NINJ1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NINJ1
Entrez Gene ID	4814
Full Name	ninjurin 1
Synonyms	NIN1,NINJURIN
General protein information	Preferred Names ninjurin 1 Names ninjurin-1 nerve injury-induced protein-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q22.31
Summary	The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009].
Disorder MIM:	602062

mRNA and Protein(s)

mRNA	Protein	Name
NM_004148.3	NP_004139.2	ninjurin-1
NM_004148.4	NP_004139.2	ninjurin-1
XM_011518716.1	XP_011517018.1	ninjurin-1 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NINJ1	XP_853215.2
Danio rerio (zebrafish)	LOC100150223	XP_001919024.1
Xenopus tropicalis (tropical clawed frog)	ninj1	NP_001008021.2
	NINJ1	XP_001108521.2
Bos taurus (cattle)	NINJ1	NP_001033171.1
Homo sapiens (human)	NINJ1	NP_004139.2
Gallus gallus (chicken)	NINJ1	NP_001264806.1
Pan troglodytes (chimpanzee)	NINJ1	XP_003312226.1
Mus musculus (house mouse)	Ninj1	NP_038638.1
Rattus norvegicus (Norway rat)	Ninj1	NP_036999.1

Gene Ontology
Bibliography

Related articles in PubMed

Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation.
Bae SJ, Shin MW, Kim RH, Shin D, Son T, Wee HJ, Kim KW
Journal of cellular biochemistry118(8)2219-2230(2017 Aug)

Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a Critical Role in Prostate Cancer Cell Motility.
Park J, Joung JY, Hwang JE, Hong D, Park WS, Lee SJ, Lee KH
Anticancer research37(4)1687-1696(2017 04)

Ninjurin1 suppresses metastatic property of lung cancer cells through inhibition of interleukin 6 signaling pathway.
Jang YS, Kang JH, Woo JK, Kim HM, Hwang JI, Lee SJ, Lee HY, Oh SH
International journal of cancer139(2)383-95(2016 07)

Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation.
Jennewein C, Sowa R, Faber AC, Dildey M, von Knethen A, Meybohm P, Scheller B, Dr?se S, Zacharowski K
American journal of respiratory cell and molecular biology53(5)656-63(2015 Nov)

Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes.
Matsuki M, Kabara M, Saito Y, Shimamura K, Minoshima A, Nishimura M, Aonuma T, Takehara N, Hasebe N, Kawabe J
Circulation journal : official journal of the Japanese Circulation Society79(6)1363-71(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that Ninj1 assembles into a homomeric protein complex and that N-glycosylation is a prerequisite for Ninj1 homomer assembly.
Title: Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation.

High ninjurin 1 expression is associated with Prostate Cancer.
Title: Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a Critical Role in Prostate Cancer Cell Motility.

Ninj1 suppresses migration, invasion and metastasis of lung cancer via inhibition of the IL-6 signaling pathway in vitro and in vivo.
Title: Ninjurin1 suppresses metastatic property of lung cancer cells through inhibition of interleukin 6 signaling pathway.

Ninj1 modulates TLR4 signaling, which itself plays a major role in systemic inflammatory response syndrome and sepsis.
Title: Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation.

Ninj1 expression was detected in both HSMCs and HUVECs, and was higher in the former. Ninj1 expression was enhanced by hypoxia in HUVECs.
Title: Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes.

The following NINJ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NINJ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04450	NM_004148.4 Latest version!	Homo sapiens ninjurin 1 (NINJ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu59278	XM_011518716.1 Latest version!	Homo sapiens ninjurin 1 (NINJ1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu04450	NM_004148.3	Homo sapiens ninjurin 1 (NINJ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NINJ1 ( NM_004148.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004139.2 Homo sapiens ninjurin 1 (NINJ1), mRNA.

