PGAM4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PGAM4
Entrez Gene ID	441531
Full Name	phosphoglycerate mutase family member 4
Synonyms	PGAM-B,PGAM1,PGAM3,dJ1000K24.1
General protein information	Preferred Names phosphoglycerate mutase family member 4 Names phosphoglycerate mutase 4 phosphoglycerate mutase family 3 phosphoglycerate mutase processed protein probable phosphoglycerate mutase 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010].
Disorder MIM:	300567

mRNA and Protein(s)

mRNA	Protein	Name
NM_001029891.2	NP_001025062.1	phosphoglycerate mutase 4
NM_001029891.3	NP_001025062.1	phosphoglycerate mutase 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PGAM4	NP_001009163.1
Schizosaccharomyces pombe (fission yeast)	gpm1	NP_594889.1
Homo sapiens (human)	PGAM4	NP_001025062.1

Gene Ontology
Bibliography

Related articles in PubMed

The PGAM4 gene in non-obstructive azoospermia.
Jin Q, Pan H, Wang B, Wang J, Liu T, Yu X, Jia C, Fang X, Peng Y, Ma X
Systems biology in reproductive medicine59(4)179-83(2013 Aug)

A single nucleotide polymorphism within the novel sex-linked testis-specific retrotransposed PGAM4 gene influences human male fertility.
Okuda H, Tsujimura A, Irie S, Yamamoto K, Fukuhara S, Matsuoka Y, Takao T, Miyagawa Y, Nonomura N, Wada M, Tanaka H
PloS one7(5)e35195(2012)

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Molecular cell23(4)607-18(2006 Aug)

Emergence of young human genes after a burst of retroposition in primates.
Marques AC, Dupanloup I, Vinckenbosch N, Reymond A, Kaessmann H
PLoS biology3(11)e357(2005 Nov)

Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene.
Betr?n E, Wang W, Jin L, Long M
Molecular biology and evolution19(5)654-63(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PGAM4 coding region mutations were not observed and the G75C polymorphism is not associated with non-obstructive azoospermia susceptibility among the Chinese Han population.
Title: The PGAM4 gene in non-obstructive azoospermia.

PGAM4, an X-linked retrogene, is a fundamental gene in human male reproduction and may escape meiotic sex chromosome inactivation.
Title: A single nucleotide polymorphism within the novel sex-linked testis-specific retrotransposed PGAM4 gene influences human male fertility.

The following PGAM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGAM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18897	NM_001029891.3 Latest version!	Homo sapiens phosphoglycerate mutase family member 4 (PGAM4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18897	NM_001029891.2	Homo sapiens phosphoglycerate mutase family member 4 (PGAM4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PGAM4 ( NM_001029891.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025062.1 Homo sapiens phosphoglycerate mutase family member 4 (PGAM4), mRNA.

Price & Availability↑

CloneID	OHu18897
Clone ID Related Accession (Same CDS sequence)	NM_001029891.2 , NM_001029891.3
Accession Version	NM_001029891.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	phosphoglycerate mutase 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF465731.1, U76194.1 and BG875904.1. This sequence is a reference standard in the RefSeqGene project. On or before Jan 5, 2006 this sequence version replaced NM_001024459.1, NM_001029891.1.

ATGGCCGCCT ACAAACTGGT GCTGATCCGG CACGGCGAGA GCACATGGAA CCTGGAGAAC 
CGCTTCAGCT GCTGGTACGA CGCCGATCTG AGCCCGGCGG GCCACGAGGA GGCGAAGCGC 
GGCGGGCAGG CGCTACGAGA TGCTGGCTAT GAGTTTGACA TCTGCCTCAC CTCAGTGCAG 
AAGAGAGTGA TCCGGACCCT CTGGACAGTG CTAGATGCCA TTGATCAGAT GTGGCTGCCA 
GTGGTGAGGA CTTGGCGCCT CAATGAGCGG CACTATGGGG GTCTAACCGG TCTCAATAAA 
GCAGAAACTG CTGCAAAGCA TGGTGAGGCC CAGGTGAAGA TCTGGAGGCG CTCCTATGAT 
GTCCCACCAC CTCCGATGGA GCCCGACCAT CCTTTCTACA GCAACATCAG TAAGGATCGC 
AGGTATGCAG ACCTCACAGA AGATCAGCTA CCCTCCTATG AGAGTCCGAA GGATACTATT 
GCCAGAGCTC TGCCCTTCTG GAATGAAGAA ATAGTTCCCC AGATCAAGGA GGGGAAACGT 
GTACTGATTG CAGCCCATGG CAACAGCCTC CAGGGCATTG CCAAGCATGT GGAGGGTCTC 
TCTGAAGAGG CTATCATGGA GCTGAACCTG CCGACTGGTA TTCCCATCGT CTATGAATTG 
GACAAGAACT TGAAGCCTAT CAAGCCCATG CAGTTTCTGG GGGATGAAGA GACGGTGTGC 
AAAGCCATAG AAGCTGTGGC TGCCCAGGGC AAGGCCAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025062.1
CDS	1..765
Translation	MAAYKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVCKAIEAVAAQGKAKK

