KLRB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLRB1
Entrez Gene ID	3820
Full Name	killer cell lectin like receptor B1
Synonyms	CD161,CLEC5B,NKR,NKR-P1,NKR-P1A,NKRP1A,hNKR-P1A
General protein information	Preferred Names killer cell lectin like receptor B1 Names killer cell lectin-like receptor subfamily B member 1 C-type lectin domain family 5 member B killer cell lectin-like receptor subfamily B, member 1 natural killer cell surface protein P1A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008].
Disorder MIM:	602890

mRNA and Protein(s)

mRNA	Protein	Name
NM_002258.2	NP_002249.1	killer cell lectin-like receptor subfamily B member 1
NM_002258.3	NP_002249.1	killer cell lectin-like receptor subfamily B member 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Klrb1b	NP_775414.2
Bos taurus (cattle)	KLRB1	NP_001193565.1
Homo sapiens (human)	KLRB1	NP_002249.1
Canis lupus familiaris (dog)	KLRB1	XP_005637227.1
Mus musculus (house mouse)	Klrb1b	NP_085102.4
Mus musculus (house mouse)	Klrb1c	NP_001153376.1
Mus musculus (house mouse)	Klrb1a	NP_034867.3
Rattus norvegicus (Norway rat)	Klrb1a	NP_001010964.1
Pan troglodytes (chimpanzee)	KLRB1	XP_001141049.1
	LOC100430783	XP_002798528.1
Bos taurus (cattle)	LOC100138381	XP_003586184.2

Gene Ontology
Bibliography

Related articles in PubMed

The killer cell lectin-like receptor B1 (KLRB1) 503T>C polymorphism (rs1135816) and acute rejection after liver transplantation.
Thude H, Rother S, Sterneck M, Klempnauer J, Nashan B, Schwinzer R, Koch M
HLA91(1)52-55(2018 Jan)

A Role of NKR-P1A (CD161) and Lectin-like Transcript 1 in Natural Cytotoxicity against Human Articular Chondrocytes.
Bia?oszewska A, Olkowska-Truchanowicz J, Bocian K, Osiecka-Iwan A, Czop A, Kieda C, Malejczyk J
Journal of immunology (Baltimore, Md. : 1950)200(2)715-724(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Purified soluble NKR-P1 is homogeneous, deglycosylatable, crystallizable and monomeric in solution, as shown by size-exclusion chromatography, multi-angle light scattering and analytical ultracentrifugation.
Title: High-level expression and purification of soluble form of human natural killer cell receptor NKR-P1 in HEK293S GnTI

A subset of virus-specific CD161(+) T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in acute myeloid leukemia.
Title: A subset of virus-specific CD161

CD161 expression levels were reduced in some NK and T cell subpopulations of systemic lupus erythematosus (SLE) patients, suggesting possible important role of CD161 and CD161-expressing immune cells in the SLE pathogenesis.
Title: Analysis of the CD161-expressing cell quantities and CD161 expression levels in peripheral blood natural killer and T cells of systemic lupus erythematosus patients.

these data suggest that LLT1-CD161 interactions play a novel and important role in B cell maturation within the Germinal center in humans.
Title: LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

Our results reveal that in combination with IGRAs, CD161-based indices provide a novel, fast diagnostic solution addressing the limitation of current tuberculosis diagnostics.
Title: Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells.

The following KLRB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLRB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03010	NM_002258.3 Latest version!	Homo sapiens killer cell lectin like receptor B1 (KLRB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03010	NM_002258.2	Homo sapiens killer cell lectin like receptor B1 (KLRB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLRB1 ( NM_002258.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002249.1 Homo sapiens killer cell lectin like receptor B1 (KLRB1), mRNA.

