KIR2DS3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KIR2DS3
Entrez Gene ID	3808
Full Name	killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3
Synonyms	NKAT7
General protein information	Preferred Names killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 Names killer cell immunoglobulin-like receptor 2DS3 LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DS3 MHC class I NK cell receptor NKAT-7 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 natural killer cell inhibitory receptor natural killer-associated transcript 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.4
Summary	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].
Disorder MIM:	604954

mRNA and Protein(s)

mRNA	Protein	Name
NM_012313.1	NP_036445.1	killer cell immunoglobulin-like receptor 2DS3 precursor
XM_017030271.1	XP_016885760.1	LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DS3 isoform X2
XM_017030243.1	XP_016885732.1	LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DS3 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

The effect of killer cell immunoglobulin-like receptor genotype on outcome of hematopoietic stem cell transplantation from matched sibling.
Elfishawi SM, Mossallam GI, El-Fattah RA, El-Haddad A, Kamel AM
Human immunology78(11-12)684-691(2017 Nov)

Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.
Alomar SY, Alkhuriji A, Trayhyrn P, Alhetheel A, Al-Jurayyan A, Mansour L
Immunogenetics69(2)69-76(2017 Feb)

Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians.
Misra MK, Prakash S, Moulik NR, Kumar A, Agrawal S
Human immunology77(1)41-6(2016 Jan)

KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.
Levinson RD, Yung M, Meguro A, Ashouri E, Yu F, Mizuki N, Ohno S, Rajalingam R
PloS one11(8)e0160392(2016)

Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.
Olaniyan SA, Amodu OK, Yindom LM, Conway DJ, Aka P, Bakare AA, Omotade OO
Human immunology75(8)816-21(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of KIR2DS3 gene is associated with breast cancer.
Title: Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.

genetic polymorphism is associated with childhood acute lymphoblastic leukemia among north Indians
Title: Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians.

Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002).
Title: KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.

The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases.
Title: Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.

the presence of host genetic risk factors, IL28B-T and KIR2DS3 alleles, resulted in increased odds of treatment failure in these rapid virological response negative patients.
Title: Variation in both IL28B and KIR2DS3 genes influence pegylated interferon and ribavirin hepatitis C treatment outcome in HIV-1 co-infection.

The following KIR2DS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KIR2DS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06173	NM_012313.1 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu100091	XM_017030243.1 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu100096	XM_017030271.1 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KIR2DS3 ( NM_012313.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_036445.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), mRNA.

Price & Availability↑

CloneID	OHu06173
Clone ID Related Accession (Same CDS sequence)	NM_012313.1
Accession Version	NM_012313.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DS3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L76670.1. On or before Mar 22, 2015 this sequence version replaced XM_011547553.1, XM_011547151.1, XM_006725434.1, XM_006725660.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L76670.1, AY366242.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCGCTCA TGGTCATCAG CATGGCATGT GTTGGGTTCT TCTGGCTGCA GGGGGCCTGG 
CCACATGAGG GATTCCGCAG AAAACCTTCC CTCCTGGCCC ACCCAGGTCG CCTGGTGAAA 
TCAGAAGAGA CAGTCATCCT GCAATGTTGG TCAGATGTCA TGTTTGAGCA CTTCCTTCTG 
CACAGAGAGG GGACGTTTAA CGACACTTTG CGCCTCATTG GAGAGCACAT TGATGGGGTC 
TCCAAGGCCA ACTTCTCCAT CGGTCGCATG AGGCAAGACC TGGCAGGGAC CTACAGATGC 
TACGGTTCTG TTCCTCACTC CCCCTATCAG TTTTCAGCTC CCAGTGACCC TCTGGACATC 
GTGATCACAG GTCTATATGA GAAACCTTCT CTCTCAGCCC AGCCGGGCCC CACGGTTCTG 
GCAGGAGAGA GCGTGACCTT GTCCTGCAGC TCCTGGAGCT CCTATGACAT GTACCATCTA 
TCCACGGAGG GGGAGGCCCA TGAACGTAGG TTCTCTGCAG GGCCCAAGGT CAACGGAACA 
TTCCAGGCCG ACTTTCCTCT GGGCCCTGCC ACCCAAGGAG GAACCTACAG ATGCTTCGGC 
TCTTTCCATG ACTCTCCCTA CGAGTGGTCA AAGTCAAGTG ACCCACTGCT TGTTTCTGTC 
ACAGGAAACC CTTCAAATAG TTGGCCTTCA CCCACTGAAC CAAGCTCCAA AACCGGTAAC 
CCCAGACACC TACACGTTCT GATTGGGACC TCAGTGGTCA AACTCCCTTT CACCATCCTC 
CTCTTCTTTC TCCTTCATCG CTGGTGCTCC GACAAAAAAA ATGCATCTGT AATGGACCAA 
GGGCCTGCGG GGAACAGAAC AGTGAACAGG GAGGATTCTG ACGAACAGGA CCATCAGGAG 
GTGTCATACG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036445.1
CDS	12..926
Translation	MSLMVISMACVGFFWLQGAWPHEGFRRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGTFNDTLRLIGEHIDGVSKANFSIGRMRQDLAGTYRCYGSVPHSPYQFSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSWSSYDMYHLSTEGEAHERRFSAGPKVNGTFQADFPLGPATQGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSDKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA

Target ORF information:

RefSeq Version	NM_012313.1
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012313.1

ORF Insert Sequence:

ATGTCGCTCA TGGTCATCAG CATGGCATGT GTTGGGTTCT TCTGGCTGCA GGGGGCCTGG 
CCACATGAGG GATTCCGCAG AAAACCTTCC CTCCTGGCCC ACCCAGGTCG CCTGGTGAAA 
TCAGAAGAGA CAGTCATCCT GCAATGTTGG TCAGATGTCA TGTTTGAGCA CTTCCTTCTG 
CACAGAGAGG GGACGTTTAA CGACACTTTG CGCCTCATTG GAGAGCACAT TGATGGGGTC 
TCCAAGGCCA ACTTCTCCAT CGGTCGCATG AGGCAAGACC TGGCAGGGAC CTACAGATGC 
TACGGTTCTG TTCCTCACTC CCCCTATCAG TTTTCAGCTC CCAGTGACCC TCTGGACATC 
GTGATCACAG GTCTATATGA GAAACCTTCT CTCTCAGCCC AGCCGGGCCC CACGGTTCTG 
GCAGGAGAGA GCGTGACCTT GTCCTGCAGC TCCTGGAGCT CCTATGACAT GTACCATCTA 
TCCACGGAGG GGGAGGCCCA TGAACGTAGG TTCTCTGCAG GGCCCAAGGT CAACGGAACA 
TTCCAGGCCG ACTTTCCTCT GGGCCCTGCC ACCCAAGGAG GAACCTACAG ATGCTTCGGC 
TCTTTCCATG ACTCTCCCTA CGAGTGGTCA AAGTCAAGTG ACCCACTGCT TGTTTCTGTC 
ACAGGAAACC CTTCAAATAG TTGGCCTTCA CCCACTGAAC CAAGCTCCAA AACCGGTAAC 
CCCAGACACC TACACGTTCT GATTGGGACC TCAGTGGTCA AACTCCCTTT CACCATCCTC 
CTCTTCTTTC TCCTTCATCG CTGGTGCTCC GACAAAAAAA ATGCATCTGT AATGGACCAA 
GGGCCTGCGG GGAACAGAAC AGTGAACAGG GAGGATTCTG ACGAACAGGA CCATCAGGAG 
GTGTCATACG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DS3 ( XM_017030243.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885732.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu100091
Clone ID Related Accession (Same CDS sequence)	XM_017030243.1
Accession Version	XM_017030243.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DS3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_187641.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## internal stop codons :: corrected 1 genomic stop codon ##RefSeq-Attributes-END##

