KRT10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT10
Entrez Gene ID	3858
Full Name	keratin 10
Synonyms	BCIE,BIE,CK10,EHK,K10,KPP
General protein information	Preferred Names keratin 10 Names keratin, type I cytoskeletal 10 CK-10 cytokeratin 10 keratin 10, type I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2
Summary	This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008].
Disorder MIM:	148080
Disorder Html:	Epidermolytic hyperkeratosis, 113800 (3); Ichthyosis, cyclic, with epidermolytic hyperkeratosis, 607602 (3); Ichthyosis with confetti, 609165 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000421.3	NP_000412.3	keratin, type I cytoskeletal 10
NM_000421.4	NP_000412.3	keratin, type I cytoskeletal 10
XM_005257343.3	XP_005257400.1	keratin, type I cytoskeletal 10 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy.
Kalinska-Bienias A, Pollak A, Kowalewski C, Lechowicz U, Stawinski P, Gergont A, Kosinska J, Pronicka E, Kowalski P, Wozniak K, Ploski R
American journal of medical genetics. Part A173(11)3093-3097(2017 Nov)

Extensive Post-zygotic Mosaicism of KRT1 or KRT10 Mutation Mimicking Classical Epider-molytic Ichthyosis.
Severino-Freire M, Jonca N, Pichery M, Tournier E, Chassaing N, Mazereeuw-Hautier J
Acta dermato-venereologica97(3)387-388(2017 03)

The X-Ray Crystal Structure of the Keratin?1-Keratin 10 Helix 2B Heterodimer Reveals?Molecular Surface Properties and?Biochemical Insights into Human Skin?Disease.
Bunick CG, Milstone LM
The Journal of investigative dermatology137(1)142-150(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis.
Title: Extensive Post-zygotic Mosaicism of KRT1 or KRT10 Mutation Mimicking Classical Epider-molytic Ichthyosis.

Mutations in the highly conserved helix initiation motif of K10 were associated with mild or severe form of epidermolytic ichthyosis
Title: S159P mutation of keratin 10 gene causes severe form of epidermolytic hyperkeratosis.

KRT10 gene mutation was present in all of the affected individuals, but absent in the five unaffected and 100 ethnically-matched healthy controls.
Title: Ichthyosis hystrix Lambert type and Curth-Macklin type are a single entity with affected (KRT1 mutation) or unaffected (KRT10 mutation) palms and soles?

Report genetic/clinical spectrum of KRT10 mutations in keratinopathic ichthyosis.
Title: Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis.

We present an autosomal dominant pedigree with epidermolytic ichthyosis resulting from a new heterozygous missense mutation in keratin 10.
Title: Intrafamilial phenotypic heterogeneity of epidermolytic ichthyosis associated with a new missense mutation in keratin 10.

The following KRT10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19931	NM_000421.4 Latest version!	Homo sapiens keratin 10 (KRT10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu50364	XM_005257343.3 Latest version!	Homo sapiens keratin 10 (KRT10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu19931	NM_000421.3	Homo sapiens keratin 10 (KRT10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT10 ( NM_000421.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000412.3 Homo sapiens keratin 10 (KRT10), mRNA.