Price & Availability↑

CloneID	OHu04450
Clone ID Related Accession (Same CDS sequence)	NM_004148.3 , NM_004148.4
Accession Version	NM_004148.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	ninjurin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC048212.1, BC000298.1 and BC019336.1. On Jun 19, 2007 this sequence version replaced NM_004148.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048212.1, ERR279839.10072.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCGG GAACCGAGGA GTACGAGCTC AACGGCGGCC TGCCTCCGGG CACACCCGGC 
TCCCCGGACG CCTCGCCGGC CCGCTGGGGC TGGAGGCACG GGCCCATCAA CGTGAACCAT 
TACGCCAGCA AGAAGAGCGC AGCCGAGAGC ATGCTGGACA TCGCGCTGCT GATGGCCAAC 
GCGTCCCAGC TGAAGGCCGT CGTGGAACAG GGCCCCAGCT TCGCCTTCTA TGTGCCCCTG 
GTGGTCCTCA TCTCCATCTC CCTTGTGCTG CAGATCGGCG TGGGGGTGCT GCTCATCTTC 
CTTGTCAAGT ACGACCTTAA CAACCCGGCC AAGCACGCCA AGCTGGACTT CCTCAACAAC 
CTGGCCACGG GCCTGGTGTT CATCATCGTG GTAGTCAACA TCTTCATCAC GGCCTTCGGG 
GTCCAGAAGC CCTTGATGGA CATGGCACCC CAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004139.2
CDS	72..530
Translation	MDSGTEEYELNGGLPPGTPGSPDASPARWGWRHGPINVNHYASKKSAAESMLDIALLMANASQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPLMDMAPQQ

Target ORF information:

RefSeq Version	NM_004148.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ninjurin 1 (NINJ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004148.3

ORF Insert Sequence:

ATGGACTCGG GAACCGAGGA GTACGAGCTC AACGGCGGCC TGCCTCCGGG CACACCCGGC 
TCCCCGGACG CCTCGCCGGC CCGCTGGGGC TGGAGGCACG GGCCCATCAA CGTGAACCAT 
TACGCCAGCA AGAAGAGCGC AGCCGAGAGC ATGCTGGACA TCGCGCTGCT GATGGCCAAC 
GCGTCCCAGC TGAAGGCCGT CGTGGAACAG GGCCCCAGCT TCGCCTTCTA TGTGCCCCTG 
GTGGTCCTCA TCTCCATCTC CCTTGTGCTG CAGATCGGCG TGGGGGTGCT GCTCATCTTC 
CTTGTCAAGT ACGACCTTAA CAACCCGGCC AAGCACGCCA AGCTGGACTT CCTCAACAAC 
CTGGCCACGG GCCTGGTGTT CATCATCGTG GTAGTCAACA TCTTCATCAC GGCCTTCGGG 
GTCCAGAAGC CCTTGATGGA CATGGCACCC CAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NINJ1 ( NM_004148.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004139.2 Homo sapiens ninjurin 1 (NINJ1), mRNA.

Price & Availability↑

CloneID	OHu04450
Clone ID Related Accession (Same CDS sequence)	NM_004148.3 , NM_004148.4
Accession Version	NM_004148.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	ninjurin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL451065.13. On Nov 23, 2018 this sequence version replaced NM_004148.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.658452.1, BC048212.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375446.5/ ENSP00000364595.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACTCGG GAACCGAGGA GTACGAGCTC AACGGCGGCC TGCCTCCGGG CACACCCGGC 
TCCCCGGACG CCTCGCCGGC CCGCTGGGGC TGGAGGCACG GGCCCATCAA CGTGAACCAT 
TACGCCAGCA AGAAGAGCGC AGCCGAGAGC ATGCTGGACA TCGCGCTGCT GATGGCCAAC 
GCGTCCCAGC TGAAGGCCGT CGTGGAACAG GGCCCCAGCT TCGCCTTCTA TGTGCCCCTG 
GTGGTCCTCA TCTCCATCTC CCTTGTGCTG CAGATCGGCG TGGGGGTGCT GCTCATCTTC 
CTTGTCAAGT ACGACCTTAA CAACCCGGCC AAGCACGCCA AGCTGGACTT CCTCAACAAC 
CTGGCCACGG GCCTGGTGTT CATCATCGTG GTAGTCAACA TCTTCATCAC GGCCTTCGGG 
GTCCAGAAGC CCTTGATGGA CATGGCACCC CAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004139.2
CDS	35..493
Translation	MDSGTEEYELNGGLPPGTPGSPDASPARWGWRHGPINVNHYASKKSAAESMLDIALLMANASQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPLMDMAPQQ

Target ORF information:

RefSeq Version	NM_004148.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ninjurin 1 (NINJ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004148.4

ORF Insert Sequence:

ATGGACTCGG GAACCGAGGA GTACGAGCTC AACGGCGGCC TGCCTCCGGG CACACCCGGC 
TCCCCGGACG CCTCGCCGGC CCGCTGGGGC TGGAGGCACG GGCCCATCAA CGTGAACCAT 
TACGCCAGCA AGAAGAGCGC AGCCGAGAGC ATGCTGGACA TCGCGCTGCT GATGGCCAAC 
GCGTCCCAGC TGAAGGCCGT CGTGGAACAG GGCCCCAGCT TCGCCTTCTA TGTGCCCCTG 
GTGGTCCTCA TCTCCATCTC CCTTGTGCTG CAGATCGGCG TGGGGGTGCT GCTCATCTTC 
CTTGTCAAGT ACGACCTTAA CAACCCGGCC AAGCACGCCA AGCTGGACTT CCTCAACAAC 
CTGGCCACGG GCCTGGTGTT CATCATCGTG GTAGTCAACA TCTTCATCAC GGCCTTCGGG 
GTCCAGAAGC CCTTGATGGA CATGGCACCC CAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NINJ1 ( XM_011518716.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517018.1 Homo sapiens ninjurin 1 (NINJ1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59278
Clone ID Related Accession (Same CDS sequence)	XM_011518716.1
Accession Version	XM_011518716.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ninjurin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGACA TCGCGCTGCT GATGGCCAAC GCGTCCCAGC TGAAGGCCGT CGTGGAACAG 
GGCCCCAGCT TCGCCTTCTA TGTGCCCCTG GTGGTCCTCA TCTCCATCTC CCTTGTGCTG 
CAGATCGGCG TGGGGGTGCT GCTCATCTTC CTTGTCAAGT ACGACCTTAA CAACCCGGCC 
AAGCACGCCA AGCTGGACTT CCTCAACAAC CTGGCCACGG GCCTGGTGTT CATCATCGTG 
GTAGTCAACA TCTTCATCAC GGCCTTCGGG GTCCAGAAGC CCTTGATGGA CATGGCACCC 
CAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517018.1
CDS	295..603
Translation	MLDIALLMANASQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPLMDMAPQQ

Target ORF information:

RefSeq Version	XM_011518716.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ninjurin 1 (NINJ1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011518716.1

ORF Insert Sequence:

ATGCTGGACA TCGCGCTGCT GATGGCCAAC GCGTCCCAGC TGAAGGCCGT CGTGGAACAG 
GGCCCCAGCT TCGCCTTCTA TGTGCCCCTG GTGGTCCTCA TCTCCATCTC CCTTGTGCTG 
CAGATCGGCG TGGGGGTGCT GCTCATCTTC CTTGTCAAGT ACGACCTTAA CAACCCGGCC 
AAGCACGCCA AGCTGGACTT CCTCAACAAC CTGGCCACGG GCCTGGTGTT CATCATCGTG 
GTAGTCAACA TCTTCATCAC GGCCTTCGGG GTCCAGAAGC CCTTGATGGA CATGGCACCC 
CAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation.
Journal of cellular biochemistry118(8)2219-2230(2017 Aug)
Bae SJ,Shin MW,Kim RH,Shin D,Son T,Wee HJ,Kim KW

Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a Critical Role in Prostate Cancer Cell Motility.
Anticancer research37(4)1687-1696(2017 04)
Park J,Joung JY,Hwang JE,Hong D,Park WS,Lee SJ,Lee KH

Ninjurin1 suppresses metastatic property of lung cancer cells through inhibition of interleukin 6 signaling pathway.
International journal of cancer139(2)383-95(2016 07)
Jang YS,Kang JH,Woo JK,Kim HM,Hwang JI,Lee SJ,Lee HY,Oh SH

Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation.
American journal of respiratory cell and molecular biology53(5)656-63(2015 Nov)
Jennewein C,Sowa R,Faber AC,Dildey M,von Knethen A,Meybohm P,Scheller B,Dr?se S,Zacharowski K

Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes.
Circulation journal : official journal of the Japanese Circulation Society79(6)1363-71(2015)
Matsuki M,Kabara M,Saito Y,Shimamura K,Minoshima A,Nishimura M,Aonuma T,Takehara N,Hasebe N,Kawabe J

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NINJ1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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