JAG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	JAG2
Entrez Gene ID	3714
Full Name	jagged 2
Synonyms	HJ2,SER2
General protein information	Preferred Names jagged 2 Names protein jagged-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.33
Summary	The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	602570

mRNA and Protein(s)

mRNA	Protein	Name
NM_002226.5	NP_002217.3	protein jagged-2 isoform a precursor
NM_145159.2	NP_660142.1	protein jagged-2 isoform b precursor
NM_002226.4	NP_002217.3	protein jagged-2 isoform a precursor
NM_145159.3	NP_660142.1	protein jagged-2 isoform b precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	JAG2	XP_001235689.2
Homo sapiens (human)	JAG2	NP_002217.3
Bos taurus (cattle)	JAG2	XP_002696840.2
Rattus norvegicus (Norway rat)	Jag2	XP_006240728.1
Pan troglodytes (chimpanzee)	JAG2	XP_510206.4
Mus musculus (house mouse)	Jag2	NP_034718.2
Danio rerio (zebrafish)	jag2b	NP_571937.1
	JAG2	XP_001097477.1
Canis lupus familiaris (dog)	JAG2	XP_005623944.1
Xenopus tropicalis (tropical clawed frog)	jag2	XP_002938845.2

Gene Ontology
Bibliography

Related articles in PubMed

Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.
Tindemans I, Lukkes M, de Bruijn MJW, Li BWS, van Nimwegen M, Amsen D, KleinJan A, Hendriks RW
The Journal of allergy and clinical immunology140(4)1079-1089(2017 Oct)

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Suckling RJ, Korona B, Whiteman P, Chillakuri C, Holt L, Handford PA, Lea SM
The EMBO journal36(15)2204-2215(2017 08)

Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells.
Xishan Z, Bin Z, Haiyue Z, Xiaowei D, Jingwen B, Guojun Z
Scientific reports514284(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results show that the Notch signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 on DCs is not required
Title: Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.

The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling.
Title: Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells
Title: Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells.

Increased expression of JAG2, a target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma.
Title: A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.

Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH activation.
Title: The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation.

The following JAG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the JAG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02038	NM_145159.3 Latest version!	Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
OHu02048	NM_002226.5 Latest version!	Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
View Old Accession Versions >>
OHu02048	NM_002226.4	Homo sapiens jagged 2 (JAG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
OHu02038	NM_145159.2	Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

