KCNA10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNA10
Entrez Gene ID	3744
Full Name	potassium voltage-gated channel subfamily A member 10
Synonyms	Kcn1,Kv1.8
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 10 Names potassium voltage-gated channel subfamily A member 10 cyclic GMP gated potassium channel potassium channel, voltage gated shaker related subfamily A, member 10 potassium voltage-gated channel, shaker-related subfamily, member 10 voltage-gated potassium channel subunit Kv1.8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.3
Summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008].
Disorder MIM:	602420

mRNA and Protein(s)

mRNA	Protein	Name
NM_005549.2	NP_005540.1	potassium voltage-gated channel subfamily A member 10

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	kcna10	XP_002938481.1
Homo sapiens (human)	KCNA10	NP_005540.1
Bos taurus (cattle)	KCNA10	XP_002686193.1
Mus musculus (house mouse)	Kcna10	NP_001074609.1
Danio rerio (zebrafish)	LOC567521	XP_695909.3
Rattus norvegicus (Norway rat)	Kcna10	NP_001178642.1
Gallus gallus (chicken)	KCNA10	NP_989793.1
Pan troglodytes (chimpanzee)	KCNA10	XP_524799.2
Rattus norvegicus (Norway rat)	LOC100911265	XP_003749427.1
	KCNA10	XP_001101275.1
Canis lupus familiaris (dog)	KCNA10	XP_547232.2
Danio rerio (zebrafish)	LOC100329515	XP_002667319.1

Gene Ontology
Bibliography

Related articles in PubMed

Pore size matters for potassium channel conductance.
Naranjo D, Moldenhauer H, Pincuntureo M, D?az-Franulic I
The Journal of general physiology148(4)277-91(2016 Oct)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, St?hmer W, Wang X
Pharmacological reviews57(4)473-508(2005 Dec)

Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.
Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV
Journal of the American Society of Nephrology : JASN13(12)2831-9(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

KCNA10 in human proximal tubular cells, glomerular and vascular endothelial cells, and also in vascular smooth muscle cells.
Title: Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.

The following KCNA10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNA10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu07898	NM_005549.2 Latest version!	Homo sapiens potassium voltage-gated channel subfamily A member 10 (KCNA10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNA10 ( NM_005549.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005540.1 Homo sapiens potassium voltage-gated channel subfamily A member 10 (KCNA10), mRNA.

Price & Availability↑

CloneID	OHu07898
Clone ID Related Accession (Same CDS sequence)	NM_005549.2
Accession Version	NM_005549.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL358215.16. On Dec 31, 2002 this sequence version replaced NM_005549.1. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369771.4/ ENSP00000358786.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGATGTGT GTGGCTGGAA AGAAATGGAG GTTGCGCTGG TCAATTTTGA TAATTCAGAT 
GAAATCCAAG AAGAGCCAGG CTATGCCACA GACTTCGACT CAACCAGCCC AAAAGGCCGG 
CCTGGGGGCA GCTCCTTCTC CAACGGGAAG ATCCTCATCA GCGAAAGCAC CAACCATGAG 
ACGGCCTTCT CCAAGCTTCC GGGAGACTAT GCTGACCCCC CAGGGCCTGA GCCAGTGGTC 
CTAAATGAAG GAAACCAGCG GGTGATCATC AACATTGCTG GGCTGAGATT TGAGACCCAG 
CTCAGAACCC TTAGTCAGTT CCCAGAGACT CTCCTGGGAG ACCGGGAAAA AAGGATGCAG 
TTCTTTGACT CCATGAGAAA TGAGTATTTC TTTGATCGGA ACCGGCCCAG TTTTGATGGA 
ATCCTATATT ATTACCAATC TGGTGGGAAA ATTCGGCGCC CAGCCAATGT TCCCATTGAT 
ATCTTTGCTG ATGAAATCTC CTTCTATGAG CTGGGTAGTG AGGCCATGGA CCAGTTCCGG 
GAGGATGAAG GCTTCATCAA AGACCCTGAA ACACTGCTAC CCACCAATGA CATCCACCGT 
CAGTTCTGGC TCCTCTTTGA GTACCCTGAA AGTTCCAGCG CTGCCCGTGC TGTGGCCGTG 
GTCTCGGTGT TGGTTGTGGT CATCTCCATC ACCATCTTCT GCCTGGAGAC ACTGCCAGAG 
TTCCGGGAGG ATAGGGAGCT AAAGGTGGTC AGAGACCCCA ATCTCAACAT GAGCAAGACA 
GTCCTCTCCC AGACCATGTT CACCGACCCT TTCTTCATGG TGGAGTCTAC CTGCATCGTG 
TGGTTCACCT TCGAGCTGGT GCTCCGGTTC GTGGTCTGCC CCAGCAAGAC TGACTTCTTC 
AGGAACATCA TGAACATCAT TGACATCATC TCCATTATCC CCTACTTTGC AACTCTCATC 
ACAGAGCTAG TCCAGGAGAC AGAGCCGAGT GCCCAACAGA ACATGTCCCT GGCCATCCTG 
AGGATCATCC GCCTGGTGAG GGTCTTCCGC ATCTTCAAGC TCTCGCGCCA CTCCAAGGGG 
CTGCAGATCC TCGGGCAAAC ACTGAAGGCG TCCATGCGGG AGTTGGGGTT GCTCATCTTC 
TTTCTCTTCA TTGGAGTCAT CCTCTTCTCC AGTGCAGTCT ACTTTGCTGA GGTGGATGAG 
CCAGAGTCCC ATTTCTCTAG CATTCCTGAT GGCTTCTGGT GGGCAGTGGT CACCATGACA 
ACTGTAGGCT ATGGGGACAT GTGCCCGACC ACCCCAGGGG GGAAGATTGT GGGCACTCTG 
TGTGCCATTG CAGGGGTCCT CACCATTGCC CTCCCTGTGC CTGTCATTGT CTCCAACTTC 
AATTACTTCT ACCACCGGGA GACTGAGAAT GAAGAAAAGC AGAACATCCC AGGAGAAATT 
GAAAGAATCC TCAACAGTGT AGGCTCAAGA ATGGGCAGCA CAGACTCTCT TAATAAGACC 
AATGGTGGCT GTTCCACAGA GAAGTCTAGG AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005540.1
CDS	389..1924
Translation	MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK