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CloneID	OHu19931
Clone ID Related Accession (Same CDS sequence)	NM_000421.3 , NM_000421.4
Accession Version	NM_000421.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1755bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-30
Organism	Homo sapiens(human)
Product	keratin, type I cytoskeletal 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CU455823.1, BC034697.1 and M77663.1. This sequence is a reference standard in the RefSeqGene project. On Aug 9, 2008 this sequence version replaced NM_000421.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034697.1, ERR279840.7708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTTC GATACAGCTC AAGCAAGCAC TACTCTTCCT CCCGCAGTGG AGGAGGAGGA 
GGAGGAGGAG GATGTGGAGG AGGAGGAGGA GTGTCATCCC TAAGAATTTC TAGCAGCAAA 
GGCTCCCTTG GTGGAGGATT TAGCTCAGGG GGGTTCAGTG GTGGCTCTTT TAGCCGTGGG 
AGCTCTGGTG GGGGCTGCTT TGGGGGCTCA TCAGGTGGCT ATGGAGGATT AGGAGGTTTT 
GGTGGAGGTA GCTTTCGTGG AAGCTATGGA AGTAGCAGCT TTGGTGGGAG TTATGGAGGC 
AGCTTTGGAG GGGGCAGTTT CGGAGGTGGC AGCTTTGGTG GGGGCAGCTT TGGTGGAGGC 
GGCTTTGGTG GAGGCGGCTT TGGAGGAGGC TTTGGTGGTG GATTTGGAGG AGATGGTGGC 
CTTCTCTCTG GAAATGAAAA AGTAACCATG CAGAATCTGA ATGACCGCCT GGCTTCCTAC 
TTGGACAAAG TTCGGGCTCT GGAAGAATCA AACTATGAGC TGGAAGGCAA AATCAAGGAG 
TGGTATGAAA AGCATGGCAA CTCACATCAG GGGGAGCCTC GTGACTACAG CAAATACTAC 
AAAACCATCG ATGACCTTAA AAATCAGATT CTCAACCTAA CAACTGATAA TGCCAACATC 
CTGCTTCAGA TCGACAATGC CAGGCTGGCA GCTGATGACT TCAGGCTGAA GTATGAGAAT 
GAGGTAGCTC TGCGCCAGAG CGTGGAGGCT GACATCAACG GCCTGCGTAG GGTGCTGGAT 
GAGCTGACCC TGACCAAGGC TGACCTGGAG ATGCAAATTG AGAGCCTGAC TGAAGAGCTG 
GCCTATCTGA AGAAGAACCA CGAGGAGGAA ATGAAAGACC TTCGAAATGT GTCCACTGGT 
GATGTGAATG TGGAAATGAA TGCTGCCCCG GGTGTTGATC TGACTCAACT TCTGAATAAC 
ATGAGAAGCC AATATGAACA ACTTGCTGAA CAAAACCGCA AAGATGCTGA AGCCTGGTTC 
AATGAAAAGA GCAAGGAACT GACTACAGAA ATTGATAATA ACATTGAACA GATATCCAGC 
TATAAATCTG AGATTACTGA ATTGAGACGT AATGTACAAG CTCTGGAGAT AGAACTACAG 
TCCCAACTGG CCTTGAAACA ATCCCTGGAA GCCTCCTTGG CAGAAACAGA AGGTCGCTAC 
TGTGTGCAGC TCTCACAGAT TCAGGCCCAG ATATCCGCTC TGGAAGAACA GTTGCAACAG 
ATTCGAGCTG AAACCGAGTG CCAGAATACT GAATACCAAC AACTCCTGGA TATTAAGATC 
CGACTGGAGA ATGAAATTCA AACCTACCGC AGCCTGCTAG AAGGAGAGGG AAGTTCCGGA 
GGCGGCGGAC GCGGCGGCGG AAGTTTCGGC GGCGGCTACG GCGGCGGAAG CTCCGGCGGC 
GGAAGCTCCG GCGGCGGCCA CGGCGGCGGC CACGGCGGCA GTTCCGGCGG CGGCTACGGA 
GGCGGAAGCT CCGGCGGCGG AAGCTCCGGC GGCGGCTACG GGGGCGGAAG CTCCAGCGGC 
GGCCACGGCG GCAGTTCCAG CGGCGGCTAC GGTGGTGGCA GTTCCGGCGG CGGCGGCGGC 
GGCTACGGGG GCGGCAGCTC CGGCGGCGGC AGCAGCTCCG GCGGCGGATA CGGCGGCGGC 
AGCTCCAGCG GAGGCCACAA GTCCTCCTCT TCCGGGTCCG TGGGCGAGTC TTCATCTAAG 
GGACCAAGAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000412.3
CDS	27..1781
Translation	MSVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRY

Target ORF information:

RefSeq Version	NM_000421.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 10 (KRT10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000421.3

