CDC40 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDC40
Entrez Gene ID	51362
Full Name	cell division cycle 40
Synonyms	EHB3,PRP17,PRPF17
General protein information	Preferred Names cell division cycle 40 Names pre-mRNA-processing factor 17 EH-binding protein 3 PRP17 homolog cell division cycle 40 homolog hPRP17 pre-mRNA splicing factor 17
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q21
Summary	Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008].
Disorder MIM:	605585

mRNA and Protein(s)

mRNA	Protein	Name
NM_015891.2	NP_056975.1	pre-mRNA-processing factor 17
NM_015891.3	NP_056975.1	pre-mRNA-processing factor 17

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDC40	NP_056975.1
	CDC40	XP_001088397.1
Bos taurus (cattle)	CDC40	NP_001069111.1
Gallus gallus (chicken)	CDC40	NP_001006407.1
Oryza sativa (rice)	Os03g0397500	NP_001050302.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008925	XP_319677.2
Caenorhabditis elegans (roundworm)	prp-17	NP_492851.1
Magnaporthe oryzae (rice blast fungus)	MGG_08133	XP_003715095.1
Neurospora crassa	NCU06921	XP_959268.2
Arabidopsis thaliana (thale cress)	AT1G10580	NP_172528.2
Pan troglodytes (chimpanzee)	CDC40	XP_518687.2
Canis lupus familiaris (dog)	CDC40	XP_532261.3
Mus musculus (house mouse)	Cdc40	NP_082155.1
Xenopus tropicalis (tropical clawed frog)	cdc40	NP_001011457.1
Rattus norvegicus (Norway rat)	Cdc40	NP_001102008.1
Danio rerio (zebrafish)	cdc40	NP_001009990.1
Drosophila melanogaster (fruit fly)	CG6015	NP_651005.1
Schizosaccharomyces pombe (fission yeast)	prp17	NP_596089.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, L?hrmann R
Nature542(7641)318-323(2017 02)

HBx-induced MiR-1269b in NF-?B dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells.
Kong XX, Lv YR, Shao LP, Nong XY, Zhang GL, Zhang Y, Fan HX, Liu M, Li X, Tang H
Journal of translational medicine14(1)189(2016 06)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

Dynamic protein-protein interaction wiring of the human spliceosome.
Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, L?hrmann R, Stelzl U
Molecular cell45(4)567-80(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HBx activates NF-kappaB to promote the expression of miR1269b, which augments CDC40 expression, contributing to malignancy in hepatocellular cancer.
Title: HBx-induced MiR-1269b in NF-?B dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors.

The following CDC40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07326	NM_015891.3 Latest version!	Homo sapiens cell division cycle 40 (CDC40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu07326	NM_015891.2	Homo sapiens cell division cycle 40 (CDC40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDC40 ( NM_015891.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_056975.1 Homo sapiens cell division cycle 40 (CDC40), mRNA.

