YARS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	YARS2
Entrez Gene ID	51067
Full Name	tyrosyl-tRNA synthetase 2
Synonyms	CGI-04,MLASA2,MT-TYRRS,TYRRS
General protein information	Preferred Names tyrosyl-tRNA synthetase 2 Names tyrosine--tRNA ligase, mitochondrial tyrosine tRNA ligase 2, mitochondrial tyrosyl-tRNA synthetase 2, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p11.21
Summary	This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011].
Disorder MIM:	610957
Disorder Html:	Myopathy, lactic acidosis, and sideroblastic anemia 2, 613561 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040436.3	NP_001035526.1	tyrosine--tRNA ligase, mitochondrial precursor
NM_001040436.2	NP_001035526.1	tyrosine--tRNA ligase, mitochondrial precursor

Pathways from BioSystems

Homologies

	LOC697033	XP_001085644.1
Canis lupus familiaris (dog)	YARS2	XP_543740.1
Bos taurus (cattle)	YARS2	NP_001091557.1
Drosophila melanogaster (fruit fly)	CG16912	NP_611967.1
Saccharomyces cerevisiae (baker's yeast)	MSY1	NP_015228.1
Schizosaccharomyces pombe (fission yeast)	SPCC576.06c	NP_588433.1
Homo sapiens (human)	YARS2	NP_001035526.1
Anopheles gambiae (African malaria mosquito)	TTRNA1	XP_311148.3
Caenorhabditis elegans (roundworm)	yars-1	NP_741382.1
Kluyveromyces lactis	KLLA0E24267g	XP_455044.1
Neurospora crassa	NCU03030	XP_965416.1
Oryza sativa (rice)	Os01g0500900	NP_001043131.1
Xenopus tropicalis (tropical clawed frog)	yars2	XP_002942334.2
Pan troglodytes (chimpanzee)	YARS2	XP_528727.1
Danio rerio (zebrafish)	LOC100534736	XP_003201421.1
Danio rerio (zebrafish)	yars2	NP_001137392.1
Mus musculus (house mouse)	Yars2	NP_937889.1
Rattus norvegicus (Norway rat)	Yars2	NP_001009627.1
Gallus gallus (chicken)	YARS2	XP_416363.2
Eremothecium gossypii	AGOS_ABR192W	NP_983140.2
Magnaporthe oryzae (rice blast fungus)	MGG_00665	XP_003718351.1
Arabidopsis thaliana (thale cress)	emb2768	NP_186915.1

Gene Ontology
Bibliography

Related articles in PubMed

Clinical Features, Molecular Heterogeneity, and Prognostic Implications in YARS2-Related Mitochondrial Myopathy.
Sommerville EW, Ng YS, Alston CL, Dallabona C, Gilberti M, He L, Knowles C, Chin SL, Schaefer AM, Falkous G, Murdoch D, Longman C, de Visser M, Bindoff LA, Rawles JM, Dean JCS, Petty RK, Farrugia ME, Haack TB, Prokisch H, McFarland R, Turnbull DM, Donnini C, Taylor RW, Gorman GS
JAMA neurology74(6)686-694(2017 Jun)

The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation.
Jiang P, Jin X, Peng Y, Wang M, Liu H, Liu X, Zhang Z, Ji Y, Zhang J, Liang M, Zhao F, Sun YH, Zhang M, Zhou X, Chen Y, Mo JQ, Huang T, Qu J, Guan MX
Human molecular genetics25(3)584-96(2016 Feb)

Phenotypic variability and identification of novel YARS2 mutations in YARS2 mitochondrial myopathy, lactic acidosis and sideroblastic anaemia.
Riley LG, Menezes MJ, Rudinger-Thirion J, Duff R, de Lonlay P, Rotig A, Tchan MC, Davis M, Cooper ST, Christodoulou J
Orphanet journal of rare diseases8193(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The p.Leu392Ser variant is likely a newly identified founder YARS2 mutation in mitochondrial myopathy.
Title: Clinical Features, Molecular Heterogeneity, and Prognostic Implications in YARS2-Related Mitochondrial Myopathy.

The mutation in YARS2 gene is a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation.
Title: The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation.

Data identified novel YARS2 mutations and noted marked phenotypic variability among YARS2 MLASA patients, with phenotypes ranging from mild to lethal, suggesting that the background mtDNA haplotype may be contributing to the phenotypic variability.
Title: Phenotypic variability and identification of novel YARS2 mutations in YARS2 mitochondrial myopathy, lactic acidosis and sideroblastic anaemia.

