MYOG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYOG
Entrez Gene ID	4656
Full Name	myogenin
Synonyms	MYF4,bHLHc3,myf-4
General protein information	Preferred Names myogenin Names myogenin class C basic helix-loop-helix protein 3 myogenic factor 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Summary	Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008].
Disorder MIM:	159980

mRNA and Protein(s)

mRNA	Protein	Name
NM_002479.5	NP_002470.2	myogenin
NM_002479.6	NP_002470.2	myogenin

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Myog	NP_112466.1
Rattus norvegicus (Norway rat)	Myog	NP_058811.2
Homo sapiens (human)	MYOG	NP_002470.2
Xenopus tropicalis (tropical clawed frog)	myog	NP_001016725.1
Gallus gallus (chicken)	MYOG	NP_989515.1
Canis lupus familiaris (dog)	MYOG	XP_547345.2
Bos taurus (cattle)	MYOG	NP_001104795.1
Danio rerio (zebrafish)	myog	NP_571081.1
	MYOG	XP_001104569.2

Gene Ontology
Bibliography

Related articles in PubMed

AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin.
Lee SW, Won JY, Yang J, Lee J, Kim SY, Lee EJ, Kim HS
Scientific reports516523(2015 Nov)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Myogenin is a positive regulator of MEGF10 expression in skeletal muscle.
Park SY, Yun Y, Kim MJ, Kim IS
Biochemical and biophysical research communications450(4)1631-7(2014 Aug)

Glycogen synthase kinase 3? represses MYOGENIN function in alveolar rhabdomyosarcoma.
Dionyssiou MG, Ehyai S, Avrutin E, Connor MK, McDermott JC
Cell death & disease5e1094(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin.
Title: AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin.

results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle
Title: Myogenin is a positive regulator of MEGF10 expression in skeletal muscle.

Data indicate that muscle MYOG mRNA expression doubled, whereas MSTN protein expression decreased following immobilization.
Title: Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content.

Sustained GSK3beta activity represses a critical regulatory step in the myogenic cascade, contributing to the undifferentiated, proliferative phenotype in alveolar rhabdomyosarcoma.
Title: Glycogen synthase kinase 3? represses MYOGENIN function in alveolar rhabdomyosarcoma.

Our study illustrates that focal myogenin immunoreactivity occurs uncommonly in fibroepithelial polyps of the lower female genital tract.
Title: Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls.

The following MYOG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYOG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15054	NM_002479.6 Latest version!	Homo sapiens myogenin (MYOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15054	NM_002479.5	Homo sapiens myogenin (MYOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYOG ( NM_002479.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002470.2 Homo sapiens myogenin (MYOG), mRNA.

Price & Availability↑

CloneID	OHu15054
Clone ID Related Accession (Same CDS sequence)	NM_002479.5 , NM_002479.6
Accession Version	NM_002479.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	myogenin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC053899.1 and AC105940.2. On Aug 10, 2012 this sequence version replaced NM_002479.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053899.1, ERR279849.7471.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCTGT ATGAGACATC CCCCTACTTC TACCAGGAAC CCCGCTTCTA TGATGGGGAA 
AACTACCTGC CTGTCCACCT CCAGGGCTTC GAACCACCAG GCTACGAGCG GACGGAGCTC 
ACCCTGAGCC CCGAGGCCCC AGGGCCCCTT GAGGACAAGG GGCTGGGGAC CCCCGAGCAC 
TGTCCAGGCC AGTGCCTGCC GTGGGCGTGT AAGGTGTGTA AGAGGAAGTC GGTGTCCGTG 
GACCGGCGGC GGGCGGCCAC ACTGAGGGAG AAGCGCAGGC TCAAGAAGGT GAATGAGGCC 
TTCGAGGCCC TGAAGAGAAG CACCCTGCTC AACCCCAACC AGCGGCTGCC CAAGGTGGAG 
ATCCTGCGCA GTGCCATCCA GTACATCGAG CGCCTCCAGG CCCTGCTCAG CTCCCTCAAC 
CAGGAGGAGC GTGACCTCCG CTACCGGGGC GGGGGCGGGC CCCAGCCAGG GGTGCCCAGC 
GAATGCAGCT CTCACAGCGC CTCCTGCAGT CCAGAGTGGG GCAGTGCACT GGAGTTCAGC 
GCCAACCCAG GGGATCATCT GCTCACGGCT GACCCTACAG ATGCCCACAA CCTGCACTCC 
CTCACCTCCA TCGTGGACAG CATCACAGTG GAAGATGTGT CTGTGGCCTT CCCAGATGAA 
ACCATGCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002470.2
CDS	78..752
Translation	MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSPEAPGPLEDKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPSECSSHSASCSPEWGSALEFSANPGDHLLTADPTDAHNLHSLTSIVDSITVEDVSVAFPDETMPN

Target ORF information:

RefSeq Version	NM_002479.5
Organism	Homo sapiens(human)
Definition	Homo sapiens myogenin (MYOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002479.5

ORF Insert Sequence:

ATGGAGCTGT ATGAGACATC CCCCTACTTC TACCAGGAAC CCCGCTTCTA TGATGGGGAA 
AACTACCTGC CTGTCCACCT CCAGGGCTTC GAACCACCAG GCTACGAGCG GACGGAGCTC 
ACCCTGAGCC CCGAGGCCCC AGGGCCCCTT GAGGACAAGG GGCTGGGGAC CCCCGAGCAC 
TGTCCAGGCC AGTGCCTGCC GTGGGCGTGT AAGGTGTGTA AGAGGAAGTC GGTGTCCGTG 
GACCGGCGGC GGGCGGCCAC ACTGAGGGAG AAGCGCAGGC TCAAGAAGGT GAATGAGGCC 
TTCGAGGCCC TGAAGAGAAG CACCCTGCTC AACCCCAACC AGCGGCTGCC CAAGGTGGAG 
ATCCTGCGCA GTGCCATCCA GTACATCGAG CGCCTCCAGG CCCTGCTCAG CTCCCTCAAC 
CAGGAGGAGC GTGACCTCCG CTACCGGGGC GGGGGCGGGC CCCAGCCAGG GGTGCCCAGC 
GAATGCAGCT CTCACAGCGC CTCCTGCAGT CCAGAGTGGG GCAGTGCACT GGAGTTCAGC 
GCCAACCCAG GGGATCATCT GCTCACGGCT GACCCTACAG ATGCCCACAA CCTGCACTCC 
CTCACCTCCA TCGTGGACAG CATCACAGTG GAAGATGTGT CTGTGGCCTT CCCAGATGAA 
ACCATGCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYOG ( NM_002479.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002470.2 Homo sapiens myogenin (MYOG), mRNA.

Price & Availability↑

CloneID	OHu15054
Clone ID Related Accession (Same CDS sequence)	NM_002479.5 , NM_002479.6
Accession Version	NM_002479.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	myogenin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC053899.1 and AC105940.2. On Nov 24, 2018 this sequence version replaced NM_002479.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053899.1, ERR279849.7471.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000241651.5/ ENSP00000241651.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCTGT ATGAGACATC CCCCTACTTC TACCAGGAAC CCCGCTTCTA TGATGGGGAA 
AACTACCTGC CTGTCCACCT CCAGGGCTTC GAACCACCAG GCTACGAGCG GACGGAGCTC 
ACCCTGAGCC CCGAGGCCCC AGGGCCCCTT GAGGACAAGG GGCTGGGGAC CCCCGAGCAC 
TGTCCAGGCC AGTGCCTGCC GTGGGCGTGT AAGGTGTGTA AGAGGAAGTC GGTGTCCGTG 
GACCGGCGGC GGGCGGCCAC ACTGAGGGAG AAGCGCAGGC TCAAGAAGGT GAATGAGGCC 
TTCGAGGCCC TGAAGAGAAG CACCCTGCTC AACCCCAACC AGCGGCTGCC CAAGGTGGAG 
ATCCTGCGCA GTGCCATCCA GTACATCGAG CGCCTCCAGG CCCTGCTCAG CTCCCTCAAC 
CAGGAGGAGC GTGACCTCCG CTACCGGGGC GGGGGCGGGC CCCAGCCAGG GGTGCCCAGC 
GAATGCAGCT CTCACAGCGC CTCCTGCAGT CCAGAGTGGG GCAGTGCACT GGAGTTCAGC 
GCCAACCCAG GGGATCATCT GCTCACGGCT GACCCTACAG ATGCCCACAA CCTGCACTCC 
CTCACCTCCA TCGTGGACAG CATCACAGTG GAAGATGTGT CTGTGGCCTT CCCAGATGAA 
ACCATGCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002470.2
CDS	52..726
Translation	MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSPEAPGPLEDKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPSECSSHSASCSPEWGSALEFSANPGDHLLTADPTDAHNLHSLTSIVDSITVEDVSVAFPDETMPN

Target ORF information:

RefSeq Version	NM_002479.6
Organism	Homo sapiens(human)
Definition	Homo sapiens myogenin (MYOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002479.6

ORF Insert Sequence:

ATGGAGCTGT ATGAGACATC CCCCTACTTC TACCAGGAAC CCCGCTTCTA TGATGGGGAA 
AACTACCTGC CTGTCCACCT CCAGGGCTTC GAACCACCAG GCTACGAGCG GACGGAGCTC 
ACCCTGAGCC CCGAGGCCCC AGGGCCCCTT GAGGACAAGG GGCTGGGGAC CCCCGAGCAC 
TGTCCAGGCC AGTGCCTGCC GTGGGCGTGT AAGGTGTGTA AGAGGAAGTC GGTGTCCGTG 
GACCGGCGGC GGGCGGCCAC ACTGAGGGAG AAGCGCAGGC TCAAGAAGGT GAATGAGGCC 
TTCGAGGCCC TGAAGAGAAG CACCCTGCTC AACCCCAACC AGCGGCTGCC CAAGGTGGAG 
ATCCTGCGCA GTGCCATCCA GTACATCGAG CGCCTCCAGG CCCTGCTCAG CTCCCTCAAC 
CAGGAGGAGC GTGACCTCCG CTACCGGGGC GGGGGCGGGC CCCAGCCAGG GGTGCCCAGC 
GAATGCAGCT CTCACAGCGC CTCCTGCAGT CCAGAGTGGG GCAGTGCACT GGAGTTCAGC 
GCCAACCCAG GGGATCATCT GCTCACGGCT GACCCTACAG ATGCCCACAA CCTGCACTCC 
CTCACCTCCA TCGTGGACAG CATCACAGTG GAAGATGTGT CTGTGGCCTT CCCAGATGAA 
ACCATGCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin.
Scientific reports516523(2015 Nov)
Lee SW,Won JY,Yang J,Lee J,Kim SY,Lee EJ,Kim HS

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Myogenin is a positive regulator of MEGF10 expression in skeletal muscle.
Biochemical and biophysical research communications450(4)1631-7(2014 Aug)
Park SY,Yun Y,Kim MJ,Kim IS

Glycogen synthase kinase 3? represses MYOGENIN function in alveolar rhabdomyosarcoma.
Cell death & disease5e1094(2014 Feb)
Dionyssiou MG,Ehyai S,Avrutin E,Connor MK,McDermott JC

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MYOG cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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