CPA4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CPA4
Entrez Gene ID	51200
Full Name	carboxypeptidase A4
Synonyms	CPA3
General protein information	Preferred Names carboxypeptidase A4 Names carboxypeptidase A4 carboxypeptidase A3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q32.2
Summary	This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008].
Disorder MIM:	607635

mRNA and Protein(s)

mRNA	Protein	Name
NM_001163446.1	NP_001156918.1	carboxypeptidase A4 isoform 2 precursor
NM_016352.3	NP_057436.2	carboxypeptidase A4 isoform 1 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CPA4	NP_057436.2
Magnaporthe oryzae (rice blast fungus)	MGG_09716	XP_003717635.1
Pan troglodytes (chimpanzee)	CPA4	XP_519380.1
	CPA4	XP_001095233.1
Bos taurus (cattle)	CPA4	XP_005205801.1
Drosophila melanogaster (fruit fly)	CG3108	NP_572262.1
Rattus norvegicus (Norway rat)	Cpa4	NP_001102816.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000621	XP_310460.5
Mus musculus (house mouse)	Cpa4	NP_082202.1
Canis lupus familiaris (dog)	CPA4	XP_005628438.1
Neurospora crassa	NCU07536	XP_959049.1

Gene Ontology
Bibliography

Related articles in PubMed

Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) - a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity.
He J, Chen DL, Samocha-Bonet D, Gillinder KR, Barclay JL, Magor GW, Perkins AC, Greenfield JR, Yang G, Whitehead JP
Growth factors (Chur, Switzerland)34(5-6)210-216(2016 Dec)

Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma.
Sun L, Guo C, Burnett J, Yang Z, Ran Y, Sun D
Oncotarget7(48)78688-78697(2016 Nov)

A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4.
Alonso del Rivero M, Reytor ML, Trejo SA, Ch?vez MA, Avil?s FX, Reverter D
Structure (London, England : 1993)21(7)1118-26(2013 Jul)

Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4.
Covaleda G, del Rivero MA, Ch?vez MA, Avil?s FX, Reverter D
The Journal of biological chemistry287(12)9250-8(2012 Mar)

Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.
Tanco S, Zhang X, Morano C, Avil?s FX, Lorenzo J, Fricker LD
The Journal of biological chemistry285(24)18385-96(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CPA4 as a negative regulator of adipogenesis that is down-regulated by FGF-1. Expression of CPA4 in subcutaneous adipose tissue correlated negatively with insulin sensitivity.
Title: Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) - a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity.

The crystal structure of the human CPA4 carboxypeptidase in complex with SmCI, a peptide protease inhibitor.
Title: A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4.

NvCL form Nerita versicolor is a tight-binding inhibitor that interacts with the active site of the CPA4 in a substrate-like manner.
Title: Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4.

CPA4 functions in neuropeptide processing and regulation in the extracellular environment
Title: Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.

Observational study of gene-disease association. (HuGE Navigator)
Title: Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer.