JAG2 ( NM_145159.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_660142.1 Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02038
Clone ID Related Accession (Same CDS sequence)	NM_145159.2 , NM_145159.3
Accession Version	NM_145159.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	protein jagged-2 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF029779.1, AL512356.6, U69180.1, AF003521.1, AJ712299.1, BX105691.1, AA775404.1 and AI276672.1. On Jun 22, 2012 this sequence version replaced NM_145159.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform b) than isoform a encoded by variant 1. Isoform b is also known as hJAG2.del-E6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF029779.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG TCAACGACTG TCGCGGGCAG TGTCAGCATG GGGGCACCTG CAAGGACCTG 
GTGAACGGGT ACCAGTGTGT GTGCCCACGG GGCTTCGGAG GCCGGCATTG CGAGCTGGAA 
CGAGACGAGT GTGCCAGCAG CCCCTGCCAC AGCGGCGGCC TCTGCGAGGA CCTGGCCGAC 
GGCTTCCACT GCCACTGCCC CCAGGGCTTC TCCGGGCCTC TCTGTGAGGT GGATGTCGAC 
CTTTGTGAGC CAAGCCCCTG CCGGAACGGC GCTCGCTGCT ATAACCTGGA GGGTGACTAT 
TACTGCGCCT GCCCTGATGA CTTTGGTGGC AAGAACTGCT CCGTGCCCCG CGAGCCGTGC 
CCTGGCGGGG CCTGCAGAGT GATCGATGGC TGCGGGTCAG ACGCGGGGCC TGGGATGCCT 
GGCACAGCAG CCTCCGGCGT GTGTGGCCCC CATGGACGCT GCGTCAGCCA GCCAGGGGGC 
AACTTTTCCT GCATCTGTGA CAGTGGCTTT ACTGGCACCT ACTGCCATGA GAACATTGAC 
GACTGCCTGG GCCAGCCCTG CCGCAATGGG GGCACATGCA TCGATGAGGT GGACGCCTTC 
CGCTGCTTCT GCCCCAGCGG CTGGGAGGGC GAGCTCTGCG ACACCAATCC CAACGACTGC 
CTTCCCGATC CCTGCCACAG CCGCGGCCGC TGCTACGACC TGGTCAATGA CTTCTACTGT 
GCGTGCGACG ACGGCTGGAA GGGCAAGACC TGCCACTCAC GCGAGTTCCA GTGCGATGCC 
TACACCTGCA GCAACGGTGG CACCTGCTAC GACAGCGGCG ACACCTTCCG CTGCGCCTGC 
CCCCCCGGCT GGAAGGGCAG CACCTGCGCC GTCGCCAAGA ACAGCAGCTG CCTGCCCAAC 
CCCTGTGTGA ATGGTGGCAC CTGCGTGGGC AGCGGGGCCT CCTTCTCCTG CATCTGCCGG 
GACGGCTGGG AGGGTCGTAC TTGCACTCAC AATACCAACG ACTGCAACCC TCTGCCTTGC 
TACAATGGTG GCATCTGTGT TGACGGCGTC AACTGGTTCC GCTGCGAGTG TGCACCTGGC 
TTCGCGGGGC CTGACTGCCG CATCAACATC GACGAGTGCC AGTCCTCGCC CTGTGCCTAC 
GGGGCCACGT GTGTGGATGA GATCAACGGG TATCGCTGTA GCTGCCCACC CGGCCGAGCC 
GGCCCCCGGT GCCAGGAAGT GATCGGGTTC GGGAGATCCT GCTGGTCCCG GGGCACTCCG 
TTCCCACACG GAAGCTCCTG GGTGGAAGAC TGCAACAGCT GCCGCTGCCT GGATGGCCGC 
CGTGACTGCA GCAAGGTGTG GTGCGGATGG AAGCCTTGTC TGCTGGCCGG CCAGCCCGAG 
GCCCTGAGCG CCCAGTGCCC ACTGGGGCAA AGGTGCCTGG AGAAGGCCCC AGGCCAGTGT 
CTGCGACCAC CCTGTGAGGC CTGGGGGGAG TGCGGCGCAG AAGAGCCACC GAGCACCCCC 
TGCCTGCCAC GCTCCGGCCA CCTGGACAAT AACTGTGCCC GCCTCACCTT GCATTTCAAC 
CGTGACCACG TGCCCCAGGG CACCACGGTG GGCGCCATTT GCTCCGGGAT CCGCTCCCTG 
CCAGCCACAA GGGCTGTGGC ACGGGACCGC CTGCTGGTGT TGCTTTGCGA CCGGGCGTCC 
TCGGGGGCCA GTGCTGTGGA GGTGGCCGTG TCCTTCAGCC CTGCCAGGGA CCTGCCTGAC 
AGCAGCCTGA TCCAGGGCGC GGCCCACGCC ATCGTGGCCG CCATCACCCA GCGGGGGAAC 
AGCTCACTGC TCCTGGCTGT CACCGAGGTC AAGGTGGAGA CGGTTGTTAC GGGCGGCTCT 
TCCACAGGTC TGCTGGTGCC TGTGCTGTGT GGTGCCTTCA GCGTGCTGTG GCTGGCGTGC 
GTGGTCCTGT GCGTGTGGTG GACACGCAAG CGCAGGAAAG AGCGGGAGAG GAGCCGGCTG 
CCGCGGGAGG AGAGCGCCAA CAACCAGTGG GCCCCGCTCA ACCCCATCCG CAACCCCATT 
GAGCGGCCGG GGGGCCACAA GGACGTGCTC TACCAGTGCA AGAACTTCAC GCCGCCGCCG 
CGCAGGGCGG ACGAGGCGCT GCCCGGGCCG GCCGGCCACG CGGCCGTCAG GGAGGATGAG 
GAGGACGAGG ATCTGGGCCG CGGTGAGGAG GACTCCCTGG AGGCGGAGAA GTTCCTCTCA 
CACAAATTCA CCAAAGATCC TGGCCGCTCG CCGGGGAGGC CGGCCCACTG GGCCTCAGGC 
CCCAAAGTGG ACAACCGCGC GGTCAGGAGC ATCAATGAGG CCCGCTACGC CGGCAAGGAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660142.1
CDS	405..4007
Translation	MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE

Target ORF information:

RefSeq Version	NM_145159.2
Organism	Homo sapiens(human)
Definition	Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145159.2

ORF Insert Sequence:

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG TCAACGACTG TCGCGGGCAG TGTCAGCATG GGGGCACCTG CAAGGACCTG 
GTGAACGGGT ACCAGTGTGT GTGCCCACGG GGCTTCGGAG GCCGGCATTG CGAGCTGGAA 
CGAGACGAGT GTGCCAGCAG CCCCTGCCAC AGCGGCGGCC TCTGCGAGGA CCTGGCCGAC 
GGCTTCCACT GCCACTGCCC CCAGGGCTTC TCCGGGCCTC TCTGTGAGGT GGATGTCGAC 
CTTTGTGAGC CAAGCCCCTG CCGGAACGGC GCTCGCTGCT ATAACCTGGA GGGTGACTAT 
TACTGCGCCT GCCCTGATGA CTTTGGTGGC AAGAACTGCT CCGTGCCCCG CGAGCCGTGC 
CCTGGCGGGG CCTGCAGAGT GATCGATGGC TGCGGGTCAG ACGCGGGGCC TGGGATGCCT 
GGCACAGCAG CCTCCGGCGT GTGTGGCCCC CATGGACGCT GCGTCAGCCA GCCAGGGGGC 
AACTTTTCCT GCATCTGTGA CAGTGGCTTT ACTGGCACCT ACTGCCATGA GAACATTGAC 
GACTGCCTGG GCCAGCCCTG CCGCAATGGG GGCACATGCA TCGATGAGGT GGACGCCTTC 
CGCTGCTTCT GCCCCAGCGG CTGGGAGGGC GAGCTCTGCG ACACCAATCC CAACGACTGC 
CTTCCCGATC CCTGCCACAG CCGCGGCCGC TGCTACGACC TGGTCAATGA CTTCTACTGT 
GCGTGCGACG ACGGCTGGAA GGGCAAGACC TGCCACTCAC GCGAGTTCCA GTGCGATGCC 
TACACCTGCA GCAACGGTGG CACCTGCTAC GACAGCGGCG ACACCTTCCG CTGCGCCTGC 
CCCCCCGGCT GGAAGGGCAG CACCTGCGCC GTCGCCAAGA ACAGCAGCTG CCTGCCCAAC 
CCCTGTGTGA ATGGTGGCAC CTGCGTGGGC AGCGGGGCCT CCTTCTCCTG CATCTGCCGG 
GACGGCTGGG AGGGTCGTAC TTGCACTCAC AATACCAACG ACTGCAACCC TCTGCCTTGC 
TACAATGGTG GCATCTGTGT TGACGGCGTC AACTGGTTCC GCTGCGAGTG TGCACCTGGC 
TTCGCGGGGC CTGACTGCCG CATCAACATC GACGAGTGCC AGTCCTCGCC CTGTGCCTAC 
GGGGCCACGT GTGTGGATGA GATCAACGGG TATCGCTGTA GCTGCCCACC CGGCCGAGCC 
GGCCCCCGGT GCCAGGAAGT GATCGGGTTC GGGAGATCCT GCTGGTCCCG GGGCACTCCG 
TTCCCACACG GAAGCTCCTG GGTGGAAGAC TGCAACAGCT GCCGCTGCCT GGATGGCCGC 
CGTGACTGCA GCAAGGTGTG GTGCGGATGG AAGCCTTGTC TGCTGGCCGG CCAGCCCGAG 
GCCCTGAGCG CCCAGTGCCC ACTGGGGCAA AGGTGCCTGG AGAAGGCCCC AGGCCAGTGT 
CTGCGACCAC CCTGTGAGGC CTGGGGGGAG TGCGGCGCAG AAGAGCCACC GAGCACCCCC 
TGCCTGCCAC GCTCCGGCCA CCTGGACAAT AACTGTGCCC GCCTCACCTT GCATTTCAAC 
CGTGACCACG TGCCCCAGGG CACCACGGTG GGCGCCATTT GCTCCGGGAT CCGCTCCCTG 
CCAGCCACAA GGGCTGTGGC ACGGGACCGC CTGCTGGTGT TGCTTTGCGA CCGGGCGTCC 
TCGGGGGCCA GTGCTGTGGA GGTGGCCGTG TCCTTCAGCC CTGCCAGGGA CCTGCCTGAC 
AGCAGCCTGA TCCAGGGCGC GGCCCACGCC ATCGTGGCCG CCATCACCCA GCGGGGGAAC 
AGCTCACTGC TCCTGGCTGT CACCGAGGTC AAGGTGGAGA CGGTTGTTAC GGGCGGCTCT 
TCCACAGGTC TGCTGGTGCC TGTGCTGTGT GGTGCCTTCA GCGTGCTGTG GCTGGCGTGC 
GTGGTCCTGT GCGTGTGGTG GACACGCAAG CGCAGGAAAG AGCGGGAGAG GAGCCGGCTG 
CCGCGGGAGG AGAGCGCCAA CAACCAGTGG GCCCCGCTCA ACCCCATCCG CAACCCCATT 
GAGCGGCCGG GGGGCCACAA GGACGTGCTC TACCAGTGCA AGAACTTCAC GCCGCCGCCG 
CGCAGGGCGG ACGAGGCGCT GCCCGGGCCG GCCGGCCACG CGGCCGTCAG GGAGGATGAG 
GAGGACGAGG ATCTGGGCCG CGGTGAGGAG GACTCCCTGG AGGCGGAGAA GTTCCTCTCA 
CACAAATTCA CCAAAGATCC TGGCCGCTCG CCGGGGAGGC CGGCCCACTG GGCCTCAGGC 
CCCAAAGTGG ACAACCGCGC GGTCAGGAGC ATCAATGAGG CCCGCTACGC CGGCAAGGAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JAG2 ( NM_145159.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_660142.1 Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02038
Clone ID Related Accession (Same CDS sequence)	NM_145159.2 , NM_145159.3
