Gene Symbol | STS |
Entrez Gene ID | 412 |
Full Name | steroid sulfatase |
Synonyms | ARSC,ARSC1,ASC,ES,SSDD,XLI |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]. |
Disorder MIM: | |
Disorder Html: | Ichthyosis, X-linked, 308100 (3) |