The study confirms mutations in YARS2 as a cause of MLASA and shows that, like some of the cytoplasmic ARSs, mitochondrial ARSs occur in high-molecular-weight complexes.
Title: A novel mutation in YARS2 causes myopathy with lactic acidosis and sideroblastic anemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following YARS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YARS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18808	NM_001040436.3 Latest version!	Homo sapiens tyrosyl-tRNA synthetase 2 (YARS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$204.50-$286.30 $409.00
View Old Accession Versions >>
OHu18808	NM_001040436.2	Homo sapiens tyrosyl-tRNA synthetase 2 (YARS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$204.50-$286.30 $409.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

YARS2 ( NM_001040436.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035526.1 Homo sapiens tyrosyl-tRNA synthetase 2 (YARS2), mRNA.

Price & Availability↑

CloneID	OHu18808
Clone ID Related Accession (Same CDS sequence)	NM_001040436.3 , NM_001040436.2
Accession Version	NM_001040436.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA748673.1, BC015625.2, BM979973.1, EB386795.1 and AI861961.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001040436.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.20663.1, SRR7410570.498135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000324868.13/ ENSP00000320658.8 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC CCATCTTGCG GTCCTTTTCC TGGGGCCGGT GGTCTGGTAC CCTAAATCTC 
TCAGTATTGT TGCCCTTGGG GCTGCGTAAG GCCCACTCGG GCGCTCAGGG GTTACTGGCA 
GCGCAGAAGG CTCGAGGTCT GTTCAAGGAC TTCTTCCCGG AGACGGGGAC GAAAATAGAG 
CTCCCAGAGC TCTTCGACCG TGGCACGGCG AGTTTTCCCC AAACCATTTA CTGTGGCTTC 
GACCCCACGG CAGACTCGCT TCATGTGGGT CATCTACTTG CGCTGCTGGG CCTGTTTCAT 
TTGCAGCGAG CGGGCCACAA CGTGATCGCG CTGGTGGGAG GCGCCACGGC GCGCCTGGGA 
GACCCGAGCG GCCGTACCAA GGAACGCGAG GCGCTGGAGA CAGAGCGCGT GCGAGCCAAC 
GCGCGAGCTC TGCGCCTAGG GCTTGAGGCC CTGGCGGCTA ATCACCAGCA GCTTTTCACT 
GATGGGCGCT CCTGGGGCAG CTTCACTGTG CTGGACAACT CGGCCTGGTA CCAGAAGCAG 
CACCTGGTGG ACTTCCTGGC GGCAGTGGGG GGTCACTTCC GCATGGGGAC GCTGCTGAGC 
CGGCAGAGCG TGCAGCTGCG GCTCAAGAGC CCCGAGGGCA TGAGCTTGGC CGAGTTCTTT 
TACCAGGTGC TCCAGGCCTA TGACTTCTAT TACCTCTTCC AGCGTTATGG ATGCAGGGTC 
CAGCTGGGCG GATCTGATCA ACTAGGCAAC ATCATGTCCG GATATGAGTT CATCAACAAG 
TTGACTGGAG AAGATGTATT TGGAATCACC GTTCCTCTAA TTACAAGTAC AACTGGAGCA 
AAGCTGGGAA AGTCTGCTGG CAACGCTGTT TGGCTAAACA GAGATAAGAC ATCTCCATTT 
GAATTGTATC AATTCTTTGT CAGGCAACCG GACGATTCAG TGGAAAGGTA CCTGAAGCTG 
TTCACTTTCC TGCCCCTTCC AGAGATTGAT CATATCATGC AGCTGCATGT CAAAGAGCCA 
GAAAGGCGGG GTCCTCAGAA ACGACTGGCA GCAGAAGTAA CAAAGCTTGT TCATGGACGA 
GAAGGATTGG ATTCTGCTAA AAGGTGTACA CAAGCCCTTT ATCACAGTAG CATAGATGCA 
CTGGAGGTCA TGTCTGATCA GGAGTTAAAA GAGTTGTTTA AAGAAGCTCC ATTTTCTGAA 
TTTTTTCTCG ATCCTGGAAC AAGTGTCCTA GATACTTGCC GCAAAGCAAA TGCCATTCCA 
GATGGTCCCC GAGGGTATCG AATGATAACA GAAGGCGGAG TCAGCATAAA TCACCAACAA 
GTAACAAATC CTGAGAGTGT TTTAATTGTT GGACAACATA TTCTCAAGAA TGGACTTTCC 
TTACTTAAAA TAGGAAAAAG AAATTTCTAC ATTATAAAAT GGCTTCAGTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035526.1
CDS	24..1457
Translation	MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL

Target ORF information:

RefSeq Version	NM_001040436.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase 2 (YARS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040436.3

ORF Insert Sequence:

ATGGCGGCGC CCATCTTGCG GTCCTTTTCC TGGGGCCGGT GGTCTGGTAC CCTAAATCTC 
TCAGTATTGT TGCCCTTGGG GCTGCGTAAG GCCCACTCGG GCGCTCAGGG GTTACTGGCA 
GCGCAGAAGG CTCGAGGTCT GTTCAAGGAC TTCTTCCCGG AGACGGGGAC GAAAATAGAG 
CTCCCAGAGC TCTTCGACCG TGGCACGGCG AGTTTTCCCC AAACCATTTA CTGTGGCTTC 
GACCCCACGG CAGACTCGCT TCATGTGGGT CATCTACTTG CGCTGCTGGG CCTGTTTCAT 
TTGCAGCGAG CGGGCCACAA CGTGATCGCG CTGGTGGGAG GCGCCACGGC GCGCCTGGGA 
GACCCGAGCG GCCGTACCAA GGAACGCGAG GCGCTGGAGA CAGAGCGCGT GCGAGCCAAC 
GCGCGAGCTC TGCGCCTAGG GCTTGAGGCC CTGGCGGCTA ATCACCAGCA GCTTTTCACT 
GATGGGCGCT CCTGGGGCAG CTTCACTGTG CTGGACAACT CGGCCTGGTA CCAGAAGCAG 
CACCTGGTGG ACTTCCTGGC GGCAGTGGGG GGTCACTTCC GCATGGGGAC GCTGCTGAGC 
CGGCAGAGCG TGCAGCTGCG GCTCAAGAGC CCCGAGGGCA TGAGCTTGGC CGAGTTCTTT 
TACCAGGTGC TCCAGGCCTA TGACTTCTAT TACCTCTTCC AGCGTTATGG ATGCAGGGTC 
CAGCTGGGCG GATCTGATCA ACTAGGCAAC ATCATGTCCG GATATGAGTT CATCAACAAG 
TTGACTGGAG AAGATGTATT TGGAATCACC GTTCCTCTAA TTACAAGTAC AACTGGAGCA 
AAGCTGGGAA AGTCTGCTGG CAACGCTGTT TGGCTAAACA GAGATAAGAC ATCTCCATTT 
GAATTGTATC AATTCTTTGT CAGGCAACCG GACGATTCAG TGGAAAGGTA CCTGAAGCTG 
TTCACTTTCC TGCCCCTTCC AGAGATTGAT CATATCATGC AGCTGCATGT CAAAGAGCCA 
GAAAGGCGGG GTCCTCAGAA ACGACTGGCA GCAGAAGTAA CAAAGCTTGT TCATGGACGA 
GAAGGATTGG ATTCTGCTAA AAGGTGTACA CAAGCCCTTT ATCACAGTAG CATAGATGCA 
CTGGAGGTCA TGTCTGATCA GGAGTTAAAA GAGTTGTTTA AAGAAGCTCC ATTTTCTGAA 
TTTTTTCTCG ATCCTGGAAC AAGTGTCCTA GATACTTGCC GCAAAGCAAA TGCCATTCCA 
GATGGTCCCC GAGGGTATCG AATGATAACA GAAGGCGGAG TCAGCATAAA TCACCAACAA 
GTAACAAATC CTGAGAGTGT TTTAATTGTT GGACAACATA TTCTCAAGAA TGGACTTTCC 
TTACTTAAAA TAGGAAAAAG AAATTTCTAC ATTATAAAAT GGCTTCAGTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YARS2 ( NM_001040436.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035526.1 Homo sapiens tyrosyl-tRNA synthetase 2 (YARS2), mRNA.

