CHCHD2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHCHD2
Entrez Gene ID	51142
Full Name	coiled-coil-helix-coiled-coil-helix domain containing 2
Synonyms	C7orf17,MNRR1,NS2TP,PARK22
General protein information	Preferred Names coiled-coil-helix-coiled-coil-helix domain containing 2 Names coiled-coil-helix-coiled-coil-helix domain-containing protein 2 16.7kD protein HCV NS2 trans-regulated protein aging-associated gene 10 protein coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial mitochondria nuclear retrograde regulator 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p11.2
Summary	The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Disorder MIM:	616244
Disorder Html:	Parkinson disease 22, autosomal dominant, 616710 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016139.3	NP_057223.1	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor isoform 2
NM_016139.4	NP_057223.1	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor isoform 2
NM_016139.2	NP_057223.1	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor
NM_001320327.1	NP_001307256.1	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor isoform 1

Pathways from BioSystems

Homologies

	LOC701053	XP_001089355.2
Gallus gallus (chicken)	CHCHD2	NP_001006218.1
Pan troglodytes (chimpanzee)	CHCHD2	XP_001161277.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000897	XP_316875.5
Rattus norvegicus (Norway rat)	Chchd2	NP_001015019.1
	CHCHD2	XP_001089512.1
Canis lupus familiaris (dog)	CHCHD2	XP_536830.2
Bos taurus (cattle)	CHCHD2	NP_001029918.1
Drosophila melanogaster (fruit fly)	CG5010	NP_573196.1
Xenopus tropicalis (tropical clawed frog)	agpat9	NP_001008432.1
Homo sapiens (human)	CHCHD2	NP_057223.1
Mus musculus (house mouse)	Gm13202	XP_485502.1
Mus musculus (house mouse)	Chchd2	NP_077128.2
Rattus norvegicus (Norway rat)	LOC100911516	XP_003750791.1
Danio rerio (zebrafish)	chchd2	NP_957061.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic analysis of CHCHD2 and CHCHD10 in Italian patients with Parkinson's disease.
Rubino E, Brusa L, Zhang M, Boschi S, Govone F, Vacca A, Gai A, Pinessi L, Lopiano L, Rogaeva E, Rainero I
Neurobiology of aging53193.e7-193.e8(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Its mutation is not arelevant cause of Parkinson's disease in Italian population.
Title: Genetic analysis of CHCHD2 and CHCHD10 in Italian patients with Parkinson's disease.

A family with Charcot-Marie-Tooth disease type 1A with an exaggerated phenotype harbors a Q112H mutation in MNRR1, located in a domain that is necessary for transcriptional activation by MNRR1
Title: Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.

CHCHD2 is probably not involved in the etiopathogenesis of PD in a southern Spanish population.
Title: Genetic analysis of CHCHD2 in a southern Spanish population.

CHCHD2 mutations might not be the common cause of PD in South Italy.
Title: Analysis of CHCHD2 gene in familial Parkinson's disease from Calabria.

CHCHD2 gene may not play a major role in our familial Chinese Han essential-tremor and Parkinson's disease patients.
Title: Mutation analysis of CHCHD2 gene in Chinese Han familial essential tremor patients and familial Parkinson's disease patients.

The following CHCHD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHCHD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08881	NM_016139.4 Latest version!	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu101696	NM_001320327.1 Latest version!	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu08881	NM_016139.3	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08881	NM_016139.2	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHCHD2 ( NM_016139.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057223.1 Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08881
Clone ID Related Accession (Same CDS sequence)	NM_016139.3 , NM_016139.4 , NM_016139.2
Accession Version	NM_016139.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006970.6, DB442753.1, BC003079.2, BC015639.2 and AI218619.1. On Feb 20, 2016 this sequence version replaced NM_016139.2. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279867.1602.1, SRR1163655.664802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGATTG GCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057223.1
CDS	218..673
Translation	MPRGSRSRTSRMAPPASRAPQMRAAPRPAPVAQPPAAAPPSAVGSSAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPARPDITYQEPQGTQPAQQQQPCLYEIKQFLECAQNQGDIKLCEGFNEVLKQCRLANGLA

Target ORF information:

