NDUFS6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NDUFS6
Entrez Gene ID	4726
Full Name	NADH:ubiquinone oxidoreductase subunit S6
Synonyms	CI-13kA,CI-13kD-A,CI13KDA
General protein information	Preferred Names NADH:ubiquinone oxidoreductase subunit S6 Names NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) NADH-ubiquinone oxidoreductase 13 kDa-A subunit NADH:ubiquinone oxidoreductase NDUFS6 subunit complex I 13kDa subunit A complex I, mitochondrial respiratory chain, 13-kD subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p15.33
Summary	This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009].
Disorder MIM:	603848
Disorder Html:	Mitochondrial complex I deficiency, 252010 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004553.4	NP_004544.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor
NM_004553.6	NP_004544.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor
NM_004553.5	NP_004544.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NDUFS6	NP_001123606.1
Caenorhabditis elegans (roundworm)	nduf-6	NP_492007.1
	NDUFS6	XP_001105649.1
Gallus gallus (chicken)	NDUFS6	XP_419061.1
Danio rerio (zebrafish)	ndufs6	NP_001004651.1
Drosophila melanogaster (fruit fly)	CG8680	NP_608909.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009072	XP_319821.3
Xenopus tropicalis (tropical clawed frog)	ndufs6	XP_002941817.1
Homo sapiens (human)	NDUFS6	NP_004544.1
Rattus norvegicus (Norway rat)	LOC100912599	XP_003748730.1
Mus musculus (house mouse)	Ndufs6	NP_035018.1
Mus musculus (house mouse)	Gm6415	XP_894909.2
Bos taurus (cattle)	NDUFS6	NP_787004.1
Rattus norvegicus (Norway rat)	LOC679739	XP_001053017.1

Gene Ontology
Bibliography

Related articles in PubMed

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT
Nature538(7623)123-126(2016 Oct)

CD147 interacts with NDUFS6 in regulating mitochondrial complex I activity and the mitochondrial apoptotic pathway in human malignant melanoma cells.
Luo Z, Zeng W, Tang W, Long T, Zhang J, Xie X, Kuang Y, Chen M, Su J, Chen X
Current molecular medicine14(10)1252-64(2014)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N
Journal of human genetics54(6)317-23(2009 Jun)

Polymorphisms in mitochondrial genes and prostate cancer risk.
Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology17(12)3558-66(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD147 appears to regulate complex I activity and apoptosis in malignant melanoma cells by interacting with mitochondrial NDUFS6.
Title: CD147 interacts with NDUFS6 in regulating mitochondrial complex I activity and the mitochondrial apoptotic pathway in human malignant melanoma cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
Title: Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

The following NDUFS6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDUFS6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18660	NM_004553.6 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18660	NM_004553.4	Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18660	NM_004553.5	Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NDUFS6 ( NM_004553.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004544.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.

Price & Availability↑

CloneID	OHu18660
Clone ID Related Accession (Same CDS sequence)	NM_004553.4 , NM_004553.6 , NM_004553.5
Accession Version	NM_004553.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE900424.1, BC038664.1 and CN285188.1. This sequence is a reference standard in the RefSeqGene project. On Oct 10, 2009 this sequence version replaced NM_004553.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB996827.1, BC038664.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGATGACCTT CTGCCGGCTG CTGAACCGGT GTGGCGAGGC GGCGCGGAGC 
CTGCCCCTGG GCGCCAGGTG TTTCGGGGTG CGGGTCTCGC CGACCGGGGA GAAGGTCACG 
CACACTGGCC AGGTTTATGA TGATAAAGAC TACAGGAGAA TTCGGTTTGT AGGTCGTCAG 
AAAGAGGTGA ATGAAAACTT TGCCATTGAT TTGATAGCAG AGCAGCCCGT GAGCGAGGTG 
GAGACTCGGG TGATAGCGTG CGATGGCGGC GGGGGAGCTC TTGGCCACCC AAAAGTGTAT 
ATAAACTTGG ACAAAGAAAC AAAAACCGGC ACATGCGGTT ACTGTGGGCT CCAGTTCAGA 
CAGCACCACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004544.1
CDS	37..411
Translation	MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHH

Target ORF information:

RefSeq Version	NM_004553.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004553.4

ORF Insert Sequence:

ATGGCGGCGG CGATGACCTT CTGCCGGCTG CTGAACCGGT GTGGCGAGGC GGCGCGGAGC 
CTGCCCCTGG GCGCCAGGTG TTTCGGGGTG CGGGTCTCGC CGACCGGGGA GAAGGTCACG 
CACACTGGCC AGGTTTATGA TGATAAAGAC TACAGGAGAA TTCGGTTTGT AGGTCGTCAG 
AAAGAGGTGA ATGAAAACTT TGCCATTGAT TTGATAGCAG AGCAGCCCGT GAGCGAGGTG 
GAGACTCGGG TGATAGCGTG CGATGGCGGC GGGGGAGCTC TTGGCCACCC AAAAGTGTAT 
ATAAACTTGG ACAAAGAAAC AAAAACCGGC ACATGCGGTT ACTGTGGGCT CCAGTTCAGA 
CAGCACCACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFS6 ( NM_004553.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_004544.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.

