SERPINA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERPINA2
Entrez Gene ID	390502
Full Name	serpin family A member 2 (gene/pseudogene)
Synonyms	ARGS,ATR,PIL,SERPINA2P,psiATR
General protein information	Preferred Names serpin family A member 2 (gene/pseudogene) Names putative alpha-1-antitrypsin-related protein serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 serpin A2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.13
Summary	This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. The encoded intracellular glycoprotein is localized at the endoplasmic reticulum. This gene is a polymorphic pseudogene, with the non-functional allele being predominant in some populations. Some individuals, as represented by the reference genome allele, contain a 2kb coding region deletion and a start code mutation. [provided by RefSeq, Feb 2014].
Disorder MIM:	107410

mRNA and Protein(s)

mRNA	Protein	Name
NM_006220.2	NP_006211.2	putative alpha-1-antitrypsin-related protein precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Update of the human and mouse SERPIN gene superfamily.
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V
Human genomics722(2013 Oct)

SERPINA2 is a novel gene with a divergent function from SERPINA1.
Marques PI, Ferreira Z, Martins M, Figueiredo J, Silva DI, Castro P, Morales-Hojas R, Sim?es-Correia J, Seixas S
PloS one8(6)e66889(2013)

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C
Archives of general psychiatry65(6)683-93(2008 Jun)

Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.
Seixas S, Suriano G, Carvalho F, Seruca R, Rocha J, Di Rienzo A
Molecular biology and evolution24(2)587-98(2007 Feb)

Organization and expression of the human serpin gene cluster at 14q32.1.
Marsden MD, Fournier RE
Frontiers in bioscience : a journal and virtual library101768-78(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Specific features of SERPINA2 include the absence of insoluble aggregates and the insignificant response to cell stress, suggesting that it is a non-polymerogenic protein with divergent activity of SERPINA1.
Title: SERPINA2 is a novel gene with a divergent function from SERPINA1.

Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

Study found that a common haplotype in Africa had a 2-kb deletion in the SERPINA2 gene is associated with remarkable long-range homozygozity as if it was quickly driven to high frequency by natural selection acting on an advantageous variant.
Title: Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.

Observational study of gene-disease association. (HuGE Navigator)
Title: A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis.

The following SERPINA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu05319	NM_006220.2 Latest version!	Homo sapiens serpin family A member 2 (gene/pseudogene) (SERPINA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERPINA2 ( NM_006220.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006211.2 Homo sapiens serpin family A member 2 (gene/pseudogene) (SERPINA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05319
Clone ID Related Accession (Same CDS sequence)	NM_006220.2
Accession Version	NM_006220.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	putative alpha-1-antitrypsin-related protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC235087.2, JX680599.1 and DB526949.1. On Feb 13, 2014 this sequence version replaced NM_006220.1. Transcript Variant: This variant (1) represents the protein coding transcript. This allele is not found in the reference genome. ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 17135331 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCATTCT CTGTCTCATG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCC 
AGCTCCCTGG TTGAGGATCC CCAGGAAGAT GCTGCCCAAA AGACGGATAC ATCCCACCAT 
GATCAAGGGG ACTGGGAGGA CCTTGCTTGC CAGAAGATCT CCTATAACGT CACCGACCTC 
GCCTTTGATT TGTACAAAGA GCTGGCTGAT CTATCACAAA CCAGCAATGT CTTAGTCACC 
CCAACAAGCG TGGCTATGGC CTTTGCAATG CTCTCCCTGG GGACCAAGGC TGACACTCGC 
ACAGAGATCC TGGAAGGCCT GAATGTCAAC CTCACAGAGA CGCCTGAGGC CAAGATCCAC 
GAATGCTTCC AGCAAGTTCT CCAAGCCCTC AGCAGGCCAG ACACCCGGCT CCAGCTGACC 
ACCGGCAGTA GCCTGTTTGT TAACAAGAGT ATGAAGCTAG TGGACACGTT TTTGGAGGAT 
ACCAAGAAGC TGTACCACTC AGAAGCCTCT TCCATCAACT TCAGGGACAC CGAGGAGGCC 
AAAGAGCAGA TCAACAATTA TGTGGAGAAA AGAACTGGAA GAAAAGTAGT GGATTTGGTC 
AAACACCTGA AAAAAGACAC AAGTCTTGCC CTGGTGGATT ACATTTCCTT TCACGGCAAG 
TGGAAAGATA AATTCAAGGC TGAGCACATT ATGGTAGAGG GCTTCCATGT GGATGATAAG 
ACCATCATCA GAGTGCCTAT GATAAACCAC CTGGGTAGAT TTGACATCCA CCGGGACAGG 
GAGTTATCCA GCTGGGTGCT GGCACAGCAC TATGTGGGGA ACGCCACTGC CTTCTTCATC 
CTGCCCGATC CAAAGAAGAT GTGGCAGTTG GAAGAAAAAT TGACCTACAG CCACCTTGAA 
AATATCCAGA GAGCCTTTGA CATAAGGTCT ATCAATCTAC ATTTTCCCAA ACTGTCCATT 
TCTGGAACCT ACAAACTCAA GAGAGTCCTT AGGAATCTGG GCATCACCAA GATCTTCAGC 
AACGAGGCCG ACCTCTCTGG AGTCAGTCAG GAGGCACCCC TGAAGCTCTC CAAGGCTGTG 
CATGTGGCTG TGCTCACCAT TGATGAGAAA GGGACCGAAG CCACCGGAGC CCCCCATCTG 
GAGGAGAAGG CCTGGTCTAA GTATCAGACA GTCATGTTCA ACCGGCCCTT CCTGGTCATC 
ATCAAGGATG ACATCACCAA CTTTCCGCTC TTCATTGGAA AAGTGGTGAA TCCCACCCAA 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006211.2
CDS	5..1270
Translation	MPFSVSWGILLLAGLCCLVPSSLVEDPQEDAAQKTDTSHHDQGDWEDLACQKISYNVTDLAFDLYKELADLSQTSNVLVTPTSVAMAFAMLSLGTKADTRTEILEGLNVNLTETPEAKIHECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEASSINFRDTEEAKEQINNYVEKRTGRKVVDLVKHLKKDTSLALVDYISFHGKWKDKFKAEHIMVEGFHVDDKTIIRVPMINHLGRFDIHRDRELSSWVLAQHYVGNATAFFILPDPKKMWQLEEKLTYSHLENIQRAFDIRSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGVSQEAPLKLSKAVHVAVLTIDEKGTEATGAPHLEEKAWSKYQTVMFNRPFLVIIKDDITNFPLFIGKVVNPTQK