Target ORF information:

RefSeq Version	NM_001029891.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoglycerate mutase family member 4 (PGAM4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029891.2

ORF Insert Sequence:

ATGGCCGCCT ACAAACTGGT GCTGATCCGG CACGGCGAGA GCACATGGAA CCTGGAGAAC 
CGCTTCAGCT GCTGGTACGA CGCCGATCTG AGCCCGGCGG GCCACGAGGA GGCGAAGCGC 
GGCGGGCAGG CGCTACGAGA TGCTGGCTAT GAGTTTGACA TCTGCCTCAC CTCAGTGCAG 
AAGAGAGTGA TCCGGACCCT CTGGACAGTG CTAGATGCCA TTGATCAGAT GTGGCTGCCA 
GTGGTGAGGA CTTGGCGCCT CAATGAGCGG CACTATGGGG GTCTAACCGG TCTCAATAAA 
GCAGAAACTG CTGCAAAGCA TGGTGAGGCC CAGGTGAAGA TCTGGAGGCG CTCCTATGAT 
GTCCCACCAC CTCCGATGGA GCCCGACCAT CCTTTCTACA GCAACATCAG TAAGGATCGC 
AGGTATGCAG ACCTCACAGA AGATCAGCTA CCCTCCTATG AGAGTCCGAA GGATACTATT 
GCCAGAGCTC TGCCCTTCTG GAATGAAGAA ATAGTTCCCC AGATCAAGGA GGGGAAACGT 
GTACTGATTG CAGCCCATGG CAACAGCCTC CAGGGCATTG CCAAGCATGT GGAGGGTCTC 
TCTGAAGAGG CTATCATGGA GCTGAACCTG CCGACTGGTA TTCCCATCGT CTATGAATTG 
GACAAGAACT TGAAGCCTAT CAAGCCCATG CAGTTTCTGG GGGATGAAGA GACGGTGTGC 
AAAGCCATAG AAGCTGTGGC TGCCCAGGGC AAGGCCAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PGAM4 ( NM_001029891.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025062.1 Homo sapiens phosphoglycerate mutase family member 4 (PGAM4), mRNA.

Price & Availability↑

CloneID	OHu18897
Clone ID Related Accession (Same CDS sequence)	NM_001029891.2 , NM_001029891.3
Accession Version	NM_001029891.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	phosphoglycerate mutase 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF465731.1, U76194.1, BG875904.1 and AL772330.3. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001029891.2. ##Evidence-Data-START## Transcript is intronless :: BX365308.2, BF304193.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000458128.3/ ENSP00000412189.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCGCCT ACAAACTGGT GCTGATCCGG CACGGCGAGA GCACATGGAA CCTGGAGAAC 
CGCTTCAGCT GCTGGTACGA CGCCGATCTG AGCCCGGCGG GCCACGAGGA GGCGAAGCGC 
GGCGGGCAGG CGCTACGAGA TGCTGGCTAT GAGTTTGACA TCTGCCTCAC CTCAGTGCAG 
AAGAGAGTGA TCCGGACCCT CTGGACAGTG CTAGATGCCA TTGATCAGAT GTGGCTGCCA 
GTGGTGAGGA CTTGGCGCCT CAATGAGCGG CACTATGGGG GTCTAACCGG TCTCAATAAA 
GCAGAAACTG CTGCAAAGCA TGGTGAGGCC CAGGTGAAGA TCTGGAGGCG CTCCTATGAT 
GTCCCACCAC CTCCGATGGA GCCCGACCAT CCTTTCTACA GCAACATCAG TAAGGATCGC 
AGGTATGCAG ACCTCACAGA AGATCAGCTA CCCTCCTATG AGAGTCCGAA GGATACTATT 
GCCAGAGCTC TGCCCTTCTG GAATGAAGAA ATAGTTCCCC AGATCAAGGA GGGGAAACGT 
GTACTGATTG CAGCCCATGG CAACAGCCTC CAGGGCATTG CCAAGCATGT GGAGGGTCTC 
TCTGAAGAGG CTATCATGGA GCTGAACCTG CCGACTGGTA TTCCCATCGT CTATGAATTG 
GACAAGAACT TGAAGCCTAT CAAGCCCATG CAGTTTCTGG GGGATGAAGA GACGGTGTGC 
AAAGCCATAG AAGCTGTGGC TGCCCAGGGC AAGGCCAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025062.1
CDS	1..765
Translation	MAAYKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQKRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLQGIAKHVEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVCKAIEAVAAQGKAKK

Target ORF information:

RefSeq Version	NM_001029891.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoglycerate mutase family member 4 (PGAM4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029891.3

ORF Insert Sequence:

ATGGCCGCCT ACAAACTGGT GCTGATCCGG CACGGCGAGA GCACATGGAA CCTGGAGAAC 
CGCTTCAGCT GCTGGTACGA CGCCGATCTG AGCCCGGCGG GCCACGAGGA GGCGAAGCGC 
GGCGGGCAGG CGCTACGAGA TGCTGGCTAT GAGTTTGACA TCTGCCTCAC CTCAGTGCAG 
AAGAGAGTGA TCCGGACCCT CTGGACAGTG CTAGATGCCA TTGATCAGAT GTGGCTGCCA 
GTGGTGAGGA CTTGGCGCCT CAATGAGCGG CACTATGGGG GTCTAACCGG TCTCAATAAA 
GCAGAAACTG CTGCAAAGCA TGGTGAGGCC CAGGTGAAGA TCTGGAGGCG CTCCTATGAT 
GTCCCACCAC CTCCGATGGA GCCCGACCAT CCTTTCTACA GCAACATCAG TAAGGATCGC 
AGGTATGCAG ACCTCACAGA AGATCAGCTA CCCTCCTATG AGAGTCCGAA GGATACTATT 
GCCAGAGCTC TGCCCTTCTG GAATGAAGAA ATAGTTCCCC AGATCAAGGA GGGGAAACGT 
GTACTGATTG CAGCCCATGG CAACAGCCTC CAGGGCATTG CCAAGCATGT GGAGGGTCTC 
TCTGAAGAGG CTATCATGGA GCTGAACCTG CCGACTGGTA TTCCCATCGT CTATGAATTG 
GACAAGAACT TGAAGCCTAT CAAGCCCATG CAGTTTCTGG GGGATGAAGA GACGGTGTGC 
AAAGCCATAG AAGCTGTGGC TGCCCAGGGC AAGGCCAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The PGAM4 gene in non-obstructive azoospermia.
Systems biology in reproductive medicine59(4)179-83(2013 Aug)
Jin Q,Pan H,Wang B,Wang J,Liu T,Yu X,Jia C,Fang X,Peng Y,Ma X

A single nucleotide polymorphism within the novel sex-linked testis-specific retrotransposed PGAM4 gene influences human male fertility.
PloS one7(5)e35195(2012)
Okuda H,Tsujimura A,Irie S,Yamamoto K,Fukuhara S,Matsuoka Y,Takao T,Miyagawa Y,Nonomura N,Wada M,Tanaka H

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Molecular cell23(4)607-18(2006 Aug)
Kim SC,Sprung R,Chen Y,Xu Y,Ball H,Pei J,Cheng T,Kho Y,Xiao H,Xiao L,Grishin NV,White M,Yang XJ,Zhao Y

Emergence of young human genes after a burst of retroposition in primates.
PLoS biology3(11)e357(2005 Nov)
Marques AC,Dupanloup I,Vinckenbosch N,Reymond A,Kaessmann H

Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene.
Molecular biology and evolution19(5)654-63(2002 May)
Betr?n E,Wang W,Jin L,Long M

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PGAM4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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