MYO1E cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYO1E
Entrez Gene ID	4643
Full Name	myosin IE
Synonyms	FSGS6,HuncM-IC,MYO1C
General protein information	Preferred Names myosin IE Names unconventional myosin-Ie MYO1E variant protein myosin-IC unconventional myosin 1E
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.2
Summary	This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012].
Disorder MIM:	601479
Disorder Html:	Glomerulosclerosis, focal segmental, 6, 614131 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004998.3	NP_004989.2	unconventional myosin-Ie
XM_024449932.1	XP_024305700.1	unconventional myosin-Ie isoform X1
NM_004998.4	NP_004989.2	unconventional myosin-Ie

Pathways from BioSystems

Homologies

Homo sapiens (human)	MYO1E	NP_004989.2
Pan troglodytes (chimpanzee)	MYO1E	XP_510448.2
	MYO1E	XP_002804857.1
Bos taurus (cattle)	MYO1E	XP_002690899.2
Mus musculus (house mouse)	Myo1e	NP_851417.2
Gallus gallus (chicken)	MYO1E	XP_413782.4
Caenorhabditis elegans (roundworm)	hum-1	NP_492393.1
Canis lupus familiaris (dog)	MYO1E	XP_535500.3
Rattus norvegicus (Norway rat)	Myo1e	NP_775124.1
Danio rerio (zebrafish)	myo1ea	XP_005168984.1
Xenopus tropicalis (tropical clawed frog)	myo1e.2	NP_001011082.1

Gene Ontology
Bibliography

Related articles in PubMed

ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips.
Tanimura S, Hashizume J, Arichika N, Watanabe K, Ohyama K, Takeda K, Kohno M
The Journal of cell biology214(4)475-89(2016 Aug)

Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation.
Ouderkirk-Pecone JL, Goreczny GJ, Chase SE, Tatum AH, Turner CE, Krendel M
Oncotarget7(29)46419-46432(2016 Jul)

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.
Lennon R, Stuart HM, Bierzynska A, Randles MJ, Kerr B, Hillman KA, Batra G, Campbell J, Storey H, Flinter FA, Koziell A, Welsh GI, Saleem MA, Webb NJ, Woolf AS
Pediatric nephrology (Berlin, Germany)30(9)1459-65(2015 Sep)

[Mutational analysis of MYO1E in Chinese children with familial steroid-resistant nephrotic syndrome].
Zhao F, Yu ZH, Yang YH, Nie XJ, Huang J, Wang CF, Xia GZ, Chen GM
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics16(4)349-55(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The ERK signaling pathway thus promotes cell motility through regulation of the subcellular localization of Myo1E.
Title: ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips.

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.
Title: Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.

MYO1E mutations are not a major cause of Chinese familial Steroid-resistant nephrotic syndrome.
Title: [Mutational analysis of MYO1E in Chinese children with familial steroid-resistant nephrotic syndrome].

Myo1e is a key component contributing to the functional integrity of podocytes.
Title: Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.

MYO1E mutations are associated with childhood-onset, glucocorticoid-resistant focal segmental glomerulosclerosis.
Title: MYO1E mutations and childhood familial focal segmental glomerulosclerosis.

The following MYO1E gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYO1E cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21690	NM_004998.4 Latest version!	Homo sapiens myosin IE (MYO1E), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
OHu104016	XM_024449932.1 Latest version!	Homo sapiens myosin IE (MYO1E), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu21690	NM_004998.3	Homo sapiens myosin IE (MYO1E), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYO1E ( NM_004998.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004989.2 Homo sapiens myosin IE (MYO1E), mRNA.