Price & Availability↑

CloneID	OHu18660
Clone ID Related Accession (Same CDS sequence)	NM_004553.4 , NM_004553.6 , NM_004553.5
Accession Version	NM_004553.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC038664.1. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2019 this sequence version replaced NM_004553.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038664.1, EB387195.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGATGACCTT CTGCCGGCTG CTGAACCGGT GTGGCGAGGC GGCGCGGAGC 
CTGCCCCTGG GCGCCAGGTG TTTCGGGGTG CGGGTCTCGC CGACCGGGGA GAAGGTCACG 
CACACTGGCC AGGTTTATGA TGATAAAGAC TACAGGAGAA TTCGGTTTGT AGGTCGTCAG 
AAAGAGGTGA ATGAAAACTT TGCCATTGAT TTGATAGCAG AGCAGCCCGT GAGCGAGGTG 
GAGACTCGGG TGATAGCGTG CGATGGCGGC GGGGGAGCTC TTGGCCACCC AAAAGTGTAT 
ATAAACTTGG ACAAAGAAAC AAAAACCGGC ACATGCGGTT ACTGTGGGCT CCAGTTCAGA 
CAGCACCACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004544.1
CDS	12..386
Translation	MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHH

Target ORF information:

RefSeq Version	NM_004553.6
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004553.6

ORF Insert Sequence:

ATGGCGGCGG CGATGACCTT CTGCCGGCTG CTGAACCGGT GTGGCGAGGC GGCGCGGAGC 
CTGCCCCTGG GCGCCAGGTG TTTCGGGGTG CGGGTCTCGC CGACCGGGGA GAAGGTCACG 
CACACTGGCC AGGTTTATGA TGATAAAGAC TACAGGAGAA TTCGGTTTGT AGGTCGTCAG 
AAAGAGGTGA ATGAAAACTT TGCCATTGAT TTGATAGCAG AGCAGCCCGT GAGCGAGGTG 
GAGACTCGGG TGATAGCGTG CGATGGCGGC GGGGGAGCTC TTGGCCACCC AAAAGTGTAT 
ATAAACTTGG ACAAAGAAAC AAAAACCGGC ACATGCGGTT ACTGTGGGCT CCAGTTCAGA 
CAGCACCACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFS6 ( NM_004553.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004544.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.

Price & Availability↑

CloneID	OHu18660
Clone ID Related Accession (Same CDS sequence)	NM_004553.4 , NM_004553.6 , NM_004553.5
Accession Version	NM_004553.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC038664.1, CN285188.1 and AC026443.4. On Jun 2, 2019 this sequence version replaced NM_004553.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM835452.1, BP225208.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGATGACCTT CTGCCGGCTG CTGAACCGGT GTGGCGAGGC GGCGCGGAGC 
CTGCCCCTGG GCGCCAGGTG TTTCGGGGTG CGGGTCTCGC CGACCGGGGA GAAGGTCACG 
CACACTGGCC AGGTTTATGA TGATAAAGAC TACAGGAGAA TTCGGTTTGT AGGTCGTCAG 
AAAGAGGTGA ATGAAAACTT TGCCATTGAT TTGATAGCAG AGCAGCCCGT GAGCGAGGTG 
GAGACTCGGG TGATAGCGTG CGATGGCGGC GGGGGAGCTC TTGGCCACCC AAAAGTGTAT 
ATAAACTTGG ACAAAGAAAC AAAAACCGGC ACATGCGGTT ACTGTGGGCT CCAGTTCAGA 
CAGCACCACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004544.1
CDS	12..386
Translation	MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHH

Target ORF information:

RefSeq Version	NM_004553.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit S6 (NDUFS6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004553.5

ORF Insert Sequence:

ATGGCGGCGG CGATGACCTT CTGCCGGCTG CTGAACCGGT GTGGCGAGGC GGCGCGGAGC 
CTGCCCCTGG GCGCCAGGTG TTTCGGGGTG CGGGTCTCGC CGACCGGGGA GAAGGTCACG 
CACACTGGCC AGGTTTATGA TGATAAAGAC TACAGGAGAA TTCGGTTTGT AGGTCGTCAG 
AAAGAGGTGA ATGAAAACTT TGCCATTGAT TTGATAGCAG AGCAGCCCGT GAGCGAGGTG 
GAGACTCGGG TGATAGCGTG CGATGGCGGC GGGGGAGCTC TTGGCCACCC AAAAGTGTAT 
ATAAACTTGG ACAAAGAAAC AAAAACCGGC ACATGCGGTT ACTGTGGGCT CCAGTTCAGA 
CAGCACCACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature538(7623)123-126(2016 Oct)
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT

CD147 interacts with NDUFS6 in regulating mitochondrial complex I activity and the mitochondrial apoptotic pathway in human malignant melanoma cells.
Current molecular medicine14(10)1252-64(2014)
Luo Z,Zeng W,Tang W,Long T,Zhang J,Xie X,Kuang Y,Chen M,Su J,Chen X

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Journal of human genetics54(6)317-23(2009 Jun)
Saito A,Kawamoto M,Kamatani N

Polymorphisms in mitochondrial genes and prostate cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology17(12)3558-66(2008 Dec)
Wang L,McDonnell SK,Hebbring SJ,Cunningham JM,St Sauver J,Cerhan JR,Isaya G,Schaid DJ,Thibodeau SN

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NDUFS6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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