Accession Version	NM_145159.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	protein jagged-2 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF029779.1, AL512356.6, U69180.1, AF003521.1, AJ712299.1, BX105691.1, AA775404.1 and AI276672.1. On May 31, 2019 this sequence version replaced NM_145159.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform b) than isoform a encoded by variant 1. Isoform b is also known as hJAG2.del-E6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF029779.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG TCAACGACTG TCGCGGGCAG TGTCAGCATG GGGGCACCTG CAAGGACCTG 
GTGAACGGGT ACCAGTGTGT GTGCCCACGG GGCTTCGGAG GCCGGCATTG CGAGCTGGAA 
CGAGACGAGT GTGCCAGCAG CCCCTGCCAC AGCGGCGGCC TCTGCGAGGA CCTGGCCGAC 
GGCTTCCACT GCCACTGCCC CCAGGGCTTC TCCGGGCCTC TCTGTGAGGT GGATGTCGAC 
CTTTGTGAGC CAAGCCCCTG CCGGAACGGC GCTCGCTGCT ATAACCTGGA GGGTGACTAT 
TACTGCGCCT GCCCTGATGA CTTTGGTGGC AAGAACTGCT CCGTGCCCCG CGAGCCGTGC 
CCTGGCGGGG CCTGCAGAGT GATCGATGGC TGCGGGTCAG ACGCGGGGCC TGGGATGCCT 
GGCACAGCAG CCTCCGGCGT GTGTGGCCCC CATGGACGCT GCGTCAGCCA GCCAGGGGGC 
AACTTTTCCT GCATCTGTGA CAGTGGCTTT ACTGGCACCT ACTGCCATGA GAACATTGAC 
GACTGCCTGG GCCAGCCCTG CCGCAATGGG GGCACATGCA TCGATGAGGT GGACGCCTTC 
CGCTGCTTCT GCCCCAGCGG CTGGGAGGGC GAGCTCTGCG ACACCAATCC CAACGACTGC 
CTTCCCGATC CCTGCCACAG CCGCGGCCGC TGCTACGACC TGGTCAATGA CTTCTACTGT 
GCGTGCGACG ACGGCTGGAA GGGCAAGACC TGCCACTCAC GCGAGTTCCA GTGCGATGCC 
TACACCTGCA GCAACGGTGG CACCTGCTAC GACAGCGGCG ACACCTTCCG CTGCGCCTGC 
CCCCCCGGCT GGAAGGGCAG CACCTGCGCC GTCGCCAAGA ACAGCAGCTG CCTGCCCAAC 
CCCTGTGTGA ATGGTGGCAC CTGCGTGGGC AGCGGGGCCT CCTTCTCCTG CATCTGCCGG 
GACGGCTGGG AGGGTCGTAC TTGCACTCAC AATACCAACG ACTGCAACCC TCTGCCTTGC 
TACAATGGTG GCATCTGTGT TGACGGCGTC AACTGGTTCC GCTGCGAGTG TGCACCTGGC 
TTCGCGGGGC CTGACTGCCG CATCAACATC GACGAGTGCC AGTCCTCGCC CTGTGCCTAC 
GGGGCCACGT GTGTGGATGA GATCAACGGG TATCGCTGTA GCTGCCCACC CGGCCGAGCC 
GGCCCCCGGT GCCAGGAAGT GATCGGGTTC GGGAGATCCT GCTGGTCCCG GGGCACTCCG 
TTCCCACACG GAAGCTCCTG GGTGGAAGAC TGCAACAGCT GCCGCTGCCT GGATGGCCGC 
CGTGACTGCA GCAAGGTGTG GTGCGGATGG AAGCCTTGTC TGCTGGCCGG CCAGCCCGAG 
GCCCTGAGCG CCCAGTGCCC ACTGGGGCAA AGGTGCCTGG AGAAGGCCCC AGGCCAGTGT 
CTGCGACCAC CCTGTGAGGC CTGGGGGGAG TGCGGCGCAG AAGAGCCACC GAGCACCCCC 
TGCCTGCCAC GCTCCGGCCA CCTGGACAAT AACTGTGCCC GCCTCACCTT GCATTTCAAC 
CGTGACCACG TGCCCCAGGG CACCACGGTG GGCGCCATTT GCTCCGGGAT CCGCTCCCTG 
CCAGCCACAA GGGCTGTGGC ACGGGACCGC CTGCTGGTGT TGCTTTGCGA CCGGGCGTCC 
TCGGGGGCCA GTGCTGTGGA GGTGGCCGTG TCCTTCAGCC CTGCCAGGGA CCTGCCTGAC 
AGCAGCCTGA TCCAGGGCGC GGCCCACGCC ATCGTGGCCG CCATCACCCA GCGGGGGAAC 
AGCTCACTGC TCCTGGCTGT CACCGAGGTC AAGGTGGAGA CGGTTGTTAC GGGCGGCTCT 
TCCACAGGTC TGCTGGTGCC TGTGCTGTGT GGTGCCTTCA GCGTGCTGTG GCTGGCGTGC 
GTGGTCCTGT GCGTGTGGTG GACACGCAAG CGCAGGAAAG AGCGGGAGAG GAGCCGGCTG 
CCGCGGGAGG AGAGCGCCAA CAACCAGTGG GCCCCGCTCA ACCCCATCCG CAACCCCATT 
GAGCGGCCGG GGGGCCACAA GGACGTGCTC TACCAGTGCA AGAACTTCAC GCCGCCGCCG 
CGCAGGGCGG ACGAGGCGCT GCCCGGGCCG GCCGGCCACG CGGCCGTCAG GGAGGATGAG 
GAGGACGAGG ATCTGGGCCG CGGTGAGGAG GACTCCCTGG AGGCGGAGAA GTTCCTCTCA 
CACAAATTCA CCAAAGATCC TGGCCGCTCG CCGGGGAGGC CGGCCCACTG GGCCTCAGGC 
CCCAAAGTGG ACAACCGCGC GGTCAGGAGC ATCAATGAGG CCCGCTACGC CGGCAAGGAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660142.1
CDS	357..3959
Translation	MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE

Target ORF information:

RefSeq Version	NM_145159.3
Organism	Homo sapiens(human)
Definition	Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145159.3

ORF Insert Sequence:

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG TCAACGACTG TCGCGGGCAG TGTCAGCATG GGGGCACCTG CAAGGACCTG 
GTGAACGGGT ACCAGTGTGT GTGCCCACGG GGCTTCGGAG GCCGGCATTG CGAGCTGGAA 
CGAGACGAGT GTGCCAGCAG CCCCTGCCAC AGCGGCGGCC TCTGCGAGGA CCTGGCCGAC 
GGCTTCCACT GCCACTGCCC CCAGGGCTTC TCCGGGCCTC TCTGTGAGGT GGATGTCGAC 
CTTTGTGAGC CAAGCCCCTG CCGGAACGGC GCTCGCTGCT ATAACCTGGA GGGTGACTAT 
TACTGCGCCT GCCCTGATGA CTTTGGTGGC AAGAACTGCT CCGTGCCCCG CGAGCCGTGC 
CCTGGCGGGG CCTGCAGAGT GATCGATGGC TGCGGGTCAG ACGCGGGGCC TGGGATGCCT 
GGCACAGCAG CCTCCGGCGT GTGTGGCCCC CATGGACGCT GCGTCAGCCA GCCAGGGGGC 
AACTTTTCCT GCATCTGTGA CAGTGGCTTT ACTGGCACCT ACTGCCATGA GAACATTGAC 
GACTGCCTGG GCCAGCCCTG CCGCAATGGG GGCACATGCA TCGATGAGGT GGACGCCTTC 
CGCTGCTTCT GCCCCAGCGG CTGGGAGGGC GAGCTCTGCG ACACCAATCC CAACGACTGC 
CTTCCCGATC CCTGCCACAG CCGCGGCCGC TGCTACGACC TGGTCAATGA CTTCTACTGT 
GCGTGCGACG ACGGCTGGAA GGGCAAGACC TGCCACTCAC GCGAGTTCCA GTGCGATGCC 
TACACCTGCA GCAACGGTGG CACCTGCTAC GACAGCGGCG ACACCTTCCG CTGCGCCTGC 
CCCCCCGGCT GGAAGGGCAG CACCTGCGCC GTCGCCAAGA ACAGCAGCTG CCTGCCCAAC 
CCCTGTGTGA ATGGTGGCAC CTGCGTGGGC AGCGGGGCCT CCTTCTCCTG CATCTGCCGG 
GACGGCTGGG AGGGTCGTAC TTGCACTCAC AATACCAACG ACTGCAACCC TCTGCCTTGC 
TACAATGGTG GCATCTGTGT TGACGGCGTC AACTGGTTCC GCTGCGAGTG TGCACCTGGC 
TTCGCGGGGC CTGACTGCCG CATCAACATC GACGAGTGCC AGTCCTCGCC CTGTGCCTAC 
GGGGCCACGT GTGTGGATGA GATCAACGGG TATCGCTGTA GCTGCCCACC CGGCCGAGCC 
GGCCCCCGGT GCCAGGAAGT GATCGGGTTC GGGAGATCCT GCTGGTCCCG GGGCACTCCG 
TTCCCACACG GAAGCTCCTG GGTGGAAGAC TGCAACAGCT GCCGCTGCCT GGATGGCCGC 
CGTGACTGCA GCAAGGTGTG GTGCGGATGG AAGCCTTGTC TGCTGGCCGG CCAGCCCGAG 
GCCCTGAGCG CCCAGTGCCC ACTGGGGCAA AGGTGCCTGG AGAAGGCCCC AGGCCAGTGT 
CTGCGACCAC CCTGTGAGGC CTGGGGGGAG TGCGGCGCAG AAGAGCCACC GAGCACCCCC 
TGCCTGCCAC GCTCCGGCCA CCTGGACAAT AACTGTGCCC GCCTCACCTT GCATTTCAAC 
CGTGACCACG TGCCCCAGGG CACCACGGTG GGCGCCATTT GCTCCGGGAT CCGCTCCCTG 
CCAGCCACAA GGGCTGTGGC ACGGGACCGC CTGCTGGTGT TGCTTTGCGA CCGGGCGTCC 
TCGGGGGCCA GTGCTGTGGA GGTGGCCGTG TCCTTCAGCC CTGCCAGGGA CCTGCCTGAC 
AGCAGCCTGA TCCAGGGCGC GGCCCACGCC ATCGTGGCCG CCATCACCCA GCGGGGGAAC 
AGCTCACTGC TCCTGGCTGT CACCGAGGTC AAGGTGGAGA CGGTTGTTAC GGGCGGCTCT 
TCCACAGGTC TGCTGGTGCC TGTGCTGTGT GGTGCCTTCA GCGTGCTGTG GCTGGCGTGC 
GTGGTCCTGT GCGTGTGGTG GACACGCAAG CGCAGGAAAG AGCGGGAGAG GAGCCGGCTG 
CCGCGGGAGG AGAGCGCCAA CAACCAGTGG GCCCCGCTCA ACCCCATCCG CAACCCCATT 
GAGCGGCCGG GGGGCCACAA GGACGTGCTC TACCAGTGCA AGAACTTCAC GCCGCCGCCG 
CGCAGGGCGG ACGAGGCGCT GCCCGGGCCG GCCGGCCACG CGGCCGTCAG GGAGGATGAG 
GAGGACGAGG ATCTGGGCCG CGGTGAGGAG GACTCCCTGG AGGCGGAGAA GTTCCTCTCA 
CACAAATTCA CCAAAGATCC TGGCCGCTCG CCGGGGAGGC CGGCCCACTG GGCCTCAGGC 
CCCAAAGTGG ACAACCGCGC GGTCAGGAGC ATCAATGAGG CCCGCTACGC CGGCAAGGAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JAG2 ( NM_002226.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002217.3 Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 1, mRNA.