RefSeq Version	NM_016139.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016139.3

ORF Insert Sequence:

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGATTG GCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHCHD2 ( NM_016139.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057223.1 Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08881
Clone ID Related Accession (Same CDS sequence)	NM_016139.3 , NM_016139.4 , NM_016139.2
Accession Version	NM_016139.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB442753.1 and BC003079.2. On Nov 22, 2018 this sequence version replaced NM_016139.3. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.167857.1, SRR1163655.201422.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000395422.4/ ENSP00000378812.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGATTG GCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057223.1
CDS	64..519
Translation	MPRGSRSRTSRMAPPASRAPQMRAAPRPAPVAQPPAAAPPSAVGSSAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPARPDITYQEPQGTQPAQQQQPCLYEIKQFLECAQNQGDIKLCEGFNEVLKQCRLANGLA

Target ORF information:

RefSeq Version	NM_016139.4
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016139.4

ORF Insert Sequence:

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGATTG GCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHCHD2 ( NM_016139.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057223.1 Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), mRNA.

Price & Availability↑

CloneID	OHu08881
Clone ID Related Accession (Same CDS sequence)	NM_016139.3 , NM_016139.4 , NM_016139.2
Accession Version	NM_016139.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-06-28
Organism	Homo sapiens(Human)
Product	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor
Comment

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGATTG GCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057223.1
Translation	MPRGSRSRTSRMAPPASRAPQMRAAPRPAPVAQPPAAAPPSAVGSSAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPARPDITYQEPQGTQPAQQQQPCLYEIKQFLECAQNQGDIKLCEGFNEVLKQCRLANGLA

Target ORF information:

RefSeq Version	NM_016139.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016139.2

ORF Insert Sequence:

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGATTG GCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHCHD2 ( NM_001320327.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307256.1 Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu101696
Clone ID Related Accession (Same CDS sequence)	NM_001320327.1
Accession Version	NM_001320327.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006970.6, DB442753.1, CN363208.1, AA398444.1 and AI218619.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.574731.1, CN363208.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGTAGG ATTGGCCTAA TGAAGAAGTT CAACCTGGAG 
AGATGGAAAA TCAGCTCTCA TAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307256.1
CDS	218..724
Translation	MPRGSRSRTSRMAPPASRAPQMRAAPRPAPVAQPPAAAPPSAVGSSAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPARPDITYQEPQGTQPAQQQQPCLYEIKQFLECAQNQGDIKLCEGFNEVLKQCRLANGRIGLMKKFNLERWKISSHN

Target ORF information:

RefSeq Version	NM_001320327.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320327.1

ORF Insert Sequence:

ATGCCGCGTG GAAGCCGAAG CCGCACCTCC CGCATGGCCC CTCCGGCCAG CCGGGCCCCT 
CAGATGAGAG CTGCACCCAG GCCAGCACCA GTCGCTCAGC CACCAGCAGC GGCACCCCCA 
TCTGCAGTTG GCTCTTCTGC TGCTGCGCCC CGGCAGCCAG GTCTGATGGC CCAGATGGCA 
ACCACTGCAG CTGGCGTGGC TGTGGGCTCT GCTGTGGGGC ACACATTGGG TCACGCCATT 
ACTGGGGGCT TCAGTGGAGG AAGTAATGCT GAGCCTGCGA GGCCTGACAT CACTTACCAG 
GAGCCTCAGG GAACCCAGCC AGCACAGCAG CAGCAGCCTT GCCTCTATGA GATCAAACAG 
TTTCTGGAGT GTGCCCAGAA CCAGGGTGAC ATCAAGCTCT GTGAGGGTTT CAATGAGGTG 
CTGAAACAGT GCCGACTTGC AAACGGTAGG ATTGGCCTAA TGAAGAAGTT CAACCTGGAG 
AGATGGAAAA TCAGCTCTCA TAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic analysis of CHCHD2 and CHCHD10 in Italian patients with Parkinson's disease.
Neurobiology of aging53193.e7-193.e8(2017 05)
Rubino E,Brusa L,Zhang M,Boschi S,Govone F,Vacca A,Gai A,Pinessi L,Lopiano L,Rogaeva E,Rainero I

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CHCHD2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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