The following CPA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CPA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu22849	NM_016352.3 Latest version!	Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu08298	NM_001163446.1 Latest version!	Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CPA4 ( NM_016352.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057436.2 Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22849
Clone ID Related Accession (Same CDS sequence)	NM_016352.3
Accession Version	NM_016352.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	carboxypeptidase A4 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290993.1 and AC024085.5. On Feb 21, 2009 this sequence version replaced NM_016352.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290993.1, BC052289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 12552318 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGTGGA TACTGTTCAT TGGGGCCCTT ATTGGGTCCA GCATCTGTGG CCAAGAAAAA 
TTTTTTGGGG ACCAAGTTTT GAGGATTAAT GTCAGAAATG GAGACGAGAT CAGCAAATTG 
AGTCAACTAG TGAATTCAAA CAACTTGAAG CTCAATTTCT GGAAATCTCC CTCCTCCTTC 
AATCGGCCTG TGGATGTCCT GGTCCCATCT GTCAGTCTGC AGGCATTTAA ATCCTTCCTG 
AGATCCCAGG GCTTAGAGTA CGCAGTGACA ATTGAGGACC TGCAGGCCCT TTTAGACAAT 
GAAGATGATG AAATGCAACA CAATGAAGGG CAAGAACGGA GCAGTAATAA CTTCAACTAC 
GGGGCTTACC ATTCCCTGGA AGCTATTTAC CACGAGATGG ACAACATTGC CGCAGACTTT 
CCTGACCTGG CGAGGAGGGT GAAGATTGGA CATTCGTTTG AAAACCGGCC GATGTATGTA 
CTGAAGTTCA GCACTGGGAA AGGCGTGAGG CGGCCGGCCG TTTGGCTGAA TGCAGGCATC 
CATTCCCGAG AGTGGATCTC CCAGGCCACT GCAATCTGGA CGGCAAGGAA GATTGTATCT 
GATTACCAGA GGGATCCAGC TATCACCTCC ATCTTGGAGA AAATGGATAT TTTCTTGTTG 
CCTGTGGCCA ATCCTGATGG ATATGTGTAT ACTCAAACTC AAAACCGATT ATGGAGGAAG 
ACGCGGTCCC GAAATCCTGG AAGCTCCTGC ATTGGTGCTG ACCCAAATAG AAACTGGAAC 
GCTAGTTTTG CAGGAAAGGG AGCCAGCGAC AACCCTTGCT CCGAAGTGTA CCATGGACCC 
CACGCCAATT CGGAAGTGGA GGTGAAATCA GTGGTAGATT TCATCCAAAA ACATGGGAAT 
TTCAAGGGCT TCATCGACCT GCACAGCTAC TCGCAGCTGC TGATGTATCC ATATGGGTAC 
TCAGTCAAAA AGGCCCCAGA TGCCGAGGAA CTCGACAAGG TGGCGAGGCT TGCGGCCAAA 
GCTCTGGCTT CTGTGTCGGG CACTGAGTAC CAAGTGGGTC CCACCTGCAC CACTGTCTAT 
CCAGCTAGCG GGAGCAGCAT CGACTGGGCG TATGACAACG GCATCAAATT TGCATTCACA 
TTTGAGTTGA GAGATACCGG GACCTATGGC TTCCTCCTGC CAGCTAACCA GATCATCCCC 
ACTGCAGAGG AGACGTGGCT GGGGCTGAAG ACCATCATGG AGCATGTGCG GGACAACCTC 
TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057436.2
CDS	48..1313
Translation	MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY

Target ORF information:

RefSeq Version	NM_016352.3
Organism	Homo sapiens(human)
Definition	Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016352.3

ORF Insert Sequence:

ATGAGGTGGA TACTGTTCAT TGGGGCCCTT ATTGGGTCCA GCATCTGTGG CCAAGAAAAA 
TTTTTTGGGG ACCAAGTTTT GAGGATTAAT GTCAGAAATG GAGACGAGAT CAGCAAATTG 
AGTCAACTAG TGAATTCAAA CAACTTGAAG CTCAATTTCT GGAAATCTCC CTCCTCCTTC 
AATCGGCCTG TGGATGTCCT GGTCCCATCT GTCAGTCTGC AGGCATTTAA ATCCTTCCTG 
AGATCCCAGG GCTTAGAGTA CGCAGTGACA ATTGAGGACC TGCAGGCCCT TTTAGACAAT 
GAAGATGATG AAATGCAACA CAATGAAGGG CAAGAACGGA GCAGTAATAA CTTCAACTAC 
GGGGCTTACC ATTCCCTGGA AGCTATTTAC CACGAGATGG ACAACATTGC CGCAGACTTT 
CCTGACCTGG CGAGGAGGGT GAAGATTGGA CATTCGTTTG AAAACCGGCC GATGTATGTA 
CTGAAGTTCA GCACTGGGAA AGGCGTGAGG CGGCCGGCCG TTTGGCTGAA TGCAGGCATC 
CATTCCCGAG AGTGGATCTC CCAGGCCACT GCAATCTGGA CGGCAAGGAA GATTGTATCT 
GATTACCAGA GGGATCCAGC TATCACCTCC ATCTTGGAGA AAATGGATAT TTTCTTGTTG 
CCTGTGGCCA ATCCTGATGG ATATGTGTAT ACTCAAACTC AAAACCGATT ATGGAGGAAG 
ACGCGGTCCC GAAATCCTGG AAGCTCCTGC ATTGGTGCTG ACCCAAATAG AAACTGGAAC 
GCTAGTTTTG CAGGAAAGGG AGCCAGCGAC AACCCTTGCT CCGAAGTGTA CCATGGACCC 
CACGCCAATT CGGAAGTGGA GGTGAAATCA GTGGTAGATT TCATCCAAAA ACATGGGAAT 
TTCAAGGGCT TCATCGACCT GCACAGCTAC TCGCAGCTGC TGATGTATCC ATATGGGTAC 
TCAGTCAAAA AGGCCCCAGA TGCCGAGGAA CTCGACAAGG TGGCGAGGCT TGCGGCCAAA 
GCTCTGGCTT CTGTGTCGGG CACTGAGTAC CAAGTGGGTC CCACCTGCAC CACTGTCTAT 
CCAGCTAGCG GGAGCAGCAT CGACTGGGCG TATGACAACG GCATCAAATT TGCATTCACA 
TTTGAGTTGA GAGATACCGG GACCTATGGC TTCCTCCTGC CAGCTAACCA GATCATCCCC 
ACTGCAGAGG AGACGTGGCT GGGGCTGAAG ACCATCATGG AGCATGTGCG GGACAACCTC 
TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CPA4 ( NM_001163446.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001156918.1 Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08298
Clone ID Related Accession (Same CDS sequence)	NM_001163446.1
Accession Version	NM_001163446.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	carboxypeptidase A4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368360.1, AK298550.1 and AC024085.5. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. The encoded isoform (2) lacks a portion of the activation peptide and the carboxypeptidase A4 chain, and lacks the intervening cleavage site compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298550.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 12552318 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGTGGA TACTGTTCAT TGGGGCCCTT ATTGGGTCCA GCATCTGTGG CCAAGAAAAA 
TTTTTTGGGG ACCAAGTTTT GAGGATTAAT GTCAGAAATG GAGACGAGAT CAGCAAATTG 
AGTCAACTAG TGAATTCAAA CAACTTGAAG CTCAATTTCT GGAAATCTCC CTCCTCCTTC 
AATCGGCCTG TGGATGTCCT GGTCCCATCT GTCAGTCTGC AGGCATTTAA ATCCTTCCTG 
AGATCCCAGG GCTTAGAGTA CGCAGTGACA ATTGAGGACC TGCAGATTTA CCACGAGATG 
GACAACATTG CCGCAGACTT TCCTGACCTG GCGAGGAGGG TGAAGATTGG ACATTCGTTT 
GAAAACCGGC CGATGTATGT ACTGAAGTTC AGCACTGGGA AAGGCGTGAG GCGGCCGGCC 
GTTTGGCTGA ATGCAGGCAT CCATTCCCGA GAGTGGATCT CCCAGGCCAC TGCAATCTGG 
ACGGCAAGGA AGATTGTATC TGATTACCAG AGGGATCCAG CTATCACCTC CATCTTGGAG 
AAAATGGATA TTTTCTTGTT GCCTGTGGCC AATCCTGATG GATATGTGTA TACTCAAACT 
CAAAACCGAT TATGGAGGAA GACGCGGTCC CGAAATCCTG GAAGCTCCTG CATTGGTGCT 
GACCCAAATA GAAACTGGAA CGCTAGTTTT GCAGGAAAGG GAGCCAGCGA CAACCCTTGC 
TCCGAAGTGT ACCATGGACC CCACGCCAAT TCGGAAGTGG AGGTGAAATC AGTGGTAGAT 
TTCATCCAAA AACATGGGAA TTTCAAGGGC TTCATCGACC TGCACAGCTA CTCGCAGCTG 
CTGATGTATC CATATGGGTA CTCAGTCAAA AAGGCCCCAG ATGCCGAGGA ACTCGACAAG 
GTGGCGAGGC TTGCGGCCAA AGCTCTGGCT TCTGTGTCGG GCACTGAGTA CCAAGTGGGT 
CCCACCTGCA CCACTGTCTA TCCAGCTAGC GGGAGCAGCA TCGACTGGGC GTATGACAAC 
GGCATCAAAT TTGCATTCAC ATTTGAGTTG AGAGATACCG GGACCTATGG CTTCCTCCTG 
CCAGCTAACC AGATCATCCC CACTGCAGAG GAGACGTGGC TGGGGCTGAA GACCATCATG 
GAGCATGTGC GGGACAACCT CTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156918.1
CDS	48..1214
Translation	MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY

Target ORF information:

RefSeq Version	NM_001163446.1
Organism	Homo sapiens(human)
Definition	Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163446.1

ORF Insert Sequence:

ATGAGGTGGA TACTGTTCAT TGGGGCCCTT ATTGGGTCCA GCATCTGTGG CCAAGAAAAA 
TTTTTTGGGG ACCAAGTTTT GAGGATTAAT GTCAGAAATG GAGACGAGAT CAGCAAATTG 
AGTCAACTAG TGAATTCAAA CAACTTGAAG CTCAATTTCT GGAAATCTCC CTCCTCCTTC 
AATCGGCCTG TGGATGTCCT GGTCCCATCT GTCAGTCTGC AGGCATTTAA ATCCTTCCTG 
AGATCCCAGG GCTTAGAGTA CGCAGTGACA ATTGAGGACC TGCAGATTTA CCACGAGATG 
GACAACATTG CCGCAGACTT TCCTGACCTG GCGAGGAGGG TGAAGATTGG ACATTCGTTT 
GAAAACCGGC CGATGTATGT ACTGAAGTTC AGCACTGGGA AAGGCGTGAG GCGGCCGGCC 
GTTTGGCTGA ATGCAGGCAT CCATTCCCGA GAGTGGATCT CCCAGGCCAC TGCAATCTGG 
ACGGCAAGGA AGATTGTATC TGATTACCAG AGGGATCCAG CTATCACCTC CATCTTGGAG 
AAAATGGATA TTTTCTTGTT GCCTGTGGCC AATCCTGATG GATATGTGTA TACTCAAACT 
CAAAACCGAT TATGGAGGAA GACGCGGTCC CGAAATCCTG GAAGCTCCTG CATTGGTGCT 
GACCCAAATA GAAACTGGAA CGCTAGTTTT GCAGGAAAGG GAGCCAGCGA CAACCCTTGC 
TCCGAAGTGT ACCATGGACC CCACGCCAAT TCGGAAGTGG AGGTGAAATC AGTGGTAGAT 
TTCATCCAAA AACATGGGAA TTTCAAGGGC TTCATCGACC TGCACAGCTA CTCGCAGCTG 
CTGATGTATC CATATGGGTA CTCAGTCAAA AAGGCCCCAG ATGCCGAGGA ACTCGACAAG 
GTGGCGAGGC TTGCGGCCAA AGCTCTGGCT TCTGTGTCGG GCACTGAGTA CCAAGTGGGT 
CCCACCTGCA CCACTGTCTA TCCAGCTAGC GGGAGCAGCA TCGACTGGGC GTATGACAAC 
GGCATCAAAT TTGCATTCAC ATTTGAGTTG AGAGATACCG GGACCTATGG CTTCCTCCTG 
CCAGCTAACC AGATCATCCC CACTGCAGAG GAGACGTGGC TGGGGCTGAA GACCATCATG 
GAGCATGTGC GGGACAACCT CTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) - a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity.
Growth factors (Chur, Switzerland)34(5-6)210-216(2016 Dec)
He J,Chen DL,Samocha-Bonet D,Gillinder KR,Barclay JL,Magor GW,Perkins AC,Greenfield JR,Yang G,Whitehead JP

Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma.
Oncotarget7(48)78688-78697(2016 Nov)
Sun L,Guo C,Burnett J,Yang Z,Ran Y,Sun D

A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4.
Structure (London, England : 1993)21(7)1118-26(2013 Jul)
Alonso del Rivero M,Reytor ML,Trejo SA,Ch?vez MA,Avil?s FX,Reverter D

Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4.
The Journal of biological chemistry287(12)9250-8(2012 Mar)
Covaleda G,del Rivero MA,Ch?vez MA,Avil?s FX,Reverter D

Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.
The Journal of biological chemistry285(24)18385-96(2010 Jun)
Tanco S,Zhang X,Morano C,Avil?s FX,Lorenzo J,Fricker LD

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CPA4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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