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CloneID	OHu02048
Clone ID Related Accession (Same CDS sequence)	NM_002226.5 , NM_002226.4
Accession Version	NM_002226.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	protein jagged-2 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF029778.1, AL512356.6, U69180.1, AF003521.1, AJ712299.1, BX105691.1, AA775404.1 and AI276672.1. On Nov 22, 2018 this sequence version replaced NM_002226.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF029778.1, AF020201.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000331782.8/ ENSP00000328169.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG CCAATGAGTG TGAAGGGAAG CCATGCCTTA ACGCTTTTTC TTGCAAAAAC 
CTGATTGGCG GCTATTACTG TGATTGCATC CCGGGCTGGA AGGGCATCAA CTGCCATATC 
AACGTCAACG ACTGTCGCGG GCAGTGTCAG CATGGGGGCA CCTGCAAGGA CCTGGTGAAC 
GGGTACCAGT GTGTGTGCCC ACGGGGCTTC GGAGGCCGGC ATTGCGAGCT GGAACGAGAC 
GAGTGTGCCA GCAGCCCCTG CCACAGCGGC GGCCTCTGCG AGGACCTGGC CGACGGCTTC 
CACTGCCACT GCCCCCAGGG CTTCTCCGGG CCTCTCTGTG AGGTGGATGT CGACCTTTGT 
GAGCCAAGCC CCTGCCGGAA CGGCGCTCGC TGCTATAACC TGGAGGGTGA CTATTACTGC 
GCCTGCCCTG ATGACTTTGG TGGCAAGAAC TGCTCCGTGC CCCGCGAGCC GTGCCCTGGC 
GGGGCCTGCA GAGTGATCGA TGGCTGCGGG TCAGACGCGG GGCCTGGGAT GCCTGGCACA 
GCAGCCTCCG GCGTGTGTGG CCCCCATGGA CGCTGCGTCA GCCAGCCAGG GGGCAACTTT 
TCCTGCATCT GTGACAGTGG CTTTACTGGC ACCTACTGCC ATGAGAACAT TGACGACTGC 
CTGGGCCAGC CCTGCCGCAA TGGGGGCACA TGCATCGATG AGGTGGACGC CTTCCGCTGC 
TTCTGCCCCA GCGGCTGGGA GGGCGAGCTC TGCGACACCA ATCCCAACGA CTGCCTTCCC 
GATCCCTGCC ACAGCCGCGG CCGCTGCTAC GACCTGGTCA ATGACTTCTA CTGTGCGTGC 
GACGACGGCT GGAAGGGCAA GACCTGCCAC TCACGCGAGT TCCAGTGCGA TGCCTACACC 
TGCAGCAACG GTGGCACCTG CTACGACAGC GGCGACACCT TCCGCTGCGC CTGCCCCCCC 
GGCTGGAAGG GCAGCACCTG CGCCGTCGCC AAGAACAGCA GCTGCCTGCC CAACCCCTGT 
GTGAATGGTG GCACCTGCGT GGGCAGCGGG GCCTCCTTCT CCTGCATCTG CCGGGACGGC 
TGGGAGGGTC GTACTTGCAC TCACAATACC AACGACTGCA ACCCTCTGCC TTGCTACAAT 
GGTGGCATCT GTGTTGACGG CGTCAACTGG TTCCGCTGCG AGTGTGCACC TGGCTTCGCG 
GGGCCTGACT GCCGCATCAA CATCGACGAG TGCCAGTCCT CGCCCTGTGC CTACGGGGCC 
ACGTGTGTGG ATGAGATCAA CGGGTATCGC TGTAGCTGCC CACCCGGCCG AGCCGGCCCC 
CGGTGCCAGG AAGTGATCGG GTTCGGGAGA TCCTGCTGGT CCCGGGGCAC TCCGTTCCCA 
CACGGAAGCT CCTGGGTGGA AGACTGCAAC AGCTGCCGCT GCCTGGATGG CCGCCGTGAC 
TGCAGCAAGG TGTGGTGCGG ATGGAAGCCT TGTCTGCTGG CCGGCCAGCC CGAGGCCCTG 
AGCGCCCAGT GCCCACTGGG GCAAAGGTGC CTGGAGAAGG CCCCAGGCCA GTGTCTGCGA 
CCACCCTGTG AGGCCTGGGG GGAGTGCGGC GCAGAAGAGC CACCGAGCAC CCCCTGCCTG 
CCACGCTCCG GCCACCTGGA CAATAACTGT GCCCGCCTCA CCTTGCATTT CAACCGTGAC 
CACGTGCCCC AGGGCACCAC GGTGGGCGCC ATTTGCTCCG GGATCCGCTC CCTGCCAGCC 
ACAAGGGCTG TGGCACGGGA CCGCCTGCTG GTGTTGCTTT GCGACCGGGC GTCCTCGGGG 
GCCAGTGCTG TGGAGGTGGC CGTGTCCTTC AGCCCTGCCA GGGACCTGCC TGACAGCAGC 
CTGATCCAGG GCGCGGCCCA CGCCATCGTG GCCGCCATCA CCCAGCGGGG GAACAGCTCA 
CTGCTCCTGG CTGTCACCGA GGTCAAGGTG GAGACGGTTG TTACGGGCGG CTCTTCCACA 
GGTCTGCTGG TGCCTGTGCT GTGTGGTGCC TTCAGCGTGC TGTGGCTGGC GTGCGTGGTC 
CTGTGCGTGT GGTGGACACG CAAGCGCAGG AAAGAGCGGG AGAGGAGCCG GCTGCCGCGG 
GAGGAGAGCG CCAACAACCA GTGGGCCCCG CTCAACCCCA TCCGCAACCC CATTGAGCGG 
CCGGGGGGCC ACAAGGACGT GCTCTACCAG TGCAAGAACT TCACGCCGCC GCCGCGCAGG 
GCGGACGAGG CGCTGCCCGG GCCGGCCGGC CACGCGGCCG TCAGGGAGGA TGAGGAGGAC 
GAGGATCTGG GCCGCGGTGA GGAGGACTCC CTGGAGGCGG AGAAGTTCCT CTCACACAAA 
TTCACCAAAG ATCCTGGCCG CTCGCCGGGG AGGCCGGCCC ACTGGGCCTC AGGCCCCAAA 
GTGGACAACC GCGCGGTCAG GAGCATCAAT GAGGCCCGCT ACGCCGGCAA GGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002217.3
CDS	357..4073
Translation	MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE

Target ORF information:

RefSeq Version	NM_002226.5
Organism	Homo sapiens(human)
Definition	Homo sapiens jagged canonical Notch ligand 2 (JAG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002226.5

ORF Insert Sequence:

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG CCAATGAGTG TGAAGGGAAG CCATGCCTTA ACGCTTTTTC TTGCAAAAAC 
CTGATTGGCG GCTATTACTG TGATTGCATC CCGGGCTGGA AGGGCATCAA CTGCCATATC 
AACGTCAACG ACTGTCGCGG GCAGTGTCAG CATGGGGGCA CCTGCAAGGA CCTGGTGAAC 
GGGTACCAGT GTGTGTGCCC ACGGGGCTTC GGAGGCCGGC ATTGCGAGCT GGAACGAGAC 
GAGTGTGCCA GCAGCCCCTG CCACAGCGGC GGCCTCTGCG AGGACCTGGC CGACGGCTTC 
CACTGCCACT GCCCCCAGGG CTTCTCCGGG CCTCTCTGTG AGGTGGATGT CGACCTTTGT 
GAGCCAAGCC CCTGCCGGAA CGGCGCTCGC TGCTATAACC TGGAGGGTGA CTATTACTGC 
GCCTGCCCTG ATGACTTTGG TGGCAAGAAC TGCTCCGTGC CCCGCGAGCC GTGCCCTGGC 
GGGGCCTGCA GAGTGATCGA TGGCTGCGGG TCAGACGCGG GGCCTGGGAT GCCTGGCACA 
GCAGCCTCCG GCGTGTGTGG CCCCCATGGA CGCTGCGTCA GCCAGCCAGG GGGCAACTTT 
TCCTGCATCT GTGACAGTGG CTTTACTGGC ACCTACTGCC ATGAGAACAT TGACGACTGC 
CTGGGCCAGC CCTGCCGCAA TGGGGGCACA TGCATCGATG AGGTGGACGC CTTCCGCTGC 
TTCTGCCCCA GCGGCTGGGA GGGCGAGCTC TGCGACACCA ATCCCAACGA CTGCCTTCCC 
GATCCCTGCC ACAGCCGCGG CCGCTGCTAC GACCTGGTCA ATGACTTCTA CTGTGCGTGC 
GACGACGGCT GGAAGGGCAA GACCTGCCAC TCACGCGAGT TCCAGTGCGA TGCCTACACC 
TGCAGCAACG GTGGCACCTG CTACGACAGC GGCGACACCT TCCGCTGCGC CTGCCCCCCC 
GGCTGGAAGG GCAGCACCTG CGCCGTCGCC AAGAACAGCA GCTGCCTGCC CAACCCCTGT 
GTGAATGGTG GCACCTGCGT GGGCAGCGGG GCCTCCTTCT CCTGCATCTG CCGGGACGGC 
TGGGAGGGTC GTACTTGCAC TCACAATACC AACGACTGCA ACCCTCTGCC TTGCTACAAT 
GGTGGCATCT GTGTTGACGG CGTCAACTGG TTCCGCTGCG AGTGTGCACC TGGCTTCGCG 
GGGCCTGACT GCCGCATCAA CATCGACGAG TGCCAGTCCT CGCCCTGTGC CTACGGGGCC 
ACGTGTGTGG ATGAGATCAA CGGGTATCGC TGTAGCTGCC CACCCGGCCG AGCCGGCCCC 
CGGTGCCAGG AAGTGATCGG GTTCGGGAGA TCCTGCTGGT CCCGGGGCAC TCCGTTCCCA 
CACGGAAGCT CCTGGGTGGA AGACTGCAAC AGCTGCCGCT GCCTGGATGG CCGCCGTGAC 
TGCAGCAAGG TGTGGTGCGG ATGGAAGCCT TGTCTGCTGG CCGGCCAGCC CGAGGCCCTG 
AGCGCCCAGT GCCCACTGGG GCAAAGGTGC CTGGAGAAGG CCCCAGGCCA GTGTCTGCGA 
CCACCCTGTG AGGCCTGGGG GGAGTGCGGC GCAGAAGAGC CACCGAGCAC CCCCTGCCTG 
CCACGCTCCG GCCACCTGGA CAATAACTGT GCCCGCCTCA CCTTGCATTT CAACCGTGAC 
CACGTGCCCC AGGGCACCAC GGTGGGCGCC ATTTGCTCCG GGATCCGCTC CCTGCCAGCC 
ACAAGGGCTG TGGCACGGGA CCGCCTGCTG GTGTTGCTTT GCGACCGGGC GTCCTCGGGG 
GCCAGTGCTG TGGAGGTGGC CGTGTCCTTC AGCCCTGCCA GGGACCTGCC TGACAGCAGC 
CTGATCCAGG GCGCGGCCCA CGCCATCGTG GCCGCCATCA CCCAGCGGGG GAACAGCTCA 
CTGCTCCTGG CTGTCACCGA GGTCAAGGTG GAGACGGTTG TTACGGGCGG CTCTTCCACA 
GGTCTGCTGG TGCCTGTGCT GTGTGGTGCC TTCAGCGTGC TGTGGCTGGC GTGCGTGGTC 
CTGTGCGTGT GGTGGACACG CAAGCGCAGG AAAGAGCGGG AGAGGAGCCG GCTGCCGCGG 
GAGGAGAGCG CCAACAACCA GTGGGCCCCG CTCAACCCCA TCCGCAACCC CATTGAGCGG 
CCGGGGGGCC ACAAGGACGT GCTCTACCAG TGCAAGAACT TCACGCCGCC GCCGCGCAGG 
GCGGACGAGG CGCTGCCCGG GCCGGCCGGC CACGCGGCCG TCAGGGAGGA TGAGGAGGAC 
GAGGATCTGG GCCGCGGTGA GGAGGACTCC CTGGAGGCGG AGAAGTTCCT CTCACACAAA 
TTCACCAAAG ATCCTGGCCG CTCGCCGGGG AGGCCGGCCC ACTGGGCCTC AGGCCCCAAA 
GTGGACAACC GCGCGGTCAG GAGCATCAAT GAGGCCCGCT ACGCCGGCAA GGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JAG2 ( NM_002226.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002217.3 Homo sapiens jagged 2 (JAG2), transcript variant 1, mRNA.