Price & Availability↑

CloneID	OHu18808
Clone ID Related Accession (Same CDS sequence)	NM_001040436.3 , NM_001040436.2
Accession Version	NM_001040436.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA748673.1, BC015625.2, BM979973.1, EB386795.1 and AI861961.1. This sequence is a reference standard in the RefSeqGene project. On Jan 29, 2011 this sequence version replaced NM_001040436.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.3025.1, SRR1803616.20663.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC CCATCTTGCG GTCCTTTTCC TGGGGCCGGT GGTCTGGTAC CCTAAATCTC 
TCAGTATTGT TGCCCTTGGG GCTGCGTAAG GCCCACTCGG GCGCTCAGGG GTTACTGGCA 
GCGCAGAAGG CTCGAGGTCT GTTCAAGGAC TTCTTCCCGG AGACGGGGAC GAAAATAGAG 
CTCCCAGAGC TCTTCGACCG TGGCACGGCG AGTTTTCCCC AAACCATTTA CTGTGGCTTC 
GACCCCACGG CAGACTCGCT TCATGTGGGT CATCTACTTG CGCTGCTGGG CCTGTTTCAT 
TTGCAGCGAG CGGGCCACAA CGTGATCGCG CTGGTGGGAG GCGCCACGGC GCGCCTGGGA 
GACCCGAGCG GCCGTACCAA GGAACGCGAG GCGCTGGAGA CAGAGCGCGT GCGAGCCAAC 
GCGCGAGCTC TGCGCCTAGG GCTTGAGGCC CTGGCGGCTA ATCACCAGCA GCTTTTCACT 
GATGGGCGCT CCTGGGGCAG CTTCACTGTG CTGGACAACT CGGCCTGGTA CCAGAAGCAG 
CACCTGGTGG ACTTCCTGGC GGCAGTGGGG GGTCACTTCC GCATGGGGAC GCTGCTGAGC 
CGGCAGAGCG TGCAGCTGCG GCTCAAGAGC CCCGAGGGCA TGAGCTTGGC CGAGTTCTTT 
TACCAGGTGC TCCAGGCCTA TGACTTCTAT TACCTCTTCC AGCGTTATGG ATGCAGGGTC 
CAGCTGGGCG GATCTGATCA ACTAGGCAAC ATCATGTCCG GATATGAGTT CATCAACAAG 
TTGACTGGAG AAGATGTATT TGGAATCACC GTTCCTCTAA TTACAAGTAC AACTGGAGCA 
AAGCTGGGAA AGTCTGCTGG CAACGCTGTT TGGCTAAACA GAGATAAGAC ATCTCCATTT 
GAATTGTATC AATTCTTTGT CAGGCAACCG GACGATTCAG TGGAAAGGTA CCTGAAGCTG 
TTCACTTTCC TGCCCCTTCC AGAGATTGAT CATATCATGC AGCTGCATGT CAAAGAGCCA 
GAAAGGCGGG GTCCTCAGAA ACGACTGGCA GCAGAAGTAA CAAAGCTTGT TCATGGACGA 
GAAGGATTGG ATTCTGCTAA AAGGTGTACA CAAGCCCTTT ATCACAGTAG CATAGATGCA 
CTGGAGGTCA TGTCTGATCA GGAGTTAAAA GAGTTGTTTA AAGAAGCTCC ATTTTCTGAA 
TTTTTTCTCG ATCCTGGAAC AAGTGTCCTA GATACTTGCC GCAAAGCAAA TGCCATTCCA 
GATGGTCCCC GAGGGTATCG AATGATAACA GAAGGCGGAG TCAGCATAAA TCACCAACAA 
GTAACAAATC CTGAGAGTGT TTTAATTGTT GGACAACATA TTCTCAAGAA TGGACTTTCC 
TTACTTAAAA TAGGAAAAAG AAATTTCTAC ATTATAAAAT GGCTTCAGTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035526.1
CDS	80..1513
Translation	MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL

Target ORF information:

RefSeq Version	NM_001040436.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase 2 (YARS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040436.2

ORF Insert Sequence:

ATGGCGGCGC CCATCTTGCG GTCCTTTTCC TGGGGCCGGT GGTCTGGTAC CCTAAATCTC 
TCAGTATTGT TGCCCTTGGG GCTGCGTAAG GCCCACTCGG GCGCTCAGGG GTTACTGGCA 
GCGCAGAAGG CTCGAGGTCT GTTCAAGGAC TTCTTCCCGG AGACGGGGAC GAAAATAGAG 
CTCCCAGAGC TCTTCGACCG TGGCACGGCG AGTTTTCCCC AAACCATTTA CTGTGGCTTC 
GACCCCACGG CAGACTCGCT TCATGTGGGT CATCTACTTG CGCTGCTGGG CCTGTTTCAT 
TTGCAGCGAG CGGGCCACAA CGTGATCGCG CTGGTGGGAG GCGCCACGGC GCGCCTGGGA 
GACCCGAGCG GCCGTACCAA GGAACGCGAG GCGCTGGAGA CAGAGCGCGT GCGAGCCAAC 
GCGCGAGCTC TGCGCCTAGG GCTTGAGGCC CTGGCGGCTA ATCACCAGCA GCTTTTCACT 
GATGGGCGCT CCTGGGGCAG CTTCACTGTG CTGGACAACT CGGCCTGGTA CCAGAAGCAG 
CACCTGGTGG ACTTCCTGGC GGCAGTGGGG GGTCACTTCC GCATGGGGAC GCTGCTGAGC 
CGGCAGAGCG TGCAGCTGCG GCTCAAGAGC CCCGAGGGCA TGAGCTTGGC CGAGTTCTTT 
TACCAGGTGC TCCAGGCCTA TGACTTCTAT TACCTCTTCC AGCGTTATGG ATGCAGGGTC 
CAGCTGGGCG GATCTGATCA ACTAGGCAAC ATCATGTCCG GATATGAGTT CATCAACAAG 
TTGACTGGAG AAGATGTATT TGGAATCACC GTTCCTCTAA TTACAAGTAC AACTGGAGCA 
AAGCTGGGAA AGTCTGCTGG CAACGCTGTT TGGCTAAACA GAGATAAGAC ATCTCCATTT 
GAATTGTATC AATTCTTTGT CAGGCAACCG GACGATTCAG TGGAAAGGTA CCTGAAGCTG 
TTCACTTTCC TGCCCCTTCC AGAGATTGAT CATATCATGC AGCTGCATGT CAAAGAGCCA 
GAAAGGCGGG GTCCTCAGAA ACGACTGGCA GCAGAAGTAA CAAAGCTTGT TCATGGACGA 
GAAGGATTGG ATTCTGCTAA AAGGTGTACA CAAGCCCTTT ATCACAGTAG CATAGATGCA 
CTGGAGGTCA TGTCTGATCA GGAGTTAAAA GAGTTGTTTA AAGAAGCTCC ATTTTCTGAA 
TTTTTTCTCG ATCCTGGAAC AAGTGTCCTA GATACTTGCC GCAAAGCAAA TGCCATTCCA 
GATGGTCCCC GAGGGTATCG AATGATAACA GAAGGCGGAG TCAGCATAAA TCACCAACAA 
GTAACAAATC CTGAGAGTGT TTTAATTGTT GGACAACATA TTCTCAAGAA TGGACTTTCC 
TTACTTAAAA TAGGAAAAAG AAATTTCTAC ATTATAAAAT GGCTTCAGTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clinical Features, Molecular Heterogeneity, and Prognostic Implications in YARS2-Related Mitochondrial Myopathy.
JAMA neurology74(6)686-694(2017 Jun)
Sommerville EW,Ng YS,Alston CL,Dallabona C,Gilberti M,He L,Knowles C,Chin SL,Schaefer AM,Falkous G,Murdoch D,Longman C,de Visser M,Bindoff LA,Rawles JM,Dean JCS,Petty RK,Farrugia ME,Haack TB,Prokisch H,McFarland R,Turnbull DM,Donnini C,Taylor RW,Gorman GS

The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation.
Human molecular genetics25(3)584-96(2016 Feb)
Jiang P,Jin X,Peng Y,Wang M,Liu H,Liu X,Zhang Z,Ji Y,Zhang J,Liang M,Zhao F,Sun YH,Zhang M,Zhou X,Chen Y,Mo JQ,Huang T,Qu J,Guan MX

Phenotypic variability and identification of novel YARS2 mutations in YARS2 mitochondrial myopathy, lactic acidosis and sideroblastic anaemia.
Orphanet journal of rare diseases8193(2013 Dec)
Riley LG,Menezes MJ,Rudinger-Thirion J,Duff R,de Lonlay P,Rotig A,Tchan MC,Davis M,Cooper ST,Christodoulou J

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YARS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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