PTRHD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTRHD1
Entrez Gene ID	391356
Full Name	peptidyl-tRNA hydrolase domain containing 1
Synonyms	C2orf79
General protein information	Preferred Names peptidyl-tRNA hydrolase domain containing 1 Names putative peptidyl-tRNA hydrolase PTRHD1 peptidyl-tRNA hydrolase domain-containing protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p23.3
Summary	This gene encodes the enzyme peptidyl-tRNA hydrolase. Peptidyl-tRNA hydrolases perform the essential function of recycling peptidyl-tRNAs. Mutations in this gene are associated with autosomal-recessive intellectual disability and parkinsonism. [provided by RefSeq, May 2017].
Disorder MIM:	617342

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013663.1	NP_001013685.1	putative peptidyl-tRNA hydrolase PTRHD1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PTRHD1	NP_001229554.1
	PTRHD1	XP_001081983.1
Gallus gallus (chicken)	PTRHD1	XP_420022.3
Drosophila melanogaster (fruit fly)	CG14903	NP_650561.1
Caenorhabditis elegans (roundworm)	Y94H6A.12	NP_001122831.1
Rattus norvegicus (Norway rat)	Ptrhd1	NP_001127996.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001796	XP_321269.5
Xenopus tropicalis (tropical clawed frog)	ptrhd1	NP_001096530.1
Mus musculus (house mouse)	Ptrhd1	NP_001191841.1
Oryza sativa (rice)	Os04g0605200	NP_001053793.1
Homo sapiens (human)	PTRHD1	NP_001013685.1
Arabidopsis thaliana (thale cress)	AT5G10700	NP_196631.1
Canis lupus familiaris (dog)	PTRHD1	XP_532892.2
Bos taurus (cattle)	PTRHD1	NP_001030568.1
Danio rerio (zebrafish)	ptrhd1	NP_001025446.1

Gene Ontology
Bibliography

Related articles in PubMed

PTRHD1 (C2orf79) mutations lead to autosomal-recessive intellectual disability and parkinsonism.
Khodadadi H, Azcona LJ, Aghamollaii V, Omrani MD, Garshasbi M, Taghavi S, Tafakhori A, Shahidi GA, Jamshidi J, Darvish H, Pais?n-Ruiz C
Movement disorders : official journal of the Movement Disorder Society32(2)287-291(2017 Feb)

Expression, purification, and buffer solubility optimization of the putative human peptidyl-tRNA hydrolase PTRHD1.
Burks GL, McFeeters H, McFeeters RL
Protein expression and purification12649-54(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PTRHD1 mutation leads to intellectual disability and parkinsonism in a consanguineous family.
Title: PTRHD1 (C2orf79) mutations lead to autosomal-recessive intellectual disability and parkinsonism.

The following PTRHD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTRHD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29803	NM_001013663.1 Latest version!	Homo sapiens peptidyl-tRNA hydrolase domain containing 1 (PTRHD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTRHD1 ( NM_001013663.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001013685.1 Homo sapiens peptidyl-tRNA hydrolase domain containing 1 (PTRHD1), mRNA.

Price & Availability↑

CloneID	OHu29803
Clone ID Related Accession (Same CDS sequence)	NM_001013663.1
Accession Version	NM_001013663.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	putative peptidyl-tRNA hydrolase PTRHD1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC073803.1. This sequence is a reference standard in the RefSeqGene project. On Mar 30, 2005 this sequence version replaced XM_372919.3. ##Evidence-Data-START## Transcript exon combination :: BC073803.1, SRR1163658.571696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACCGGG GAGTAGGTCC GGCCTTTCGG GTGGTCAGGA AGATGGCGGC CTCTGGGGCG 
GAGCCGCAGG TCCTGGTACA ATACTTGGTG TTACGAAAGG ATCTATCACA AGCTCCGTTC 
TCCTGGCCGG CGGGCGCACT GGTAGCGCAG GCTTGTCACG CGGCCACCGC GGCCTTGCAC 
ACTCACCGCG ACCACCCGCA CACAGCCGCT TACCTCCAAG AGCTGGGGCG CATGCGCAAA 
GTGGTCCTCG AGGCCCCAGA TGAGACCACC CTAAAGGAGC TGGCCGAGAC CCTGCAACAG 
AAGAACATTG ACCACATGCT GTGGCTTGAG CAACCAGAGA ATATCGCCAC TTGTATTGCT 
CTCCGGCCCT ACCCCAAGGA AGAAGTGGGC CAGTATTTGA AGAAGTTCCG ATTGTTCAAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013685.1
CDS	6..428
Translation	MHRGVGPAFRVVRKMAASGAEPQVLVQYLVLRKDLSQAPFSWPAGALVAQACHAATAALHTHRDHPHTAAYLQELGRMRKVVLEAPDETTLKELAETLQQKNIDHMLWLEQPENIATCIALRPYPKEEVGQYLKKFRLFK

Target ORF information:

RefSeq Version	NM_001013663.1
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidyl-tRNA hydrolase domain containing 1 (PTRHD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013663.1

ORF Insert Sequence:

ATGCACCGGG GAGTAGGTCC GGCCTTTCGG GTGGTCAGGA AGATGGCGGC CTCTGGGGCG 
GAGCCGCAGG TCCTGGTACA ATACTTGGTG TTACGAAAGG ATCTATCACA AGCTCCGTTC 
TCCTGGCCGG CGGGCGCACT GGTAGCGCAG GCTTGTCACG CGGCCACCGC GGCCTTGCAC 
ACTCACCGCG ACCACCCGCA CACAGCCGCT TACCTCCAAG AGCTGGGGCG CATGCGCAAA 
GTGGTCCTCG AGGCCCCAGA TGAGACCACC CTAAAGGAGC TGGCCGAGAC CCTGCAACAG 
AAGAACATTG ACCACATGCT GTGGCTTGAG CAACCAGAGA ATATCGCCAC TTGTATTGCT 
CTCCGGCCCT ACCCCAAGGA AGAAGTGGGC CAGTATTTGA AGAAGTTCCG ATTGTTCAAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PTRHD1 (C2orf79) mutations lead to autosomal-recessive intellectual disability and parkinsonism.
Movement disorders : official journal of the Movement Disorder Society32(2)287-291(2017 Feb)
Khodadadi H,Azcona LJ,Aghamollaii V,Omrani MD,Garshasbi M,Taghavi S,Tafakhori A,Shahidi GA,Jamshidi J,Darvish H,Pais?n-Ruiz C

Expression, purification, and buffer solubility optimization of the putative human peptidyl-tRNA hydrolase PTRHD1.
Protein expression and purification12649-54(2016 Oct)
Burks GL,McFeeters H,McFeeters RL

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PTRHD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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