MAP1LC3C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAP1LC3C
Entrez Gene ID	440738
Full Name	microtubule associated protein 1 light chain 3 gamma
Synonyms	ATG8J,LC3C
General protein information	Preferred Names microtubule associated protein 1 light chain 3 gamma Names microtubule-associated proteins 1A/1B light chain 3C LC3-like protein 2 MAP1 light chain 3-like protein 2 MAP1 light chain 3-like protein 3 MAP1A/MAP1B LC3 C MAP1A/MAP1B light chain 3 C autophagy-related protein LC3 C autophagy-related ubiquitin-like modifier LC3 C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q43
Summary	Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010].
Disorder MIM:	609605

mRNA and Protein(s)

mRNA	Protein	Name
XM_005273139.3	XP_005273196.1	microtubule-associated proteins 1A/1B light chain 3C isoform X1
NM_001004343.3	NP_001004343.1	microtubule-associated proteins 1A/1B light chain 3C
NM_001004343.2	NP_001004343.1	microtubule-associated proteins 1A/1B light chain 3C

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	MAP1LC3C	XP_419549.2
Homo sapiens (human)	MAP1LC3C	NP_001004343.1
Pan troglodytes (chimpanzee)	MAP1LC3C	XP_514305.2
Canis lupus familiaris (dog)	MAP1LC3C	XP_005622638.1
	MAP1LC3B2	XP_001104437.1
Bos taurus (cattle)	LOC507432	NP_001094528.1
Danio rerio (zebrafish)	map1lc3c	NP_956592.1
Xenopus tropicalis (tropical clawed frog)	map1lc3c	NP_001037987.1

Gene Ontology
Bibliography

Related articles in PubMed

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.
Le Guerrou? F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, Behrends C
Molecular cell68(4)786-796.e6(2017 Nov)

The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.
Liu X, Li Y, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W, Yang C
The Journal of cell biology216(5)1301-1320(2017 May)

Human CLEC16A regulates autophagy through modulating mTOR activity.
Tam RC, Li MW, Gao YP, Pang YT, Yan S, Ge W, Lau CS, Chan VS
Experimental cell research352(2)304-312(2017 03)

LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.
Madjo U, Leymarie O, Fr?mont S, Kuster A, Nehlich M, Gallois-Montbrun S, Janvier K, Berlioz-Torrent C
Cell reports17(9)2221-2233(2016 11)

TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, D?tsch V, Elazar Z, Rogov V, Farhan H, Behrends C
Molecular cell60(1)89-104(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a basal, housekeeping mitophagy pathway that involves piecemeal degradation of mitochondrial proteins in a LC3C- and p62-dependent manner and contributes to mitochondrial homeostasis maintenance when cells rely on oxidative phosphorylation.
Title: Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.

The WDR81 interacts with LC3C through canonical LC3-interacting regions in the BEACH domain, promoting LC3C recruitment to ubiquitinated proteins.
Title: The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.

a non-canonical autophagy pathway reminiscent of LC3-associated phagocytosis contributes to Vpu counteraction of BST2 restriction.
Title: LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.

Results indicate that TECPR2 Binds LC3and the complex is required for autophagosome formation, possibly through regulation of functional ER exit sites
Title: TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.

both autophagy-related 5 and microtubule-associated protein 1 light chain 3B levels are decreased in patients with melanomas as compared with those with benign nevi
Title: Autophagy suppresses melanoma tumorigenesis by inducing senescence.

The following MAP1LC3C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAP1LC3C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03553	NM_001004343.3 Latest version!	Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu03553	XM_005273139.3 Latest version!	Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu03553	NM_001004343.2	Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAP1LC3C ( NM_001004343.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001004343.1 Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), mRNA.

