CDRT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDRT1
Entrez Gene ID	374286
Full Name	CMT1A duplicated region transcript 1
Synonyms	C170RF1,C17ORF1,C17ORF1A,FBXW10B,FBXW10P1,HREP,SM25H2
General protein information	Preferred Names CMT1A duplicated region transcript 1 Names CMT1A duplicated region transcript 1 protein Charcot-Marie-Tooth duplicated region transcript 1 F-box and WD repeat domain containing 10 pseudogene 1 F-box and WD-40 domain protein 10 pseudogene 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p12
Summary	Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
Disorder MIM:	604596

mRNA and Protein(s)

mRNA	Protein	Name
NM_006382.3	NP_006373.2	CMT1A duplicated region transcript 1 protein isoform a
NM_001282540.1	NP_001269469.1	CMT1A duplicated region transcript 1 protein isoform b
NM_006382.4	NP_006373.2	CMT1A duplicated region transcript 1 protein isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDRT1	NP_006373.2
Pan troglodytes (chimpanzee)	CDRT1	XP_003318143.1

Gene Ontology
Bibliography

Related articles in PubMed

Systematic analysis and nomenclature of mammalian F-box proteins.
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW
Genes & development18(21)2573-80(2004 Nov)

The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes.
Inoue K, Dewar K, Katsanis N, Reiter LT, Lander ES, Devon KL, Wyman DW, Lupski JR, Birren B
Genome research11(6)1018-33(2001 Jun)

Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat.
Kennerson ML, Nassif NT, Nicholson GA
Genomics53(1)110-2(1998 Oct)

The Charcot-Marie-Tooth binary repeat contains a gene transcribed from the opposite strand of a partially duplicated region of the COX10 gene.
Kennerson ML, Nassif NT, Dawkins JL, DeKroon RM, Yang JG, Nicholson GA
Genomics46(1)61-9(1997 Nov)

Single test for two hereditary neuropathies, CMT1A and HNPP.
Kennerson ML, Gordon MJ, Blair IP, Nicholson GA
Clinical chemistry41(10)1534-5(1995 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CDRT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDRT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31400	NM_006382.4 Latest version!	Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$379.50-$531.30 $759.00
OHu05419	NM_001282540.1 Latest version!	Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu31400	NM_006382.3	Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$379.50-$531.30 $759.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDRT1 ( NM_006382.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006373.2 Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 1, mRNA.