Price & Availability↑

CloneID	OHu03010
Clone ID Related Accession (Same CDS sequence)	NM_002258.2 , NM_002258.3
Accession Version	NM_002258.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	killer cell lectin-like receptor subfamily B member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF432813.1 and U11276.1. On Feb 8, 2005 this sequence version replaced NM_002258.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U11276.1, AK292022.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGACCAAC AAGCAATATA TGCTGAGTTA AACTTACCCA CAGACTCAGG CCCAGAAAGT 
TCTTCACCTT CATCTCTTCC TCGGGATGTC TGTCAGGGTT CACCTTGGCA TCAATTTGCC 
CTGAAACTTA GCTGTGCTGG GATTATTCTC CTTGTCTTGG TTGTTACTGG GTTGAGTGTT 
TCAGTGACAT CCTTAATACA GAAATCATCA ATAGAAAAAT GCAGTGTGGA CATTCAACAG 
AGCAGGAATA AAACAACAGA GAGACCGGGT CTCTTAAACT GCCCAATATA TTGGCAGCAA 
CTCCGAGAGA AATGCTTGTT ATTTTCTCAC ACTGTCAACC CTTGGAATAA CAGTCTAGCT 
GATTGTTCCA CCAAAGAATC CAGCCTGCTG CTTATTCGAG ATAAGGATGA ATTGATACAC 
ACACAGAACC TGATACGTGA CAAAGCAATT CTGTTTTGGA TTGGATTAAA TTTTTCATTA 
TCAGAAAAGA ACTGGAAGTG GATAAACGGC TCTTTTTTAA ATTCTAATGA CTTAGAAATT 
AGAGGTGATG CTAAAGAAAA CAGCTGTATT TCCATCTCAC AGACATCTGT GTATTCTGAG 
TACTGTAGTA CAGAAATCAG ATGGATCTGC CAAAAAGAAC TAACACCTGT GAGAAATAAA 
GTGTATCCTG ACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002249.1
CDS	63..740
Translation	MDQQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALKLSCAGIILLVLVVTGLSVSVTSLIQKSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLREKCLLFSHTVNPWNNSLADCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSLSEKNWKWINGSFLNSNDLEIRGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVRNKVYPDS

Target ORF information:

RefSeq Version	NM_002258.2
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell lectin like receptor B1 (KLRB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002258.2

ORF Insert Sequence:

ATGGACCAAC AAGCAATATA TGCTGAGTTA AACTTACCCA CAGACTCAGG CCCAGAAAGT 
TCTTCACCTT CATCTCTTCC TCGGGATGTC TGTCAGGGTT CACCTTGGCA TCAATTTGCC 
CTGAAACTTA GCTGTGCTGG GATTATTCTC CTTGTCTTGG TTGTTACTGG GTTGAGTGTT 
TCAGTGACAT CCTTAATACA GAAATCATCA ATAGAAAAAT GCAGTGTGGA CATTCAACAG 
AGCAGGAATA AAACAACAGA GAGACCGGGT CTCTTAAACT GCCCAATATA TTGGCAGCAA 
CTCCGAGAGA AATGCTTGTT ATTTTCTCAC ACTGTCAACC CTTGGAATAA CAGTCTAGCT 
GATTGTTCCA CCAAAGAATC CAGCCTGCTG CTTATTCGAG ATAAGGATGA ATTGATACAC 
ACACAGAACC TGATACGTGA CAAAGCAATT CTGTTTTGGA TTGGATTAAA TTTTTCATTA 
TCAGAAAAGA ACTGGAAGTG GATAAACGGC TCTTTTTTAA ATTCTAATGA CTTAGAAATT 
AGAGGTGATG CTAAAGAAAA CAGCTGTATT TCCATCTCAC AGACATCTGT GTATTCTGAG 
TACTGTAGTA CAGAAATCAG ATGGATCTGC CAAAAAGAAC TAACACCTGT GAGAAATAAA 
GTGTATCCTG ACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLRB1 ( NM_002258.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002249.1 Homo sapiens killer cell lectin like receptor B1 (KLRB1), mRNA.