Price & Availability↑

CloneID	OHu03553
Clone ID Related Accession (Same CDS sequence)	XM_005273139.3 , NM_001004343.3 , NM_001004343.2
Accession Version	NM_001004343.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	microtubule-associated proteins 1A/1B light chain 3C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX571673.8, CN260933.1, BC127722.1 and AF276659.1. On May 17, 2019 this sequence version replaced NM_001004343.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF276659.1, BC132988.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357246.4/ ENSP00000349785.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCCGCCTC CACAGAAAAT CCCAAGCGTC AGACCCTTCA AGCAGAGGAA AAGCTTGGCA 
ATCAGACAAG AGGAAGTTGC TGGAATCCGG GCAAAGTTCC CCAACAAAAT CCCGGTGGTA 
GTGGAGCGCT ACCCCAGGGA GACGTTCCTG CCCCCGCTGG ACAAAACCAA GTTCCTGGTC 
CCGCAGGAGC TGACCATGAC CCAGTTCCTC AGCATCATCC GGAGCCGCAT GGTCCTGAGA 
GCCACGGAAG CCTTTTACTT GCTGGTGAAC AACAAGAGCC TGGTCAGCAT GAGCGCAACC 
ATGGCAGAGA TCTACAGAGA CTACAAGGAT GAGGATGGCT TCGTGTACAT GACCTACGCC 
TCCCAGGAGA CATTTGGCTG CCTGGAGTCA GCAGCCCCCA GGGATGGGAG CAGCCTTGAG 
GACAGACCCT GCAATCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004343.1
CDS	91..534
Translation	MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL

Target ORF information:

RefSeq Version	NM_001004343.3
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004343.3

ORF Insert Sequence:

ATGCCGCCTC CACAGAAAAT CCCAAGCGTC AGACCCTTCA AGCAGAGGAA AAGCTTGGCA 
ATCAGACAAG AGGAAGTTGC TGGAATCCGG GCAAAGTTCC CCAACAAAAT CCCGGTGGTA 
GTGGAGCGCT ACCCCAGGGA GACGTTCCTG CCCCCGCTGG ACAAAACCAA GTTCCTGGTC 
CCGCAGGAGC TGACCATGAC CCAGTTCCTC AGCATCATCC GGAGCCGCAT GGTCCTGAGA 
GCCACGGAAG CCTTTTACTT GCTGGTGAAC AACAAGAGCC TGGTCAGCAT GAGCGCAACC 
ATGGCAGAGA TCTACAGAGA CTACAAGGAT GAGGATGGCT TCGTGTACAT GACCTACGCC 
TCCCAGGAGA CATTTGGCTG CCTGGAGTCA GCAGCCCCCA GGGATGGGAG CAGCCTTGAG 
GACAGACCCT GCAATCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP1LC3C ( NM_001004343.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001004343.1 Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), mRNA.

Price & Availability↑

CloneID	OHu03553
Clone ID Related Accession (Same CDS sequence)	XM_005273139.3 , NM_001004343.3 , NM_001004343.2
Accession Version	NM_001004343.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	microtubule-associated proteins 1A/1B light chain 3C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN260933.1, BC127722.1 and AF276659.1. On Nov 5, 2008 this sequence version replaced NM_001004343.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF276659.1, BC132986.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END##

ATGCCGCCTC CACAGAAAAT CCCAAGCGTC AGACCCTTCA AGCAGAGGAA AAGCTTGGCA 
ATCAGACAAG AGGAAGTTGC TGGAATCCGG GCAAAGTTCC CCAACAAAAT CCCGGTGGTA 
GTGGAGCGCT ACCCCAGGGA GACGTTCCTG CCCCCGCTGG ACAAAACCAA GTTCCTGGTC 
CCGCAGGAGC TGACCATGAC CCAGTTCCTC AGCATCATCC GGAGCCGCAT GGTCCTGAGA 
GCCACGGAAG CCTTTTACTT GCTGGTGAAC AACAAGAGCC TGGTCAGCAT GAGCGCAACC 
ATGGCAGAGA TCTACAGAGA CTACAAGGAT GAGGATGGCT TCGTGTACAT GACCTACGCC 
TCCCAGGAGA CATTTGGCTG CCTGGAGTCA GCAGCCCCCA GGGATGGGAG CAGCCTTGAG 
GACAGACCCT GCAATCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004343.1
CDS	76..519
Translation	MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL

Target ORF information:

RefSeq Version	NM_001004343.2
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004343.2

ORF Insert Sequence:

ATGCCGCCTC CACAGAAAAT CCCAAGCGTC AGACCCTTCA AGCAGAGGAA AAGCTTGGCA 
ATCAGACAAG AGGAAGTTGC TGGAATCCGG GCAAAGTTCC CCAACAAAAT CCCGGTGGTA 
GTGGAGCGCT ACCCCAGGGA GACGTTCCTG CCCCCGCTGG ACAAAACCAA GTTCCTGGTC 
CCGCAGGAGC TGACCATGAC CCAGTTCCTC AGCATCATCC GGAGCCGCAT GGTCCTGAGA 
GCCACGGAAG CCTTTTACTT GCTGGTGAAC AACAAGAGCC TGGTCAGCAT GAGCGCAACC 
ATGGCAGAGA TCTACAGAGA CTACAAGGAT GAGGATGGCT TCGTGTACAT GACCTACGCC 
TCCCAGGAGA CATTTGGCTG CCTGGAGTCA GCAGCCCCCA GGGATGGGAG CAGCCTTGAG 
GACAGACCCT GCAATCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP1LC3C ( XM_005273139.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005273196.1 Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03553
Clone ID Related Accession (Same CDS sequence)	XM_005273139.3 , NM_001004343.3 , NM_001004343.2
Accession Version	XM_005273139.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	microtubule-associated proteins 1A/1B light chain 3C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005273139.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCCTC CACAGAAAAT CCCAAGCGTC AGACCCTTCA AGCAGAGGAA AAGCTTGGCA 
ATCAGACAAG AGGAAGTTGC TGGAATCCGG GCAAAGTTCC CCAACAAAAT CCCGGTGGTA 
GTGGAGCGCT ACCCCAGGGA GACGTTCCTG CCCCCGCTGG ACAAAACCAA GTTCCTGGTC 
CCGCAGGAGC TGACCATGAC CCAGTTCCTC AGCATCATCC GGAGCCGCAT GGTCCTGAGA 
GCCACGGAAG CCTTTTACTT GCTGGTGAAC AACAAGAGCC TGGTCAGCAT GAGCGCAACC 
ATGGCAGAGA TCTACAGAGA CTACAAGGAT GAGGATGGCT TCGTGTACAT GACCTACGCC 
TCCCAGGAGA CATTTGGCTG CCTGGAGTCA GCAGCCCCCA GGGATGGGAG CAGCCTTGAG 
GACAGACCCT GCAATCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005273196.1
CDS	104..547
Translation	MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL

Target ORF information:

RefSeq Version	XM_005273139.3
Organism	Homo sapiens(human)
Definition	Homo sapiens microtubule associated protein 1 light chain 3 gamma (MAP1LC3C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273139.3

ORF Insert Sequence:

ATGCCGCCTC CACAGAAAAT CCCAAGCGTC AGACCCTTCA AGCAGAGGAA AAGCTTGGCA 
ATCAGACAAG AGGAAGTTGC TGGAATCCGG GCAAAGTTCC CCAACAAAAT CCCGGTGGTA 
GTGGAGCGCT ACCCCAGGGA GACGTTCCTG CCCCCGCTGG ACAAAACCAA GTTCCTGGTC 
CCGCAGGAGC TGACCATGAC CCAGTTCCTC AGCATCATCC GGAGCCGCAT GGTCCTGAGA 
GCCACGGAAG CCTTTTACTT GCTGGTGAAC AACAAGAGCC TGGTCAGCAT GAGCGCAACC 
ATGGCAGAGA TCTACAGAGA CTACAAGGAT GAGGATGGCT TCGTGTACAT GACCTACGCC 
TCCCAGGAGA CATTTGGCTG CCTGGAGTCA GCAGCCCCCA GGGATGGGAG CAGCCTTGAG 
GACAGACCCT GCAATCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.
Molecular cell68(4)786-796.e6(2017 Nov)
Le Guerrou? F,Eck F,Jung J,Starzetz T,Mittelbronn M,Kaulich M,Behrends C

The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.
The Journal of cell biology216(5)1301-1320(2017 May)
Liu X,Li Y,Wang X,Xing R,Liu K,Gan Q,Tang C,Gao Z,Jian Y,Luo S,Guo W,Yang C

Human CLEC16A regulates autophagy through modulating mTOR activity.
Experimental cell research352(2)304-312(2017 03)
Tam RC,Li MW,Gao YP,Pang YT,Yan S,Ge W,Lau CS,Chan VS

LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.
Cell reports17(9)2221-2233(2016 11)
Madjo U,Leymarie O,Fr?mont S,Kuster A,Nehlich M,Gallois-Montbrun S,Janvier K,Berlioz-Torrent C

TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Molecular cell60(1)89-104(2015 Oct)
Stadel D,Millarte V,Tillmann KD,Huber J,Tamin-Yecheskel BC,Akutsu M,Demishtein A,Ben-Zeev B,Anikster Y,Perez F,D?tsch V,Elazar Z,Rogov V,Farhan H,Behrends C

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MAP1LC3C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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