Target ORF information:

RefSeq Version	NM_005549.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 10 (KCNA10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005549.2

ORF Insert Sequence:

ATGGATGTGT GTGGCTGGAA AGAAATGGAG GTTGCGCTGG TCAATTTTGA TAATTCAGAT 
GAAATCCAAG AAGAGCCAGG CTATGCCACA GACTTCGACT CAACCAGCCC AAAAGGCCGG 
CCTGGGGGCA GCTCCTTCTC CAACGGGAAG ATCCTCATCA GCGAAAGCAC CAACCATGAG 
ACGGCCTTCT CCAAGCTTCC GGGAGACTAT GCTGACCCCC CAGGGCCTGA GCCAGTGGTC 
CTAAATGAAG GAAACCAGCG GGTGATCATC AACATTGCTG GGCTGAGATT TGAGACCCAG 
CTCAGAACCC TTAGTCAGTT CCCAGAGACT CTCCTGGGAG ACCGGGAAAA AAGGATGCAG 
TTCTTTGACT CCATGAGAAA TGAGTATTTC TTTGATCGGA ACCGGCCCAG TTTTGATGGA 
ATCCTATATT ATTACCAATC TGGTGGGAAA ATTCGGCGCC CAGCCAATGT TCCCATTGAT 
ATCTTTGCTG ATGAAATCTC CTTCTATGAG CTGGGTAGTG AGGCCATGGA CCAGTTCCGG 
GAGGATGAAG GCTTCATCAA AGACCCTGAA ACACTGCTAC CCACCAATGA CATCCACCGT 
CAGTTCTGGC TCCTCTTTGA GTACCCTGAA AGTTCCAGCG CTGCCCGTGC TGTGGCCGTG 
GTCTCGGTGT TGGTTGTGGT CATCTCCATC ACCATCTTCT GCCTGGAGAC ACTGCCAGAG 
TTCCGGGAGG ATAGGGAGCT AAAGGTGGTC AGAGACCCCA ATCTCAACAT GAGCAAGACA 
GTCCTCTCCC AGACCATGTT CACCGACCCT TTCTTCATGG TGGAGTCTAC CTGCATCGTG 
TGGTTCACCT TCGAGCTGGT GCTCCGGTTC GTGGTCTGCC CCAGCAAGAC TGACTTCTTC 
AGGAACATCA TGAACATCAT TGACATCATC TCCATTATCC CCTACTTTGC AACTCTCATC 
ACAGAGCTAG TCCAGGAGAC AGAGCCGAGT GCCCAACAGA ACATGTCCCT GGCCATCCTG 
AGGATCATCC GCCTGGTGAG GGTCTTCCGC ATCTTCAAGC TCTCGCGCCA CTCCAAGGGG 
CTGCAGATCC TCGGGCAAAC ACTGAAGGCG TCCATGCGGG AGTTGGGGTT GCTCATCTTC 
TTTCTCTTCA TTGGAGTCAT CCTCTTCTCC AGTGCAGTCT ACTTTGCTGA GGTGGATGAG 
CCAGAGTCCC ATTTCTCTAG CATTCCTGAT GGCTTCTGGT GGGCAGTGGT CACCATGACA 
ACTGTAGGCT ATGGGGACAT GTGCCCGACC ACCCCAGGGG GGAAGATTGT GGGCACTCTG 
TGTGCCATTG CAGGGGTCCT CACCATTGCC CTCCCTGTGC CTGTCATTGT CTCCAACTTC 
AATTACTTCT ACCACCGGGA GACTGAGAAT GAAGAAAAGC AGAACATCCC AGGAGAAATT 
GAAAGAATCC TCAACAGTGT AGGCTCAAGA ATGGGCAGCA CAGACTCTCT TAATAAGACC 
AATGGTGGCT GTTCCACAGA GAAGTCTAGG AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pore size matters for potassium channel conductance.
The Journal of general physiology148(4)277-91(2016 Oct)
Naranjo D,Moldenhauer H,Pincuntureo M,D?az-Franulic I

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Pharmacological reviews57(4)473-508(2005 Dec)
Gutman GA,Chandy KG,Grissmer S,Lazdunski M,McKinnon D,Pardo LA,Robertson GA,Rudy B,Sanguinetti MC,St?hmer W,Wang X

Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.
Journal of the American Society of Nephrology : JASN13(12)2831-9(2002 Dec)
Yao X,Tian S,Chan HY,Biemesderfer D,Desir GV

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KCNA10 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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