Price & Availability↑

CloneID	OHu03010
Clone ID Related Accession (Same CDS sequence)	NM_002258.2 , NM_002258.3
Accession Version	NM_002258.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	killer cell lectin-like receptor subfamily B member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006432.15, BF432813.1 and U11276.1. On May 17, 2019 this sequence version replaced NM_002258.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027885.1, AK292022.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000229402.4/ ENSP00000229402.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGACCAAC AAGCAATATA TGCTGAGTTA AACTTACCCA CAGACTCAGG CCCAGAAAGT 
TCTTCACCTT CATCTCTTCC TCGGGATGTC TGTCAGGGTT CACCTTGGCA TCAATTTGCC 
CTGAAACTTA GCTGTGCTGG GATTATTCTC CTTGTCTTGG TTGTTACTGG GTTGAGTGTT 
TCAGTGACAT CCTTAATACA GAAATCATCA ATAGAAAAAT GCAGTGTGGA CATTCAACAG 
AGCAGGAATA AAACAACAGA GAGACCGGGT CTCTTAAACT GCCCAATATA TTGGCAGCAA 
CTCCGAGAGA AATGCTTGTT ATTTTCTCAC ACTGTCAACC CTTGGAATAA CAGTCTAGCT 
GATTGTTCCA CCAAAGAATC CAGCCTGCTG CTTATTCGAG ATAAGGATGA ATTGATACAC 
ACACAGAACC TGATACGTGA CAAAGCAATT CTGTTTTGGA TTGGATTAAA TTTTTCATTA 
TCAGAAAAGA ACTGGAAGTG GATAAACGGC TCTTTTTTAA ATTCTAATGA CTTAGAAATT 
AGAGGTGATG CTAAAGAAAA CAGCTGTATT TCCATCTCAC AGACATCTGT GTATTCTGAG 
TACTGTAGTA CAGAAATCAG ATGGATCTGC CAAAAAGAAC TAACACCTGT GAGAAATAAA 
GTGTATCCTG ACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002249.1
CDS	78..755
Translation	MDQQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALKLSCAGIILLVLVVTGLSVSVTSLIQKSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLREKCLLFSHTVNPWNNSLADCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSLSEKNWKWINGSFLNSNDLEIRGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVRNKVYPDS

Target ORF information:

RefSeq Version	NM_002258.3
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell lectin like receptor B1 (KLRB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002258.3

ORF Insert Sequence:

ATGGACCAAC AAGCAATATA TGCTGAGTTA AACTTACCCA CAGACTCAGG CCCAGAAAGT 
TCTTCACCTT CATCTCTTCC TCGGGATGTC TGTCAGGGTT CACCTTGGCA TCAATTTGCC 
CTGAAACTTA GCTGTGCTGG GATTATTCTC CTTGTCTTGG TTGTTACTGG GTTGAGTGTT 
TCAGTGACAT CCTTAATACA GAAATCATCA ATAGAAAAAT GCAGTGTGGA CATTCAACAG 
AGCAGGAATA AAACAACAGA GAGACCGGGT CTCTTAAACT GCCCAATATA TTGGCAGCAA 
CTCCGAGAGA AATGCTTGTT ATTTTCTCAC ACTGTCAACC CTTGGAATAA CAGTCTAGCT 
GATTGTTCCA CCAAAGAATC CAGCCTGCTG CTTATTCGAG ATAAGGATGA ATTGATACAC 
ACACAGAACC TGATACGTGA CAAAGCAATT CTGTTTTGGA TTGGATTAAA TTTTTCATTA 
TCAGAAAAGA ACTGGAAGTG GATAAACGGC TCTTTTTTAA ATTCTAATGA CTTAGAAATT 
AGAGGTGATG CTAAAGAAAA CAGCTGTATT TCCATCTCAC AGACATCTGT GTATTCTGAG 
TACTGTAGTA CAGAAATCAG ATGGATCTGC CAAAAAGAAC TAACACCTGT GAGAAATAAA 
GTGTATCCTG ACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The killer cell lectin-like receptor B1 (KLRB1) 503T>C polymorphism (rs1135816) and acute rejection after liver transplantation.
HLA91(1)52-55(2018 Jan)
Thude H,Rother S,Sterneck M,Klempnauer J,Nashan B,Schwinzer R,Koch M

A Role of NKR-P1A (CD161) and Lectin-like Transcript 1 in Natural Cytotoxicity against Human Articular Chondrocytes.
Journal of immunology (Baltimore, Md. : 1950)200(2)715-724(2018 Jan)
Bia?oszewska A,Olkowska-Truchanowicz J,Bocian K,Osiecka-Iwan A,Czop A,Kieda C,Malejczyk J

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KLRB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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