ATIC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATIC
Entrez Gene ID	471
Full Name	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms	AICAR,AICARFT,HEL-S-70p,IMPCHASE,PURH
General protein information	Preferred Names 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Names bifunctional purine biosynthesis protein PURH 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme AICARFT/IMPCHASE epididymis secretory sperm binding protein Li 70p phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Summary	This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009].
Disorder MIM:	601731
Disorder Html:	AICA-ribosiduria due to ATIC deficiency, 608688 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024452919.1	XP_024308687.1	bifunctional purine biosynthesis protein PURH isoform X2
NM_004044.7	NP_004035.2	bifunctional purine biosynthesis protein PURH
NM_004044.6	NP_004035.2	bifunctional purine biosynthesis protein PURH
XM_017004187.2	XP_016859676.1	bifunctional purine biosynthesis protein PURH isoform X1
XM_017004187.1	XP_016859676.1	bifunctional purine biosynthesis protein PURH isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATIC	XP_001150761.1
Danio rerio (zebrafish)	atic	NP_001076265.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001423	XP_321707.4
Neurospora crassa	NCU02629	XP_964054.1
Homo sapiens (human)	ATIC	NP_004035.2
Drosophila melanogaster (fruit fly)	CG11089	NP_651305.1
Caenorhabditis elegans (roundworm)	C55F2.1	NP_741452.2
Eremothecium gossypii	AGOS_AFR213C	NP_985760.2
Schizosaccharomyces pombe (fission yeast)	ade10	NP_588027.1
Magnaporthe oryzae (rice blast fungus)	MGG_04435	XP_003713530.1
Bos taurus (cattle)	ATIC	NP_001068722.1
Mus musculus (house mouse)	Atic	NP_080471.2
Rattus norvegicus (Norway rat)	Atic	NP_112276.2
Canis lupus familiaris (dog)	ATIC	XP_545634.2
Gallus gallus (chicken)	ATIC	NP_990509.1
Saccharomyces cerevisiae (baker's yeast)	ADE17	NP_013839.1
Xenopus tropicalis (tropical clawed frog)	atic	NP_001005460.1
	LOC694819	XP_002808069.1
Kluyveromyces lactis	KLLA0F17655g	XP_455873.1
Arabidopsis thaliana (thale cress)	AT2G35040	NP_001189681.1
Oryza sativa (rice)	Os08g0206600	NP_001061240.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of substrate binding in individual active sites of bifunctional human ATIC.
Witkowska D, Cox HL, Hall TC, Wildsmith GC, Machin DC, Webb ME
Biochimica et biophysica acta1866(2)254-263(2018 Feb)

Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6?K1 signaling.
Li M, Jin C, Xu M, Zhou L, Li D, Yin Y
Cell communication and signaling : CCS15(1)52(2017 Dec)

ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.
Park JA, Shin HY
Journal of pediatric hematology/oncology39(5)e270-e274(2017 Jul)

Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
Lee YH, Bae SC
Rheumatology international36(11)1591-1599(2016 Nov)

ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis.
Muralidharan N, Mariaselvam CM, Jain VK, Gulati R, Negi VS
Pharmacogenomics17(3)241-8(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy
Title: ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.

The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients.
Title: Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.

ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events.
Title: ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis.

PTPLAD1 and AMPK are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC later accumulates in the Golgi/endosome fraction.
Title: The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma
Title: Correlation of genetic polymorphisms with clinical outcomes in pemetrexed-treated advanced lung adenocarcinoma patients.

The following ATIC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATIC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19458	NM_004044.7 Latest version!	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu104902	XM_024452919.1 Latest version!	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu89504	XM_017004187.2 Latest version!	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu19458	NM_004044.6	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu89504	XM_017004187.1	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
Hide Old Accession Versions >>

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Reference Sequences (Refseq)

ATIC ( NM_004044.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_004035.2 Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), mRNA.