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CloneID	OHu31400
Clone ID Related Accession (Same CDS sequence)	NM_006382.3 , NM_006382.4
Accession Version	NM_006382.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2259bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	CMT1A duplicated region transcript 1 protein isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK057407.1, AC005324.1, AB209899.1, U65652.1, AC005838.2 and BU738380.1. On Sep 27, 2007 this sequence version replaced NM_006382.2. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a). ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAAACC TGGAATCAAG GCTCAAGAAT GCCCCCTATT TTCGTTGTGA GAAGGGAACC 
GATTCCATCC CTCTATGCCG GAAGTGTGAG ACGCGTGTCT TAGCCTGGAA GATCTTCTCT 
ACCAAAGAGT GGTTCTGCAG GATCAATGAC ATATCACAGA GGAGGTTTCT AGTTGGCATT 
CTGAAGCAGT TAAATAGCTT ATATTTGTTA CACTATTTCC AAAATATCCT TCAGACCACA 
CAGGGAAAGG ATTTCATCTA TAACAGGTCC CGGATCGACC TCAGCAAGAA AGAGGGGAAA 
GTTGTGAAGT CCTCCTTGAA CCAAATGTTG GATAAAACAG TAGAACAGAA GATGAAAGAG 
ATCTTGTATT GGTTTGCGAA CAGCACCCAG TGGACCAAGG CGAATTATAC TCTCTTACTG 
CTGCAGATGT GCAACCCCAA ATTACTGCTC ACTGCTGCCA ATGTGATCAG AGTCCTGTTT 
CTGAGAGAGG AGAACAATAT CTCAGGGCTC AATCAAGACA TCACAGATGT GTGTTTTTCC 
CCTGAGAAAG ACCACAGCTC CAAGTCTGCG ACCTCACAAG TCTATTGGAC AGCCAAAACT 
CAGCACACAT CCCTTCCTTT GTCCAAAGCC CCAGAAAATG AACACTTCCT TGGGGCAGCA 
TCTAACCCTG AGGAACCATG GAGGAATTCA CTCCGGTGTA TATCCGAAAT GAATAGGCTG 
TTTTCTGGAA AAGCAGACAT AACCAAGCCA GGGTACGATC CCTGCAATCT ATTGGTTGAC 
CTGGATGACA TCAGAGACCT GTCTTCTGGG TTCAGCAAAT ACCGAGACTT CATCCGTTAC 
CTGCCCATCC ACCTCTCCAA GTACATTCTA AGAATGCTGG ATAGACACAC CCTGAACAAG 
TGCGCCTCTG TGAGCCAGCA CTGGGCCGCC ATGGCTCAAC AGGTCAAGAT GGACTTGTCA 
GCGCACGGCT TCATTCAGAA CCAGATTACC TTCTTGCAGG GGTCCTATAC AAGAGGAATT 
GATCCTAATT ATGCCAATAA GGTTTCTATC CCAGTTCCTA AAATGGTAGA TGACGGGAAG 
AGCATGCGTG TGAAACATCC GAAGTGGAAG TTGAGAACGA AGAATGAGTA CAACCTGTGG 
ACTGCATACC AGAACGAGGA AACGCAGCAG GTCCTGATGG AGGAGAGAAA TGTTTTCTGT 
GGGACCTACA ATGTTCGCAT TCTCTCTGAC ACGTGGGATC AAAACCGAGT CATCCACTAT 
TCCGGGGGAG ATCTGATAGC TGTGTCATCT AATCGAAAGA TCCATCTTCT GGACATCATA 
CAAGTGAAAG CGATACCCGT TGAATTCCGA GGCCATGCTG GGAGTGTCCG GGCCCTCTTC 
CTGTGTGAGG AGGAAAACTT TCTCCTAAGC GGGAGCTATG ACCTAAGTAT CAGATACTGG 
GATCTGAAAA GTGGGGTTTG CACACGAATC TTCGGTGGTC ACCAGGGGAC TATCACTTGC 
ATGGACTTGT GTAAGAACAG GCTCGTATCT GGAGGAAGAG ATTGCCAGGT AAAAGTATGG 
GATGTAGACA CAGGGAAGTG CCTGAAGACG TTTAGACACA AAGACCCCAT CTTGGCCACC 
AGGATCAATG ATACCTACAT TGTGAGCAGC TGTGAGCGAG GGCTGGTGAA AGTGTGGCAC 
ATTGCCATGG CCCAGTTGGT AAAGACTCTC AGTGGCCACG AGGGAGCTGT GAAATGCCTG 
TTCTTTGACC AGTGGCATCT CCTCTCAGGA AGCACTGATG GCCTGGTCAT GGCCTGGAGC 
ATGGTGGGGA AGTACGAGCG CTGCCTGATG GCCTTCAAGC ATCCCAAAGA GGTGCTCGAC 
GTGTCCCTTC TCTTCCTCCG GGTCATCAGC GCCTGTGCAG ATGGCAAGAT CCGAATTTAC 
AATTTCTTCA ATGGGAACTG TATGAAGGTG ATAAAAGCCA ATGGCAGAGG CGATCCTGTG 
CTGTCCTTCT TTATTCAGGG CAACAGAATT TCAGTCTGCC ACATCAGCAC ATTTGCTAAA 
AGAATTAACG TGGGATGGAA TGGAATCGAA CCAAGTGCTA CAGCTCAGGG AGGAAATGCC 
TCCTTGACCG AGTGTGCTCA TGTGAGACTC CACATCGCAG GACACTTACC AGCATCGAGG 
CTGCCCGTGG CCGCTGTCCA GCCCATGACA GGCGGGATGG CCCCAACCAC AGCTCCGACC 
CATGTGTTGG CAATGCTGAT CCTTTTCAGT GGTGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006373.2
CDS	193..2451
Translation	MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGILKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKEILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRLFSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSFFIQGNRISVCHISTFAKRINVGWNGIEPSATAQGGNASLTECAHVRLHIAGHLPASRLPVAAVQPMTGGMAPTTAPTHVLAMLILFSGV

Target ORF information:

RefSeq Version	NM_006382.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006382.3

ORF Insert Sequence:

ATGGAAAACC TGGAATCAAG GCTCAAGAAT GCCCCCTATT TTCGTTGTGA GAAGGGAACC 
GATTCCATCC CTCTATGCCG GAAGTGTGAG ACGCGTGTCT TAGCCTGGAA GATCTTCTCT 
ACCAAAGAGT GGTTCTGCAG GATCAATGAC ATATCACAGA GGAGGTTTCT AGTTGGCATT 
CTGAAGCAGT TAAATAGCTT ATATTTGTTA CACTATTTCC AAAATATCCT TCAGACCACA 
CAGGGAAAGG ATTTCATCTA TAACAGGTCC CGGATCGACC TCAGCAAGAA AGAGGGGAAA 
GTTGTGAAGT CCTCCTTGAA CCAAATGTTG GATAAAACAG TAGAACAGAA GATGAAAGAG 
ATCTTGTATT GGTTTGCGAA CAGCACCCAG TGGACCAAGG CGAATTATAC TCTCTTACTG 
CTGCAGATGT GCAACCCCAA ATTACTGCTC ACTGCTGCCA ATGTGATCAG AGTCCTGTTT 
CTGAGAGAGG AGAACAATAT CTCAGGGCTC AATCAAGACA TCACAGATGT GTGTTTTTCC 
CCTGAGAAAG ACCACAGCTC CAAGTCTGCG ACCTCACAAG TCTATTGGAC AGCCAAAACT 
CAGCACACAT CCCTTCCTTT GTCCAAAGCC CCAGAAAATG AACACTTCCT TGGGGCAGCA 
TCTAACCCTG AGGAACCATG GAGGAATTCA CTCCGGTGTA TATCCGAAAT GAATAGGCTG 
TTTTCTGGAA AAGCAGACAT AACCAAGCCA GGGTACGATC CCTGCAATCT ATTGGTTGAC 
CTGGATGACA TCAGAGACCT GTCTTCTGGG TTCAGCAAAT ACCGAGACTT CATCCGTTAC 
CTGCCCATCC ACCTCTCCAA GTACATTCTA AGAATGCTGG ATAGACACAC CCTGAACAAG 
TGCGCCTCTG TGAGCCAGCA CTGGGCCGCC ATGGCTCAAC AGGTCAAGAT GGACTTGTCA 
GCGCACGGCT TCATTCAGAA CCAGATTACC TTCTTGCAGG GGTCCTATAC AAGAGGAATT 
GATCCTAATT ATGCCAATAA GGTTTCTATC CCAGTTCCTA AAATGGTAGA TGACGGGAAG 
AGCATGCGTG TGAAACATCC GAAGTGGAAG TTGAGAACGA AGAATGAGTA CAACCTGTGG 
ACTGCATACC AGAACGAGGA AACGCAGCAG GTCCTGATGG AGGAGAGAAA TGTTTTCTGT 
GGGACCTACA ATGTTCGCAT TCTCTCTGAC ACGTGGGATC AAAACCGAGT CATCCACTAT 
TCCGGGGGAG ATCTGATAGC TGTGTCATCT AATCGAAAGA TCCATCTTCT GGACATCATA 
CAAGTGAAAG CGATACCCGT TGAATTCCGA GGCCATGCTG GGAGTGTCCG GGCCCTCTTC 
CTGTGTGAGG AGGAAAACTT TCTCCTAAGC GGGAGCTATG ACCTAAGTAT CAGATACTGG 
GATCTGAAAA GTGGGGTTTG CACACGAATC TTCGGTGGTC ACCAGGGGAC TATCACTTGC 
ATGGACTTGT GTAAGAACAG GCTCGTATCT GGAGGAAGAG ATTGCCAGGT AAAAGTATGG 
GATGTAGACA CAGGGAAGTG CCTGAAGACG TTTAGACACA AAGACCCCAT CTTGGCCACC 
AGGATCAATG ATACCTACAT TGTGAGCAGC TGTGAGCGAG GGCTGGTGAA AGTGTGGCAC 
ATTGCCATGG CCCAGTTGGT AAAGACTCTC AGTGGCCACG AGGGAGCTGT GAAATGCCTG 
TTCTTTGACC AGTGGCATCT CCTCTCAGGA AGCACTGATG GCCTGGTCAT GGCCTGGAGC 
