NDUFB6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NDUFB6
Entrez Gene ID	4712
Full Name	NADH:ubiquinone oxidoreductase subunit B6
Synonyms	B17,CI
General protein information	Preferred Names NADH:ubiquinone oxidoreductase subunit B6 Names NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 CI-B17 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa NADH-ubiquinone oxidoreductase B17 subunit NADH-ubiquinone oxidoreductase beta subunit, 6 complex I, mitochondrial respiratory chain, B17 subunit complex I-B17
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.1
Summary	The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011].
Disorder MIM:	603322

mRNA and Protein(s)

mRNA	Protein	Name
NM_002493.4	NP_002484.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 1
NM_001199987.1	NP_001186916.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 3
NM_002493.5	NP_002484.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 1
NM_182739.3	NP_877416.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 2
NM_182739.2	NP_877416.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	ndufb6	NP_957102.1
Xenopus tropicalis (tropical clawed frog)	ndufb6	NP_001016490.1
Pan troglodytes (chimpanzee)	NDUFB6	NP_001233137.1
Mus musculus (house mouse)	Ndufb6	NP_001028477.1
Rattus norvegicus (Norway rat)	Ndufb6	NP_001100116.1
Homo sapiens (human)	NDUFB6	NP_002484.1
Canis lupus familiaris (dog)	NDUFB6	NP_001239210.1
Gallus gallus (chicken)	NDUFB6	NP_001264454.1
	NDUFB6	XP_001103422.1
Bos taurus (cattle)	NDUFB6	NP_786981.1

Gene Ontology
Bibliography

Related articles in PubMed

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT
Nature538(7623)123-126(2016 Oct)

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.
Kmita K, Wirth C, Warnau J, Guerrero-Castillo S, Hunte C, Hummer G, Kaila VR, Zwicker K, Brandt U, Zickermann V
Proceedings of the National Academy of Sciences of the United States of America112(18)5685-90(2015 May)

Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.
Narimatsu T, Matsuura K, Nakada C, Tsukamoto Y, Hijiya N, Kai T, Inoue T, Uchida T, Nomura T, Sato F, Seto M, Takeuchi I, Mimata H, Moriyama M
Cancer medicine4(1)112-24(2015 Jan)

Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A, Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, Duru N, He F, Chen M, Finkel T, Weinstein LS, Li JJ
Developmental cell29(2)217-32(2014 Apr)

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Kennedy RB, Ovsyannikova IG, Pankratz VS, Haralambieva IH, Vierkant RA, Poland GA
Human genetics131(9)1403-21(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NDUFS6 has a Zn-binding site and is essential for biogenesis of mitochondrial complex I
Title: Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.

we propose that NDUFB6 is a possible tumor suppressor of metastatic ccRCCs.
Title: Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.

NDUFB6 subunit is required for complex I activity.
Title: The NDUFB6 subunit of the mitochondrial respiratory chain complex I is required for electron transfer activity: a proof of principle study on stable and controlled RNA interference in human cell lines.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes.

The following NDUFB6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDUFB6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55668	NM_002493.5 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09421	NM_001199987.1 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu18632	NM_182739.3 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu55668	NM_002493.4	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18632	NM_182739.2	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NDUFB6 ( NM_002493.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002484.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55668
Clone ID Related Accession (Same CDS sequence)	NM_002493.4 , NM_002493.5
Accession Version	NM_002493.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB140469.1, BP208846.1, BI669356.1 and BG220924.1. On Jan 5, 2011 this sequence version replaced NM_002493.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI670433.1, ERR279826.4538.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGAAAAAC CATATGGCAT AGTTGAAAAG 
AAGTCCAGAA TATTCCCTGG TGATACAATT CTGGAGACTG GAGAAGTAAT TCCACCAATG 
AAAGAATTTC CTGATCAACA TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002484.1
CDS	125..511
Translation	MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSEKPYGIVEKKSRIFPGDTILETGEVIPPMKEFPDQHH

Target ORF information:

RefSeq Version	NM_002493.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002493.4

ORF Insert Sequence:

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGAAAAAC CATATGGCAT AGTTGAAAAG 
AAGTCCAGAA TATTCCCTGG TGATACAATT CTGGAGACTG GAGAAGTAAT TCCACCAATG 
AAAGAATTTC CTGATCAACA TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB6 ( NM_002493.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002484.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55668
Clone ID Related Accession (Same CDS sequence)	NM_002493.4 , NM_002493.5
Accession Version	NM_002493.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP208846.1, BI669356.1, BG220924.1 and AL353671.6. On Nov 22, 2018 this sequence version replaced NM_002493.4. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1014428.1, SRR5189655.211686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000379847.8/ ENSP00000369176.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGAAAAAC CATATGGCAT AGTTGAAAAG 
AAGTCCAGAA TATTCCCTGG TGATACAATT CTGGAGACTG GAGAAGTAAT TCCACCAATG 
AAAGAATTTC CTGATCAACA TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002484.1
CDS	100..486
Translation	MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSEKPYGIVEKKSRIFPGDTILETGEVIPPMKEFPDQHH