Price & Availability↑

CloneID	OHu21690
Clone ID Related Accession (Same CDS sequence)	NM_004998.3 , NM_004998.4
Accession Version	NM_004998.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	unconventional myosin-Ie
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092868.2, BC098392.1 and AC092757.2. This sequence is a reference standard in the RefSeqGene project. On Jan 5, 2012 this sequence version replaced NM_004998.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098392.1, SRR1803611.85379.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAAGCA AAGGTGTCTA CCAGTACCAC TGGCAAAGCC ACAATGTCAA GCACAGTGGT 
GTGGACGACA TGGTGCTACT GTCCAAGATC ACAGAGAACT CCATCGTGGA GAATCTGAAG 
AAGAGATACA TGGATGACTA CATTTTTACA TATATAGGAT CTGTATTAAT CTCAGTCAAC 
CCTTTCAAGC AGATGCCATA TTTTGGGGAA AAGGAAATTG AAATGTACCA AGGAGCGGCA 
CAGTATGAAA ACCCACCACA TATCTATGCC CTTGCAGATA ATATGTACAG AAACATGATC 
ATTGACAGAG AGAACCAGTG CGTCATTATC AGTGGTGAAA GTGGTGCTGG AAAAACAGTG 
GCTGCCAAAT ATATCATGAG CTACATCTCC AGAGTGTCTG GAGGAGGGAC CAAAGTCCAG 
CACGTGAAGG ACATTATCCT GCAGTCCAAC CCGCTGCTGG AGGCCTTCGG GAACGCCAAG 
ACCGTCCGGA ACAACAACTC CAGCCGATTT GGAAAATACT TTGAAATCCA GTTCAGTCCA 
GGTGGGGAAC CAGATGGTGG AAAGATCTCC AACTTCCTTC TGGAAAAATC TAGGGTGGTG 
ATGAGGAACC CAGGAGAGCG GAGTTTTCAC ATATTTTACC AGCTCATCGA GGGCGCCTCT 
GCAGAGCAGA AACACAGCCT TGGCATCACC AGCATGGACT ATTATTACTA CCTGAGCCTC 
TCGGGCTCAT ACAAGGTTGA TGACATTGAC GACAGGCGGG AGTTTCAGGA AACTCTGCAC 
GCCATGAATG TGATTGGGAT CTTTGCAGAA GAGCAAACGC TGGTGTTGCA GATAGTGGCG 
GGTATTCTCC ACCTGGGAAA CATCAGCTTC AAAGAAGTTG GCAACTACGC GGCTGTGGAG 
AGTGAAGAGT TTTTAGCTTT TCCTGCATAT CTGCTAGGGA TAAACCAGGA CCGGTTGAAA 
GAAAAGCTAA CAAGCCGGCA GATGGATAGC AAGTGGGGAG GCAAATCCGA ATCCATCCAC 
GTGACCCTCA ACGTAGAGCA GGCCTGTTAC ACCCGGGATG CGCTCGCCAA GGCCCTGCAC 
GCCCGGGTCT TTGATTTCTT GGTAGATTCC ATCAATAAAG CCATGGAGAA AGACCATGAA 
GAATACAACA TTGGCGTCCT AGACATCTAT GGCTTTGAAA TATTCCAGAA AAATGGCTTT 
GAACAGTTTT GTATCAATTT TGTTAATGAA AAACTGCAGC AGATTTTTAT TGAACTGACA 
TTAAAGGCAG AACAGGAAGA ATATGTTCAA GAGGGAATAA GATGGACACC CATTGAGTAC 
TTTAATAATA AAATCGTATG TGACCTCATA GAGAACAAAG TGAACCCTCC TGGCATCATG 
AGCATCCTGG ATGACGTGTG CGCCACGATG CATGCGGTGG GTGAGGGGGC AGATCAGACG 
CTGCTCCAGA AACTTCAGAT GCAGATTGGG AGTCATGAGC ACTTCAACAG TTGGAACCAA 
GGCTTCATCA TTCATCATTA TGCTGGGAAG GTATCCTATG ACATGGATGG CTTTTGTGAA 
AGGAACCGGG ATGTGCTTTT TATGGATCTC ATCGAGCTTA TGCAGAGCAG CGAGCTGCCT 
TTCATAAAGT CTTTATTTCC GGAAAATCTG CAGGCTGACA AGAAAGGGCG CCCAACTACT 
GCCGGAAGCA AAATAAAGAA ACAAGCCAAT GACCTTGTGA GCACCCTGAT GAAATGTACG 
CCCCACTACA TTCGCTGCAT CAAGCCAAAC GAAACCAAGA AGCCCAGAGA CTGGGAGGAA 
AGCAGGGTAA AGCATCAAGT CGAATATTTG GGTCTGAAAG AGAACATTCG AGTGAGAAGA 
GCTGGCTATG CCTATCGGCG CATCTTCCAA AAATTCCTAC AGAGGTATGC CATTCTGACC 
AAAGCCACCT GGCCTTCTTG GCAGGGAGAG GAGAAGCAAG GCGTCCTGCA CCTGCTGCAG 
TCGGTCAACA TGGACAGCGA CCAGTTCCAG CTGGGGAGGA GTAAAGTGTT CATCAAAGCC 
CCCGAGTCTC TATTTCTTTT AGAAGAGATG AGAGAGAGAA AGTATGATGG GTATGCTCGA 
GTGATACAGA AATCATGGAG GAAATTCGTG GCCCGGAAGA AATACGTTCA AATGAGAGAA 
GAAGCCTCAG ACCTCTTATT GAACAAGAAG GAGAGAAGGA GAAACAGTAT TAACAGGAAC 
TTTATAGGGG ATTATATTGG GATGGAAGAG CACCCAGAAC TCCAGCAGTT CGTGGGCAAG 
AGGGAGAAGA TTGATTTCGC AGACACAGTC ACCAAGTATG ACAGGAGGTT CAAGGGTGTA 
AAGCGAGACC TGCTCCTTAC CCCAAAGTGC TTGTACTTAA TCGGACGAGA AAAAGTCAAA 
CAGGGCCCAG ACAAGGGCCT GGTGAAAGAA GTCCTGAAGC GGAAAATCGA GATAGAACGG 
ATCTTGTCTG TGTCCCTCAG TACTATGCAG GATGACATTT TTATTCTCCA TGAGCAAGAG 
TATGACAGTT TGCTTGAATC TGTCTTCAAA ACTGAATTCC TAAGCCTCTT AGCAAAGCGT 
TACGAGGAGA AGACCCAGAA GCAACTACCT CTGAAATTCA GCAATACGCT TGAACTGAAG 
TTGAAAAAGG AAAACTGGGG CCCCTGGAGT GCAGGGGGCT CCCGGCAAGT GCAGTTCCAC 
CAAGGGTTTG GGGACCTGGC TGTCCTCAAG CCCAGTAACA AAGTGCTGCA GGTCAGCATC 
GGACCTGGAC TGCCCAAGAA CTCCCGTCCT ACCAGAAGGA ACACTACCCA AAATACAGGT 
TATTCCAGTG GGACTCAAAA TGCCAACTAC CCAGTGAGAG CTGCCCCTCC TCCCCCAGGA 
TACCATCAGA ACGGAGTCAT CAGAAACCAG TATGTGCCAT ATCCCCATGC TCCTGGAAGC 
CAGAGGTCCA ATCAGAAAAG CCTGTACACC TCCATGGCCC GCCCGCCCTT GCCTCGGCAG 
CAGTCTACCA GTTCAGACCG AGTGTCACAG ACGCCAGAGA GCCTGGATTT CCTCAAGGTC 
CCGGACCAGG GAGCTGCAGG GGTCAGGAGA CAAACAACCA GTCGGCCTCC CCCAGCAGGG 
GGCAGACCCA AGCCCCAGCC CAAGCCCAAG CCTCAGGTGC CACAGTGCAA GGCTTTGTAT 
GCCTATGACG CTCAGGACAC AGACGAACTC AGCTTTAATG CCAATGACAT TATTGATATT 
ATCAAAGAAG ATCCTTCTGG CTGGTGGACG GGTCGACTAC GAGGCAAGCA GGGCCTGTTC 
CCCAACAACT ATGTGACCAA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004989.2
CDS	373..3699
Translation	MGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI

Target ORF information:

RefSeq Version	NM_004998.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin IE (MYO1E), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004998.3

ORF Insert Sequence:

ATGGGAAGCA AAGGTGTCTA CCAGTACCAC TGGCAAAGCC ACAATGTCAA GCACAGTGGT 
GTGGACGACA TGGTGCTACT GTCCAAGATC ACAGAGAACT CCATCGTGGA GAATCTGAAG 
AAGAGATACA TGGATGACTA CATTTTTACA TATATAGGAT CTGTATTAAT CTCAGTCAAC 
CCTTTCAAGC AGATGCCATA TTTTGGGGAA AAGGAAATTG AAATGTACCA AGGAGCGGCA 
CAGTATGAAA ACCCACCACA TATCTATGCC CTTGCAGATA ATATGTACAG AAACATGATC 
ATTGACAGAG AGAACCAGTG CGTCATTATC AGTGGTGAAA GTGGTGCTGG AAAAACAGTG 
GCTGCCAAAT ATATCATGAG CTACATCTCC AGAGTGTCTG GAGGAGGGAC CAAAGTCCAG 
CACGTGAAGG ACATTATCCT GCAGTCCAAC CCGCTGCTGG AGGCCTTCGG GAACGCCAAG 
ACCGTCCGGA ACAACAACTC CAGCCGATTT GGAAAATACT TTGAAATCCA GTTCAGTCCA 
GGTGGGGAAC CAGATGGTGG AAAGATCTCC AACTTCCTTC TGGAAAAATC TAGGGTGGTG 
ATGAGGAACC CAGGAGAGCG GAGTTTTCAC ATATTTTACC AGCTCATCGA GGGCGCCTCT 
GCAGAGCAGA AACACAGCCT TGGCATCACC AGCATGGACT ATTATTACTA CCTGAGCCTC 
TCGGGCTCAT ACAAGGTTGA TGACATTGAC GACAGGCGGG AGTTTCAGGA AACTCTGCAC 
GCCATGAATG TGATTGGGAT CTTTGCAGAA GAGCAAACGC TGGTGTTGCA GATAGTGGCG 
GGTATTCTCC ACCTGGGAAA CATCAGCTTC AAAGAAGTTG GCAACTACGC GGCTGTGGAG 
AGTGAAGAGT TTTTAGCTTT TCCTGCATAT CTGCTAGGGA TAAACCAGGA CCGGTTGAAA 
GAAAAGCTAA CAAGCCGGCA GATGGATAGC AAGTGGGGAG GCAAATCCGA ATCCATCCAC 
GTGACCCTCA ACGTAGAGCA GGCCTGTTAC ACCCGGGATG CGCTCGCCAA GGCCCTGCAC 
GCCCGGGTCT TTGATTTCTT GGTAGATTCC ATCAATAAAG CCATGGAGAA AGACCATGAA 
GAATACAACA TTGGCGTCCT AGACATCTAT GGCTTTGAAA TATTCCAGAA AAATGGCTTT 
GAACAGTTTT GTATCAATTT TGTTAATGAA AAACTGCAGC AGATTTTTAT TGAACTGACA 
TTAAAGGCAG AACAGGAAGA ATATGTTCAA GAGGGAATAA GATGGACACC CATTGAGTAC 
TTTAATAATA AAATCGTATG TGACCTCATA GAGAACAAAG TGAACCCTCC TGGCATCATG 
AGCATCCTGG ATGACGTGTG CGCCACGATG CATGCGGTGG GTGAGGGGGC AGATCAGACG 
CTGCTCCAGA AACTTCAGAT GCAGATTGGG AGTCATGAGC ACTTCAACAG TTGGAACCAA 
GGCTTCATCA TTCATCATTA TGCTGGGAAG GTATCCTATG ACATGGATGG CTTTTGTGAA 
AGGAACCGGG ATGTGCTTTT TATGGATCTC ATCGAGCTTA TGCAGAGCAG CGAGCTGCCT 
TTCATAAAGT CTTTATTTCC GGAAAATCTG CAGGCTGACA AGAAAGGGCG CCCAACTACT 
GCCGGAAGCA AAATAAAGAA ACAAGCCAAT GACCTTGTGA GCACCCTGAT GAAATGTACG 
CCCCACTACA TTCGCTGCAT CAAGCCAAAC GAAACCAAGA AGCCCAGAGA CTGGGAGGAA 
AGCAGGGTAA AGCATCAAGT CGAATATTTG GGTCTGAAAG AGAACATTCG AGTGAGAAGA 
GCTGGCTATG CCTATCGGCG CATCTTCCAA AAATTCCTAC AGAGGTATGC CATTCTGACC 
AAAGCCACCT GGCCTTCTTG GCAGGGAGAG GAGAAGCAAG GCGTCCTGCA CCTGCTGCAG 
TCGGTCAACA TGGACAGCGA CCAGTTCCAG CTGGGGAGGA GTAAAGTGTT CATCAAAGCC 
CCCGAGTCTC TATTTCTTTT AGAAGAGATG AGAGAGAGAA AGTATGATGG GTATGCTCGA 
GTGATACAGA AATCATGGAG GAAATTCGTG GCCCGGAAGA AATACGTTCA AATGAGAGAA 
GAAGCCTCAG ACCTCTTATT GAACAAGAAG GAGAGAAGGA GAAACAGTAT TAACAGGAAC 
TTTATAGGGG ATTATATTGG GATGGAAGAG CACCCAGAAC TCCAGCAGTT CGTGGGCAAG 
AGGGAGAAGA TTGATTTCGC AGACACAGTC ACCAAGTATG ACAGGAGGTT CAAGGGTGTA 
AAGCGAGACC TGCTCCTTAC CCCAAAGTGC TTGTACTTAA TCGGACGAGA AAAAGTCAAA 
CAGGGCCCAG ACAAGGGCCT GGTGAAAGAA GTCCTGAAGC GGAAAATCGA GATAGAACGG 
ATCTTGTCTG TGTCCCTCAG TACTATGCAG GATGACATTT TTATTCTCCA TGAGCAAGAG 
TATGACAGTT TGCTTGAATC TGTCTTCAAA ACTGAATTCC TAAGCCTCTT AGCAAAGCGT 
TACGAGGAGA AGACCCAGAA GCAACTACCT CTGAAATTCA GCAATACGCT TGAACTGAAG 
TTGAAAAAGG AAAACTGGGG CCCCTGGAGT GCAGGGGGCT CCCGGCAAGT GCAGTTCCAC 
CAAGGGTTTG GGGACCTGGC TGTCCTCAAG CCCAGTAACA AAGTGCTGCA GGTCAGCATC 
GGACCTGGAC TGCCCAAGAA CTCCCGTCCT ACCAGAAGGA ACACTACCCA AAATACAGGT 
TATTCCAGTG GGACTCAAAA TGCCAACTAC CCAGTGAGAG CTGCCCCTCC TCCCCCAGGA 
TACCATCAGA ACGGAGTCAT CAGAAACCAG TATGTGCCAT ATCCCCATGC TCCTGGAAGC 
CAGAGGTCCA ATCAGAAAAG CCTGTACACC TCCATGGCCC GCCCGCCCTT GCCTCGGCAG 
CAGTCTACCA GTTCAGACCG AGTGTCACAG ACGCCAGAGA GCCTGGATTT CCTCAAGGTC 
CCGGACCAGG GAGCTGCAGG GGTCAGGAGA CAAACAACCA GTCGGCCTCC CCCAGCAGGG 
GGCAGACCCA AGCCCCAGCC CAAGCCCAAG CCTCAGGTGC CACAGTGCAA GGCTTTGTAT 
GCCTATGACG CTCAGGACAC AGACGAACTC AGCTTTAATG CCAATGACAT TATTGATATT 
ATCAAAGAAG ATCCTTCTGG CTGGTGGACG GGTCGACTAC GAGGCAAGCA GGGCCTGTTC 
CCCAACAACT ATGTGACCAA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYO1E ( NM_004998.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004989.2 Homo sapiens myosin IE (MYO1E), mRNA.

