CUTC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CUTC
Entrez Gene ID	51076
Full Name	cutC copper transporter
Synonyms	CGI-32
General protein information	Preferred Names cutC copper transporter Names copper homeostasis protein cutC homolog cutC copper transporter homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.2
Summary	Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610101

mRNA and Protein(s)

mRNA	Protein	Name
NM_015960.2	NP_057044.2	copper homeostasis protein cutC homolog
NM_015960.3	NP_057044.2	copper homeostasis protein cutC homolog

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG6136	NP_001189224.1
Caenorhabditis elegans (roundworm)	cutc-1	NP_498855.1
	CUTC	XP_001106529.1
Xenopus tropicalis (tropical clawed frog)	cutc	NP_001011220.1
Homo sapiens (human)	CUTC	NP_057044.2
Pan troglodytes (chimpanzee)	CUTC	XP_003312774.1
Canis lupus familiaris (dog)	CUTC	XP_534987.2
Rattus norvegicus (Norway rat)	Cutc	NP_001101995.1
Gallus gallus (chicken)	CUTC	NP_001006503.1
Danio rerio (zebrafish)	cutc	NP_001006046.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002402	XP_312550.4
Bos taurus (cattle)	CUTC	NP_001193825.1
Mus musculus (house mouse)	Cutc	NP_001107034.1

Gene Ontology
Bibliography

Related articles in PubMed

Silencing of Human CutC Gene (hCutC) Induces Apoptosis in HepG2 Cells.
Kunjunni R, Sathianathan S, Behari M, Chattopadhyay P, Subbiah V
Biological trace element research172(1)120-6(2016 Jul)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I
PLoS genetics8(3)e1002559(2012)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

present study reveals copper induced damage in cells upon hCutC silencing and provides evidence for the role of hCutC protein in intracellular copper homeostasis
Title: Silencing of Human CutC Gene (hCutC) Induces Apoptosis in HepG2 Cells.

Results suggest that hCutC functions as an enzyme with Cu(I) as a cofactor rather than a copper transporter and the potential Cu(I)-binding site consists of the two Cys residues and other conserved residues in the vicinity.
Title: Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site.

Cloning, expression and subcellular localization of CutC.
Title: Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC.

The following CUTC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CUTC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13504	NM_015960.3 Latest version!	Homo sapiens cutC copper transporter (CUTC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu13504	NM_015960.2	Homo sapiens cutC copper transporter (CUTC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CUTC ( NM_015960.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057044.2 Homo sapiens cutC copper transporter (CUTC), mRNA.

Price & Availability↑

CloneID	OHu13504
Clone ID Related Accession (Same CDS sequence)	NM_015960.2 , NM_015960.3
Accession Version	NM_015960.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	copper homeostasis protein cutC homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD107559.1, BC011016.1 and BM738181.1. On Jun 5, 2007 this sequence version replaced NM_015960.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.382111.1, SRR1803611.182915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAAAAGGC AGGGGGCCTC CTCTGAGCGA AAACGAGCGC GGATACCGTC CGGGAAGGCC 
GGAGCAGCAA ATGGATTTCT CATGGAAGTT TGTGTTGATT CAGTGGAATC AGCTGTGAAT 
GCAGAAAGAG GAGGTGCTGA TCGGATTGAA TTATGTTCTG GTTTATCAGA GGGGGGAACT 
ACACCCAGCA TGGGTGTCCT TCAAGTAGTG AAGCAGAGTG TTCAGATCCC AGTTTTTGTG 
ATGATTCGGC CACGGGGAGG TGATTTTTTG TATTCAGATC GTGAAATTGA GGTGATGAAG 
GCTGACATTC GTCTTGCCAA GCTTTATGGT GCTGATGGTT TGGTTTTTGG GGCATTGACT 
GAAGATGGAC ACATTGACAA AGAGCTGTGT ATGTCCCTTA TGGCTATTTG CCGCCCTCTG 
CCAGTCACTT TCCACCGAGC CTTTGACATG GTTCATGATC CAATGGCAGC TCTGGAGACC 
CTCTTAACCT TGGGATTTGA ACGCGTGTTG ACCAGTGGAT GTGACAGTTC AGCATTAGAA 
GGGCTACCCC TAATAAAGCG ACTCATTGAG CAGGCAAAAG GCAGGATTGT GGTAATGCCA 
GGAGGTGGTA TAACAGACAG AAATCTACAA AGGATCCTTG AGGGTTCAGG TGCTACAGAA 
TTCCACTGTT CTGCTCGGTC TACTAGAGAC TCGGGAATGA AGTTTCGAAA TTCATCTGTT 
GCCATGGGAG CCTCACTTTC TTGCTCAGAA TATTCCCTAA AGGTAACAGA TGTGACCAAA 
GTAAGGACTT TGAATGCTAT CGCAAAGAAC ATCCTGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057044.2
CDS	149..970
Translation	MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV

Target ORF information:

RefSeq Version	NM_015960.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cutC copper transporter (CUTC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015960.2

ORF Insert Sequence:

ATGAAAAGGC AGGGGGCCTC CTCTGAGCGA AAACGAGCGC GGATACCGTC CGGGAAGGCC 
GGAGCAGCAA ATGGATTTCT CATGGAAGTT TGTGTTGATT CAGTGGAATC AGCTGTGAAT 
GCAGAAAGAG GAGGTGCTGA TCGGATTGAA TTATGTTCTG GTTTATCAGA GGGGGGAACT 
ACACCCAGCA TGGGTGTCCT TCAAGTAGTG AAGCAGAGTG TTCAGATCCC AGTTTTTGTG 
ATGATTCGGC CACGGGGAGG TGATTTTTTG TATTCAGATC GTGAAATTGA GGTGATGAAG 
GCTGACATTC GTCTTGCCAA GCTTTATGGT GCTGATGGTT TGGTTTTTGG GGCATTGACT 
GAAGATGGAC ACATTGACAA AGAGCTGTGT ATGTCCCTTA TGGCTATTTG CCGCCCTCTG 
CCAGTCACTT TCCACCGAGC CTTTGACATG GTTCATGATC CAATGGCAGC TCTGGAGACC 
CTCTTAACCT TGGGATTTGA ACGCGTGTTG ACCAGTGGAT GTGACAGTTC AGCATTAGAA 
GGGCTACCCC TAATAAAGCG ACTCATTGAG CAGGCAAAAG GCAGGATTGT GGTAATGCCA 
GGAGGTGGTA TAACAGACAG AAATCTACAA AGGATCCTTG AGGGTTCAGG TGCTACAGAA 
TTCCACTGTT CTGCTCGGTC TACTAGAGAC TCGGGAATGA AGTTTCGAAA TTCATCTGTT 
GCCATGGGAG CCTCACTTTC TTGCTCAGAA TATTCCCTAA AGGTAACAGA TGTGACCAAA 
GTAAGGACTT TGAATGCTAT CGCAAAGAAC ATCCTGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CUTC ( NM_015960.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057044.2 Homo sapiens cutC copper transporter (CUTC), mRNA.

Price & Availability↑

CloneID	OHu13504
Clone ID Related Accession (Same CDS sequence)	NM_015960.2 , NM_015960.3
Accession Version	NM_015960.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	copper homeostasis protein cutC homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD107559.1, BC011016.1 and BM738181.1. On Nov 23, 2018 this sequence version replaced NM_015960.2. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.263541.1, SRR1803611.256703.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370476.10/ ENSP00000359507.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAAGGC AGGGGGCCTC CTCTGAGCGA AAACGAGCGC GGATACCGTC CGGGAAGGCC 
GGAGCAGCAA ATGGATTTCT CATGGAAGTT TGTGTTGATT CAGTGGAATC AGCTGTGAAT 
GCAGAAAGAG GAGGTGCTGA TCGGATTGAA TTATGTTCTG GTTTATCAGA GGGGGGAACT 
ACACCCAGCA TGGGTGTCCT TCAAGTAGTG AAGCAGAGTG TTCAGATCCC AGTTTTTGTG 
ATGATTCGGC CACGGGGAGG TGATTTTTTG TATTCAGATC GTGAAATTGA GGTGATGAAG 
GCTGACATTC GTCTTGCCAA GCTTTATGGT GCTGATGGTT TGGTTTTTGG GGCATTGACT 
GAAGATGGAC ACATTGACAA AGAGCTGTGT ATGTCCCTTA TGGCTATTTG CCGCCCTCTG 
CCAGTCACTT TCCACCGAGC CTTTGACATG GTTCATGATC CAATGGCAGC TCTGGAGACC 
CTCTTAACCT TGGGATTTGA ACGCGTGTTG ACCAGTGGAT GTGACAGTTC AGCATTAGAA 
GGGCTACCCC TAATAAAGCG ACTCATTGAG CAGGCAAAAG GCAGGATTGT GGTAATGCCA 
GGAGGTGGTA TAACAGACAG AAATCTACAA AGGATCCTTG AGGGTTCAGG TGCTACAGAA 
TTCCACTGTT CTGCTCGGTC TACTAGAGAC TCGGGAATGA AGTTTCGAAA TTCATCTGTT 
GCCATGGGAG CCTCACTTTC TTGCTCAGAA TATTCCCTAA AGGTAACAGA TGTGACCAAA 
GTAAGGACTT TGAATGCTAT CGCAAAGAAC ATCCTGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057044.2
CDS	116..937
Translation	MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV

