OXT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OXT
Entrez Gene ID	5020
Full Name	oxytocin/neurophysin I prepropeptide
Synonyms	OT,OT-NPI,OXT-NPI
General protein information	Preferred Names oxytocin/neurophysin I prepropeptide Names oxytocin-neurophysin 1 neurophysin I oxytocin, prepro- (neurophysin I) oxytocin, prepropeptide oxytocin-neurophysin I, preproprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p13
Summary	This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013].
Disorder MIM:	167050

mRNA and Protein(s)

mRNA	Protein	Name
NM_000915.3	NP_000906.1	oxytocin-neurophysin 1 preproprotein
XM_011529238.1	XP_011527540.1	oxytocin-neurophysin 1 isoform X1
NM_000915.4	NP_000906.1	oxytocin-neurophysin 1 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	OXT	NP_000906.1
	OXT	XP_001115045.1
Canis lupus familiaris (dog)	OXT	XP_003639897.2
Bos taurus (cattle)	OXT	NP_789825.1
Gallus gallus (chicken)	OXT	XP_001231492.3
Pan troglodytes (chimpanzee)	OXT	XP_001160221.1
Mus musculus (house mouse)	Oxt	NP_035155.1
Rattus norvegicus (Norway rat)	Oxt	NP_037128.1
Xenopus tropicalis (tropical clawed frog)	LOC100485685	XP_002936405.1

Gene Ontology
Bibliography

Related articles in PubMed

Oxytocin and Its Relationship to Body Composition, Bone Mineral Density, and Hip Geometry Across the Weight Spectrum.
Schorr M, Marengi DA, Pulumo RL, Yu E, Eddy KT, Klibanski A, Miller KK, Lawson EA
The Journal of clinical endocrinology and metabolism102(8)2814-2824(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low oxytocin expression is associated with diabetic metabolic syndrome.
Title: The correlation between plasma levels of oxytocin and betatrophin in non-diabetic and diabetic metabolic syndrome patients: A cross sectional study from Jordan.

OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density.
Title: Oxytocin and Its Relationship to Body Composition, Bone Mineral Density, and Hip Geometry Across the Weight Spectrum.

Oxytocin prevents cartilage matrix destruction via regulating MMP1 and MMP13.
Title: Oxytocin prevents cartilage matrix destruction via regulating matrix metalloproteinases.

study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population
Title: Association between oxytocin and receptor genetic polymorphisms and aggression in a northern Chinese Han population with alcohol dependence.

epigenetic modification of OXT is linked to several overt measures of sociability
Title: Epigenetic modification of OXT and human sociability.

The following OXT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OXT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27584	NM_000915.4 Latest version!	Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27584	XM_011529238.1 Latest version!	Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27584	NM_000915.3	Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OXT ( NM_000915.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000906.1 Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA.

Price & Availability↑

CloneID	OHu27584
Clone ID Related Accession (Same CDS sequence)	NM_000915.3 , XM_011529238.1 , NM_000915.4
Accession Version	NM_000915.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	oxytocin-neurophysin 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069144.1 and AI185553.1. On Jun 28, 2013 this sequence version replaced NM_000915.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069144.1, M25650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGCC CCAGCCTCGC TTGCTGTCTG CTCGGCCTCC TGGCGCTGAC CTCCGCCTGC 
TACATCCAGA ACTGCCCCCT GGGAGGCAAG AGGGCCGCGC CGGACCTCGA CGTGCGCAAG 
TGCCTCCCCT GCGGCCCCGG GGGCAAAGGC CGCTGCTTCG GGCCCAATAT CTGCTGCGCG 
GAAGAGCTGG GCTGCTTCGT GGGCACCGCC GAAGCGCTGC GCTGCCAGGA GGAGAACTAC 
CTGCCGTCGC CCTGCCAGTC CGGCCAGAAG GCGTGCGGGA GCGGGGGCCG CTGCGCGGTC 
TTGGGCCTCT GCTGCAGCCC GGACGGCTGC CACGCCGACC CTGCCTGCGA CGCGGAAGCC 
ACCTTCTCCC AGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000906.1
CDS	37..414
Translation	MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR

Target ORF information:

RefSeq Version	NM_000915.3
Organism	Homo sapiens(human)
Definition	Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000915.3

ORF Insert Sequence:

ATGGCCGGCC CCAGCCTCGC TTGCTGTCTG CTCGGCCTCC TGGCGCTGAC CTCCGCCTGC 
TACATCCAGA ACTGCCCCCT GGGAGGCAAG AGGGCCGCGC CGGACCTCGA CGTGCGCAAG 
TGCCTCCCCT GCGGCCCCGG GGGCAAAGGC CGCTGCTTCG GGCCCAATAT CTGCTGCGCG 
GAAGAGCTGG GCTGCTTCGT GGGCACCGCC GAAGCGCTGC GCTGCCAGGA GGAGAACTAC 
CTGCCGTCGC CCTGCCAGTC CGGCCAGAAG GCGTGCGGGA GCGGGGGCCG CTGCGCGGTC 
TTGGGCCTCT GCTGCAGCCC GGACGGCTGC CACGCCGACC CTGCCTGCGA CGCGGAAGCC 
ACCTTCTCCC AGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OXT ( NM_000915.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000906.1 Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA.