ORF Insert Sequence:

ATGTCTGTTC GATACAGCTC AAGCAAGCAC TACTCTTCCT CCCGCAGTGG AGGAGGAGGA 
GGAGGAGGAG GATGTGGAGG AGGAGGAGGA GTGTCATCCC TAAGAATTTC TAGCAGCAAA 
GGCTCCCTTG GTGGAGGATT TAGCTCAGGG GGGTTCAGTG GTGGCTCTTT TAGCCGTGGG 
AGCTCTGGTG GGGGCTGCTT TGGGGGCTCA TCAGGTGGCT ATGGAGGATT AGGAGGTTTT 
GGTGGAGGTA GCTTTCGTGG AAGCTATGGA AGTAGCAGCT TTGGTGGGAG TTATGGAGGC 
AGCTTTGGAG GGGGCAGTTT CGGAGGTGGC AGCTTTGGTG GGGGCAGCTT TGGTGGAGGC 
GGCTTTGGTG GAGGCGGCTT TGGAGGAGGC TTTGGTGGTG GATTTGGAGG AGATGGTGGC 
CTTCTCTCTG GAAATGAAAA AGTAACCATG CAGAATCTGA ATGACCGCCT GGCTTCCTAC 
TTGGACAAAG TTCGGGCTCT GGAAGAATCA AACTATGAGC TGGAAGGCAA AATCAAGGAG 
TGGTATGAAA AGCATGGCAA CTCACATCAG GGGGAGCCTC GTGACTACAG CAAATACTAC 
AAAACCATCG ATGACCTTAA AAATCAGATT CTCAACCTAA CAACTGATAA TGCCAACATC 
CTGCTTCAGA TCGACAATGC CAGGCTGGCA GCTGATGACT TCAGGCTGAA GTATGAGAAT 
GAGGTAGCTC TGCGCCAGAG CGTGGAGGCT GACATCAACG GCCTGCGTAG GGTGCTGGAT 
GAGCTGACCC TGACCAAGGC TGACCTGGAG ATGCAAATTG AGAGCCTGAC TGAAGAGCTG 
GCCTATCTGA AGAAGAACCA CGAGGAGGAA ATGAAAGACC TTCGAAATGT GTCCACTGGT 
GATGTGAATG TGGAAATGAA TGCTGCCCCG GGTGTTGATC TGACTCAACT TCTGAATAAC 
ATGAGAAGCC AATATGAACA ACTTGCTGAA CAAAACCGCA AAGATGCTGA AGCCTGGTTC 
AATGAAAAGA GCAAGGAACT GACTACAGAA ATTGATAATA ACATTGAACA GATATCCAGC 
TATAAATCTG AGATTACTGA ATTGAGACGT AATGTACAAG CTCTGGAGAT AGAACTACAG 
TCCCAACTGG CCTTGAAACA ATCCCTGGAA GCCTCCTTGG CAGAAACAGA AGGTCGCTAC 
TGTGTGCAGC TCTCACAGAT TCAGGCCCAG ATATCCGCTC TGGAAGAACA GTTGCAACAG 
ATTCGAGCTG AAACCGAGTG CCAGAATACT GAATACCAAC AACTCCTGGA TATTAAGATC 
CGACTGGAGA ATGAAATTCA AACCTACCGC AGCCTGCTAG AAGGAGAGGG AAGTTCCGGA 
GGCGGCGGAC GCGGCGGCGG AAGTTTCGGC GGCGGCTACG GCGGCGGAAG CTCCGGCGGC 
GGAAGCTCCG GCGGCGGCCA CGGCGGCGGC CACGGCGGCA GTTCCGGCGG CGGCTACGGA 
GGCGGAAGCT CCGGCGGCGG AAGCTCCGGC GGCGGCTACG GGGGCGGAAG CTCCAGCGGC 
GGCCACGGCG GCAGTTCCAG CGGCGGCTAC GGTGGTGGCA GTTCCGGCGG CGGCGGCGGC 
GGCTACGGGG GCGGCAGCTC CGGCGGCGGC AGCAGCTCCG GCGGCGGATA CGGCGGCGGC 
AGCTCCAGCG GAGGCCACAA GTCCTCCTCT TCCGGGTCCG TGGGCGAGTC TTCATCTAAG 
GGACCAAGAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT10 ( NM_000421.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000412.3 Homo sapiens keratin 10 (KRT10), mRNA.