Price & Availability↑

CloneID	OHu07326
Clone ID Related Accession (Same CDS sequence)	NM_015891.2 , NM_015891.3
Accession Version	NM_015891.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Homo sapiens(human)
Product	pre-mRNA-processing factor 17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF038392.1, AK001426.1 and CB242479.1. On Dec 1, 2003 this sequence version replaced NM_015891.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.72205.1, SRR1660803.204920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGCTG CGATTGCAGC TCTGGCCGCT TCCTATGGTT CGGGTTCAGG GTCCGAATCG 
GACTCGGACA GTGAGAGCAG TCGGTGTCCG CTGCCAGCCG CCGACTCCCT CATGCACTTG 
ACTAAATCGC CTTCATCAAA GCCGTCTCTA GCAGTGGCAG TGGACTCGGC TCCGGAGGTG 
GCAGTTAAGG AAGATTTGGA GACTGGAGTT CACCTTGACC CTGCCGTCAA AGAAGTTCAG 
TATAATCCTA CCTATGAGAC CATGTTTGCT CCTGAGTTTG GACCAGAAAA TCCCTTTAGG 
ACACAGCAAA TGGCTGCCCC TAGAAATATG CTTTCTGGAT ATGCCGAACC AGCTCATATC 
AATGATTTCA TGTTTGAGCA GCAAAGGAGA ACTTTTGCAA CATATGGTTA TGCATTAGAC 
CCTTCATTAG ATAATCATCA AGTGTCTGCT AAATATATTG GTTCTGTAGA AGAAGCTGAA 
AAAAATCAAG GTTTAACTGT ATTTGAAACT GGTCAGAAGA AAACAGAAAA GAGGAAAAAG 
TTTAAAGAAA ATGATGCATC CAATATTGAT GGTTTTTTGG GACCATGGGC AAAATATGTG 
GATGAAAAAG ATGTAGCCAA ACCTTCAGAA GAAGAGCAAA AAGAATTGGA TGAAATCACA 
GCAAAGAGGC AGAAAAAAGG AAAACAGGAA GAAGAGAAAC CTGGGGAGGA GAAGACAATC 
TTACATGTTA AAGAAATGTA TGACTATCAA GGCAGGTCCT ATCTTCACAT ACCTCAGGAT 
GTTGGTGTTA ATCTACGGTC AACTATGCCA CCTGAGAAGT GTTATCTTCC CAAAAAACAA 
ATTCATGTGT GGTCTGGACA CACAAAGGGC GTCAGTGCAG TCAGATTGTT TCCTCTCTCT 
GGCCATTTAT TGCTGTCTTG TTCCATGGAC TGTAAAATTA AGCTATGGGA GGTTTATGGA 
GAACGGCGCT GTCTGAGAAC ATTTATTGGT CACAGTAAGG CTGTTAGGGA TATCTGCTTC 
AATACTGCAG GAACACAGTT CCTCAGTGCA GCCTATGACA GGTATCTTAA GCTCTGGGAC 
ACTGAGACAG GACAGTGTAT ATCAAGATTT ACAAACCGAA AAGTACCTTA TTGTGTCAAA 
TTCAATCCTG ATGAAGATAA GCAAAATCTC TTTGTGGCTG GGATGTCTGA TAAGAAGATT 
GTGCAATGGG ACATTCGAAG TGGAGAAATT GTGCAGGAAT ATGATCGGCA TTTGGGAGCT 
GTCAACACCA TTGTTTTTGT GGATGAGAAT AGGAGATTTG TGAGCACATC TGATGATAAA 
AGCCTAAGAG TTTGGGAATG GGATATCCCT GTGGATTTCA AGTACATAGC AGAACCCAGT 
ATGCACTCAA TGCCTGCAGT GACTTTGTCT CCAAATGGAA AATGGCTAGC ATGCCAATCA 
ATGGACAACC AAATCTTAAT TTTTGGAGCA CAGAACAGAT TTAGATTAAA TAAGAAAAAA 
ATTTTTAAGG GCCATATGGT AGCAGGCTAT GCTTGTCAGG TGGACTTTTC ACCAGACATG 
AGTTATGTGA TTTCAGGAGA TGGAAATGGA AAATTAAACA TTTGGGACTG GAAGACCACA 
AAACTCTACA GTCGATTTAA AGCTCATGAT AAAGTGTGTA TAGGTGCAGT GTGGCATCCT 
CATGAAACTT CTAAGGTCAT AACATGTGGT TGGGATGGTC TCATTAAATT GTGGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056975.1
CDS	25..1764
Translation	MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD

Target ORF information:

RefSeq Version	NM_015891.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 40 (CDC40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015891.2

ORF Insert Sequence:

ATGTCGGCTG CGATTGCAGC TCTGGCCGCT TCCTATGGTT CGGGTTCAGG GTCCGAATCG 
GACTCGGACA GTGAGAGCAG TCGGTGTCCG CTGCCAGCCG CCGACTCCCT CATGCACTTG 
ACTAAATCGC CTTCATCAAA GCCGTCTCTA GCAGTGGCAG TGGACTCGGC TCCGGAGGTG 
GCAGTTAAGG AAGATTTGGA GACTGGAGTT CACCTTGACC CTGCCGTCAA AGAAGTTCAG 
TATAATCCTA CCTATGAGAC CATGTTTGCT CCTGAGTTTG GACCAGAAAA TCCCTTTAGG 
ACACAGCAAA TGGCTGCCCC TAGAAATATG CTTTCTGGAT ATGCCGAACC AGCTCATATC 
AATGATTTCA TGTTTGAGCA GCAAAGGAGA ACTTTTGCAA CATATGGTTA TGCATTAGAC 
CCTTCATTAG ATAATCATCA AGTGTCTGCT AAATATATTG GTTCTGTAGA AGAAGCTGAA 
AAAAATCAAG GTTTAACTGT ATTTGAAACT GGTCAGAAGA AAACAGAAAA GAGGAAAAAG 
TTTAAAGAAA ATGATGCATC CAATATTGAT GGTTTTTTGG GACCATGGGC AAAATATGTG 
GATGAAAAAG ATGTAGCCAA ACCTTCAGAA GAAGAGCAAA AAGAATTGGA TGAAATCACA 
GCAAAGAGGC AGAAAAAAGG AAAACAGGAA GAAGAGAAAC CTGGGGAGGA GAAGACAATC 
TTACATGTTA AAGAAATGTA TGACTATCAA GGCAGGTCCT ATCTTCACAT ACCTCAGGAT 
GTTGGTGTTA ATCTACGGTC AACTATGCCA CCTGAGAAGT GTTATCTTCC CAAAAAACAA 
ATTCATGTGT GGTCTGGACA CACAAAGGGC GTCAGTGCAG TCAGATTGTT TCCTCTCTCT 
GGCCATTTAT TGCTGTCTTG TTCCATGGAC TGTAAAATTA AGCTATGGGA GGTTTATGGA 
GAACGGCGCT GTCTGAGAAC ATTTATTGGT CACAGTAAGG CTGTTAGGGA TATCTGCTTC 
AATACTGCAG GAACACAGTT CCTCAGTGCA GCCTATGACA GGTATCTTAA GCTCTGGGAC 
ACTGAGACAG GACAGTGTAT ATCAAGATTT ACAAACCGAA AAGTACCTTA TTGTGTCAAA 
TTCAATCCTG ATGAAGATAA GCAAAATCTC TTTGTGGCTG GGATGTCTGA TAAGAAGATT 
GTGCAATGGG ACATTCGAAG TGGAGAAATT GTGCAGGAAT ATGATCGGCA TTTGGGAGCT 
GTCAACACCA TTGTTTTTGT GGATGAGAAT AGGAGATTTG TGAGCACATC TGATGATAAA 
AGCCTAAGAG TTTGGGAATG GGATATCCCT GTGGATTTCA AGTACATAGC AGAACCCAGT 
ATGCACTCAA TGCCTGCAGT GACTTTGTCT CCAAATGGAA AATGGCTAGC ATGCCAATCA 
ATGGACAACC AAATCTTAAT TTTTGGAGCA CAGAACAGAT TTAGATTAAA TAAGAAAAAA 
ATTTTTAAGG GCCATATGGT AGCAGGCTAT GCTTGTCAGG TGGACTTTTC ACCAGACATG 
AGTTATGTGA TTTCAGGAGA TGGAAATGGA AAATTAAACA TTTGGGACTG GAAGACCACA 
AAACTCTACA GTCGATTTAA AGCTCATGAT AAAGTGTGTA TAGGTGCAGT GTGGCATCCT 
CATGAAACTT CTAAGGTCAT AACATGTGGT TGGGATGGTC TCATTAAATT GTGGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDC40 ( NM_015891.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056975.1 Homo sapiens cell division cycle 40 (CDC40), mRNA.