Price & Availability↑

CloneID	OHu21690
Clone ID Related Accession (Same CDS sequence)	NM_004998.3 , NM_004998.4
Accession Version	NM_004998.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	unconventional myosin-Ie
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092868.2, BC098392.1 and AC092757.2. On May 17, 2019 this sequence version replaced NM_004998.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098392.1, SRR1803611.85379.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000288235.9/ ENSP00000288235.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGAAGCA AAGGTGTCTA CCAGTACCAC TGGCAAAGCC ACAATGTCAA GCACAGTGGT 
GTGGACGACA TGGTGCTACT GTCCAAGATC ACAGAGAACT CCATCGTGGA GAATCTGAAG 
AAGAGATACA TGGATGACTA CATTTTTACA TATATAGGAT CTGTATTAAT CTCAGTCAAC 
CCTTTCAAGC AGATGCCATA TTTTGGGGAA AAGGAAATTG AAATGTACCA AGGAGCGGCA 
CAGTATGAAA ACCCACCACA TATCTATGCC CTTGCAGATA ATATGTACAG AAACATGATC 
ATTGACAGAG AGAACCAGTG CGTCATTATC AGTGGTGAAA GTGGTGCTGG AAAAACAGTG 
GCTGCCAAAT ATATCATGAG CTACATCTCC AGAGTGTCTG GAGGAGGGAC CAAAGTCCAG 
CACGTGAAGG ACATTATCCT GCAGTCCAAC CCGCTGCTGG AGGCCTTCGG GAACGCCAAG 
ACCGTCCGGA ACAACAACTC CAGCCGATTT GGAAAATACT TTGAAATCCA GTTCAGTCCA 
GGTGGGGAAC CAGATGGTGG AAAGATCTCC AACTTCCTTC TGGAAAAATC TAGGGTGGTG 
ATGAGGAACC CAGGAGAGCG GAGTTTTCAC ATATTTTACC AGCTCATCGA GGGCGCCTCT 
GCAGAGCAGA AACACAGCCT TGGCATCACC AGCATGGACT ATTATTACTA CCTGAGCCTC 
TCGGGCTCAT ACAAGGTTGA TGACATTGAC GACAGGCGGG AGTTTCAGGA AACTCTGCAC 
GCCATGAATG TGATTGGGAT CTTTGCAGAA GAGCAAACGC TGGTGTTGCA GATAGTGGCG 
GGTATTCTCC ACCTGGGAAA CATCAGCTTC AAAGAAGTTG GCAACTACGC GGCTGTGGAG 
AGTGAAGAGT TTTTAGCTTT TCCTGCATAT CTGCTAGGGA TAAACCAGGA CCGGTTGAAA 
GAAAAGCTAA CAAGCCGGCA GATGGATAGC AAGTGGGGAG GCAAATCCGA ATCCATCCAC 
GTGACCCTCA ACGTAGAGCA GGCCTGTTAC ACCCGGGATG CGCTCGCCAA GGCCCTGCAC 
GCCCGGGTCT TTGATTTCTT GGTAGATTCC ATCAATAAAG CCATGGAGAA AGACCATGAA 
GAATACAACA TTGGCGTCCT AGACATCTAT GGCTTTGAAA TATTCCAGAA AAATGGCTTT 
GAACAGTTTT GTATCAATTT TGTTAATGAA AAACTGCAGC AGATTTTTAT TGAACTGACA 
TTAAAGGCAG AACAGGAAGA ATATGTTCAA GAGGGAATAA GATGGACACC CATTGAGTAC 
TTTAATAATA AAATCGTATG TGACCTCATA GAGAACAAAG TGAACCCTCC TGGCATCATG 
AGCATCCTGG ATGACGTGTG CGCCACGATG CATGCGGTGG GTGAGGGGGC AGATCAGACG 
CTGCTCCAGA AACTTCAGAT GCAGATTGGG AGTCATGAGC ACTTCAACAG TTGGAACCAA 
GGCTTCATCA TTCATCATTA TGCTGGGAAG GTATCCTATG ACATGGATGG CTTTTGTGAA 