Price & Availability↑

CloneID	OHu19931
Clone ID Related Accession (Same CDS sequence)	NM_000421.3 , NM_000421.4
Accession Version	NM_000421.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1755bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	keratin, type I cytoskeletal 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090283.7, CU455823.1, BC034697.1 and M77663.1. On Nov 22, 2018 this sequence version replaced NM_000421.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034697.1, ERR279840.7708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGTTC GATACAGCTC AAGCAAGCAC TACTCTTCCT CCCGCAGTGG AGGAGGAGGA 
GGAGGAGGAG GATGTGGAGG AGGAGGAGGA GTGTCATCCC TAAGAATTTC TAGCAGCAAA 
GGCTCCCTTG GTGGAGGATT TAGCTCAGGG GGGTTCAGTG GTGGCTCTTT TAGCCGTGGG 
AGCTCTGGTG GGGGCTGCTT TGGGGGCTCA TCAGGTGGCT ATGGAGGATT AGGAGGTTTT 
GGTGGAGGTA GCTTTCGTGG AAGCTATGGA AGTAGCAGCT TTGGTGGGAG TTATGGAGGC 
AGCTTTGGAG GGGGCAGTTT CGGAGGTGGC AGCTTTGGTG GGGGCAGCTT TGGTGGAGGC 
GGCTTTGGTG GAGGCGGCTT TGGAGGAGGC TTTGGTGGTG GATTTGGAGG AGATGGTGGC 
CTTCTCTCTG GAAATGAAAA AGTAACCATG CAGAATCTGA ATGACCGCCT GGCTTCCTAC 
TTGGACAAAG TTCGGGCTCT GGAAGAATCA AACTATGAGC TGGAAGGCAA AATCAAGGAG 
TGGTATGAAA AGCATGGCAA CTCACATCAG GGGGAGCCTC GTGACTACAG CAAATACTAC 
AAAACCATCG ATGACCTTAA AAATCAGATT CTCAACCTAA CAACTGATAA TGCCAACATC 
CTGCTTCAGA TCGACAATGC CAGGCTGGCA GCTGATGACT TCAGGCTGAA GTATGAGAAT 
GAGGTAGCTC TGCGCCAGAG CGTGGAGGCT GACATCAACG GCCTGCGTAG GGTGCTGGAT 
GAGCTGACCC TGACCAAGGC TGACCTGGAG ATGCAAATTG AGAGCCTGAC TGAAGAGCTG 
GCCTATCTGA AGAAGAACCA CGAGGAGGAA ATGAAAGACC TTCGAAATGT GTCCACTGGT 
GATGTGAATG TGGAAATGAA TGCTGCCCCG GGTGTTGATC TGACTCAACT TCTGAATAAC 
ATGAGAAGCC AATATGAACA ACTTGCTGAA CAAAACCGCA AAGATGCTGA AGCCTGGTTC 
AATGAAAAGA GCAAGGAACT GACTACAGAA ATTGATAATA ACATTGAACA GATATCCAGC 
TATAAATCTG AGATTACTGA ATTGAGACGT AATGTACAAG CTCTGGAGAT AGAACTACAG 
TCCCAACTGG CCTTGAAACA ATCCCTGGAA GCCTCCTTGG CAGAAACAGA AGGTCGCTAC 
TGTGTGCAGC TCTCACAGAT TCAGGCCCAG ATATCCGCTC TGGAAGAACA GTTGCAACAG 
ATTCGAGCTG AAACCGAGTG CCAGAATACT GAATACCAAC AACTCCTGGA TATTAAGATC 
CGACTGGAGA ATGAAATTCA AACCTACCGC AGCCTGCTAG AAGGAGAGGG AAGTTCCGGA 
GGCGGCGGAC GCGGCGGCGG AAGTTTCGGC GGCGGCTACG GCGGCGGAAG CTCCGGCGGC 
GGAAGCTCCG GCGGCGGCCA CGGCGGCGGC CACGGCGGCA GTTCCGGCGG CGGCTACGGA 
GGCGGAAGCT CCGGCGGCGG AAGCTCCGGC GGCGGCTACG GGGGCGGAAG CTCCAGCGGC 
GGCCACGGCG GCAGTTCCAG CGGCGGCTAC GGTGGTGGCA GTTCCGGCGG CGGCGGCGGC 
GGCTACGGGG GCGGCAGCTC CGGCGGCGGC AGCAGCTCCG GCGGCGGATA CGGCGGCGGC 
AGCTCCAGCG GAGGCCACAA GTCCTCCTCT TCCGGGTCCG TGGGCGAGTC TTCATCTAAG 
GGACCAAGAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000412.3
CDS	30..1784
Translation	MSVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRY

Target ORF information:

RefSeq Version	NM_000421.4
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 10 (KRT10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000421.4

ORF Insert Sequence:

ATGTCTGTTC GATACAGCTC AAGCAAGCAC TACTCTTCCT CCCGCAGTGG AGGAGGAGGA 
GGAGGAGGAG GATGTGGAGG AGGAGGAGGA GTGTCATCCC TAAGAATTTC TAGCAGCAAA 
GGCTCCCTTG GTGGAGGATT TAGCTCAGGG GGGTTCAGTG GTGGCTCTTT TAGCCGTGGG 
AGCTCTGGTG GGGGCTGCTT TGGGGGCTCA TCAGGTGGCT ATGGAGGATT AGGAGGTTTT 
GGTGGAGGTA GCTTTCGTGG AAGCTATGGA AGTAGCAGCT TTGGTGGGAG TTATGGAGGC 
AGCTTTGGAG GGGGCAGTTT CGGAGGTGGC AGCTTTGGTG GGGGCAGCTT TGGTGGAGGC 
GGCTTTGGTG GAGGCGGCTT TGGAGGAGGC TTTGGTGGTG GATTTGGAGG AGATGGTGGC 
CTTCTCTCTG GAAATGAAAA AGTAACCATG CAGAATCTGA ATGACCGCCT GGCTTCCTAC 
TTGGACAAAG TTCGGGCTCT GGAAGAATCA AACTATGAGC TGGAAGGCAA AATCAAGGAG 
TGGTATGAAA AGCATGGCAA CTCACATCAG GGGGAGCCTC GTGACTACAG CAAATACTAC 
AAAACCATCG ATGACCTTAA AAATCAGATT CTCAACCTAA CAACTGATAA TGCCAACATC 
CTGCTTCAGA TCGACAATGC CAGGCTGGCA GCTGATGACT TCAGGCTGAA GTATGAGAAT 
GAGGTAGCTC TGCGCCAGAG CGTGGAGGCT GACATCAACG GCCTGCGTAG GGTGCTGGAT 
GAGCTGACCC TGACCAAGGC TGACCTGGAG ATGCAAATTG AGAGCCTGAC TGAAGAGCTG 
GCCTATCTGA AGAAGAACCA CGAGGAGGAA ATGAAAGACC TTCGAAATGT GTCCACTGGT 
GATGTGAATG TGGAAATGAA TGCTGCCCCG GGTGTTGATC TGACTCAACT TCTGAATAAC 
ATGAGAAGCC AATATGAACA ACTTGCTGAA CAAAACCGCA AAGATGCTGA AGCCTGGTTC 
AATGAAAAGA GCAAGGAACT GACTACAGAA ATTGATAATA ACATTGAACA GATATCCAGC 
TATAAATCTG AGATTACTGA ATTGAGACGT AATGTACAAG CTCTGGAGAT AGAACTACAG 
TCCCAACTGG CCTTGAAACA ATCCCTGGAA GCCTCCTTGG CAGAAACAGA AGGTCGCTAC 
TGTGTGCAGC TCTCACAGAT TCAGGCCCAG ATATCCGCTC TGGAAGAACA GTTGCAACAG 
ATTCGAGCTG AAACCGAGTG CCAGAATACT GAATACCAAC AACTCCTGGA TATTAAGATC 
CGACTGGAGA ATGAAATTCA AACCTACCGC AGCCTGCTAG AAGGAGAGGG AAGTTCCGGA 
GGCGGCGGAC GCGGCGGCGG AAGTTTCGGC GGCGGCTACG GCGGCGGAAG CTCCGGCGGC 
GGAAGCTCCG GCGGCGGCCA CGGCGGCGGC CACGGCGGCA GTTCCGGCGG CGGCTACGGA 
GGCGGAAGCT CCGGCGGCGG AAGCTCCGGC GGCGGCTACG GGGGCGGAAG CTCCAGCGGC 
GGCCACGGCG GCAGTTCCAG CGGCGGCTAC GGTGGTGGCA GTTCCGGCGG CGGCGGCGGC 
GGCTACGGGG GCGGCAGCTC CGGCGGCGGC AGCAGCTCCG GCGGCGGATA CGGCGGCGGC 
AGCTCCAGCG GAGGCCACAA GTCCTCCTCT TCCGGGTCCG TGGGCGAGTC TTCATCTAAG 
GGACCAAGAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT10 ( XM_005257343.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005257400.1 Homo sapiens keratin 10 (KRT10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu50364
Clone ID Related Accession (Same CDS sequence)	XM_005257343.3
