MAGEA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAGEA1
Entrez Gene ID	4100
Full Name	MAGE family member A1
Synonyms	CT1.1,MAGE1
General protein information	Preferred Names MAGE family member A1 Names melanoma-associated antigen 1 MAGE-1 antigen antigen MZ2-E cancer/testis antigen 1.1 cancer/testis antigen family 1, member 1 melanoma antigen MAGE-1 melanoma antigen family A 1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) melanoma antigen family A1 melanoma-associated antigen MZ2-E
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008].
Disorder MIM:	300016

mRNA and Protein(s)

mRNA	Protein	Name
NM_004988.4	NP_004979.3	melanoma-associated antigen 1
NM_004988.5	NP_004979.3	melanoma-associated antigen 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAGEA1	NP_004979.3
Pan troglodytes (chimpanzee)	MAGEA1	XP_529226.2

Gene Ontology
Bibliography

Related articles in PubMed

Expansion of cancer germline antigen-specific cytotoxic T lymphocytes for immunotherapy.
Krishnadas DK, Wang Y, Sundaram K, Bai F, Lucas KG
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317701309(2017 Jul)

[Cancer-testis genes in colon cancer].
Hilal NR, Novikov DV, Novikov VV, Karaulov AV
Terapevticheskii arkhiv89(5)113-117(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors revealed a novel interaction between MAGEA1 and the intracellular segment of NOTCH1 receptor (NICD1). MAGEA1 reduced NICD1's stability by promoting the ubiquitin modification of NICD1.
Title: MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells.

These data demonstrate that MAGE-A1-, MAGE-A3-, and NY-ESO-1-specific T cells with antigen-specific cytotoxicity can be cultured from healthy donors and patient-derived cells making adoptive immunotherapy with these cytotoxic T lymphocyte feasible.
Title: Expansion of cancer germline antigen-specific cytotoxic T lymphocytes for immunotherapy.

MAGEA1 was expression in 15% of synovial sarcomas and was not associated with prognosis.
Title: Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1.

Data show that overall survival (OS) was significantly lower for patients expressing pan-MAGE or MAGE-A1/A3/A4 in both independent cohorts.
Title: MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy.

In patients with Colon cancer, the expression of MAGE-A(1-6) gene was associated with a poor prognosis.
Title: [Cancer-testis genes in colon cancer].

The following MAGEA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGEA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18587	NM_004988.5 Latest version!	Homo sapiens MAGE family member A1 (MAGEA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu18587	NM_004988.4	Homo sapiens MAGE family member A1 (MAGEA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAGEA1 ( NM_004988.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004979.3 Homo sapiens MAGE family member A1 (MAGEA1), mRNA.

Price & Availability↑

CloneID	OHu18587
Clone ID Related Accession (Same CDS sequence)	NM_004988.4 , NM_004988.5
Accession Version	NM_004988.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	melanoma-associated antigen 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB053667.1, BC017555.1, BP314195.1 and CA428506.1. This sequence is a reference standard in the RefSeqGene project. On May 23, 2007 this sequence version replaced NM_004988.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017555.1, AY148486.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTCTTG AGCAGAGGAG TCTGCACTGC AAGCCTGAGG AAGCCCTTGA GGCCCAACAA 
GAGGCCCTGG GCCTGGTGTG TGTGCAGGCT GCCACCTCCT CCTCCTCTCC TCTGGTCCTG 
GGCACCCTGG AGGAGGTGCC CACTGCTGGG TCAACAGATC CTCCCCAGAG TCCTCAGGGA 
GCCTCCGCCT TTCCCACTAC CATCAACTTC ACTCGACAGA GGCAACCCAG TGAGGGTTCC 
AGCAGCCGTG AAGAGGAGGG GCCAAGCACC TCTTGTATCC TGGAGTCCTT GTTCCGAGCA 
GTAATCACTA AGAAGGTGGC TGATTTGGTT GGTTTTCTGC TCCTCAAATA TCGAGCCAGG 
GAGCCAGTCA CAAAGGCAGA AATGCTGGAG AGTGTCATCA AAAATTACAA GCACTGTTTT 
CCTGAGATCT TCGGCAAAGC CTCTGAGTCC TTGCAGCTGG TCTTTGGCAT TGACGTGAAG 
GAAGCAGACC CCACCGGCCA CTCCTATGTC CTTGTCACCT GCCTAGGTCT CTCCTATGAT 
GGCCTGCTGG GTGATAATCA GATCATGCCC AAGACAGGCT TCCTGATAAT TGTCCTGGTC 
ATGATTGCAA TGGAGGGCGG CCATGCTCCT GAGGAGGAAA TCTGGGAGGA GCTGAGTGTG 
ATGGAGGTGT ATGATGGGAG GGAGCACAGT GCCTATGGGG AGCCCAGGAA GCTGCTCACC 
CAAGATTTGG TGCAGGAAAA GTACCTGGAG TACCGGCAGG TGCCGGACAG TGATCCCGCA 
CGCTATGAGT TCCTGTGGGG TCCAAGGGCC CTCGCTGAAA CCAGCTATGT GAAAGTCCTT 
GAGTATGTGA TCAAGGTCAG TGCAAGAGTT CGCTTTTTCT TCCCATCCCT GCGTGAAGCA 
GCTTTGAGAG AGGAGGAAGA GGGAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004979.3
CDS	221..1150
Translation	MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV

Target ORF information:

RefSeq Version	NM_004988.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MAGE family member A1 (MAGEA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004988.4

ORF Insert Sequence:

ATGTCTCTTG AGCAGAGGAG TCTGCACTGC AAGCCTGAGG AAGCCCTTGA GGCCCAACAA 
GAGGCCCTGG GCCTGGTGTG TGTGCAGGCT GCCACCTCCT CCTCCTCTCC TCTGGTCCTG 
GGCACCCTGG AGGAGGTGCC CACTGCTGGG TCAACAGATC CTCCCCAGAG TCCTCAGGGA 
GCCTCCGCCT TTCCCACTAC CATCAACTTC ACTCGACAGA GGCAACCCAG TGAGGGTTCC 
AGCAGCCGTG AAGAGGAGGG GCCAAGCACC TCTTGTATCC TGGAGTCCTT GTTCCGAGCA 
GTAATCACTA AGAAGGTGGC TGATTTGGTT GGTTTTCTGC TCCTCAAATA TCGAGCCAGG 
GAGCCAGTCA CAAAGGCAGA AATGCTGGAG AGTGTCATCA AAAATTACAA GCACTGTTTT 
CCTGAGATCT TCGGCAAAGC CTCTGAGTCC TTGCAGCTGG TCTTTGGCAT TGACGTGAAG 
GAAGCAGACC CCACCGGCCA CTCCTATGTC CTTGTCACCT GCCTAGGTCT CTCCTATGAT 
GGCCTGCTGG GTGATAATCA GATCATGCCC AAGACAGGCT TCCTGATAAT TGTCCTGGTC 
ATGATTGCAA TGGAGGGCGG CCATGCTCCT GAGGAGGAAA TCTGGGAGGA GCTGAGTGTG 
ATGGAGGTGT ATGATGGGAG GGAGCACAGT GCCTATGGGG AGCCCAGGAA GCTGCTCACC 
CAAGATTTGG TGCAGGAAAA GTACCTGGAG TACCGGCAGG TGCCGGACAG TGATCCCGCA 
CGCTATGAGT TCCTGTGGGG TCCAAGGGCC CTCGCTGAAA CCAGCTATGT GAAAGTCCTT 
GAGTATGTGA TCAAGGTCAG TGCAAGAGTT CGCTTTTTCT TCCCATCCCT GCGTGAAGCA 
GCTTTGAGAG AGGAGGAAGA GGGAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAGEA1 ( NM_004988.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004979.3 Homo sapiens MAGE family member A1 (MAGEA1), mRNA.