Price & Availability↑

CloneID	OHu07326
Clone ID Related Accession (Same CDS sequence)	NM_015891.2 , NM_015891.3
Accession Version	NM_015891.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	pre-mRNA-processing factor 17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF038392.1, AK001426.1, CB242479.1 and AL671518.3. On Nov 23, 2018 this sequence version replaced NM_015891.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.242774.1, SRR1660809.250792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307731.2/ ENSP00000304370.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGCTG CGATTGCAGC TCTGGCCGCT TCCTATGGTT CGGGTTCAGG GTCCGAATCG 
GACTCGGACA GTGAGAGCAG TCGGTGTCCG CTGCCAGCCG CCGACTCCCT CATGCACTTG 
ACTAAATCGC CTTCATCAAA GCCGTCTCTA GCAGTGGCAG TGGACTCGGC TCCGGAGGTG 
GCAGTTAAGG AAGATTTGGA GACTGGAGTT CACCTTGACC CTGCCGTCAA AGAAGTTCAG 
TATAATCCTA CCTATGAGAC CATGTTTGCT CCTGAGTTTG GACCAGAAAA TCCCTTTAGG 
ACACAGCAAA TGGCTGCCCC TAGAAATATG CTTTCTGGAT ATGCCGAACC AGCTCATATC 
AATGATTTCA TGTTTGAGCA GCAAAGGAGA ACTTTTGCAA CATATGGTTA TGCATTAGAC 
CCTTCATTAG ATAATCATCA AGTGTCTGCT AAATATATTG GTTCTGTAGA AGAAGCTGAA 
AAAAATCAAG GTTTAACTGT ATTTGAAACT GGTCAGAAGA AAACAGAAAA GAGGAAAAAG 
TTTAAAGAAA ATGATGCATC CAATATTGAT GGTTTTTTGG GACCATGGGC AAAATATGTG 
GATGAAAAAG ATGTAGCCAA ACCTTCAGAA GAAGAGCAAA AAGAATTGGA TGAAATCACA 
GCAAAGAGGC AGAAAAAAGG AAAACAGGAA GAAGAGAAAC CTGGGGAGGA GAAGACAATC 
TTACATGTTA AAGAAATGTA TGACTATCAA GGCAGGTCCT ATCTTCACAT ACCTCAGGAT 
GTTGGTGTTA ATCTACGGTC AACTATGCCA CCTGAGAAGT GTTATCTTCC CAAAAAACAA 
ATTCATGTGT GGTCTGGACA CACAAAGGGC GTCAGTGCAG TCAGATTGTT TCCTCTCTCT 
GGCCATTTAT TGCTGTCTTG TTCCATGGAC TGTAAAATTA AGCTATGGGA GGTTTATGGA 
GAACGGCGCT GTCTGAGAAC ATTTATTGGT CACAGTAAGG CTGTTAGGGA TATCTGCTTC 
AATACTGCAG GAACACAGTT CCTCAGTGCA GCCTATGACA GGTATCTTAA GCTCTGGGAC 
ACTGAGACAG GACAGTGTAT ATCAAGATTT ACAAACCGAA AAGTACCTTA TTGTGTCAAA 
TTCAATCCTG ATGAAGATAA GCAAAATCTC TTTGTGGCTG GGATGTCTGA TAAGAAGATT 
GTGCAATGGG ACATTCGAAG TGGAGAAATT GTGCAGGAAT ATGATCGGCA TTTGGGAGCT 
GTCAACACCA TTGTTTTTGT GGATGAGAAT AGGAGATTTG TGAGCACATC TGATGATAAA 
AGCCTAAGAG TTTGGGAATG GGATATCCCT GTGGATTTCA AGTACATAGC AGAACCCAGT 
ATGCACTCAA TGCCTGCAGT GACTTTGTCT CCAAATGGAA AATGGCTAGC ATGCCAATCA 
ATGGACAACC AAATCTTAAT TTTTGGAGCA CAGAACAGAT TTAGATTAAA TAAGAAAAAA 
ATTTTTAAGG GCCATATGGT AGCAGGCTAT GCTTGTCAGG TGGACTTTTC ACCAGACATG 
AGTTATGTGA TTTCAGGAGA TGGAAATGGA AAATTAAACA TTTGGGACTG GAAGACCACA 
AAACTCTACA GTCGATTTAA AGCTCATGAT AAAGTGTGTA TAGGTGCAGT GTGGCATCCT 
CATGAAACTT CTAAGGTCAT AACATGTGGT TGGGATGGTC TCATTAAATT GTGGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056975.1
CDS	19..1758
Translation	MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD

Target ORF information:

RefSeq Version	NM_015891.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 40 (CDC40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015891.3

ORF Insert Sequence:

ATGTCGGCTG CGATTGCAGC TCTGGCCGCT TCCTATGGTT CGGGTTCAGG GTCCGAATCG 
GACTCGGACA GTGAGAGCAG TCGGTGTCCG CTGCCAGCCG CCGACTCCCT CATGCACTTG 
ACTAAATCGC CTTCATCAAA GCCGTCTCTA GCAGTGGCAG TGGACTCGGC TCCGGAGGTG 
GCAGTTAAGG AAGATTTGGA GACTGGAGTT CACCTTGACC CTGCCGTCAA AGAAGTTCAG 
TATAATCCTA CCTATGAGAC CATGTTTGCT CCTGAGTTTG GACCAGAAAA TCCCTTTAGG 
ACACAGCAAA TGGCTGCCCC TAGAAATATG CTTTCTGGAT ATGCCGAACC AGCTCATATC 
AATGATTTCA TGTTTGAGCA GCAAAGGAGA ACTTTTGCAA CATATGGTTA TGCATTAGAC 
CCTTCATTAG ATAATCATCA AGTGTCTGCT AAATATATTG GTTCTGTAGA AGAAGCTGAA 
AAAAATCAAG GTTTAACTGT ATTTGAAACT GGTCAGAAGA AAACAGAAAA GAGGAAAAAG 
TTTAAAGAAA ATGATGCATC CAATATTGAT GGTTTTTTGG GACCATGGGC AAAATATGTG 
GATGAAAAAG ATGTAGCCAA ACCTTCAGAA GAAGAGCAAA AAGAATTGGA TGAAATCACA 
GCAAAGAGGC AGAAAAAAGG AAAACAGGAA GAAGAGAAAC CTGGGGAGGA GAAGACAATC 
TTACATGTTA AAGAAATGTA TGACTATCAA GGCAGGTCCT ATCTTCACAT ACCTCAGGAT 
GTTGGTGTTA ATCTACGGTC AACTATGCCA CCTGAGAAGT GTTATCTTCC CAAAAAACAA 
ATTCATGTGT GGTCTGGACA CACAAAGGGC GTCAGTGCAG TCAGATTGTT TCCTCTCTCT 
GGCCATTTAT TGCTGTCTTG TTCCATGGAC TGTAAAATTA AGCTATGGGA GGTTTATGGA 
GAACGGCGCT GTCTGAGAAC ATTTATTGGT CACAGTAAGG CTGTTAGGGA TATCTGCTTC 
AATACTGCAG GAACACAGTT CCTCAGTGCA GCCTATGACA GGTATCTTAA GCTCTGGGAC 
ACTGAGACAG GACAGTGTAT ATCAAGATTT ACAAACCGAA AAGTACCTTA TTGTGTCAAA 
TTCAATCCTG ATGAAGATAA GCAAAATCTC TTTGTGGCTG GGATGTCTGA TAAGAAGATT 
GTGCAATGGG ACATTCGAAG TGGAGAAATT GTGCAGGAAT ATGATCGGCA TTTGGGAGCT 
GTCAACACCA TTGTTTTTGT GGATGAGAAT AGGAGATTTG TGAGCACATC TGATGATAAA 
AGCCTAAGAG TTTGGGAATG GGATATCCCT GTGGATTTCA AGTACATAGC AGAACCCAGT 
ATGCACTCAA TGCCTGCAGT GACTTTGTCT CCAAATGGAA AATGGCTAGC ATGCCAATCA 
ATGGACAACC AAATCTTAAT TTTTGGAGCA CAGAACAGAT TTAGATTAAA TAAGAAAAAA 
ATTTTTAAGG GCCATATGGT AGCAGGCTAT GCTTGTCAGG TGGACTTTTC ACCAGACATG 
AGTTATGTGA TTTCAGGAGA TGGAAATGGA AAATTAAACA TTTGGGACTG GAAGACCACA 
AAACTCTACA GTCGATTTAA AGCTCATGAT AAAGTGTGTA TAGGTGCAGT GTGGCATCCT 
CATGAAACTT CTAAGGTCAT AACATGTGGT TGGGATGGTC TCATTAAATT GTGGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,L?hrmann R

HBx-induced MiR-1269b in NF-?B dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells.
Journal of translational medicine14(1)189(2016 06)
Kong XX,Lv YR,Shao LP,Nong XY,Zhang GL,Zhang Y,Fan HX,Liu M,Li X,Tang H

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,L?hrmann R,Stelzl U

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CDC40 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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