Accession Version	XM_005257343.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	keratin, type I cytoskeletal 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005257343.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGTTC GATACAGCTC AAGCAAGCAC TACTCTTCCT CCCGCAGTGG AGGAGGAGGA 
GGAGGAGGAG GATGTGGAGG AGGAGGAGGA GTGTCATCCC TAAGAATTTC TAGCAGCAAA 
GGCTCCCTTG GTGGAGGATT TAGCTCAGGG GGGTTCAGTG GTGGCTCTTT TAGCCGTGGG 
AGCTCTGGTG GGGGCTGCTT TGGGGGCTCA TCAGGTGGCT ATGGAGGATT AGGAGGTTTT 
GGTGGAGGTA GCTTTCGTGG AAGCTATGGA AGTAGCAGCT TTGGTGGGAG TTATGGAGGC 
ATCTTTGGAG GGGGCAGTTT CGGAGGTGGC AGCTTTGGTG GGGGCAGCTT TGGTGGAGGC 
GGCTTTGGTG GAGGCGGCTT TGGAGGAGGC TTTGGTGGTG GATTTGGAGG AGATGGTGGC 
CTTCTCTCTG GAAATGAAAA AGTAACCATG CAGAATCTGA ATGACCGCCT GGCTTCCTAC 
TTGGACAAAG TTCGGGCTCT GGAAGAATCA AACTATGAGC TGGAAGGCAA AATCAAGGAG 
TGGTATGAAA AGCATGGCAA CTCACATCAG GGGGAGCCTC GTGACTACAG CAAATACTAC 
AAAACCATCG ATGACCTTAA AAATCAGATT CTCAACCTAA CAACTGATAA TGCCAACATC 
CTGCTTCAGA TCGACAATGC CAGGCTGGCA GCTGATGACT TCAGGCTGAA GTATGAGAAT 
GAGGTAGCTC TGCGCCAGAG CGTGGAGGCT GACATCAACG GCCTGCGTAG GGTGCTGGAT 
GAGCTGACCC TGACCAAGGC TGACCTGGAG ATGCAAATTG AGAGCCTGAC TGAAGAGCTG 
GCCTATCTGA AGAAGAACCA CGAGGAGGAA ATGAAAGACC TTCGAAATGT GTCCACTGGT 
GATGTGAATG TGGAAATGAA TGCTGCCCCG GGTGTTGATC TGACTCAACT TCTGAATAAC 
ATGAGAAGCC AATATGAACA ACTTGCTGAA CAAAACCGCA AAGATGCTGA AGCCTGGTTC 
AATGAAAAGA GCAAGGAACT GACTACAGAA ATTGATAATA ACATTGAACA GATATCCAGC 
TATAAATCTG AGATTACTGA ATTGAGACGT AATGTACAAG CTCTGGAGAT AGAACTACAG 
TCCCAACTGG CCTTGAAACA ATCCCTGGAA GCCTCCTTGG CAGAAACAGA AGGTCGCTAC 
TGTGTGCAGC TCTCACAGAT TCAGGCCCAG ATATCCGCTC TGGAAGAACA GTTGCAACAG 
ATTCGAGCTG AAACCGAGTG CCAGAATACT GAATACCAAC AACTCCTGGA TATTAAGATC 
CGACTGGAGA ATGAAATTCA AACCTACCGC AGCCTGCTAG AAGGAGAGGG AAGTTCCGGA 
GGCGGCGGAC GCGGCGGCGG AAGTTTCGGC GGCGGCTACG GCGGCGGAAG CTCCGGCGGC 
GGAAGCTCCG GCGGCGGCCA CGGCGGCGGC CACGGCGGCA GTTCCGGCGG CGGCTACGGA 
GGCGGAAGCT CCGGCGGCGG AAGCTCCGGC GGCGGCTACG GGGGCGGAAG CTCCAGCGGC 
GGCCACGGCG GCAGTTCCAG CGGCGGCTAC GGTGGTGGCA GTTCCGGCGG CGGCGGCGGC 
GGCTACGGGG GCGGCAGCTC CGGCGGCGGC AGCAGCTCCG GCGGCGGATA CGGCGGCGGC 
AGCTCCAGCG GAGGCCACAA GTCCTCCTCT TCCGGGTCCG TGGGCGAGTC TTCATCTAAG 
GGACCAAGGT CAGCAGAAAC TAGCTGGGAT ACTAACAAAA CCAGAGTAAT CAAGACAATT 
ATTGAAGAGG TGGCGCCCGA CGGTAGAGTT CTTTCATCTA TGGTTGAATC AGAAACCAAG 
AAACACTACT ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005257400.1
CDS	37..1911
Translation	MSVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGIFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRSAETSWDTNKTRVIKTIIEEVAPDGRVLSSMVESETKKHYY