ATGGTGGGGA AGTACGAGCG CTGCCTGATG GCCTTCAAGC ATCCCAAAGA GGTGCTCGAC 
GTGTCCCTTC TCTTCCTCCG GGTCATCAGC GCCTGTGCAG ATGGCAAGAT CCGAATTTAC 
AATTTCTTCA ATGGGAACTG TATGAAGGTG ATAAAAGCCA ATGGCAGAGG CGATCCTGTG 
CTGTCCTTCT TTATTCAGGG CAACAGAATT TCAGTCTGCC ACATCAGCAC ATTTGCTAAA 
AGAATTAACG TGGGATGGAA TGGAATCGAA CCAAGTGCTA CAGCTCAGGG AGGAAATGCC 
TCCTTGACCG AGTGTGCTCA TGTGAGACTC CACATCGCAG GACACTTACC AGCATCGAGG 
CTGCCCGTGG CCGCTGTCCA GCCCATGACA GGCGGGATGG CCCCAACCAC AGCTCCGACC 
CATGTGTTGG CAATGCTGAT CCTTTTCAGT GGTGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDRT1 ( NM_006382.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006373.2 Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31400
Clone ID Related Accession (Same CDS sequence)	NM_006382.3 , NM_006382.4
Accession Version	NM_006382.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2259bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	CMT1A duplicated region transcript 1 protein isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK057407.1, AC005324.1, AB209899.1, U65652.1, AC005838.2 and BU738380.1. On Dec 4, 2019 this sequence version replaced NM_006382.3. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAAACC TGGAATCAAG GCTCAAGAAT GCCCCCTATT TTCGTTGTGA GAAGGGAACC 
GATTCCATCC CTCTATGCCG GAAGTGTGAG ACGCGTGTCT TAGCCTGGAA GATCTTCTCT 
ACCAAAGAGT GGTTCTGCAG GATCAATGAC ATATCACAGA GGAGGTTTCT AGTTGGCATT 
CTGAAGCAGT TAAATAGCTT ATATTTGTTA CACTATTTCC AAAATATCCT TCAGACCACA 
CAGGGAAAGG ATTTCATCTA TAACAGGTCC CGGATCGACC TCAGCAAGAA AGAGGGGAAA 
GTTGTGAAGT CCTCCTTGAA CCAAATGTTG GATAAAACAG TAGAACAGAA GATGAAAGAG 
ATCTTGTATT GGTTTGCGAA CAGCACCCAG TGGACCAAGG CGAATTATAC TCTCTTACTG 
CTGCAGATGT GCAACCCCAA ATTACTGCTC ACTGCTGCCA ATGTGATCAG AGTCCTGTTT 
CTGAGAGAGG AGAACAATAT CTCAGGGCTC AATCAAGACA TCACAGATGT GTGTTTTTCC 
CCTGAGAAAG ACCACAGCTC CAAGTCTGCG ACCTCACAAG TCTATTGGAC AGCCAAAACT 
CAGCACACAT CCCTTCCTTT GTCCAAAGCC CCAGAAAATG AACACTTCCT TGGGGCAGCA 
TCTAACCCTG AGGAACCATG GAGGAATTCA CTCCGGTGTA TATCCGAAAT GAATAGGCTG 
TTTTCTGGAA AAGCAGACAT AACCAAGCCA GGGTACGATC CCTGCAATCT ATTGGTTGAC 
