SOST cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOST
Entrez Gene ID	50964
Full Name	sclerostin
Synonyms	CDD,DAND6,SOST1,VBCH
General protein information	Preferred Names sclerostin Names sclerostin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.31
Summary	Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].
Disorder MIM:	605740
Disorder Html:	Sclerosteosis 1, 269500 (3); Van Buchem disease, 239100 (3); Craniodiaphyseal dysplasia, autosomal dominant, 122860 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_025237.2	NP_079513.1	sclerostin precursor
NM_025237.3	NP_079513.1	sclerostin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SOST	NP_079513.1
Rattus norvegicus (Norway rat)	Sost	NP_085073.1
	SOST	XP_001113701.1
Canis lupus familiaris (dog)	SOST	XP_548071.2
Danio rerio (zebrafish)	sost	XP_001340683.1
Bos taurus (cattle)	SOST	NP_001159986.1
Pan troglodytes (chimpanzee)	SOST	XP_001153653.1
Mus musculus (house mouse)	Sost	NP_077769.3
Gallus gallus (chicken)	SOST	XP_004948608.1

Gene Ontology
Bibliography

Related articles in PubMed

Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation.
Tartaglione L, Pasquali M, Rotondi S, Muci ML, Leonangeli C, Farcomeni A, Fassino V, Mazzaferro S
PloS one12(5)e0178637(2017)

Circulating levels of sclerostin but not DKK1 associate with laboratory parameters of CKD-MBD.
Behets GJ, Viaene L, Meijers B, Blocki F, Brandenburg VM, Verhulst A, D'Haese PC, Evenepoel P
PloS one12(5)e0176411(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SOST silencing promotes the proliferation, invasion and migration, and decreases the apoptosis of human retinoblastoma cells by activating the Wnt/beta-catenin signaling pathway.
Title: SOST silencing promotes proliferation and invasion and reduces apoptosis of retinoblastoma cells by activating Wnt/?-catenin signaling pathway.

observed an association between sclerostin levels with fasting insulin levels and homoeostatic model assessment-insulin resistance, but there was no clear association with type 2 diabetes risk.
Title: The association between sclerostin and incident type 2 diabetes risk: a cohort study.

Our study highlighted the high serum levels of DKK-1 and sclerostin in T1DM children and their relationship with altered glycemic control
Title: High Sclerostin and Dickkopf-1 (DKK-1) Serum Levels in Children and Adolescents With Type 1 Diabetes Mellitus.

Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR. Its involvement with other hormones of mineral homeostasis (FGF23/Klotho and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney
Title: Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation.

In chronic kidney disease, serum levels of the Wnt inhibitors DKK1 and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1, may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD), particularly in dialysis patients.
Title: Circulating levels of sclerostin but not DKK1 associate with laboratory parameters of CKD-MBD.

The following SOST gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOST cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17742	NM_025237.3 Latest version!	Homo sapiens sclerostin (SOST), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu17742	NM_025237.2	Homo sapiens sclerostin (SOST), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOST ( NM_025237.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_079513.1 Homo sapiens sclerostin (SOST), mRNA.

Price & Availability↑

CloneID	OHu17742
Clone ID Related Accession (Same CDS sequence)	NM_025237.2 , NM_025237.3
Accession Version	NM_025237.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	sclerostin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF326739.1. This sequence is a reference standard in the RefSeqGene project. On Mar 22, 2005 this sequence version replaced NM_025237.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF326739.1, AY358627.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTCC CACTGGCCCT GTGTCTCGTC TGCCTGCTGG TACACACAGC CTTCCGTGTA 
GTGGAGGGCC AGGGGTGGCA GGCGTTCAAG AATGATGCCA CGGAAATCAT CCCCGAGCTC 
GGAGAGTACC CCGAGCCTCC ACCGGAGCTG GAGAACAACA AGACCATGAA CCGGGCGGAG 
AACGGAGGGC GGCCTCCCCA CCACCCCTTT GAGACCAAAG ACGTGTCCGA GTACAGCTGC 
CGCGAGCTGC ACTTCACCCG CTACGTGACC GATGGGCCGT GCCGCAGCGC CAAGCCGGTC 
ACCGAGCTGG TGTGCTCCGG CCAGTGCGGC CCGGCGCGCC TGCTGCCCAA CGCCATCGGC 
CGCGGCAAGT GGTGGCGACC TAGTGGGCCC GACTTCCGCT GCATCCCCGA CCGCTACCGC 
GCGCAGCGCG TGCAGCTGCT GTGTCCCGGT GGTGAGGCGC CGCGCGCGCG CAAGGTGCGC 
CTGGTGGCCT CGTGCAAGTG CAAGCGCCTC ACCCGCTTCC ACAACCAGTC GGAGCTCAAG 
GACTTCGGGA CCGAGGCCGC TCGGCCGCAG AAGGGCCGGA AGCCGCGGCC CCGCGCCCGG 
AGCGCCAAAG CCAACCAGGC CGAGCTGGAG AACGCCTACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079513.1
CDS	48..689
Translation	MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY

Target ORF information:

RefSeq Version	NM_025237.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sclerostin (SOST), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025237.2

ORF Insert Sequence:

ATGCAGCTCC CACTGGCCCT GTGTCTCGTC TGCCTGCTGG TACACACAGC CTTCCGTGTA 
GTGGAGGGCC AGGGGTGGCA GGCGTTCAAG AATGATGCCA CGGAAATCAT CCCCGAGCTC 
GGAGAGTACC CCGAGCCTCC ACCGGAGCTG GAGAACAACA AGACCATGAA CCGGGCGGAG 
AACGGAGGGC GGCCTCCCCA CCACCCCTTT GAGACCAAAG ACGTGTCCGA GTACAGCTGC 
CGCGAGCTGC ACTTCACCCG CTACGTGACC GATGGGCCGT GCCGCAGCGC CAAGCCGGTC 
ACCGAGCTGG TGTGCTCCGG CCAGTGCGGC CCGGCGCGCC TGCTGCCCAA CGCCATCGGC 
CGCGGCAAGT GGTGGCGACC TAGTGGGCCC GACTTCCGCT GCATCCCCGA CCGCTACCGC 
GCGCAGCGCG TGCAGCTGCT GTGTCCCGGT GGTGAGGCGC CGCGCGCGCG CAAGGTGCGC 
CTGGTGGCCT CGTGCAAGTG CAAGCGCCTC ACCCGCTTCC ACAACCAGTC GGAGCTCAAG 
GACTTCGGGA CCGAGGCCGC TCGGCCGCAG AAGGGCCGGA AGCCGCGGCC CCGCGCCCGG 
AGCGCCAAAG CCAACCAGGC CGAGCTGGAG AACGCCTACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOST ( NM_025237.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079513.1 Homo sapiens sclerostin (SOST), mRNA.

Price & Availability↑

CloneID	OHu17742
Clone ID Related Accession (Same CDS sequence)	NM_025237.2 , NM_025237.3
Accession Version	NM_025237.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	sclerostin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC055813.9 and AF326739.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_025237.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF331844.1, AF326739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301691.3/ ENSP00000301691.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCTCC CACTGGCCCT GTGTCTCGTC TGCCTGCTGG TACACACAGC CTTCCGTGTA 
GTGGAGGGCC AGGGGTGGCA GGCGTTCAAG AATGATGCCA CGGAAATCAT CCCCGAGCTC 
GGAGAGTACC CCGAGCCTCC ACCGGAGCTG GAGAACAACA AGACCATGAA CCGGGCGGAG 
AACGGAGGGC GGCCTCCCCA CCACCCCTTT GAGACCAAAG ACGTGTCCGA GTACAGCTGC 
CGCGAGCTGC ACTTCACCCG CTACGTGACC GATGGGCCGT GCCGCAGCGC CAAGCCGGTC 
ACCGAGCTGG TGTGCTCCGG CCAGTGCGGC CCGGCGCGCC TGCTGCCCAA CGCCATCGGC 
CGCGGCAAGT GGTGGCGACC TAGTGGGCCC GACTTCCGCT GCATCCCCGA CCGCTACCGC 
GCGCAGCGCG TGCAGCTGCT GTGTCCCGGT GGTGAGGCGC CGCGCGCGCG CAAGGTGCGC 
CTGGTGGCCT CGTGCAAGTG CAAGCGCCTC ACCCGCTTCC ACAACCAGTC GGAGCTCAAG 
GACTTCGGGA CCGAGGCCGC TCGGCCGCAG AAGGGCCGGA AGCCGCGGCC CCGCGCCCGG 
AGCGCCAAAG CCAACCAGGC CGAGCTGGAG AACGCCTACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079513.1
CDS	51..692
Translation	MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY

Target ORF information:

RefSeq Version	NM_025237.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sclerostin (SOST), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025237.3

ORF Insert Sequence:

ATGCAGCTCC CACTGGCCCT GTGTCTCGTC TGCCTGCTGG TACACACAGC CTTCCGTGTA 
GTGGAGGGCC AGGGGTGGCA GGCGTTCAAG AATGATGCCA CGGAAATCAT CCCCGAGCTC 
GGAGAGTACC CCGAGCCTCC ACCGGAGCTG GAGAACAACA AGACCATGAA CCGGGCGGAG 
AACGGAGGGC GGCCTCCCCA CCACCCCTTT GAGACCAAAG ACGTGTCCGA GTACAGCTGC 
CGCGAGCTGC ACTTCACCCG CTACGTGACC GATGGGCCGT GCCGCAGCGC CAAGCCGGTC 
ACCGAGCTGG TGTGCTCCGG CCAGTGCGGC CCGGCGCGCC TGCTGCCCAA CGCCATCGGC 
CGCGGCAAGT GGTGGCGACC TAGTGGGCCC GACTTCCGCT GCATCCCCGA CCGCTACCGC 
GCGCAGCGCG TGCAGCTGCT GTGTCCCGGT GGTGAGGCGC CGCGCGCGCG CAAGGTGCGC 
CTGGTGGCCT CGTGCAAGTG CAAGCGCCTC ACCCGCTTCC ACAACCAGTC GGAGCTCAAG 
GACTTCGGGA CCGAGGCCGC TCGGCCGCAG AAGGGCCGGA AGCCGCGGCC CCGCGCCCGG 
AGCGCCAAAG CCAACCAGGC CGAGCTGGAG AACGCCTACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation.
PloS one12(5)e0178637(2017)
Tartaglione L,Pasquali M,Rotondi S,Muci ML,Leonangeli C,Farcomeni A,Fassino V,Mazzaferro S

Circulating levels of sclerostin but not DKK1 associate with laboratory parameters of CKD-MBD.
PloS one12(5)e0176411(2017)
Behets GJ,Viaene L,Meijers B,Blocki F,Brandenburg VM,Verhulst A,D'Haese PC,Evenepoel P

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SOST cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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