Target ORF information:

RefSeq Version	XM_005257343.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 10 (KRT10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005257343.3

ORF Insert Sequence:

ATGTCTGTTC GATACAGCTC AAGCAAGCAC TACTCTTCCT CCCGCAGTGG AGGAGGAGGA 
GGAGGAGGAG GATGTGGAGG AGGAGGAGGA GTGTCATCCC TAAGAATTTC TAGCAGCAAA 
GGCTCCCTTG GTGGAGGATT TAGCTCAGGG GGGTTCAGTG GTGGCTCTTT TAGCCGTGGG 
AGCTCTGGTG GGGGCTGCTT TGGGGGCTCA TCAGGTGGCT ATGGAGGATT AGGAGGTTTT 
GGTGGAGGTA GCTTTCGTGG AAGCTATGGA AGTAGCAGCT TTGGTGGGAG TTATGGAGGC 
ATCTTTGGAG GGGGCAGTTT CGGAGGTGGC AGCTTTGGTG GGGGCAGCTT TGGTGGAGGC 
GGCTTTGGTG GAGGCGGCTT TGGAGGAGGC TTTGGTGGTG GATTTGGAGG AGATGGTGGC 
CTTCTCTCTG GAAATGAAAA AGTAACCATG CAGAATCTGA ATGACCGCCT GGCTTCCTAC 
TTGGACAAAG TTCGGGCTCT GGAAGAATCA AACTATGAGC TGGAAGGCAA AATCAAGGAG 
TGGTATGAAA AGCATGGCAA CTCACATCAG GGGGAGCCTC GTGACTACAG CAAATACTAC 
AAAACCATCG ATGACCTTAA AAATCAGATT CTCAACCTAA CAACTGATAA TGCCAACATC 
CTGCTTCAGA TCGACAATGC CAGGCTGGCA GCTGATGACT TCAGGCTGAA GTATGAGAAT 
GAGGTAGCTC TGCGCCAGAG CGTGGAGGCT GACATCAACG GCCTGCGTAG GGTGCTGGAT 
GAGCTGACCC TGACCAAGGC TGACCTGGAG ATGCAAATTG AGAGCCTGAC TGAAGAGCTG 
GCCTATCTGA AGAAGAACCA CGAGGAGGAA ATGAAAGACC TTCGAAATGT GTCCACTGGT 
GATGTGAATG TGGAAATGAA TGCTGCCCCG GGTGTTGATC TGACTCAACT TCTGAATAAC 
ATGAGAAGCC AATATGAACA ACTTGCTGAA CAAAACCGCA AAGATGCTGA AGCCTGGTTC 
AATGAAAAGA GCAAGGAACT GACTACAGAA ATTGATAATA ACATTGAACA GATATCCAGC 
TATAAATCTG AGATTACTGA ATTGAGACGT AATGTACAAG CTCTGGAGAT AGAACTACAG 
TCCCAACTGG CCTTGAAACA ATCCCTGGAA GCCTCCTTGG CAGAAACAGA AGGTCGCTAC 
TGTGTGCAGC TCTCACAGAT TCAGGCCCAG ATATCCGCTC TGGAAGAACA GTTGCAACAG 