CTGGATGACA TCAGAGACCT GTCTTCTGGG TTCAGCAAAT ACCGAGACTT CATCCGTTAC 
CTGCCCATCC ACCTCTCCAA GTACATTCTA AGAATGCTGG ATAGACACAC CCTGAACAAG 
TGCGCCTCTG TGAGCCAGCA CTGGGCCGCC ATGGCTCAAC AGGTCAAGAT GGACTTGTCA 
GCGCACGGCT TCATTCAGAA CCAGATTACC TTCTTGCAGG GGTCCTATAC AAGAGGAATT 
GATCCTAATT ATGCCAATAA GGTTTCTATC CCAGTTCCTA AAATGGTAGA TGACGGGAAG 
AGCATGCGTG TGAAACATCC GAAGTGGAAG TTGAGAACGA AGAATGAGTA CAACCTGTGG 
ACTGCATACC AGAACGAGGA AACGCAGCAG GTCCTGATGG AGGAGAGAAA TGTTTTCTGT 
GGGACCTACA ATGTTCGCAT TCTCTCTGAC ACGTGGGATC AAAACCGAGT CATCCACTAT 
TCCGGGGGAG ATCTGATAGC TGTGTCATCT AATCGAAAGA TCCATCTTCT GGACATCATA 
CAAGTGAAAG CGATACCCGT TGAATTCCGA GGCCATGCTG GGAGTGTCCG GGCCCTCTTC 
CTGTGTGAGG AGGAAAACTT TCTCCTAAGC GGGAGCTATG ACCTAAGTAT CAGATACTGG 
GATCTGAAAA GTGGGGTTTG CACACGAATC TTCGGTGGTC ACCAGGGGAC TATCACTTGC 
ATGGACTTGT GTAAGAACAG GCTCGTATCT GGAGGAAGAG ATTGCCAGGT AAAAGTATGG 
GATGTAGACA CAGGGAAGTG CCTGAAGACG TTTAGACACA AAGACCCCAT CTTGGCCACC 
AGGATCAATG ATACCTACAT TGTGAGCAGC TGTGAGCGAG GGCTGGTGAA AGTGTGGCAC 
ATTGCCATGG CCCAGTTGGT AAAGACTCTC AGTGGCCACG AGGGAGCTGT GAAATGCCTG 
TTCTTTGACC AGTGGCATCT CCTCTCAGGA AGCACTGATG GCCTGGTCAT GGCCTGGAGC 
ATGGTGGGGA AGTACGAGCG CTGCCTGATG GCCTTCAAGC ATCCCAAAGA GGTGCTCGAC 
GTGTCCCTTC TCTTCCTCCG GGTCATCAGC GCCTGTGCAG ATGGCAAGAT CCGAATTTAC 
AATTTCTTCA ATGGGAACTG TATGAAGGTG ATAAAAGCCA ATGGCAGAGG CGATCCTGTG 
CTGTCCTTCT TTATTCAGGG CAACAGAATT TCAGTCTGCC ACATCAGCAC ATTTGCTAAA 
AGAATTAACG TGGGATGGAA TGGAATCGAA CCAAGTGCTA CAGCTCAGGG AGGAAATGCC 
TCCTTGACCG AGTGTGCTCA TGTGAGACTC CACATCGCAG GACACTTACC AGCATCGAGG 
CTGCCCGTGG CCGCTGTCCA GCCCATGACA GGCGGGATGG CCCCAACCAC AGCTCCGACC 
CATGTGTTGG CAATGCTGAT CCTTTTCAGT GGTGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006373.2
CDS	193..2451
Translation	MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGILKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKEILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRLFSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSFFIQGNRISVCHISTFAKRINVGWNGIEPSATAQGGNASLTECAHVRLHIAGHLPASRLPVAAVQPMTGGMAPTTAPTHVLAMLILFSGV