ATGTCGCTCA TGGTCATCAG CATGGCATGT GTTGGGTTCT TCTGGCTGCA GGGGGCCTGG 
CCACATGAGG GTGGTCAGGA CAAGCCCTTG CTTTCTACCT GGCCCAGCCT TGTGGTGCCT 
CCAGAACATG TGACTCTTCG GTGTCACTCT AATCTTGGGT TTAACAACTT CAGTCTGTAC 
AAGGATGATG GGGTGCCTGT CCCTGAACAC TACAACAGAA TATTCTGGAA AAGCCTTTTC 
ATGGGCCCTG TGACCCCGTC ACACACAGGG ACCTATAGAT GCCGGGGTTC ACACCCACAC 
TCCCCCAGTG GGTGGTCGGC ACCCAGCAAC CCCCTGCTGA TCATGGTCAC AGGATTCCGC 
AGAAAACCTT CCCTCCTGGC CCACCCAGGT CGCCTGGTGA AATCAGAAGA GACAGTCATC 
CTGCAATGTT GGTCAGATGT CATGTTTGAG CACTTCCTTC TGCACAGAGA GGGGACGTTT 
AACGACACTT TGCGCCTCAT TGGAGAGCAC ATTGATGGGG TCTCCAAGGC CAACTTCTCC 
ATCGGTCGCA TGAGGCAAGA CCTGGCAGGG ACCTACAGAT GCTACGGTTC TGTTCCTCAC 
TCCCCCTATC AGTTTTCAGC TCCCAGTGAC CCTCTGGACA TCGTGATCAC AGGTCTATAT 
GAGAAACCTT CTCTCTCAGC CCAGCCGGGC CCCACGGTTC TGGCAGGAGA GAGCGTGACC 
TTGTCCTGCA GCTCCTGGAG CTCCTATGAC ATGTACCATC TATCCACGGA GGGGGAGGCC 
CATGAACGTA GGTTCTCTGC AGGGCCCAAG GTCAACGGAA CATTCCAGGC CGACTTTCCT 
CTGGGCCCTG CCACCCAAGG AGGAACCTAC AGATGCTTCG GCTCTTTCCA TGACTCTCCC 
TACGAGTGGT CAAAGTCAAG TGACCCACTG CTTGTTTCTG TCACAGGAAA CCCTTCAAAT 
AGTTGGCCTT CACCCACTGA ACCAAGCTCC AAAACCGGTA ACCCCAGACA CCTACACGTT 
CTGATTGGGA CCTCAGTGGT CAAACTCCCT TTCACCATCC TCCTCTTCTT TCTCCTTCAT 
CGCTGGTGCT CCAACAAAAA AAATGCATCT GTAATGGACC AAGGGCCTGC GGGGAACAGA 
ACAGTGAACA GGGAGGATTC TGATGAACAG GACCATCAGG AGGTGTCATA CGCATAATTG 
GATCACTGTG TTTTCACACA GAGAAAAATC ACTCCCCCTT CTCAGAGGCC CAAGACACCC 
CCAACAGATA CCAGCATGTA CATAGAACTT CCAAATGCTG AGTCCAGATC CAAAGCTGTC 
TTCTGTCCAC GAGCACCACA GTCAGGCCTT GAGGGGATCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885732.1
CDS	23..1387
Translation	MSLMVISMACVGFFWLQGAWPHEGGQDKPLLSTWPSLVVPPEHVTLRCHSNLGFNNFSLYKDDGVPVPEHYNRIFWKSLFMGPVTPSHTGTYRCRGSHPHSPSGWSAPSNPLLIMVTGFRRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGTFNDTLRLIGEHIDGVSKANFSIGRMRQDLAGTYRCYGSVPHSPYQFSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSWSSYDMYHLSTEGEAHERRFSAGPKVNGTFQADFPLGPATQGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSNKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA*LDHCVFTQRKITPPSQRPKTPPTDTSMYIELPNAESRSKAVFCPRAPQSGLEGIF

Target ORF information:

RefSeq Version	XM_017030243.1
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030243.1

ORF Insert Sequence:

ATGTCGCTCA TGGTCATCAG CATGGCATGT GTTGGGTTCT TCTGGCTGCA GGGGGCCTGG 
CCACATGAGG GTGGTCAGGA CAAGCCCTTG CTTTCTACCT GGCCCAGCCT TGTGGTGCCT 
CCAGAACATG TGACTCTTCG GTGTCACTCT AATCTTGGGT TTAACAACTT CAGTCTGTAC 
AAGGATGATG GGGTGCCTGT CCCTGAACAC TACAACAGAA TATTCTGGAA AAGCCTTTTC 
ATGGGCCCTG TGACCCCGTC ACACACAGGG ACCTATAGAT GCCGGGGTTC ACACCCACAC 
TCCCCCAGTG GGTGGTCGGC ACCCAGCAAC CCCCTGCTGA TCATGGTCAC AGGATTCCGC 
AGAAAACCTT CCCTCCTGGC CCACCCAGGT CGCCTGGTGA AATCAGAAGA GACAGTCATC 
CTGCAATGTT GGTCAGATGT CATGTTTGAG CACTTCCTTC TGCACAGAGA GGGGACGTTT 
AACGACACTT TGCGCCTCAT TGGAGAGCAC ATTGATGGGG TCTCCAAGGC CAACTTCTCC 
ATCGGTCGCA TGAGGCAAGA CCTGGCAGGG ACCTACAGAT GCTACGGTTC TGTTCCTCAC 
TCCCCCTATC AGTTTTCAGC TCCCAGTGAC CCTCTGGACA TCGTGATCAC AGGTCTATAT 
GAGAAACCTT CTCTCTCAGC CCAGCCGGGC CCCACGGTTC TGGCAGGAGA GAGCGTGACC 
TTGTCCTGCA GCTCCTGGAG CTCCTATGAC ATGTACCATC TATCCACGGA GGGGGAGGCC 
CATGAACGTA GGTTCTCTGC AGGGCCCAAG GTCAACGGAA CATTCCAGGC CGACTTTCCT 
CTGGGCCCTG CCACCCAAGG AGGAACCTAC AGATGCTTCG GCTCTTTCCA TGACTCTCCC 
TACGAGTGGT CAAAGTCAAG TGACCCACTG CTTGTTTCTG TCACAGGAAA CCCTTCAAAT 
AGTTGGCCTT CACCCACTGA ACCAAGCTCC AAAACCGGTA ACCCCAGACA CCTACACGTT 
CTGATTGGGA CCTCAGTGGT CAAACTCCCT TTCACCATCC TCCTCTTCTT TCTCCTTCAT 
CGCTGGTGCT CCAACAAAAA AAATGCATCT GTAATGGACC AAGGGCCTGC GGGGAACAGA 
ACAGTGAACA GGGAGGATTC TGATGAACAG GACCATCAGG AGGTGTCATA CGCATAATTG 
GATCACTGTG TTTTCACACA GAGAAAAATC ACTCCCCCTT CTCAGAGGCC CAAGACACCC 
CCAACAGATA CCAGCATGTA CATAGAACTT CCAAATGCTG AGTCCAGATC CAAAGCTGTC 
TTCTGTCCAC GAGCACCACA GTCAGGCCTT GAGGGGATCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DS3 ( XM_017030271.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885760.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu100096
Clone ID Related Accession (Same CDS sequence)	XM_017030271.1
Accession Version	XM_017030271.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DS3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_187670.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## internal stop codons :: corrected 1 genomic stop codon ##RefSeq-Attributes-END##

ATGTCGCTCA TGGTCATCAG CATGGCATGT GTTGGGTTCT TCTGGCTGCA GGGGGCCTGG 
CCACATGAGG GATTCCGCAG AAAACCTTCC CTCCTGGCCC ACCCAGGTCG CCTGGTGAAA 
TCAGAAGAGA CAGTCATCCT GCAATGTTGG TCAGATGTCA TGTTTGAGCA CTTCCTTCTG 
CACAGAGAGG GGACGTTTAA CGACACTTTG CGCCTCATTG GAGAGCACAT TGATGGGGTC 
TCCAAGGCCA ACTTCTCCAT CGGTCGCATG AGGCAAGACC TGGCAGGGAC CTACAGATGC 
TACGGTTCTG TTCCTCACTC CCCCTATCAG TTTTCAGCTC CCAGTGACCC TCTGGACATC 
GTGATCACAG GTCTATATGA GAAACCTTCT CTCTCAGCCC AGCCGGGCCC CACGGTTCTG 
GCAGGAGAGA GCGTGACCTT GTCCTGCAGC TCCTGGAGCT CCTATGACAT GTACCATCTA 
TCCACGGAGG GGGAGGCCCA TGAACGTAGG TTCTCTGCAG GGCCCAAGGT CAACGGAACA 
TTCCAGGCCG ACTTTCCTCT GGGCCCTGCC ACCCAAGGAG GAACCTACAG ATGCTTCGGC 
TCTTTCCATG ACTCTCCCTA CGAGTGGTCA AAGTCAAGTG ACCCACTGCT TGTTTCTGTC 
ACAGGAAACC CTTCAAATAG TTGGCCTTCA CCCACTGAAC CAAGCTCCAA AACCGGTAAC 
CCCAGACACC TACACGTTCT GATTGGGACC TCAGTGGTCA AACTCCCTTT CACCATCCTC 
CTCTTCTTTC TCCTTCATCG CTGGTGCTCC AACAAAAAAA ATGCATCTGT AATGGACCAA 
GGGCCTGCGG GGAACAGAAC AGTGAACAGG GAGGATTCTG ATGAACAGGA CCATCAGGAG 
GTGTCATACG CATAATTGGA TCACTGTGTT TTCACACAGA GAAAAATCAC TCCCCCTTCT 
CAGAGGCCCA AGACACCCCC AACAGATACC AGCATGTACA TAGAACTTCC AAATGCTGAG 
TCCAGATCCA AAGCTGTCTT CTGTCCACGA GCACCACAGT CAGGCCTTGA GGGGATCTTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885760.1
CDS	23..1105
Translation	MSLMVISMACVGFFWLQGAWPHEGFRRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGTFNDTLRLIGEHIDGVSKANFSIGRMRQDLAGTYRCYGSVPHSPYQFSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSWSSYDMYHLSTEGEAHERRFSAGPKVNGTFQADFPLGPATQGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSNKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA*LDHCVFTQRKITPPSQRPKTPPTDTSMYIELPNAESRSKAVFCPRAPQSGLEGIF