ATTCGAGCTG AAACCGAGTG CCAGAATACT GAATACCAAC AACTCCTGGA TATTAAGATC 
CGACTGGAGA ATGAAATTCA AACCTACCGC AGCCTGCTAG AAGGAGAGGG AAGTTCCGGA 
GGCGGCGGAC GCGGCGGCGG AAGTTTCGGC GGCGGCTACG GCGGCGGAAG CTCCGGCGGC 
GGAAGCTCCG GCGGCGGCCA CGGCGGCGGC CACGGCGGCA GTTCCGGCGG CGGCTACGGA 
GGCGGAAGCT CCGGCGGCGG AAGCTCCGGC GGCGGCTACG GGGGCGGAAG CTCCAGCGGC 
GGCCACGGCG GCAGTTCCAG CGGCGGCTAC GGTGGTGGCA GTTCCGGCGG CGGCGGCGGC 
GGCTACGGGG GCGGCAGCTC CGGCGGCGGC AGCAGCTCCG GCGGCGGATA CGGCGGCGGC 
AGCTCCAGCG GAGGCCACAA GTCCTCCTCT TCCGGGTCCG TGGGCGAGTC TTCATCTAAG 
GGACCAAGGT CAGCAGAAAC TAGCTGGGAT ACTAACAAAA CCAGAGTAAT CAAGACAATT 
ATTGAAGAGG TGGCGCCCGA CGGTAGAGTT CTTTCATCTA TGGTTGAATC AGAAACCAAG 
AAACACTACT ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy.
American journal of medical genetics. Part A173(11)3093-3097(2017 Nov)
Kalinska-Bienias A,Pollak A,Kowalewski C,Lechowicz U,Stawinski P,Gergont A,Kosinska J,Pronicka E,Kowalski P,Wozniak K,Ploski R

Extensive Post-zygotic Mosaicism of KRT1 or KRT10 Mutation Mimicking Classical Epider-molytic Ichthyosis.
Acta dermato-venereologica97(3)387-388(2017 03)
Severino-Freire M,Jonca N,Pichery M,Tournier E,Chassaing N,Mazereeuw-Hautier J

The X-Ray Crystal Structure of the Keratin?1-Keratin 10 Helix 2B Heterodimer Reveals?Molecular Surface Properties and?Biochemical Insights into Human Skin?Disease.
The Journal of investigative dermatology137(1)142-150(2017 Jan)
Bunick CG,Milstone LM

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KRT10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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