAAGATTTTG ACTGGAATCT GAAACATGGC 
CGGGTTTTCA TCATTAAGAG CTACTCTGAG GACGATATTC ACCGTTCCAT TAAGTATAAT 
ATTTGGTGCA GCACAGAGCA TGGTAACAAG AGACTGGATG CTGCTTATCG TTCCATGAAC 
GGGAAAGGCC CCGTTTACTT ACTTTTCAGT GTCAACGGCA GTGGACACTT CTGTGGCGTG 
GCAGAAATGA AATCTGCTGT GGACTACAAC ACATGTGCAG GTGTGTGGTC CCAGGACAAA 
TGGAAGGGTC GTTTTGATGT CAGGTGGATT TTTGTGAAGG ACGTTCCCAA TAGCCAACTG 
CGACACATTC GCCTAGAGAA CAACGAGAAT AAACCAGTGA CCAACTCTAG GGACACTCAG 
GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG TTGAAAATTA TAGCCAGCTA CAAGCACACC 
ACTTCCATTT TTGATGACTT CTCACACTAT GAGAAACGCC AAGAGGAAGA AGAAAGTGTT 
AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166299.1
CDS	307..1896
Translation	MSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQGRGK

Target ORF information:

RefSeq Version	NM_001172828.1
Organism	Homo sapiens(human)
Definition	Homo sapiens YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172828.1

ORF Insert Sequence:

ATGTCAGATT CCTACTTACC CAGTTACTAC AGTCCCTCCA TTGGCTTCTC CTATTCTTTG 
GGTGAAGCTG CTTGGTCTAC GGGGGGTGAC ACAGCCATGC CCTACTTAAC TTCTTATGGA 
CAGCTGAGCA ACGGAGAGCC CCACTTCCTA CCAGATGCAA TGTTTGGGCA ACCAGGAGCC 
CTAGGTAGCA CTCCATTTCT TGGTCAGCAT GGTTTTAATT TCTTTCCCAG TGGGATTGAC 
TTCTCAGCAT GGGGAAATAA CAGTTCTCAG GGACAGTCTA CTCAGAGCTC TGGATATAGT 
AGCAATTATG CTTATGCACC TAGCTCCTTA GGTGGAGCCA TGATTGATGG ACAGTCAGCT 
TTTGCCAATG AGACCCTCAA TAAGGCTCCT GGCATGAATA CTATAGACCA AGGGATGGCA 
GCACTGAAGT TGGGTAGCAC AGAAGTTGCA AGCAATGTTC CAAAAGTTGT AGGTTCTGCT 
GTTGGTAGCG GGTCCATTAC TAGTAACATC GTGGCTTCCA ATAGTTTGCC TCCAGCCACC 
ATTGCTCCTC CAAAACCAGC ATCTTGGGCT GATATTGCTA GCAAGCCTGC AAAACAGCAA 
CCTAAACTGA AGACCAAGAA TGGCATTGCA GGGTCAAGTC TTCCGCCACC CCCGATAAAG 
CATAACATGG ATATTGGAAC TTGGGATAAC AAGGGTCCCG TTGCAAAAGC CCCCTCACAG 
GCTTTGGTTC AGAATATAGG TCAGCCAACC CAGGGGTCTC CTCAGCCTGT AGGTCAGCAG 
GCTAACAATA GCCCACCAGT GGCTCAGGCA TCAGTAGGGC AACAGACACA GCCATTGCCT 
CCACCTCCAC CACAGCCTGC CCAGCTTTCA GTCCAGCAAC AGGCAGCTCA GCCAACCCGC 
TGGGTAGCAC CTCGGAACCG TGGCAGTGGG TTCGGTCATA ATGGGGTGGA TGGTAATGGA 
GTAGGACAGT CTCAGGCTGG TTCTGGATCT ACTCCTTCAG AACCCCACCC AGTGTTGGAG 
AAGCTTCGGT CCATTAATAA CTATAACCCC AAAGATTTTG ACTGGAATCT GAAACATGGC 
CGGGTTTTCA TCATTAAGAG CTACTCTGAG GACGATATTC ACCGTTCCAT TAAGTATAAT 
ATTTGGTGCA GCACAGAGCA TGGTAACAAG AGACTGGATG CTGCTTATCG TTCCATGAAC 
GGGAAAGGCC CCGTTTACTT ACTTTTCAGT GTCAACGGCA GTGGACACTT CTGTGGCGTG 
GCAGAAATGA AATCTGCTGT GGACTACAAC ACATGTGCAG GTGTGTGGTC CCAGGACAAA 
TGGAAGGGTC GTTTTGATGT CAGGTGGATT TTTGTGAAGG ACGTTCCCAA TAGCCAACTG 
CGACACATTC GCCTAGAGAA CAACGAGAAT AAACCAGTGA CCAACTCTAG GGACACTCAG 
GAAGTGCCTC TGGAAAAGGC TAAGCAGGTG TTGAAAATTA TAGCCAGCTA CAAGCACACC 
ACTTCCATTT TTGATGACTT CTCACACTAT GAGAAACGCC AAGAGGAAGA AGAAAGTGTT 
AAAAAGGAAC GTCAAGGTCG TGGGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells.
Cell cycle (Georgetown, Tex.)16(23)2259-2271(2017)
Chen J,Sun Y,Xu X,Wang D,He J,Zhou H,Lu Y,Zeng J,Du F,Gong A,Xu M

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YTHDF2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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