Target ORF information:

RefSeq Version	NM_006382.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006382.4

ORF Insert Sequence:

ATGGAAAACC TGGAATCAAG GCTCAAGAAT GCCCCCTATT TTCGTTGTGA GAAGGGAACC 
GATTCCATCC CTCTATGCCG GAAGTGTGAG ACGCGTGTCT TAGCCTGGAA GATCTTCTCT 
ACCAAAGAGT GGTTCTGCAG GATCAATGAC ATATCACAGA GGAGGTTTCT AGTTGGCATT 
CTGAAGCAGT TAAATAGCTT ATATTTGTTA CACTATTTCC AAAATATCCT TCAGACCACA 
CAGGGAAAGG ATTTCATCTA TAACAGGTCC CGGATCGACC TCAGCAAGAA AGAGGGGAAA 
GTTGTGAAGT CCTCCTTGAA CCAAATGTTG GATAAAACAG TAGAACAGAA GATGAAAGAG 
ATCTTGTATT GGTTTGCGAA CAGCACCCAG TGGACCAAGG CGAATTATAC TCTCTTACTG 
CTGCAGATGT GCAACCCCAA ATTACTGCTC ACTGCTGCCA ATGTGATCAG AGTCCTGTTT 
CTGAGAGAGG AGAACAATAT CTCAGGGCTC AATCAAGACA TCACAGATGT GTGTTTTTCC 
CCTGAGAAAG ACCACAGCTC CAAGTCTGCG ACCTCACAAG TCTATTGGAC AGCCAAAACT 
CAGCACACAT CCCTTCCTTT GTCCAAAGCC CCAGAAAATG AACACTTCCT TGGGGCAGCA 
TCTAACCCTG AGGAACCATG GAGGAATTCA CTCCGGTGTA TATCCGAAAT GAATAGGCTG 
TTTTCTGGAA AAGCAGACAT AACCAAGCCA GGGTACGATC CCTGCAATCT ATTGGTTGAC 
CTGGATGACA TCAGAGACCT GTCTTCTGGG TTCAGCAAAT ACCGAGACTT CATCCGTTAC 
CTGCCCATCC ACCTCTCCAA GTACATTCTA AGAATGCTGG ATAGACACAC CCTGAACAAG 
TGCGCCTCTG TGAGCCAGCA CTGGGCCGCC ATGGCTCAAC AGGTCAAGAT GGACTTGTCA 
GCGCACGGCT TCATTCAGAA CCAGATTACC TTCTTGCAGG GGTCCTATAC AAGAGGAATT 
GATCCTAATT ATGCCAATAA GGTTTCTATC CCAGTTCCTA AAATGGTAGA TGACGGGAAG 
AGCATGCGTG TGAAACATCC GAAGTGGAAG TTGAGAACGA AGAATGAGTA CAACCTGTGG 
ACTGCATACC AGAACGAGGA AACGCAGCAG GTCCTGATGG AGGAGAGAAA TGTTTTCTGT 
GGGACCTACA ATGTTCGCAT TCTCTCTGAC ACGTGGGATC AAAACCGAGT CATCCACTAT 
TCCGGGGGAG ATCTGATAGC TGTGTCATCT AATCGAAAGA TCCATCTTCT GGACATCATA 
CAAGTGAAAG CGATACCCGT TGAATTCCGA GGCCATGCTG GGAGTGTCCG GGCCCTCTTC 
CTGTGTGAGG AGGAAAACTT TCTCCTAAGC GGGAGCTATG ACCTAAGTAT CAGATACTGG 
GATCTGAAAA GTGGGGTTTG CACACGAATC TTCGGTGGTC ACCAGGGGAC TATCACTTGC 
ATGGACTTGT GTAAGAACAG GCTCGTATCT GGAGGAAGAG ATTGCCAGGT AAAAGTATGG 
GATGTAGACA CAGGGAAGTG CCTGAAGACG TTTAGACACA AAGACCCCAT CTTGGCCACC 
AGGATCAATG ATACCTACAT TGTGAGCAGC TGTGAGCGAG GGCTGGTGAA AGTGTGGCAC 
ATTGCCATGG CCCAGTTGGT AAAGACTCTC AGTGGCCACG AGGGAGCTGT GAAATGCCTG 
TTCTTTGACC AGTGGCATCT CCTCTCAGGA AGCACTGATG GCCTGGTCAT GGCCTGGAGC 
ATGGTGGGGA AGTACGAGCG CTGCCTGATG GCCTTCAAGC ATCCCAAAGA GGTGCTCGAC 
GTGTCCCTTC TCTTCCTCCG GGTCATCAGC GCCTGTGCAG ATGGCAAGAT CCGAATTTAC 
AATTTCTTCA ATGGGAACTG TATGAAGGTG ATAAAAGCCA ATGGCAGAGG CGATCCTGTG 
CTGTCCTTCT TTATTCAGGG CAACAGAATT TCAGTCTGCC ACATCAGCAC ATTTGCTAAA 
AGAATTAACG TGGGATGGAA TGGAATCGAA CCAAGTGCTA CAGCTCAGGG AGGAAATGCC 
TCCTTGACCG AGTGTGCTCA TGTGAGACTC CACATCGCAG GACACTTACC AGCATCGAGG 
CTGCCCGTGG CCGCTGTCCA GCCCATGACA GGCGGGATGG CCCCAACCAC AGCTCCGACC 
CATGTGTTGG CAATGCTGAT CCTTTTCAGT GGTGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDRT1 ( NM_001282540.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269469.1 Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 2, mRNA.