Price & Availability↑

CloneID	OHu18587
Clone ID Related Accession (Same CDS sequence)	NM_004988.4 , NM_004988.5
Accession Version	NM_004988.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	melanoma-associated antigen 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB053667.1, BC017555.1, BP314195.1, CA428506.1 and AC236972.3. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004988.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.81782.1, SRR5189667.200285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000356661.7/ ENSP00000349085.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTCTTG AGCAGAGGAG TCTGCACTGC AAGCCTGAGG AAGCCCTTGA GGCCCAACAA 
GAGGCCCTGG GCCTGGTGTG TGTGCAGGCT GCCACCTCCT CCTCCTCTCC TCTGGTCCTG 
GGCACCCTGG AGGAGGTGCC CACTGCTGGG TCAACAGATC CTCCCCAGAG TCCTCAGGGA 
GCCTCCGCCT TTCCCACTAC CATCAACTTC ACTCGACAGA GGCAACCCAG TGAGGGTTCC 
AGCAGCCGTG AAGAGGAGGG GCCAAGCACC TCTTGTATCC TGGAGTCCTT GTTCCGAGCA 
GTAATCACTA AGAAGGTGGC TGATTTGGTT GGTTTTCTGC TCCTCAAATA TCGAGCCAGG 
GAGCCAGTCA CAAAGGCAGA AATGCTGGAG AGTGTCATCA AAAATTACAA GCACTGTTTT 
CCTGAGATCT TCGGCAAAGC CTCTGAGTCC TTGCAGCTGG TCTTTGGCAT TGACGTGAAG 
GAAGCAGACC CCACCGGCCA CTCCTATGTC CTTGTCACCT GCCTAGGTCT CTCCTATGAT 
GGCCTGCTGG GTGATAATCA GATCATGCCC AAGACAGGCT TCCTGATAAT TGTCCTGGTC 
ATGATTGCAA TGGAGGGCGG CCATGCTCCT GAGGAGGAAA TCTGGGAGGA GCTGAGTGTG 
ATGGAGGTGT ATGATGGGAG GGAGCACAGT GCCTATGGGG AGCCCAGGAA GCTGCTCACC 
CAAGATTTGG TGCAGGAAAA GTACCTGGAG TACCGGCAGG TGCCGGACAG TGATCCCGCA 
CGCTATGAGT TCCTGTGGGG TCCAAGGGCC CTCGCTGAAA CCAGCTATGT GAAAGTCCTT 
GAGTATGTGA TCAAGGTCAG TGCAAGAGTT CGCTTTTTCT TCCCATCCCT GCGTGAAGCA 
GCTTTGAGAG AGGAGGAAGA GGGAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004979.3
CDS	221..1150
Translation	MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV

Target ORF information:

RefSeq Version	NM_004988.5
Organism	Homo sapiens(human)
Definition	Homo sapiens MAGE family member A1 (MAGEA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004988.5

ORF Insert Sequence:

ATGTCTCTTG AGCAGAGGAG TCTGCACTGC AAGCCTGAGG AAGCCCTTGA GGCCCAACAA 
GAGGCCCTGG GCCTGGTGTG TGTGCAGGCT GCCACCTCCT CCTCCTCTCC TCTGGTCCTG 
GGCACCCTGG AGGAGGTGCC CACTGCTGGG TCAACAGATC CTCCCCAGAG TCCTCAGGGA 
GCCTCCGCCT TTCCCACTAC CATCAACTTC ACTCGACAGA GGCAACCCAG TGAGGGTTCC 
AGCAGCCGTG AAGAGGAGGG GCCAAGCACC TCTTGTATCC TGGAGTCCTT GTTCCGAGCA 
GTAATCACTA AGAAGGTGGC TGATTTGGTT GGTTTTCTGC TCCTCAAATA TCGAGCCAGG 
GAGCCAGTCA CAAAGGCAGA AATGCTGGAG AGTGTCATCA AAAATTACAA GCACTGTTTT 
CCTGAGATCT TCGGCAAAGC CTCTGAGTCC TTGCAGCTGG TCTTTGGCAT TGACGTGAAG 
GAAGCAGACC CCACCGGCCA CTCCTATGTC CTTGTCACCT GCCTAGGTCT CTCCTATGAT 
GGCCTGCTGG GTGATAATCA GATCATGCCC AAGACAGGCT TCCTGATAAT TGTCCTGGTC 
ATGATTGCAA TGGAGGGCGG CCATGCTCCT GAGGAGGAAA TCTGGGAGGA GCTGAGTGTG 
ATGGAGGTGT ATGATGGGAG GGAGCACAGT GCCTATGGGG AGCCCAGGAA GCTGCTCACC 
CAAGATTTGG TGCAGGAAAA GTACCTGGAG TACCGGCAGG TGCCGGACAG TGATCCCGCA 
CGCTATGAGT TCCTGTGGGG TCCAAGGGCC CTCGCTGAAA CCAGCTATGT GAAAGTCCTT 
GAGTATGTGA TCAAGGTCAG TGCAAGAGTT CGCTTTTTCT TCCCATCCCT GCGTGAAGCA 
GCTTTGAGAG AGGAGGAAGA GGGAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expansion of cancer germline antigen-specific cytotoxic T lymphocytes for immunotherapy.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317701309(2017 Jul)
Krishnadas DK,Wang Y,Sundaram K,Bai F,Lucas KG

[Cancer-testis genes in colon cancer].
Terapevticheskii arkhiv89(5)113-117(2017)
Hilal NR,Novikov DV,Novikov VV,Karaulov AV

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MAGEA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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