AGGAACCGGG ATGTGCTTTT TATGGATCTC ATCGAGCTTA TGCAGAGCAG CGAGCTGCCT 
TTCATAAAGT CTTTATTTCC GGAAAATCTG CAGGCTGACA AGAAAGGGCG CCCAACTACT 
GCCGGAAGCA AAATAAAGAA ACAAGCCAAT GACCTTGTGA GCACCCTGAT GAAATGTACG 
CCCCACTACA TTCGCTGCAT CAAGCCAAAC GAAACCAAGA AGCCCAGAGA CTGGGAGGAA 
AGCAGGGTAA AGCATCAAGT CGAATATTTG GGTCTGAAAG AGAACATTCG AGTGAGAAGA 
GCTGGCTATG CCTATCGGCG CATCTTCCAA AAATTCCTAC AGAGGTATGC CATTCTGACC 
AAAGCCACCT GGCCTTCTTG GCAGGGAGAG GAGAAGCAAG GCGTCCTGCA CCTGCTGCAG 
TCGGTCAACA TGGACAGCGA CCAGTTCCAG CTGGGGAGGA GTAAAGTGTT CATCAAAGCC 
CCCGAGTCTC TATTTCTTTT AGAAGAGATG AGAGAGAGAA AGTATGATGG GTATGCTCGA 
GTGATACAGA AATCATGGAG GAAATTCGTG GCCCGGAAGA AATACGTTCA AATGAGAGAA 
GAAGCCTCAG ACCTCTTATT GAACAAGAAG GAGAGAAGGA GAAACAGTAT TAACAGGAAC 
TTTATAGGGG ATTATATTGG GATGGAAGAG CACCCAGAAC TCCAGCAGTT CGTGGGCAAG 
AGGGAGAAGA TTGATTTCGC AGACACAGTC ACCAAGTATG ACAGGAGGTT CAAGGGTGTA 
AAGCGAGACC TGCTCCTTAC CCCAAAGTGC TTGTACTTAA TCGGACGAGA AAAAGTCAAA 
CAGGGCCCAG ACAAGGGCCT GGTGAAAGAA GTCCTGAAGC GGAAAATCGA GATAGAACGG 
ATCTTGTCTG TGTCCCTCAG TACTATGCAG GATGACATTT TTATTCTCCA TGAGCAAGAG 
TATGACAGTT TGCTTGAATC TGTCTTCAAA ACTGAATTCC TAAGCCTCTT AGCAAAGCGT 
TACGAGGAGA AGACCCAGAA GCAACTACCT CTGAAATTCA GCAATACGCT TGAACTGAAG 
TTGAAAAAGG AAAACTGGGG CCCCTGGAGT GCAGGGGGCT CCCGGCAAGT GCAGTTCCAC 
CAAGGGTTTG GGGACCTGGC TGTCCTCAAG CCCAGTAACA AAGTGCTGCA GGTCAGCATC 
GGACCTGGAC TGCCCAAGAA CTCCCGTCCT ACCAGAAGGA ACACTACCCA AAATACAGGT 
TATTCCAGTG GGACTCAAAA TGCCAACTAC CCAGTGAGAG CTGCCCCTCC TCCCCCAGGA 
TACCATCAGA ACGGAGTCAT CAGAAACCAG TATGTGCCAT ATCCCCATGC TCCTGGAAGC 
CAGAGGTCCA ATCAGAAAAG CCTGTACACC TCCATGGCCC GCCCGCCCTT GCCTCGGCAG 
CAGTCTACCA GTTCAGACCG AGTGTCACAG ACGCCAGAGA GCCTGGATTT CCTCAAGGTC 
CCGGACCAGG GAGCTGCAGG GGTCAGGAGA CAAACAACCA GTCGGCCTCC CCCAGCAGGG 
GGCAGACCCA AGCCCCAGCC CAAGCCCAAG CCTCAGGTGC CACAGTGCAA GGCTTTGTAT 
GCCTATGACG CTCAGGACAC AGACGAACTC AGCTTTAATG CCAATGACAT TATTGATATT 
ATCAAAGAAG ATCCTTCTGG CTGGTGGACG GGTCGACTAC GAGGCAAGCA GGGCCTGTTC 
CCCAACAACT ATGTGACCAA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004989.2
CDS	372..3698
Translation	MGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI

Target ORF information:

RefSeq Version	NM_004998.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin IE (MYO1E), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004998.4

ORF Insert Sequence:

ATGGGAAGCA AAGGTGTCTA CCAGTACCAC TGGCAAAGCC ACAATGTCAA GCACAGTGGT 
GTGGACGACA TGGTGCTACT GTCCAAGATC ACAGAGAACT CCATCGTGGA GAATCTGAAG 
AAGAGATACA TGGATGACTA CATTTTTACA TATATAGGAT CTGTATTAAT CTCAGTCAAC 
CCTTTCAAGC AGATGCCATA TTTTGGGGAA AAGGAAATTG AAATGTACCA AGGAGCGGCA 
CAGTATGAAA ACCCACCACA TATCTATGCC CTTGCAGATA ATATGTACAG AAACATGATC 
ATTGACAGAG AGAACCAGTG CGTCATTATC AGTGGTGAAA GTGGTGCTGG AAAAACAGTG 
GCTGCCAAAT ATATCATGAG CTACATCTCC AGAGTGTCTG GAGGAGGGAC CAAAGTCCAG 
CACGTGAAGG ACATTATCCT GCAGTCCAAC CCGCTGCTGG AGGCCTTCGG GAACGCCAAG 
ACCGTCCGGA ACAACAACTC CAGCCGATTT GGAAAATACT TTGAAATCCA GTTCAGTCCA 
GGTGGGGAAC CAGATGGTGG AAAGATCTCC AACTTCCTTC TGGAAAAATC TAGGGTGGTG 
ATGAGGAACC CAGGAGAGCG GAGTTTTCAC ATATTTTACC AGCTCATCGA GGGCGCCTCT 
GCAGAGCAGA AACACAGCCT TGGCATCACC AGCATGGACT ATTATTACTA CCTGAGCCTC 
TCGGGCTCAT ACAAGGTTGA TGACATTGAC GACAGGCGGG AGTTTCAGGA AACTCTGCAC 
GCCATGAATG TGATTGGGAT CTTTGCAGAA GAGCAAACGC TGGTGTTGCA GATAGTGGCG 
GGTATTCTCC ACCTGGGAAA CATCAGCTTC AAAGAAGTTG GCAACTACGC GGCTGTGGAG 
AGTGAAGAGT TTTTAGCTTT TCCTGCATAT CTGCTAGGGA TAAACCAGGA CCGGTTGAAA 
GAAAAGCTAA CAAGCCGGCA GATGGATAGC AAGTGGGGAG GCAAATCCGA ATCCATCCAC 
GTGACCCTCA ACGTAGAGCA GGCCTGTTAC ACCCGGGATG CGCTCGCCAA GGCCCTGCAC 
GCCCGGGTCT TTGATTTCTT GGTAGATTCC ATCAATAAAG CCATGGAGAA AGACCATGAA 
GAATACAACA TTGGCGTCCT AGACATCTAT GGCTTTGAAA TATTCCAGAA AAATGGCTTT 
GAACAGTTTT GTATCAATTT TGTTAATGAA AAACTGCAGC AGATTTTTAT TGAACTGACA 
TTAAAGGCAG AACAGGAAGA ATATGTTCAA GAGGGAATAA GATGGACACC CATTGAGTAC 
TTTAATAATA AAATCGTATG TGACCTCATA GAGAACAAAG TGAACCCTCC TGGCATCATG 
AGCATCCTGG ATGACGTGTG CGCCACGATG CATGCGGTGG GTGAGGGGGC AGATCAGACG 
CTGCTCCAGA AACTTCAGAT GCAGATTGGG AGTCATGAGC ACTTCAACAG TTGGAACCAA 
GGCTTCATCA TTCATCATTA TGCTGGGAAG GTATCCTATG ACATGGATGG CTTTTGTGAA 
AGGAACCGGG ATGTGCTTTT TATGGATCTC ATCGAGCTTA TGCAGAGCAG CGAGCTGCCT 
TTCATAAAGT CTTTATTTCC GGAAAATCTG CAGGCTGACA AGAAAGGGCG CCCAACTACT 
GCCGGAAGCA AAATAAAGAA ACAAGCCAAT GACCTTGTGA GCACCCTGAT GAAATGTACG 
CCCCACTACA TTCGCTGCAT CAAGCCAAAC GAAACCAAGA AGCCCAGAGA CTGGGAGGAA 
AGCAGGGTAA AGCATCAAGT CGAATATTTG GGTCTGAAAG AGAACATTCG AGTGAGAAGA 
GCTGGCTATG CCTATCGGCG CATCTTCCAA AAATTCCTAC AGAGGTATGC CATTCTGACC 
AAAGCCACCT GGCCTTCTTG GCAGGGAGAG GAGAAGCAAG GCGTCCTGCA CCTGCTGCAG 
TCGGTCAACA TGGACAGCGA CCAGTTCCAG CTGGGGAGGA GTAAAGTGTT CATCAAAGCC 
CCCGAGTCTC TATTTCTTTT AGAAGAGATG AGAGAGAGAA AGTATGATGG GTATGCTCGA 
GTGATACAGA AATCATGGAG GAAATTCGTG GCCCGGAAGA AATACGTTCA AATGAGAGAA 
GAAGCCTCAG ACCTCTTATT GAACAAGAAG GAGAGAAGGA GAAACAGTAT TAACAGGAAC 
TTTATAGGGG ATTATATTGG GATGGAAGAG CACCCAGAAC TCCAGCAGTT CGTGGGCAAG 
AGGGAGAAGA TTGATTTCGC AGACACAGTC ACCAAGTATG ACAGGAGGTT CAAGGGTGTA 
AAGCGAGACC TGCTCCTTAC CCCAAAGTGC TTGTACTTAA TCGGACGAGA AAAAGTCAAA 
CAGGGCCCAG ACAAGGGCCT GGTGAAAGAA GTCCTGAAGC GGAAAATCGA GATAGAACGG 
ATCTTGTCTG TGTCCCTCAG TACTATGCAG GATGACATTT TTATTCTCCA TGAGCAAGAG 
TATGACAGTT TGCTTGAATC TGTCTTCAAA ACTGAATTCC TAAGCCTCTT AGCAAAGCGT 
TACGAGGAGA AGACCCAGAA GCAACTACCT CTGAAATTCA GCAATACGCT TGAACTGAAG 
TTGAAAAAGG AAAACTGGGG CCCCTGGAGT GCAGGGGGCT CCCGGCAAGT GCAGTTCCAC 
CAAGGGTTTG GGGACCTGGC TGTCCTCAAG CCCAGTAACA AAGTGCTGCA GGTCAGCATC 
GGACCTGGAC TGCCCAAGAA CTCCCGTCCT ACCAGAAGGA ACACTACCCA AAATACAGGT 
TATTCCAGTG GGACTCAAAA TGCCAACTAC CCAGTGAGAG CTGCCCCTCC TCCCCCAGGA 
TACCATCAGA ACGGAGTCAT CAGAAACCAG TATGTGCCAT ATCCCCATGC TCCTGGAAGC 
CAGAGGTCCA ATCAGAAAAG CCTGTACACC TCCATGGCCC GCCCGCCCTT GCCTCGGCAG 
CAGTCTACCA GTTCAGACCG AGTGTCACAG ACGCCAGAGA GCCTGGATTT CCTCAAGGTC 
CCGGACCAGG GAGCTGCAGG GGTCAGGAGA CAAACAACCA GTCGGCCTCC CCCAGCAGGG 
GGCAGACCCA AGCCCCAGCC CAAGCCCAAG CCTCAGGTGC CACAGTGCAA GGCTTTGTAT 
GCCTATGACG CTCAGGACAC AGACGAACTC AGCTTTAATG CCAATGACAT TATTGATATT 
ATCAAAGAAG ATCCTTCTGG CTGGTGGACG GGTCGACTAC GAGGCAAGCA GGGCCTGTTC 
CCCAACAACT ATGTGACCAA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYO1E ( XM_024449932.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305700.1 Homo sapiens myosin IE (MYO1E), transcript variant X1, mRNA.