Target ORF information:

RefSeq Version	NM_006220.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family A member 2 (gene/pseudogene) (SERPINA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006220.2

ORF Insert Sequence:

ATGCCATTCT CTGTCTCATG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCC 
AGCTCCCTGG TTGAGGATCC CCAGGAAGAT GCTGCCCAAA AGACGGATAC ATCCCACCAT 
GATCAAGGGG ACTGGGAGGA CCTTGCTTGC CAGAAGATCT CCTATAACGT CACCGACCTC 
GCCTTTGATT TGTACAAAGA GCTGGCTGAT CTATCACAAA CCAGCAATGT CTTAGTCACC 
CCAACAAGCG TGGCTATGGC CTTTGCAATG CTCTCCCTGG GGACCAAGGC TGACACTCGC 
ACAGAGATCC TGGAAGGCCT GAATGTCAAC CTCACAGAGA CGCCTGAGGC CAAGATCCAC 
GAATGCTTCC AGCAAGTTCT CCAAGCCCTC AGCAGGCCAG ACACCCGGCT CCAGCTGACC 
ACCGGCAGTA GCCTGTTTGT TAACAAGAGT ATGAAGCTAG TGGACACGTT TTTGGAGGAT 
ACCAAGAAGC TGTACCACTC AGAAGCCTCT TCCATCAACT TCAGGGACAC CGAGGAGGCC 
AAAGAGCAGA TCAACAATTA TGTGGAGAAA AGAACTGGAA GAAAAGTAGT GGATTTGGTC 
AAACACCTGA AAAAAGACAC AAGTCTTGCC CTGGTGGATT ACATTTCCTT TCACGGCAAG 
TGGAAAGATA AATTCAAGGC TGAGCACATT ATGGTAGAGG GCTTCCATGT GGATGATAAG 
ACCATCATCA GAGTGCCTAT GATAAACCAC CTGGGTAGAT TTGACATCCA CCGGGACAGG 
GAGTTATCCA GCTGGGTGCT GGCACAGCAC TATGTGGGGA ACGCCACTGC CTTCTTCATC 
CTGCCCGATC CAAAGAAGAT GTGGCAGTTG GAAGAAAAAT TGACCTACAG CCACCTTGAA 
AATATCCAGA GAGCCTTTGA CATAAGGTCT ATCAATCTAC ATTTTCCCAA ACTGTCCATT 
TCTGGAACCT ACAAACTCAA GAGAGTCCTT AGGAATCTGG GCATCACCAA GATCTTCAGC 
AACGAGGCCG ACCTCTCTGG AGTCAGTCAG GAGGCACCCC TGAAGCTCTC CAAGGCTGTG 
CATGTGGCTG TGCTCACCAT TGATGAGAAA GGGACCGAAG CCACCGGAGC CCCCCATCTG 
GAGGAGAAGG CCTGGTCTAA GTATCAGACA GTCATGTTCA ACCGGCCCTT CCTGGTCATC 
ATCAAGGATG ACATCACCAA CTTTCCGCTC TTCATTGGAA AAGTGGTGAA TCCCACCCAA 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Update of the human and mouse SERPIN gene superfamily.
Human genomics722(2013 Oct)
Heit C,Jackson BC,McAndrews M,Wright MW,Thompson DC,Silverman GA,Nebert DW,Vasiliou V

SERPINA2 is a novel gene with a divergent function from SERPINA1.
PloS one8(6)e66889(2013)
Marques PI,Ferreira Z,Martins M,Figueiredo J,Silva DI,Castro P,Morales-Hojas R,Sim?es-Correia J,Seixas S

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Archives of general psychiatry65(6)683-93(2008 Jun)
Uhl GR,Liu QR,Drgon T,Johnson C,Walther D,Rose JE,David SP,Niaura R,Lerman C

Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.
Molecular biology and evolution24(2)587-98(2007 Feb)
Seixas S,Suriano G,Carvalho F,Seruca R,Rocha J,Di Rienzo A

Organization and expression of the human serpin gene cluster at 14q32.1.
Frontiers in bioscience : a journal and virtual library101768-78(2005 May)
Marsden MD,Fournier RE

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SERPINA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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