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CloneID	OHu05419
Clone ID Related Accession (Same CDS sequence)	NM_001282540.1
Accession Version	NM_001282540.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2145bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	CMT1A duplicated region transcript 1 protein isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK057407.1, AC005324.1, CB989113.1, AW891009.1, BF091455.1, AC005838.2 and AF337810.1. Transcript Variant: This variant (2) has alternate 3' exon structure and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAAACC TGGAATCAAG GCTCAAGAAT GCCCCCTATT TTCGTTGTGA GAAGGGAACC 
GATTCCATCC CTCTATGCCG GAAGTGTGAG ACGCGTGTCT TAGCCTGGAA GATCTTCTCT 
ACCAAAGAGT GGTTCTGCAG GATCAATGAC ATATCACAGA GGAGGTTTCT AGTTGGCATT 
CTGAAGCAGT TAAATAGCTT ATATTTGTTA CACTATTTCC AAAATATCCT TCAGACCACA 
CAGGGAAAGG ATTTCATCTA TAACAGGTCC CGGATCGACC TCAGCAAGAA AGAGGGGAAA 
GTTGTGAAGT CCTCCTTGAA CCAAATGTTG GATAAAACAG TAGAACAGAA GATGAAAGAG 
ATCTTGTATT GGTTTGCGAA CAGCACCCAG TGGACCAAGG CGAATTATAC TCTCTTACTG 
CTGCAGATGT GCAACCCCAA ATTACTGCTC ACTGCTGCCA ATGTGATCAG AGTCCTGTTT 
CTGAGAGAGG AGAACAATAT CTCAGGGCTC AATCAAGACA TCACAGATGT GTGTTTTTCC 
CCTGAGAAAG ACCACAGCTC CAAGTCTGCG ACCTCACAAG TCTATTGGAC AGCCAAAACT 
CAGCACACAT CCCTTCCTTT GTCCAAAGCC CCAGAAAATG AACACTTCCT TGGGGCAGCA 
TCTAACCCTG AGGAACCATG GAGGAATTCA CTCCGGTGTA TATCCGAAAT GAATAGGCTG 
TTTTCTGGAA AAGCAGACAT AACCAAGCCA GGGTACGATC CCTGCAATCT ATTGGTTGAC 
CTGGATGACA TCAGAGACCT GTCTTCTGGG TTCAGCAAAT ACCGAGACTT CATCCGTTAC 
CTGCCCATCC ACCTCTCCAA GTACATTCTA AGAATGCTGG ATAGACACAC CCTGAACAAG 
TGCGCCTCTG TGAGCCAGCA CTGGGCCGCC ATGGCTCAAC AGGTCAAGAT GGACTTGTCA 
GCGCACGGCT TCATTCAGAA CCAGATTACC TTCTTGCAGG GGTCCTATAC AAGAGGAATT 
GATCCTAATT ATGCCAATAA GGTTTCTATC CCAGTTCCTA AAATGGTAGA TGACGGGAAG 
AGCATGCGTG TGAAACATCC GAAGTGGAAG TTGAGAACGA AGAATGAGTA CAACCTGTGG 
ACTGCATACC AGAACGAGGA AACGCAGCAG GTCCTGATGG AGGAGAGAAA TGTTTTCTGT 
GGGACCTACA ATGTTCGCAT TCTCTCTGAC ACGTGGGATC AAAACCGAGT CATCCACTAT 
TCCGGGGGAG ATCTGATAGC TGTGTCATCT AATCGAAAGA TCCATCTTCT GGACATCATA 
CAAGTGAAAG CGATACCCGT TGAATTCCGA GGCCATGCTG GGAGTGTCCG GGCCCTCTTC 
CTGTGTGAGG AGGAAAACTT TCTCCTAAGC GGGAGCTATG ACCTAAGTAT CAGATACTGG 
GATCTGAAAA GTGGGGTTTG CACACGAATC TTCGGTGGTC ACCAGGGGAC TATCACTTGC 
ATGGACTTGT GTAAGAACAG GCTCGTATCT GGAGGAAGAG ATTGCCAGGT AAAAGTATGG 
GATGTAGACA CAGGGAAGTG CCTGAAGACG TTTAGACACA AAGACCCCAT CTTGGCCACC 
AGGATCAATG ATACCTACAT TGTGAGCAGC TGTGAGCGAG GGCTGGTGAA AGTGTGGCAC 
ATTGCCATGG CCCAGTTGGT AAAGACTCTC AGTGGCCACG AGGGAGCTGT GAAATGCCTG 
TTCTTTGACC AGTGGCATCT CCTCTCAGGA AGCACTGATG GCCTGGTCAT GGCCTGGAGC 
ATGGTGGGGA AGTACGAGCG CTGCCTGATG GCCTTCAAGC ATCCCAAAGA GGTGCTCGAC 
GTGTCCCTTC TCTTCCTCCG GGTCATCAGC GCCTGTGCAG ATGGCAAGAT CCGAATTTAC 
AATTTCTTCA ATGGGAACTG TATGAAGGTG ATAAAAGCCA ATGGCAGAGG CGATCCTGTG 
CTGTCCTTCT TTATTCAGGG CAACAGTGAT CACTTACGGA AGACCTATCT GCCAGTTGAG 
TGGAAGACAG ATGGAAGGAG GGTTAGGAAG AAGGCAGAGA AGTCAGCTGG GATGTGCTGT 
AATAACCCAC GCAAAACCGA TGATGGGCTG AAGCTAAAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269469.1
CDS	193..2337
Translation	MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGILKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKEILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRLFSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSFFIQGNSDHLRKTYLPVEWKTDGRRVRKKAEKSAGMCCNNPRKTDDGLKLKH