Target ORF information:

RefSeq Version	NM_002493.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002493.5

ORF Insert Sequence:

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGAAAAAC CATATGGCAT AGTTGAAAAG 
AAGTCCAGAA TATTCCCTGG TGATACAATT CTGGAGACTG GAGAAGTAAT TCCACCAATG 
AAAGAATTTC CTGATCAACA TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB6 ( NM_001199987.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186916.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09421
Clone ID Related Accession (Same CDS sequence)	NM_001199987.1
Accession Version	NM_001199987.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB140469.1, AW160372.1, BI669356.1 and BG220924.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW160372.1, ERR279875.3567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GAAAAACCAT ATGGCATAGT TGAAAAGAAG TCCAGAATAT TCCCTGGTGA TACAATTCTG 
GAGACTGGAG AAGTAATTCC ACCAATGAAA GAATTTCCTG ATCAACATCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186916.1
CDS	125..418
Translation	MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMEKPYGIVEKKSRIFPGDTILETGEVIPPMKEFPDQHH

Target ORF information:

RefSeq Version	NM_001199987.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199987.1

ORF Insert Sequence:

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GAAAAACCAT ATGGCATAGT TGAAAAGAAG TCCAGAATAT TCCCTGGTGA TACAATTCTG 
GAGACTGGAG AAGTAATTCC ACCAATGAAA GAATTTCCTG ATCAACATCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB6 ( NM_182739.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_877416.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18632
Clone ID Related Accession (Same CDS sequence)	NM_182739.3 , NM_182739.2
Accession Version	NM_182739.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB140469.1, BI669356.1, BG220924.1 and AL353671.6. This sequence is a reference standard in the RefSeqGene project. On Jun 1, 2019 this sequence version replaced NM_182739.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.146307.1, BI669356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGGTGATA CAATTCTGGA GACTGGAGAA 
GTAATTCCAC CAATGAAAGA ATTTCCTGAT CAACATCATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877416.1
CDS	100..441
Translation	MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSGDTILETGEVIPPMKEFPDQHH

Target ORF information:

RefSeq Version	NM_182739.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182739.3

ORF Insert Sequence:

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGGTGATA CAATTCTGGA GACTGGAGAA 
GTAATTCCAC CAATGAAAGA ATTTCCTGAT CAACATCATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFB6 ( NM_182739.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_877416.1 Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18632
Clone ID Related Accession (Same CDS sequence)	NM_182739.3 , NM_182739.2
Accession Version	NM_182739.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB140469.1, BI669356.1 and BG220924.1. This sequence is a reference standard in the RefSeqGene project. On Jan 5, 2011 this sequence version replaced NM_182739.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI669356.1, SRR1163655.418863.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGGTGATA CAATTCTGGA GACTGGAGAA 
GTAATTCCAC CAATGAAAGA ATTTCCTGAT CAACATCATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877416.1
CDS	125..466
Translation	MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSGDTILETGEVIPPMKEFPDQHH

Target ORF information:

RefSeq Version	NM_182739.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit B6 (NDUFB6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182739.2

ORF Insert Sequence:

ATGACGGGGT ACACTCCGGA TGAGAAACTG CGGCTGCAGC AGCTGCGAGA GCTGAGAAGG 
CGATGGCTGA AGGACCAGGA GCTGAGCCCT CGGGAGCCGG TGCTGCCCCC ACAGAAGATG 
GGGCCTATGG AGAAATTCTG GAATAAATTT TTGGAGAATA AATCCCCTTG GAGGAAAATG 
GTCCATGGGG TATACAAAAA GAGTATCTTT GTTTTCACTC ATGTACTTGT ACCTGTCTGG 
ATTATTCATT ATTACATGAA GTATCATGTT TCTGGTGATA CAATTCTGGA GACTGGAGAA 
GTAATTCCAC CAATGAAAGA ATTTCCTGAT CAACATCATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature538(7623)123-126(2016 Oct)
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.
Proceedings of the National Academy of Sciences of the United States of America112(18)5685-90(2015 May)
Kmita K,Wirth C,Warnau J,Guerrero-Castillo S,Hunte C,Hummer G,Kaila VR,Zwicker K,Brandt U,Zickermann V

Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.
Cancer medicine4(1)112-24(2015 Jan)
Narimatsu T,Matsuura K,Nakada C,Tsukamoto Y,Hijiya N,Kai T,Inoue T,Uchida T,Nomura T,Sato F,Seto M,Takeuchi I,Mimata H,Moriyama M

Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
Developmental cell29(2)217-32(2014 Apr)
Wang Z,Fan M,Candas D,Zhang TQ,Qin L,Eldridge A,Wachsmann-Hogiu S,Ahmed KM,Chromy BA,Nantajit D,Duru N,He F,Chen M,Finkel T,Weinstein LS,Li JJ

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Human genetics131(9)1403-21(2012 Sep)
Kennedy RB,Ovsyannikova IG,Pankratz VS,Haralambieva IH,Vierkant RA,Poland GA

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NDUFB6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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