ORM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ORM1
Entrez Gene ID	5004
Full Name	orosomucoid 1
Synonyms	AGP-A,AGP1,HEL-S-153w,ORM
General protein information	Preferred Names orosomucoid 1 Names alpha-1-acid glycoprotein 1 AGP 1 OMD 1 epididymis secretory sperm binding protein Li 153w
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q32
Summary	This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008].
Disorder MIM:	138600

mRNA and Protein(s)

mRNA	Protein	Name
NM_000607.3	NP_000598.2	alpha-1-acid glycoprotein 1 precursor
NM_000607.2	NP_000598.2	alpha-1-acid glycoprotein 1 precursor

Pathways from BioSystems

Homologies

	LOC703984	XP_001100289.1
Homo sapiens (human)	ORM1	NP_000598.2
Bos taurus (cattle)	ORM1	NP_001035592.1
Pan troglodytes (chimpanzee)	ORM1	XP_003312295.1
Rattus norvegicus (Norway rat)	Orm1	NP_445740.1
Canis lupus familiaris (dog)	ORM1	XP_003431634.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.
Qin XY, Hara M, Arner E, Kawaguchi Y, Inoue I, Tatsukawa H, Furutani Y, Nagatsuma K, Matsuura T, Wei F, Kikuchi J, Sone H, Daub C, Kawaji H, Lassmann T, Itoh M, Suzuki H, Carninci P, Hayashizaki Y, , Kokudo N, Forrest ARR, Kojima S
EBioMedicine24257-266(2017 Oct)

Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.
Jabir RS, Ho GF, Annuar MABA, Stanslas J
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals1-5(2017 Jun)

Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents.
Can U, Buyukinan M, Guzelant A, Ugur A, Karaibrahimoglu A, Yabanc?un S
Journal of pediatric endocrinology & metabolism : JPEM29(11)1277-1283(2016 Nov)

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects.
Title: Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents.

Results indicate that advanced extranodal NK/T cell lymphoma (ENKL) patients with unfavourable treatment outcomes displayed higher levels of S100A9 and ORM1.
Title: S100A9 and ORM1 serve as predictors of therapeutic response and prognostic factors in advanced extranodal NK/T cell lymphoma patients treated with pegaspargase/gemcitabine.

Altogether, these results indicate that alpha1-3 fucosylated glycoforms of AGP are increased in PDAC and could be potentially regarded as a PDAC biomarker.
Title: Increased ?1-3 fucosylation of ?-1-acid glycoprotein (AGP) in pancreatic cancer.

Glycosylated Alpha-1-acid glycoprotein 1 is ostensibly expressed in lung cancer patients and is a potential lung cancer serum biomarker.
Title: Glycosylated Alpha-1-acid glycoprotein 1 as a potential lung cancer serum biomarker.

The results of this study suggest that the expression of VEGF-A and ORM-1 may be associated with two mechanisms (angiogenesis and tumor structural viscosity) that may influence tumor growth in odontogenic myxoma.
Title: Immunolocalization of VEGF-A and orosomucoid-1 in odontogenic myxoma.

The following ORM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18859	NM_000607.3 Latest version!	Homo sapiens orosomucoid 1 (ORM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18859	NM_000607.2	Homo sapiens orosomucoid 1 (ORM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ORM1 ( NM_000607.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000598.2 Homo sapiens orosomucoid 1 (ORM1), mRNA.

Price & Availability↑

CloneID	OHu18859
Clone ID Related Accession (Same CDS sequence)	NM_000607.3 , NM_000607.2
Accession Version	NM_000607.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	alpha-1-acid glycoprotein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL356796.16. On Nov 26, 2019 this sequence version replaced NM_000607.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007032.1, BU930416.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTCACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGACA GGACCAGTGC ATCTATAACA CCACCTACCT GAATGTCCAG 
CGGGAAAATG GGACCATCTC CAGATACGTG GGAGGCCAAG AGCATTTCGC TCACTTGCTG 
ATCCTCAGGG ACACCAAGAC CTACATGCTT GCTTTTGACG TGAACGATGA GAAGAACTGG 
GGGCTGTCTG TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGCG CATTCCCAAG TCAGATGTCG TGTACACCGA TTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000598.2
CDS	507..1112
Translation	MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES

Target ORF information:

RefSeq Version	NM_000607.3
Organism	Homo sapiens(human)
Definition	Homo sapiens orosomucoid 1 (ORM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000607.3

ORF Insert Sequence:

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTCACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGACA GGACCAGTGC ATCTATAACA CCACCTACCT GAATGTCCAG 
CGGGAAAATG GGACCATCTC CAGATACGTG GGAGGCCAAG AGCATTTCGC TCACTTGCTG 
ATCCTCAGGG ACACCAAGAC CTACATGCTT GCTTTTGACG TGAACGATGA GAAGAACTGG 
GGGCTGTCTG TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGCG CATTCCCAAG TCAGATGTCG TGTACACCGA TTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORM1 ( NM_000607.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000598.2 Homo sapiens orosomucoid 1 (ORM1), mRNA.

Price & Availability↑

CloneID	OHu18859
Clone ID Related Accession (Same CDS sequence)	NM_000607.3 , NM_000607.2
Accession Version	NM_000607.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	alpha-1-acid glycoprotein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI908589.1, M13692.1 and N68733.1. This sequence is a reference standard in the RefSeqGene project. On Feb 14, 2008 this sequence version replaced NM_000607.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279839.6545.1, ERR279829.7115.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTCACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGACA GGACCAGTGC ATCTATAACA CCACCTACCT GAATGTCCAG 
CGGGAAAATG GGACCATCTC CAGATACGTG GGAGGCCAAG AGCATTTCGC TCACTTGCTG 
ATCCTCAGGG ACACCAAGAC CTACATGCTT GCTTTTGACG TGAACGATGA GAAGAACTGG 
GGGCTGTCTG TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGCG CATTCCCAAG TCAGATGTCG TGTACACCGA TTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000598.2
CDS	112..717
Translation	MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES

Target ORF information:

RefSeq Version	NM_000607.2
Organism	Homo sapiens(human)
Definition	Homo sapiens orosomucoid 1 (ORM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000607.2

ORF Insert Sequence:

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTCACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGACA GGACCAGTGC ATCTATAACA CCACCTACCT GAATGTCCAG 
CGGGAAAATG GGACCATCTC CAGATACGTG GGAGGCCAAG AGCATTTCGC TCACTTGCTG 
ATCCTCAGGG ACACCAAGAC CTACATGCTT GCTTTTGACG TGAACGATGA GAAGAACTGG 
GGGCTGTCTG TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGCG CATTCCCAAG TCAGATGTCG TGTACACCGA TTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.
EBioMedicine24257-266(2017 Oct)
Qin XY,Hara M,Arner E,Kawaguchi Y,Inoue I,Tatsukawa H,Furutani Y,Nagatsuma K,Matsuura T,Wei F,Kikuchi J,Sone H,Daub C,Kawaji H,Lassmann T,Itoh M,Suzuki H,Carninci P,Hayashizaki Y,,Kokudo N,Forrest ARR,Kojima S

Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals1-5(2017 Jun)
Jabir RS,Ho GF,Annuar MABA,Stanslas J

Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents.
Journal of pediatric endocrinology & metabolism : JPEM29(11)1277-1283(2016 Nov)
Can U,Buyukinan M,Guzelant A,Ugur A,Karaibrahimoglu A,Yabanc?un S

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

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ORM1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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