REG3A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	REG3A
Entrez Gene ID	5068
Full Name	regenerating family member 3 alpha
Synonyms	HIP,HIP/PAP,INGAP,PAP,PAP-H,PAP1,PBCGF,REG-III,REG3
General protein information	Preferred Names regenerating family member 3 alpha Names regenerating islet-derived protein 3-alpha PAP homologous protein REG-3-alpha hepatocarcinoma-intestine-pancreas hepatointestinal pancreatic protein human proislet peptide pancreatic beta cell growth factor pancreatitis-associated protein 1 proliferation-inducing protein 34 proliferation-inducing protein 42 reg III-alpha regenerating islet-derived 3 alpha regenerating islet-derived protein III-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p12
Summary	This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014].
Disorder MIM:	167805

mRNA and Protein(s)

mRNA	Protein	Name
NM_002580.2	NP_002571.1	regenerating islet-derived protein 3-alpha precursor
NM_138937.2	NP_620354.1	regenerating islet-derived protein 3-alpha precursor
NM_002580.3	NP_002571.1	regenerating islet-derived protein 3-alpha precursor
NM_138937.3	NP_620354.1	regenerating islet-derived protein 3-alpha precursor
NM_138938.2	NP_620355.1	regenerating islet-derived protein 3-alpha precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	REG3A	XP_001164369.1
Rattus norvegicus (Norway rat)	Reg3b	NP_445741.1
	LOC716890	XP_001107916.1
Mus musculus (house mouse)	Reg3b	NP_035166.1
Homo sapiens (human)	REG3A	NP_620355.1

Gene Ontology
Bibliography

Related articles in PubMed

Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis.
Darnaud M, Santos AD, Gonzalez P, Augui S, Lacoste C, Desterke C, De Hertogh G, Valentino E, Braun E, Zheng J, Boisgard R, Neut C, Dubuquoy L, Chiappini F, Samuel D, Lepage P, Guerrieri F, Dor? J, Br?chot C, Moniaux N, Faivre J
Gastroenterology(2017 Nov)

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.
Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Julamanee J, Takagi E, Hirano D, Miyao K, Sakemura R, Goto T, Hayakawa F, Seto A, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H
PloS one12(9)e0185213(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

skin injury increases IL-36gamma via the activation of TLR3-SLUG-VDR axis and IL-36gamma induces REG3A to promote wound healing
Title: IL-36? Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A.

Patients with high levels of PAP/REG3A had overall shorter survival as well as poor surgical outcomes with reduced disease-free survival.
Title: PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker.

Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality.
Title: Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide.

Association between a SNP in the REG3A gene, rs7588571, located upstream of the REG3A gene, and bone marrow transplant outcomes including the incidence of chronic GVHD. Since REG proteins control intestinal microbiota, and since intestinal dysbiosis is in part responsible for the development of GVHD, findings lead to the concept that REG3A could have some protective effect through the regulation of gut microbiota.
Title: High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.

Regulation network analysis confirmed the cell growth related differentially expressed genes, and further uncovered three transcription factor families with immune functions regulated by REG3A
Title: Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells.

The following REG3A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the REG3A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09306	NM_002580.3 Latest version!	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09306	NM_138937.3 Latest version!	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09306	NM_138938.2 Latest version!	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09306	NM_002580.2	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09306	NM_138937.2	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

REG3A ( NM_002580.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002571.1 Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09306
Clone ID Related Accession (Same CDS sequence)	NM_002580.2 , NM_138937.2 , NM_002580.3 , NM_138937.3 , NM_138938.2
Accession Version	NM_002580.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-21
Organism	Homo sapiens(human)
Product	regenerating islet-derived protein 3-alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ777112.1 and BC036776.1. This sequence is a reference standard in the RefSeqGene project. On Dec 16, 2010 this sequence version replaced NM_002580.1. Transcript Variant: This variant (1) represents the functional protein. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036776.1, ERR279869.1331.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16931762 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002571.1
CDS	62..589
Translation	MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD

Target ORF information:

RefSeq Version	NM_002580.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002580.2

ORF Insert Sequence:

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REG3A ( NM_138937.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620354.1 Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09306
Clone ID Related Accession (Same CDS sequence)	NM_002580.2 , NM_138937.2 , NM_002580.3 , NM_138937.3 , NM_138938.2
Accession Version	NM_138937.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-21
Organism	Homo sapiens(human)
Product	regenerating islet-derived protein 3-alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ777112.1, AK291973.1 and BC036776.1. On Dec 16, 2010 this sequence version replaced NM_138937.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279841.8348.1, ERR279875.1088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835, SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16931762 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620354.1
CDS	39..566
Translation	MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD

Target ORF information:

RefSeq Version	NM_138937.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138937.2

ORF Insert Sequence:

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REG3A ( NM_002580.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002571.1 Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09306
Clone ID Related Accession (Same CDS sequence)	NM_002580.2 , NM_138937.2 , NM_002580.3 , NM_138937.3 , NM_138938.2
Accession Version	NM_002580.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	regenerating islet-derived protein 3-alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ777112.1 and BC036776.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_002580.2. Transcript Variant: This variant (1) represents the functional protein. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138519.380797.1, DRR138519.38737.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16931762 RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002571.1
CDS	61..588
Translation	MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD

Target ORF information:

RefSeq Version	NM_002580.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002580.3

ORF Insert Sequence:

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REG3A ( NM_138937.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620354.1 Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09306
Clone ID Related Accession (Same CDS sequence)	NM_002580.2 , NM_138937.2 , NM_002580.3 , NM_138937.3 , NM_138938.2
Accession Version	NM_138937.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	regenerating islet-derived protein 3-alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291973.1 and BC036776.1. On Jun 2, 2019 this sequence version replaced NM_138937.2. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138519.353817.1, DRR138519.22298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835, SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16931762 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620354.1
CDS	38..565
Translation	MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD

Target ORF information:

RefSeq Version	NM_138937.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138937.3

ORF Insert Sequence:

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REG3A ( NM_138938.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620355.1 Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09306
Clone ID Related Accession (Same CDS sequence)	NM_002580.2 , NM_138937.2 , NM_002580.3 , NM_138937.3 , NM_138938.2
Accession Version	NM_138938.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	regenerating islet-derived protein 3-alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC300833.1, AY544128.1 and BC036776.1. On Dec 16, 2010 this sequence version replaced NM_138938.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279830.8940.1, ERR279827.2612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835, SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16931762 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620355.1
CDS	349..876
Translation	MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD

Target ORF information:

RefSeq Version	NM_138938.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 3 alpha (REG3A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138938.2

ORF Insert Sequence:

ATGCTGCCTC CCATGGCCCT GCCCAGTGTA TCTTGGATGC TGCTTTCCTG CCTCATGCTG 
CTGTCTCAGG TTCAAGGTGA AGAACCCCAG AGGGAACTGC CCTCTGCACG GATCCGCTGT 
CCCAAAGGCT CCAAGGCCTA TGGCTCCCAC TGCTATGCCT TGTTTTTGTC ACCAAAATCC 
TGGACAGATG CAGATCTGGC CTGCCAGAAG CGGCCCTCTG GAAACCTGGT GTCTGTGCTC 
AGTGGGGCTG AGGGATCCTT CGTGTCCTCC CTGGTGAAGA GCATTGGTAA CAGCTACTCA 
TACGTCTGGA TTGGGCTCCA TGACCCCACA CAGGGCACCG AGCCCAATGG AGAAGGTTGG 
GAGTGGAGTA GCAGTGATGT GATGAATTAC TTTGCATGGG AGAGAAATCC CTCCACCATC 
TCAAGCCCCG GCCACTGTGC GAGCCTGTCG AGAAGCACAG CATTTCTGAG GTGGAAAGAT 
TATAACTGTA ATGTGAGGTT ACCCTATGTC TGCAAGTTCA CTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis.
Gastroenterology(2017 Nov)
Darnaud M,Santos AD,Gonzalez P,Augui S,Lacoste C,Desterke C,De Hertogh G,Valentino E,Braun E,Zheng J,Boisgard R,Neut C,Dubuquoy L,Chiappini F,Samuel D,Lepage P,Guerrieri F,Dor? J,Br?chot C,Moniaux N,Faivre J

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.
PloS one12(9)e0185213(2017)
Koyama D,Murata M,Hanajiri R,Okuno S,Kamoshita S,Julamanee J,Takagi E,Hirano D,Miyao K,Sakemura R,Goto T,Hayakawa F,Seto A,Ozawa Y,Miyamura K,Terakura S,Nishida T,Kiyoi H

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REG3A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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