OMD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OMD
Entrez Gene ID	4958
Full Name	osteomodulin
Synonyms	OSAD,SLRR2C
General protein information	Preferred Names osteomodulin Names osteomodulin KSPG osteomodulin keratan sulfate proteoglycan osteomodulin osteoadherin proteoglycan
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q22.31

mRNA and Protein(s)

mRNA	Protein	Name
NM_005014.2	NP_005005.1	osteomodulin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	OMD	NP_005005.1
Bos taurus (cattle)	OMD	NP_776372.1
Mus musculus (house mouse)	Omd	NP_036180.1
Danio rerio (zebrafish)	omd	XP_686160.1
	OMD	XP_001103677.1
Canis lupus familiaris (dog)	OMD	XP_005616050.1
Gallus gallus (chicken)	OMD	XP_004944561.1
Pan troglodytes (chimpanzee)	OMD	XP_001146339.1

Gene Ontology
Bibliography

Related articles in PubMed

Osteomodulin regulates diameter and alters shape of collagen fibrils.
Tashima T, Nagatoishi S, Sagara H, Ohnuma S, Tsumoto K
Biochemical and biophysical research communications463(3)292-6(2015 Jul)

Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage.
Juchtmans N, Dhollander AA, Coudenys J, Audenaert EA, Pattyn C, Lambrecht S, Elewaut D
Arthritis & rheumatology (Hoboken, N.J.)67(2)435-41(2015 Feb)

The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors.
Tillgren V, Onnerfjord P, Haglund L, Heineg?rd D
The Journal of biological chemistry284(42)28543-53(2009 Oct)

Immunodetection of osteoadherin in murine tooth extracellular matrices.
Couble ML, Bleicher F, Farges JC, Peyrol S, Lucchini M, Magloire H, Staquet MJ
Histochemistry and cell biology121(1)47-53(2004 Jan)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research13(10)2265-70(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Osteomodulin (OMD) directly binds to type 1 collagen. OMD suppresses formation of collagen fibrils.
Title: Osteomodulin regulates diameter and alters shape of collagen fibrils.

Osteomodulin, osteoglycin, and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
Title: Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage.

tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors
Title: The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors.

TGF beta 1 signaling and stimulation of osteoadherin in human pulpal fibroblasts and in early secretory and mature odontoblasts
Title: TGF beta 1 signaling and stimulation of osteoadherin in human odontoblasts in vitro.

The following OMD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OMD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24305	NM_005014.2 Latest version!	Homo sapiens osteomodulin (OMD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OMD ( NM_005014.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005005.1 Homo sapiens osteomodulin (OMD), mRNA.

Price & Availability↑

CloneID	OHu24305
Clone ID Related Accession (Same CDS sequence)	NM_005014.2
Accession Version	NM_005014.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	osteomodulin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL137848.5. On Apr 8, 2008 this sequence version replaced NM_005014.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.236018.1, SRR1803612.274315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGGTTTTT TAAGTCCAAT ATATGTTATT TTCTTCTTTT TTGGAGTCAA AGTACATTGC 
CAATATGAAA CTTATCAGTG GGATGAAGAC TATGACCAAG AGCCAGATGA TGATTACCAA 
ACAGGATTCC CATTTCGTCA AAATGTAGAC TACGGAGTTC CTTTTCATCA GTATACTTTA 
GGCTGTGTCA GTGAATGCTT CTGTCCAACT AACTTTCCAT CATCAATGTA CTGTGATAAT 
CGCAAACTCA AGACTATCCC AAATATTCCG ATGCACATTC AGCAACTCTA CCTTCAGTTC 
AATGAAATTG AGGCTGTGAC TGCAAATTCA TTCATCAATG CAACTCATCT TAAAGAAATT 
AACCTCAGCC ACAACAAAAT TAAATCTCAA AAGATTGATT ATGGTGTGTT TGCTAAGCTT 
CCAAATCTAC TACAACTTCA TCTAGAGCAT AATAATTTAG AAGAATTTCC ATTTCCTCTT 
CCTAAATCTC TGGAAAGACT CCTTCTTGGT TACAATGAAA TCTCCAAACT GCAGACAAAT 
GCTATGGATG GGCTAGTAAA CTTGACCATG CTTGATCTCT GTTATAATTA TCTTCATGAT 
TCTCTGCTAA AAGACAAAAT CTTTGCCAAA ATGGAAAAAC TAATGCAGCT CAACCTCTGC 
AGTAACAGAT TAGAATCAAT GCCTCCTGGT TTGCCTTCTT CACTTATGTA TCTGTCTTTA 
GAAAATAATT CAATTTCTTC TATACCCGAA AAATACTTCG ACAAACTTCC AAAACTTCAT 
ACTCTAAGAA TGTCACACAA CAAACTACAA GACATCCCAT ATAATATTTT TAATCTTCCC 
AACATTGTAG AACTCAGTGT TGGACACAAC AAATTGAAGC AAGCATTCTA TATTCCAAGA 
AATTTGGAAC ACCTATACCT ACAAAATAAT GAAATAGAAA AGATGAATCT TACAGTGATG 
TGTCCTTCTA TTGACCCACT ACATTACCAC CATTTAACAT ACATTCGTGT GGACCAAAAT 
AAACTAAAAG AACCAATAAG CTCATACATC TTCTTCTGCT TCCCTCATAT ACACACTATT 
TATTATGGTG AACAACGAAG CACTAATGGT CAAACAATAC AACTAAAGAC ACAAGTTTTC 
AGGAGATTTC CAGATGATGA TGATGAAAGT GAAGATCACG ATGATCCTGA CAATGCTCAT 
GAGAGCCCAG AACAAGAAGG AGCAGAAGGG CACTTTGACC TTCATTATTA TGAAAATCAA 
GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005005.1
CDS	370..1635
Translation	MGFLSPIYVIFFFFGVKVHCQYETYQWDEDYDQEPDDDYQTGFPFRQNVDYGVPFHQYTLGCVSECFCPTNFPSSMYCDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKLKEPISSYIFFCFPHIHTIYYGEQRSTNGQTIQLKTQVFRRFPDDDDESEDHDDPDNAHESPEQEGAEGHFDLHYYENQE