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CloneID	OHu104016
Clone ID Related Accession (Same CDS sequence)	XM_024449932.1
Accession Version	XM_024449932.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	unconventional myosin-Ie isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGGCT TTTGTGAAAG GAACCGGGAT GTGCTTTTTA TGGATCTCAT CGAGCTTATG 
CAGAGCAGCG AGCTGCCTTT CATAAAGTCT TTATTTCCGG AAAATCTGCA GGCTGACAAG 
AAAGGGCGCC CAACTACTGC CGGAAGCAAA ATAAAGAAAC AAGCCAATGA CCTTGTGAGC 
ACCCTGATGA AATGTACGCC CCACTACATT CGCTGCATCA AGCCAAACGA AACCAAGAAG 
CCCAGAGACT GGGAGGAAAG CAGGGTAAAG CATCAAGTCG AATATTTGGG TCTGAAAGAG 
AACATTCGAG TGAGAAGAGC TGGCTATGCC TATCGGCGCA TCTTCCAAAA ATTCCTACAG 
AGGTATGCCA TTCTGACCAA AGCCACCTGG CCTTCTTGGC AGGGAGAGGA GAAGCAAGGC 
GTCCTGCACC TGCTGCAGTC GGTCAACATG GACAGCGACC AGTTCCAGCT GGGGAGGAGT 
AAAGTGTTCA TCAAAGCCCC CGAGTCTCTA TTTCTTTTAG AAGAGATGAG AGAGAGAAAG 
TATGATGGGT ATGCTCGAGT GATACAGAAA TCATGGAGGA AATTCGTGGC CCGGAAGAAA 
TACGTTCAAA TGAGAGAAGA AGCCTCAGAC CTCTTATTGA ACAAGAAGGA GAGAAGGAGA 
AACAGTATTA ACAGGAACTT TATAGGGGAT TATATTGGGA TGGAAGAGCA CCCAGAACTC 
CAGCAGTTCG TGGGCAAGAG GGAGAAGATT GATTTCGCAG ACACAGTCAC CAAGTATGAC 
AGGAGGTTCA AGGGTGTAAA GCGAGACCTG CTCCTTACCC CAAAGTGCTT GTACTTAATC 
GGACGAGAAA AAGTCAAACA GGGCCCAGAC AAGGGCCTGG TGAAAGAAGT CCTGAAGCGG 
AAAATCGAGA TAGAACGGAT CTTGTCTGTG TCCCTCAGTA CTATGCAGGA TGACATTTTT 
ATTCTCCATG AGCAAGAGTA TGACAGTTTG CTTGAATCTG TCTTCAAAAC TGAATTCCTA 
AGCCTCTTAG CAAAGCGTTA CGAGGAGAAG ACCCAGAAGC AACTACCTCT GAAATTCAGC 
AATACGCTTG AACTGAAGTT GAAAAAGGAA AACTGGGGCC CCTGGAGTGC AGGGGGCTCC 
CGGCAAGTGC AGTTCCACCA AGGGTTTGGG GACCTGGCTG TCCTCAAGCC CAGTAACAAA 
GTGCTGCAGG TCAGCATCGG ACCTGGACTG CCCAAGAACT CCCGTCCTAC CAGAAGGAAC 
ACTACCCAAA ATACAGGTTA TTCCAGTGGG ACTCAAAATG CCAACTACCC AGTGAGAGCT 
GCCCCTCCTC CCCCAGGATA CCATCAGAAC GGAGTCATCA GAAACCAGTA TGTGCCATAT 
CCCCATGCTC CTGGAAGCCA GAGGTCCAAT CAGAAAAGCC TGTACACCTC CATGGCCCGC 
CCGCCCTTGC CTCGGCAGCA GTCTACCAGT TCAGACCGAG TGTCACAGAC GCCAGAGAGC 
CTGGATTTCC TCAAGGTCCC GGACCAGGGA GCTGCAGGGG TCAGGAGACA AACAACCAGT 
CGGCCTCCCC CAGCAGGGGG CAGACCCAAG CCCCAGCCCA AGCCCAAGCC TCAGGTGCCA 
CAGTGCAAGG CTTTGTATGC CTATGACGCT CAGGACACAG ACGAACTCAG CTTTAATGCC 
AATGACATTA TTGATATTAT CAAAGAAGAT CCTTCTGGCT GGTGGACGGG TCGACTACGA 
GGCAAGCAGG GCCTGTTCCC CAACAACTAT GTGACCAAGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305700.1
CDS	591..2375
Translation	MDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI

Target ORF information:

RefSeq Version	XM_024449932.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin IE (MYO1E), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449932.1

ORF Insert Sequence:

ATGGATGGCT TTTGTGAAAG GAACCGGGAT GTGCTTTTTA TGGATCTCAT CGAGCTTATG 
CAGAGCAGCG AGCTGCCTTT CATAAAGTCT TTATTTCCGG AAAATCTGCA GGCTGACAAG 
AAAGGGCGCC CAACTACTGC CGGAAGCAAA ATAAAGAAAC AAGCCAATGA CCTTGTGAGC 
ACCCTGATGA AATGTACGCC CCACTACATT CGCTGCATCA AGCCAAACGA AACCAAGAAG 
CCCAGAGACT GGGAGGAAAG CAGGGTAAAG CATCAAGTCG AATATTTGGG TCTGAAAGAG 
AACATTCGAG TGAGAAGAGC TGGCTATGCC TATCGGCGCA TCTTCCAAAA ATTCCTACAG 
AGGTATGCCA TTCTGACCAA AGCCACCTGG CCTTCTTGGC AGGGAGAGGA GAAGCAAGGC 
GTCCTGCACC TGCTGCAGTC GGTCAACATG GACAGCGACC AGTTCCAGCT GGGGAGGAGT 
AAAGTGTTCA TCAAAGCCCC CGAGTCTCTA TTTCTTTTAG AAGAGATGAG AGAGAGAAAG 
TATGATGGGT ATGCTCGAGT GATACAGAAA TCATGGAGGA AATTCGTGGC CCGGAAGAAA 
TACGTTCAAA TGAGAGAAGA AGCCTCAGAC CTCTTATTGA ACAAGAAGGA GAGAAGGAGA 
AACAGTATTA ACAGGAACTT TATAGGGGAT TATATTGGGA TGGAAGAGCA CCCAGAACTC 
CAGCAGTTCG TGGGCAAGAG GGAGAAGATT GATTTCGCAG ACACAGTCAC CAAGTATGAC 
AGGAGGTTCA AGGGTGTAAA GCGAGACCTG CTCCTTACCC CAAAGTGCTT GTACTTAATC 
GGACGAGAAA AAGTCAAACA GGGCCCAGAC AAGGGCCTGG TGAAAGAAGT CCTGAAGCGG 
AAAATCGAGA TAGAACGGAT CTTGTCTGTG TCCCTCAGTA CTATGCAGGA TGACATTTTT 
ATTCTCCATG AGCAAGAGTA TGACAGTTTG CTTGAATCTG TCTTCAAAAC TGAATTCCTA 
AGCCTCTTAG CAAAGCGTTA CGAGGAGAAG ACCCAGAAGC AACTACCTCT GAAATTCAGC 
AATACGCTTG AACTGAAGTT GAAAAAGGAA AACTGGGGCC CCTGGAGTGC AGGGGGCTCC 
CGGCAAGTGC AGTTCCACCA AGGGTTTGGG GACCTGGCTG TCCTCAAGCC CAGTAACAAA 
GTGCTGCAGG TCAGCATCGG ACCTGGACTG CCCAAGAACT CCCGTCCTAC CAGAAGGAAC 
ACTACCCAAA ATACAGGTTA TTCCAGTGGG ACTCAAAATG CCAACTACCC AGTGAGAGCT 
GCCCCTCCTC CCCCAGGATA CCATCAGAAC GGAGTCATCA GAAACCAGTA TGTGCCATAT 
CCCCATGCTC CTGGAAGCCA GAGGTCCAAT CAGAAAAGCC TGTACACCTC CATGGCCCGC 
CCGCCCTTGC CTCGGCAGCA GTCTACCAGT TCAGACCGAG TGTCACAGAC GCCAGAGAGC 
CTGGATTTCC TCAAGGTCCC GGACCAGGGA GCTGCAGGGG TCAGGAGACA AACAACCAGT 
CGGCCTCCCC CAGCAGGGGG CAGACCCAAG CCCCAGCCCA AGCCCAAGCC TCAGGTGCCA 
CAGTGCAAGG CTTTGTATGC CTATGACGCT CAGGACACAG ACGAACTCAG CTTTAATGCC 
AATGACATTA TTGATATTAT CAAAGAAGAT CCTTCTGGCT GGTGGACGGG TCGACTACGA 
GGCAAGCAGG GCCTGTTCCC CAACAACTAT GTGACCAAGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips.
The Journal of cell biology214(4)475-89(2016 Aug)
Tanimura S,Hashizume J,Arichika N,Watanabe K,Ohyama K,Takeda K,Kohno M

Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation.
Oncotarget7(29)46419-46432(2016 Jul)
Ouderkirk-Pecone JL,Goreczny GJ,Chase SE,Tatum AH,Turner CE,Krendel M

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.
Pediatric nephrology (Berlin, Germany)30(9)1459-65(2015 Sep)
Lennon R,Stuart HM,Bierzynska A,Randles MJ,Kerr B,Hillman KA,Batra G,Campbell J,Storey H,Flinter FA,Koziell A,Welsh GI,Saleem MA,Webb NJ,Woolf AS

[Mutational analysis of MYO1E in Chinese children with familial steroid-resistant nephrotic syndrome].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics16(4)349-55(2014 Apr)
Zhao F,Yu ZH,Yang YH,Nie XJ,Huang J,Wang CF,Xia GZ,Chen GM

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MYO1E cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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