Target ORF information:

RefSeq Version	NM_001282540.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282540.1

ORF Insert Sequence:

ATGGAAAACC TGGAATCAAG GCTCAAGAAT GCCCCCTATT TTCGTTGTGA GAAGGGAACC 
GATTCCATCC CTCTATGCCG GAAGTGTGAG ACGCGTGTCT TAGCCTGGAA GATCTTCTCT 
ACCAAAGAGT GGTTCTGCAG GATCAATGAC ATATCACAGA GGAGGTTTCT AGTTGGCATT 
CTGAAGCAGT TAAATAGCTT ATATTTGTTA CACTATTTCC AAAATATCCT TCAGACCACA 
CAGGGAAAGG ATTTCATCTA TAACAGGTCC CGGATCGACC TCAGCAAGAA AGAGGGGAAA 
GTTGTGAAGT CCTCCTTGAA CCAAATGTTG GATAAAACAG TAGAACAGAA GATGAAAGAG 
ATCTTGTATT GGTTTGCGAA CAGCACCCAG TGGACCAAGG CGAATTATAC TCTCTTACTG 
CTGCAGATGT GCAACCCCAA ATTACTGCTC ACTGCTGCCA ATGTGATCAG AGTCCTGTTT 
CTGAGAGAGG AGAACAATAT CTCAGGGCTC AATCAAGACA TCACAGATGT GTGTTTTTCC 
CCTGAGAAAG ACCACAGCTC CAAGTCTGCG ACCTCACAAG TCTATTGGAC AGCCAAAACT 
CAGCACACAT CCCTTCCTTT GTCCAAAGCC CCAGAAAATG AACACTTCCT TGGGGCAGCA 
TCTAACCCTG AGGAACCATG GAGGAATTCA CTCCGGTGTA TATCCGAAAT GAATAGGCTG 
TTTTCTGGAA AAGCAGACAT AACCAAGCCA GGGTACGATC CCTGCAATCT ATTGGTTGAC 
CTGGATGACA TCAGAGACCT GTCTTCTGGG TTCAGCAAAT ACCGAGACTT CATCCGTTAC 
CTGCCCATCC ACCTCTCCAA GTACATTCTA AGAATGCTGG ATAGACACAC CCTGAACAAG 
TGCGCCTCTG TGAGCCAGCA CTGGGCCGCC ATGGCTCAAC AGGTCAAGAT GGACTTGTCA 
GCGCACGGCT TCATTCAGAA CCAGATTACC TTCTTGCAGG GGTCCTATAC AAGAGGAATT 
GATCCTAATT ATGCCAATAA GGTTTCTATC CCAGTTCCTA AAATGGTAGA TGACGGGAAG 
AGCATGCGTG TGAAACATCC GAAGTGGAAG TTGAGAACGA AGAATGAGTA CAACCTGTGG 
ACTGCATACC AGAACGAGGA AACGCAGCAG GTCCTGATGG AGGAGAGAAA TGTTTTCTGT 
GGGACCTACA ATGTTCGCAT TCTCTCTGAC ACGTGGGATC AAAACCGAGT CATCCACTAT 
TCCGGGGGAG ATCTGATAGC TGTGTCATCT AATCGAAAGA TCCATCTTCT GGACATCATA 
CAAGTGAAAG CGATACCCGT TGAATTCCGA GGCCATGCTG GGAGTGTCCG GGCCCTCTTC 
CTGTGTGAGG AGGAAAACTT TCTCCTAAGC GGGAGCTATG ACCTAAGTAT CAGATACTGG 
GATCTGAAAA GTGGGGTTTG CACACGAATC TTCGGTGGTC ACCAGGGGAC TATCACTTGC 
ATGGACTTGT GTAAGAACAG GCTCGTATCT GGAGGAAGAG ATTGCCAGGT AAAAGTATGG 
GATGTAGACA CAGGGAAGTG CCTGAAGACG TTTAGACACA AAGACCCCAT CTTGGCCACC 
AGGATCAATG ATACCTACAT TGTGAGCAGC TGTGAGCGAG GGCTGGTGAA AGTGTGGCAC 
ATTGCCATGG CCCAGTTGGT AAAGACTCTC AGTGGCCACG AGGGAGCTGT GAAATGCCTG 
TTCTTTGACC AGTGGCATCT CCTCTCAGGA AGCACTGATG GCCTGGTCAT GGCCTGGAGC 
ATGGTGGGGA AGTACGAGCG CTGCCTGATG GCCTTCAAGC ATCCCAAAGA GGTGCTCGAC 
GTGTCCCTTC TCTTCCTCCG GGTCATCAGC GCCTGTGCAG ATGGCAAGAT CCGAATTTAC 
AATTTCTTCA ATGGGAACTG TATGAAGGTG ATAAAAGCCA ATGGCAGAGG CGATCCTGTG 
CTGTCCTTCT TTATTCAGGG CAACAGTGAT CACTTACGGA AGACCTATCT GCCAGTTGAG 
TGGAAGACAG ATGGAAGGAG GGTTAGGAAG AAGGCAGAGA AGTCAGCTGG GATGTGCTGT 
AATAACCCAC GCAAAACCGA TGATGGGCTG AAGCTAAAGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic analysis and nomenclature of mammalian F-box proteins.
Genes & development18(21)2573-80(2004 Nov)
Jin J,Cardozo T,Lovering RC,Elledge SJ,Pagano M,Harper JW

The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes.
Genome research11(6)1018-33(2001 Jun)
Inoue K,Dewar K,Katsanis N,Reiter LT,Lander ES,Devon KL,Wyman DW,Lupski JR,Birren B

Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat.
Genomics53(1)110-2(1998 Oct)
Kennerson ML,Nassif NT,Nicholson GA

The Charcot-Marie-Tooth binary repeat contains a gene transcribed from the opposite strand of a partially duplicated region of the COX10 gene.
Genomics46(1)61-9(1997 Nov)
Kennerson ML,Nassif NT,Dawkins JL,DeKroon RM,Yang JG,Nicholson GA

Single test for two hereditary neuropathies, CMT1A and HNPP.
Clinical chemistry41(10)1534-5(1995 Oct)
Kennerson ML,Gordon MJ,Blair IP,Nicholson GA

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CDRT1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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