Target ORF information:

RefSeq Version	NM_015960.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cutC copper transporter (CUTC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015960.3

ORF Insert Sequence:

ATGAAAAGGC AGGGGGCCTC CTCTGAGCGA AAACGAGCGC GGATACCGTC CGGGAAGGCC 
GGAGCAGCAA ATGGATTTCT CATGGAAGTT TGTGTTGATT CAGTGGAATC AGCTGTGAAT 
GCAGAAAGAG GAGGTGCTGA TCGGATTGAA TTATGTTCTG GTTTATCAGA GGGGGGAACT 
ACACCCAGCA TGGGTGTCCT TCAAGTAGTG AAGCAGAGTG TTCAGATCCC AGTTTTTGTG 
ATGATTCGGC CACGGGGAGG TGATTTTTTG TATTCAGATC GTGAAATTGA GGTGATGAAG 
GCTGACATTC GTCTTGCCAA GCTTTATGGT GCTGATGGTT TGGTTTTTGG GGCATTGACT 
GAAGATGGAC ACATTGACAA AGAGCTGTGT ATGTCCCTTA TGGCTATTTG CCGCCCTCTG 
CCAGTCACTT TCCACCGAGC CTTTGACATG GTTCATGATC CAATGGCAGC TCTGGAGACC 
CTCTTAACCT TGGGATTTGA ACGCGTGTTG ACCAGTGGAT GTGACAGTTC AGCATTAGAA 
GGGCTACCCC TAATAAAGCG ACTCATTGAG CAGGCAAAAG GCAGGATTGT GGTAATGCCA 
GGAGGTGGTA TAACAGACAG AAATCTACAA AGGATCCTTG AGGGTTCAGG TGCTACAGAA 
TTCCACTGTT CTGCTCGGTC TACTAGAGAC TCGGGAATGA AGTTTCGAAA TTCATCTGTT 
GCCATGGGAG CCTCACTTTC TTGCTCAGAA TATTCCCTAA AGGTAACAGA TGTGACCAAA 
GTAAGGACTT TGAATGCTAT CGCAAAGAAC ATCCTGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Silencing of Human CutC Gene (hCutC) Induces Apoptosis in HepG2 Cells.
Biological trace element research172(1)120-6(2016 Jul)
Kunjunni R,Sathianathan S,Behari M,Chattopadhyay P,Subbiah V

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
PLoS genetics8(3)e1002559(2012)
Kenny EE,Pe'er I,Karban A,Ozelius L,Mitchell AA,Ng SM,Erazo M,Ostrer H,Abraham C,Abreu MT,Atzmon G,Barzilai N,Brant SR,Bressman S,Burns ER,Chowers Y,Clark LN,Darvasi A,Doheny D,Duerr RH,Eliakim R,Giladi N,Gregersen PK,Hakonarson H,Jones MR,Marder K,McGovern DP,Mulle J,Orr-Urtreger A,Proctor DD,Pulver A,Rotter JI,Silverberg MS,Ullman T,Warren ST,Waterman M,Zhang W,Bergman A,Mayer L,Katz S,Desnick RJ,Cho JH,Peter I

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

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CUTC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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