Price & Availability↑

CloneID	OHu27584
Clone ID Related Accession (Same CDS sequence)	NM_000915.3 , XM_011529238.1 , NM_000915.4
Accession Version	NM_000915.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	oxytocin-neurophysin 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069144.1 and AI185553.1. On Nov 22, 2018 this sequence version replaced NM_000915.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069144.1, M25650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000217386.2/ ENSP00000217386.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGGCC CCAGCCTCGC TTGCTGTCTG CTCGGCCTCC TGGCGCTGAC CTCCGCCTGC 
TACATCCAGA ACTGCCCCCT GGGAGGCAAG AGGGCCGCGC CGGACCTCGA CGTGCGCAAG 
TGCCTCCCCT GCGGCCCCGG GGGCAAAGGC CGCTGCTTCG GGCCCAATAT CTGCTGCGCG 
GAAGAGCTGG GCTGCTTCGT GGGCACCGCC GAAGCGCTGC GCTGCCAGGA GGAGAACTAC 
CTGCCGTCGC CCTGCCAGTC CGGCCAGAAG GCGTGCGGGA GCGGGGGCCG CTGCGCGGTC 
TTGGGCCTCT GCTGCAGCCC GGACGGCTGC CACGCCGACC CTGCCTGCGA CGCGGAAGCC 
ACCTTCTCCC AGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000906.1
CDS	37..414
Translation	MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR

Target ORF information:

RefSeq Version	NM_000915.4
Organism	Homo sapiens(human)
Definition	Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000915.4

ORF Insert Sequence:

ATGGCCGGCC CCAGCCTCGC TTGCTGTCTG CTCGGCCTCC TGGCGCTGAC CTCCGCCTGC 
TACATCCAGA ACTGCCCCCT GGGAGGCAAG AGGGCCGCGC CGGACCTCGA CGTGCGCAAG 
TGCCTCCCCT GCGGCCCCGG GGGCAAAGGC CGCTGCTTCG GGCCCAATAT CTGCTGCGCG 
GAAGAGCTGG GCTGCTTCGT GGGCACCGCC GAAGCGCTGC GCTGCCAGGA GGAGAACTAC 
CTGCCGTCGC CCTGCCAGTC CGGCCAGAAG GCGTGCGGGA GCGGGGGCCG CTGCGCGGTC 
TTGGGCCTCT GCTGCAGCCC GGACGGCTGC CACGCCGACC CTGCCTGCGA CGCGGAAGCC 
ACCTTCTCCC AGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OXT ( XM_011529238.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527540.1 Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu27584
Clone ID Related Accession (Same CDS sequence)	NM_000915.3 , XM_011529238.1 , NM_000915.4
Accession Version	XM_011529238.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	oxytocin-neurophysin 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGGCC CCAGCCTCGC TTGCTGTCTG CTCGGCCTCC TGGCGCTGAC CTCCGCCTGC 
TACATCCAGA ACTGCCCCCT GGGAGGCAAG AGGGCCGCGC CGGACCTCGA CGTGCGCAAG 
TGCCTCCCCT GCGGCCCCGG GGGCAAAGGC CGCTGCTTCG GGCCCAATAT CTGCTGCGCG 
GAAGAGCTGG GCTGCTTCGT GGGCACCGCC GAAGCGCTGC GCTGCCAGGA GGAGAACTAC 
CTGCCGTCGC CCTGCCAGTC CGGCCAGAAG GCGTGCGGGA GCGGGGGCCG CTGCGCGGTC 
TTGGGCCTCT GCTGCAGCCC GGACGGCTGC CACGCCGACC CTGCCTGCGA CGCGGAAGCC 
ACCTTCTCCC AGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527540.1
CDS	174..551
Translation	MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR

Target ORF information:

RefSeq Version	XM_011529238.1
Organism	Homo sapiens(human)
Definition	Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011529238.1

ORF Insert Sequence:

ATGGCCGGCC CCAGCCTCGC TTGCTGTCTG CTCGGCCTCC TGGCGCTGAC CTCCGCCTGC 
TACATCCAGA ACTGCCCCCT GGGAGGCAAG AGGGCCGCGC CGGACCTCGA CGTGCGCAAG 
TGCCTCCCCT GCGGCCCCGG GGGCAAAGGC CGCTGCTTCG GGCCCAATAT CTGCTGCGCG 
GAAGAGCTGG GCTGCTTCGT GGGCACCGCC GAAGCGCTGC GCTGCCAGGA GGAGAACTAC 
CTGCCGTCGC CCTGCCAGTC CGGCCAGAAG GCGTGCGGGA GCGGGGGCCG CTGCGCGGTC 
TTGGGCCTCT GCTGCAGCCC GGACGGCTGC CACGCCGACC CTGCCTGCGA CGCGGAAGCC 
ACCTTCTCCC AGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oxytocin and Its Relationship to Body Composition, Bone Mineral Density, and Hip Geometry Across the Weight Spectrum.
The Journal of clinical endocrinology and metabolism102(8)2814-2824(2017 Aug)
Schorr M,Marengi DA,Pulumo RL,Yu E,Eddy KT,Klibanski A,Miller KK,Lawson EA

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

OXT cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報