Price & Availability↑

CloneID	OHu19458
Clone ID Related Accession (Same CDS sequence)	NM_004044.7 , NM_004044.6
Accession Version	NM_004044.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	bifunctional purine biosynthesis protein PURH
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA074758.1, BC008879.2 and AA494525.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004044.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.22572.1, SRR1803613.156414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000236959.14/ ENSP00000236959.9 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA GTGGTGTGGC GTACATTGCG 
GCTCCCTCCG GTTCTGCTGC TGACAAAGTT GTGATTGAGG CCTGCGACGA ACTGGGAATC 
ATCCTCGCTC ATACGAACCT TCGGCTCTTC CACCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004035.2
CDS	85..1863
Translation	MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH

Target ORF information:

RefSeq Version	NM_004044.7
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004044.7

ORF Insert Sequence:

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA GTGGTGTGGC GTACATTGCG 
GCTCCCTCCG GTTCTGCTGC TGACAAAGTT GTGATTGAGG CCTGCGACGA ACTGGGAATC 
ATCCTCGCTC ATACGAACCT TCGGCTCTTC CACCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATIC ( NM_004044.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_004035.2 Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), mRNA.

Price & Availability↑

CloneID	OHu19458
Clone ID Related Accession (Same CDS sequence)	NM_004044.7 , NM_004044.6
Accession Version	NM_004044.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	bifunctional purine biosynthesis protein PURH
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA043224.1, DA074758.1, BC008879.2 and AA494525.1. This sequence is a reference standard in the RefSeqGene project. On Sep 17, 2009 this sequence version replaced NM_004044.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.156414.1, SRR1660803.88811.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA GTGGTGTGGC GTACATTGCG 
GCTCCCTCCG GTTCTGCTGC TGACAAAGTT GTGATTGAGG CCTGCGACGA ACTGGGAATC 
ATCCTCGCTC ATACGAACCT TCGGCTCTTC CACCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004035.2
CDS	188..1966
Translation	MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH

Target ORF information:

RefSeq Version	NM_004044.6
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004044.6

ORF Insert Sequence:

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA GTGGTGTGGC GTACATTGCG 
GCTCCCTCCG GTTCTGCTGC TGACAAAGTT GTGATTGAGG CCTGCGACGA ACTGGGAATC 
ATCCTCGCTC ATACGAACCT TCGGCTCTTC CACCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATIC ( XM_024452919.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024308687.1 Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu104902
Clone ID Related Accession (Same CDS sequence)	XM_024452919.1
Accession Version	XM_024452919.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1602bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	bifunctional purine biosynthesis protein PURH isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGGGGG GACGTGTGAA AACTTTGCAT CCTGCAGTCC ATGCTGGAAT CCTAGCTCGT 
AATATTCCAG AAGATAATGC TGACATGGCC AGACTTGATT TCAATCTTAT AAGAGTTGTT 
GCCTGCAATC TCTATCCCTT TGTAAAGACA GTGGCTTCTC CAGGTGTAAC TGTTGAGGAG 
GCTGTGGAGC AAATTGACAT TGGTGGAGTA ACCTTACTGA GAGCTGCAGC CAAAAACCAC 
GCTCGAGTGA CAGTGGTGTG TGAACCAGAG GACTATGTGG TGGTGTCCAC GGAGATGCAG 
AGCTCCGAGA GTAAGGACAC CTCCTTGGAG ACTAGACGCC AGTTAGCCTT GAAGGCATTC 
ACTCATACGG CACAATATGA TGAAGCAATT TCAGATTATT TCAGGAAACA GTACAGCAAA 
GGCGTATCTC AGATGCCCTT GAGATATGGA ATGAACCCAC ATCAGACCCC TGCCCAGCTG 
TACACACTGC AGCCCAAGCT TCCCATCACA GTTCTAAATG GAGCCCCTGG ATTTATAAAC 
TTGTGCGATG CTTTGAACGC CTGGCAGCTG GTGAAGGAAC TCAAGGAGGC TTTAGGTATT 
CCAGCCGCTG CCTCTTTCAA ACATGTCAGC CCAGCAGGTG CTGCTGTTGG AATTCCACTC 
AGTGAAGATG AGGCCAAAGT CTGCATGGTT TATGATCTCT ATAAAACCCT CACACCCATC 
TCAGCGGCAT ATGCAAGAGC AAGAGGGGCT GATAGGATGT CTTCATTTGG TGATTTTGTT 
GCATTGTCCG ATGTTTGTGA TGTACCAACT GCAAAAATTA TTTCCAGAGA AGTATCTGAT 
GGTATAATTG CCCCAGGATA TGAAGAAGAA GCCTTGACAA TACTTTCCAA AAAGAAAAAT 
GGAAACTATT GTGTCCTTCA GATGGACCAA TCTTACAAAC CAGATGAAAA TGAAGTTCGA 
ACTCTCTTTG GTCTTCATTT AAGCCAGAAG AGAAATAATG GTGTCGTCGA CAAGTCATTA 
TTTAGCAATG TTGTTACCAA AAATAAAGAT TTGCCAGAGT CTGCCCTCCG AGACCTCATC 
GTAGCCACCA TTGCTGTCAA GTACACTCAG TCTAACTCTG TGTGCTACGC CAAGAACGGG 
CAGGTTATCG GCATTGGAGC AGGACAGCAG TCTCGTATAC ACTGCACTCG CCTTGCAGGA 
GATAAGGCAA ACTATTGGTG GCTTAGACAC CATCCACAAG TGCTTTCGAT GAAGTTTAAA 
ACAGGAGTGA AGAGAGCAGA AATCTCCAAT GCCATCGATC AATATGTGAC TGGAACCATT 
GGCGAGGATG AAGATTTGAT AAAGTGGAAG GCACTGTTTG AGGAAGTCCC TGAGTTACTC 
ACTGAGGCAG AGAAGAAGGA ATGGGTTGAG AAACTGACTG AAGTTTCTAT CAGCTCTGAT 
GCCTTCTTCC CTTTCCGAGA TAACGTAGAC AGAGCTAAAA GGAGTGGTGT GGCGTACATT 
GCGGCTCCCT CCGGTTCTGC TGCTGACAAA GTTGTGATTG AGGCCTGCGA CGAACTGGGA 
ATCATCCTCG CTCATACGAA CCTTCGGCTC TTCCACCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024308687.1
CDS	473..2074
Translation	MLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH

Target ORF information:

RefSeq Version	XM_024452919.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024452919.1

ORF Insert Sequence:

ATGTTGGGGG GACGTGTGAA AACTTTGCAT CCTGCAGTCC ATGCTGGAAT CCTAGCTCGT 
AATATTCCAG AAGATAATGC TGACATGGCC AGACTTGATT TCAATCTTAT AAGAGTTGTT 
GCCTGCAATC TCTATCCCTT TGTAAAGACA GTGGCTTCTC CAGGTGTAAC TGTTGAGGAG 
GCTGTGGAGC AAATTGACAT TGGTGGAGTA ACCTTACTGA GAGCTGCAGC CAAAAACCAC 
GCTCGAGTGA CAGTGGTGTG TGAACCAGAG GACTATGTGG TGGTGTCCAC GGAGATGCAG 
AGCTCCGAGA GTAAGGACAC CTCCTTGGAG ACTAGACGCC AGTTAGCCTT GAAGGCATTC 
ACTCATACGG CACAATATGA TGAAGCAATT TCAGATTATT TCAGGAAACA GTACAGCAAA 
GGCGTATCTC AGATGCCCTT GAGATATGGA ATGAACCCAC ATCAGACCCC TGCCCAGCTG 
TACACACTGC AGCCCAAGCT TCCCATCACA GTTCTAAATG GAGCCCCTGG ATTTATAAAC 
TTGTGCGATG CTTTGAACGC CTGGCAGCTG GTGAAGGAAC TCAAGGAGGC TTTAGGTATT 
CCAGCCGCTG CCTCTTTCAA ACATGTCAGC CCAGCAGGTG CTGCTGTTGG AATTCCACTC 
AGTGAAGATG AGGCCAAAGT CTGCATGGTT TATGATCTCT ATAAAACCCT CACACCCATC 
TCAGCGGCAT ATGCAAGAGC AAGAGGGGCT GATAGGATGT CTTCATTTGG TGATTTTGTT 
GCATTGTCCG ATGTTTGTGA TGTACCAACT GCAAAAATTA TTTCCAGAGA AGTATCTGAT 
GGTATAATTG CCCCAGGATA TGAAGAAGAA GCCTTGACAA TACTTTCCAA AAAGAAAAAT 
GGAAACTATT GTGTCCTTCA GATGGACCAA TCTTACAAAC CAGATGAAAA TGAAGTTCGA 
ACTCTCTTTG GTCTTCATTT AAGCCAGAAG AGAAATAATG GTGTCGTCGA CAAGTCATTA 
TTTAGCAATG TTGTTACCAA AAATAAAGAT TTGCCAGAGT CTGCCCTCCG AGACCTCATC 
GTAGCCACCA TTGCTGTCAA GTACACTCAG TCTAACTCTG TGTGCTACGC CAAGAACGGG 
CAGGTTATCG GCATTGGAGC AGGACAGCAG TCTCGTATAC ACTGCACTCG CCTTGCAGGA 
GATAAGGCAA ACTATTGGTG GCTTAGACAC CATCCACAAG TGCTTTCGAT GAAGTTTAAA 
ACAGGAGTGA AGAGAGCAGA AATCTCCAAT GCCATCGATC AATATGTGAC TGGAACCATT 
GGCGAGGATG AAGATTTGAT AAAGTGGAAG GCACTGTTTG AGGAAGTCCC TGAGTTACTC 
ACTGAGGCAG AGAAGAAGGA ATGGGTTGAG AAACTGACTG AAGTTTCTAT CAGCTCTGAT 
GCCTTCTTCC CTTTCCGAGA TAACGTAGAC AGAGCTAAAA GGAGTGGTGT GGCGTACATT 
GCGGCTCCCT CCGGTTCTGC TGCTGACAAA GTTGTGATTG AGGCCTGCGA CGAACTGGGA 
ATCATCCTCG CTCATACGAA CCTTCGGCTC TTCCACCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATIC ( XM_017004187.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016859676.1 Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu89504
Clone ID Related Accession (Same CDS sequence)	XM_017004187.2 , XM_017004187.1
Accession Version	XM_017004187.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	bifunctional purine biosynthesis protein PURH isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017004187.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA TATCAAGGCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016859676.1
CDS	170..1843
Translation	MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRISRL

Target ORF information:

RefSeq Version	XM_017004187.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017004187.2

ORF Insert Sequence:

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA TATCAAGGCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATIC ( XM_017004187.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016859676.1 Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu89504
Clone ID Related Accession (Same CDS sequence)	XM_017004187.2 , XM_017004187.1
Accession Version	XM_017004187.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	bifunctional purine biosynthesis protein PURH isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA TATCAAGGCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016859676.1
CDS	111..1784
Translation	MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRISRL

Target ORF information:

RefSeq Version	XM_017004187.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017004187.1

ORF Insert Sequence:

ATGGCTCCCG GCCAGCTCGC CTTATTTAGT GTCTCTGACA AAACCGGCCT TGTGGAATTT 
GCAAGAAACC TGACCGCTCT TGGTTTGAAT CTGGTCGCTT CCGGAGGGAC TGCAAAAGCT 
CTCAGGGATG CTGGTCTGGC AGTCAGAGAT GTCTCTGAGT TGACGGGATT TCCTGAAATG 
TTGGGGGGAC GTGTGAAAAC TTTGCATCCT GCAGTCCATG CTGGAATCCT AGCTCGTAAT 
ATTCCAGAAG ATAATGCTGA CATGGCCAGA CTTGATTTCA ATCTTATAAG AGTTGTTGCC 
TGCAATCTCT ATCCCTTTGT AAAGACAGTG GCTTCTCCAG GTGTAACTGT TGAGGAGGCT 
GTGGAGCAAA TTGACATTGG TGGAGTAACC TTACTGAGAG CTGCAGCCAA AAACCACGCT 
CGAGTGACAG TGGTGTGTGA ACCAGAGGAC TATGTGGTGG TGTCCACGGA GATGCAGAGC 
TCCGAGAGTA AGGACACCTC CTTGGAGACT AGACGCCAGT TAGCCTTGAA GGCATTCACT 
CATACGGCAC AATATGATGA AGCAATTTCA GATTATTTCA GGAAACAGTA CAGCAAAGGC 
GTATCTCAGA TGCCCTTGAG ATATGGAATG AACCCACATC AGACCCCTGC CCAGCTGTAC 
ACACTGCAGC CCAAGCTTCC CATCACAGTT CTAAATGGAG CCCCTGGATT TATAAACTTG 
TGCGATGCTT TGAACGCCTG GCAGCTGGTG AAGGAACTCA AGGAGGCTTT AGGTATTCCA 
GCCGCTGCCT CTTTCAAACA TGTCAGCCCA GCAGGTGCTG CTGTTGGAAT TCCACTCAGT 
GAAGATGAGG CCAAAGTCTG CATGGTTTAT GATCTCTATA AAACCCTCAC ACCCATCTCA 
GCGGCATATG CAAGAGCAAG AGGGGCTGAT AGGATGTCTT CATTTGGTGA TTTTGTTGCA 
TTGTCCGATG TTTGTGATGT ACCAACTGCA AAAATTATTT CCAGAGAAGT ATCTGATGGT 
ATAATTGCCC CAGGATATGA AGAAGAAGCC TTGACAATAC TTTCCAAAAA GAAAAATGGA 
AACTATTGTG TCCTTCAGAT GGACCAATCT TACAAACCAG ATGAAAATGA AGTTCGAACT 
CTCTTTGGTC TTCATTTAAG CCAGAAGAGA AATAATGGTG TCGTCGACAA GTCATTATTT 
AGCAATGTTG TTACCAAAAA TAAAGATTTG CCAGAGTCTG CCCTCCGAGA CCTCATCGTA 
GCCACCATTG CTGTCAAGTA CACTCAGTCT AACTCTGTGT GCTACGCCAA GAACGGGCAG 
GTTATCGGCA TTGGAGCAGG ACAGCAGTCT CGTATACACT GCACTCGCCT TGCAGGAGAT 
AAGGCAAACT ATTGGTGGCT TAGACACCAT CCACAAGTGC TTTCGATGAA GTTTAAAACA 
GGAGTGAAGA GAGCAGAAAT CTCCAATGCC ATCGATCAAT ATGTGACTGG AACCATTGGC 
GAGGATGAAG ATTTGATAAA GTGGAAGGCA CTGTTTGAGG AAGTCCCTGA GTTACTCACT 
GAGGCAGAGA AGAAGGAATG GGTTGAGAAA CTGACTGAAG TTTCTATCAG CTCTGATGCC 
TTCTTCCCTT TCCGAGATAA CGTAGACAGA GCTAAAAGGA TATCAAGGCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of substrate binding in individual active sites of bifunctional human ATIC.
Biochimica et biophysica acta1866(2)254-263(2018 Feb)
Witkowska D,Cox HL,Hall TC,Wildsmith GC,Machin DC,Webb ME

Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6?K1 signaling.
Cell communication and signaling : CCS15(1)52(2017 Dec)
Li M,Jin C,Xu M,Zhou L,Li D,Yin Y

ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.
Journal of pediatric hematology/oncology39(5)e270-e274(2017 Jul)
Park JA,Shin HY

Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
Rheumatology international36(11)1591-1599(2016 Nov)
Lee YH,Bae SC

ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis.
Pharmacogenomics17(3)241-8(2016 Feb)
Muralidharan N,Mariaselvam CM,Jain VK,Gulati R,Negi VS

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ATIC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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