Target ORF information:

RefSeq Version	NM_005014.2
Organism	Homo sapiens(human)
Definition	Homo sapiens osteomodulin (OMD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005014.2

ORF Insert Sequence:

ATGGGTTTTT TAAGTCCAAT ATATGTTATT TTCTTCTTTT TTGGAGTCAA AGTACATTGC 
CAATATGAAA CTTATCAGTG GGATGAAGAC TATGACCAAG AGCCAGATGA TGATTACCAA 
ACAGGATTCC CATTTCGTCA AAATGTAGAC TACGGAGTTC CTTTTCATCA GTATACTTTA 
GGCTGTGTCA GTGAATGCTT CTGTCCAACT AACTTTCCAT CATCAATGTA CTGTGATAAT 
CGCAAACTCA AGACTATCCC AAATATTCCG ATGCACATTC AGCAACTCTA CCTTCAGTTC 
AATGAAATTG AGGCTGTGAC TGCAAATTCA TTCATCAATG CAACTCATCT TAAAGAAATT 
AACCTCAGCC ACAACAAAAT TAAATCTCAA AAGATTGATT ATGGTGTGTT TGCTAAGCTT 
CCAAATCTAC TACAACTTCA TCTAGAGCAT AATAATTTAG AAGAATTTCC ATTTCCTCTT 
CCTAAATCTC TGGAAAGACT CCTTCTTGGT TACAATGAAA TCTCCAAACT GCAGACAAAT 
GCTATGGATG GGCTAGTAAA CTTGACCATG CTTGATCTCT GTTATAATTA TCTTCATGAT 
TCTCTGCTAA AAGACAAAAT CTTTGCCAAA ATGGAAAAAC TAATGCAGCT CAACCTCTGC 
AGTAACAGAT TAGAATCAAT GCCTCCTGGT TTGCCTTCTT CACTTATGTA TCTGTCTTTA 
GAAAATAATT CAATTTCTTC TATACCCGAA AAATACTTCG ACAAACTTCC AAAACTTCAT 
ACTCTAAGAA TGTCACACAA CAAACTACAA GACATCCCAT ATAATATTTT TAATCTTCCC 
AACATTGTAG AACTCAGTGT TGGACACAAC AAATTGAAGC AAGCATTCTA TATTCCAAGA 
AATTTGGAAC ACCTATACCT ACAAAATAAT GAAATAGAAA AGATGAATCT TACAGTGATG 
TGTCCTTCTA TTGACCCACT ACATTACCAC CATTTAACAT ACATTCGTGT GGACCAAAAT 
AAACTAAAAG AACCAATAAG CTCATACATC TTCTTCTGCT TCCCTCATAT ACACACTATT 
TATTATGGTG AACAACGAAG CACTAATGGT CAAACAATAC AACTAAAGAC ACAAGTTTTC 
AGGAGATTTC CAGATGATGA TGATGAAAGT GAAGATCACG ATGATCCTGA CAATGCTCAT 
GAGAGCCCAG AACAAGAAGG AGCAGAAGGG CACTTTGACC TTCATTATTA TGAAAATCAA 
GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Osteomodulin regulates diameter and alters shape of collagen fibrils.
Biochemical and biophysical research communications463(3)292-6(2015 Jul)
Tashima T,Nagatoishi S,Sagara H,Ohnuma S,Tsumoto K

Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage.
Arthritis & rheumatology (Hoboken, N.J.)67(2)435-41(2015 Feb)
Juchtmans N,Dhollander AA,Coudenys J,Audenaert EA,Pattyn C,Lambrecht S,Elewaut D

The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors.
The Journal of biological chemistry284(42)28543-53(2009 Oct)
Tillgren V,Onnerfjord P,Haglund L,Heineg?rd D

Immunodetection of osteoadherin in murine tooth extracellular matrices.
Histochemistry and cell biology121(1)47-53(2004 Jan)
Couble ML,Bleicher F,Farges JC,Peyrol S,Lucchini M,Magloire H,Staquet MJ

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome research13(10)2265-70(2003 Oct)
Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A

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OMD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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