Target ORF information:

RefSeq Version	XM_017030271.1
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030271.1

ORF Insert Sequence:

ATGTCGCTCA TGGTCATCAG CATGGCATGT GTTGGGTTCT TCTGGCTGCA GGGGGCCTGG 
CCACATGAGG GATTCCGCAG AAAACCTTCC CTCCTGGCCC ACCCAGGTCG CCTGGTGAAA 
TCAGAAGAGA CAGTCATCCT GCAATGTTGG TCAGATGTCA TGTTTGAGCA CTTCCTTCTG 
CACAGAGAGG GGACGTTTAA CGACACTTTG CGCCTCATTG GAGAGCACAT TGATGGGGTC 
TCCAAGGCCA ACTTCTCCAT CGGTCGCATG AGGCAAGACC TGGCAGGGAC CTACAGATGC 
TACGGTTCTG TTCCTCACTC CCCCTATCAG TTTTCAGCTC CCAGTGACCC TCTGGACATC 
GTGATCACAG GTCTATATGA GAAACCTTCT CTCTCAGCCC AGCCGGGCCC CACGGTTCTG 
GCAGGAGAGA GCGTGACCTT GTCCTGCAGC TCCTGGAGCT CCTATGACAT GTACCATCTA 
TCCACGGAGG GGGAGGCCCA TGAACGTAGG TTCTCTGCAG GGCCCAAGGT CAACGGAACA 
TTCCAGGCCG ACTTTCCTCT GGGCCCTGCC ACCCAAGGAG GAACCTACAG ATGCTTCGGC 
TCTTTCCATG ACTCTCCCTA CGAGTGGTCA AAGTCAAGTG ACCCACTGCT TGTTTCTGTC 
ACAGGAAACC CTTCAAATAG TTGGCCTTCA CCCACTGAAC CAAGCTCCAA AACCGGTAAC 
CCCAGACACC TACACGTTCT GATTGGGACC TCAGTGGTCA AACTCCCTTT CACCATCCTC 
CTCTTCTTTC TCCTTCATCG CTGGTGCTCC AACAAAAAAA ATGCATCTGT AATGGACCAA 
GGGCCTGCGG GGAACAGAAC AGTGAACAGG GAGGATTCTG ATGAACAGGA CCATCAGGAG 
GTGTCATACG CATAATTGGA TCACTGTGTT TTCACACAGA GAAAAATCAC TCCCCCTTCT 
CAGAGGCCCA AGACACCCCC AACAGATACC AGCATGTACA TAGAACTTCC AAATGCTGAG 
TCCAGATCCA AAGCTGTCTT CTGTCCACGA GCACCACAGT CAGGCCTTGA GGGGATCTTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The effect of killer cell immunoglobulin-like receptor genotype on outcome of hematopoietic stem cell transplantation from matched sibling.
Human immunology78(11-12)684-691(2017 Nov)
Elfishawi SM,Mossallam GI,El-Fattah RA,El-Haddad A,Kamel AM

Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.
Immunogenetics69(2)69-76(2017 Feb)
Alomar SY,Alkhuriji A,Trayhyrn P,Alhetheel A,Al-Jurayyan A,Mansour L

Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians.
Human immunology77(1)41-6(2016 Jan)
Misra MK,Prakash S,Moulik NR,Kumar A,Agrawal S

KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.
PloS one11(8)e0160392(2016)
Levinson RD,Yung M,Meguro A,Ashouri E,Yu F,Mizuki N,Ohno S,Rajalingam R

Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.
Human immunology75(8)816-21(2014 Aug)
Olaniyan SA,Amodu OK,Yindom LM,Conway DJ,Aka P,Bakare AA,Omotade OO

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KIR2DS3 cDNA ORF clone, Homo sapiens(human)

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