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CloneID	OHu02048
Clone ID Related Accession (Same CDS sequence)	NM_002226.5 , NM_002226.4
Accession Version	NM_002226.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-01
Organism	Homo sapiens(human)
Product	protein jagged-2 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF029778.1, AL512356.6, U69180.1, AF003521.1, AJ712299.1, BX105691.1, AA775404.1 and AI276672.1. On Jun 22, 2012 this sequence version replaced NM_002226.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF029778.1, AF020201.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG CCAATGAGTG TGAAGGGAAG CCATGCCTTA ACGCTTTTTC TTGCAAAAAC 
CTGATTGGCG GCTATTACTG TGATTGCATC CCGGGCTGGA AGGGCATCAA CTGCCATATC 
AACGTCAACG ACTGTCGCGG GCAGTGTCAG CATGGGGGCA CCTGCAAGGA CCTGGTGAAC 
GGGTACCAGT GTGTGTGCCC ACGGGGCTTC GGAGGCCGGC ATTGCGAGCT GGAACGAGAC 
GAGTGTGCCA GCAGCCCCTG CCACAGCGGC GGCCTCTGCG AGGACCTGGC CGACGGCTTC 
CACTGCCACT GCCCCCAGGG CTTCTCCGGG CCTCTCTGTG AGGTGGATGT CGACCTTTGT 
GAGCCAAGCC CCTGCCGGAA CGGCGCTCGC TGCTATAACC TGGAGGGTGA CTATTACTGC 
GCCTGCCCTG ATGACTTTGG TGGCAAGAAC TGCTCCGTGC CCCGCGAGCC GTGCCCTGGC 
GGGGCCTGCA GAGTGATCGA TGGCTGCGGG TCAGACGCGG GGCCTGGGAT GCCTGGCACA 
GCAGCCTCCG GCGTGTGTGG CCCCCATGGA CGCTGCGTCA GCCAGCCAGG GGGCAACTTT 
TCCTGCATCT GTGACAGTGG CTTTACTGGC ACCTACTGCC ATGAGAACAT TGACGACTGC 
CTGGGCCAGC CCTGCCGCAA TGGGGGCACA TGCATCGATG AGGTGGACGC CTTCCGCTGC 
TTCTGCCCCA GCGGCTGGGA GGGCGAGCTC TGCGACACCA ATCCCAACGA CTGCCTTCCC 
GATCCCTGCC ACAGCCGCGG CCGCTGCTAC GACCTGGTCA ATGACTTCTA CTGTGCGTGC 
GACGACGGCT GGAAGGGCAA GACCTGCCAC TCACGCGAGT TCCAGTGCGA TGCCTACACC 
TGCAGCAACG GTGGCACCTG CTACGACAGC GGCGACACCT TCCGCTGCGC CTGCCCCCCC 
GGCTGGAAGG GCAGCACCTG CGCCGTCGCC AAGAACAGCA GCTGCCTGCC CAACCCCTGT 
GTGAATGGTG GCACCTGCGT GGGCAGCGGG GCCTCCTTCT CCTGCATCTG CCGGGACGGC 
TGGGAGGGTC GTACTTGCAC TCACAATACC AACGACTGCA ACCCTCTGCC TTGCTACAAT 
GGTGGCATCT GTGTTGACGG CGTCAACTGG TTCCGCTGCG AGTGTGCACC TGGCTTCGCG 
GGGCCTGACT GCCGCATCAA CATCGACGAG TGCCAGTCCT CGCCCTGTGC CTACGGGGCC 
ACGTGTGTGG ATGAGATCAA CGGGTATCGC TGTAGCTGCC CACCCGGCCG AGCCGGCCCC 
CGGTGCCAGG AAGTGATCGG GTTCGGGAGA TCCTGCTGGT CCCGGGGCAC TCCGTTCCCA 
CACGGAAGCT CCTGGGTGGA AGACTGCAAC AGCTGCCGCT GCCTGGATGG CCGCCGTGAC 
TGCAGCAAGG TGTGGTGCGG ATGGAAGCCT TGTCTGCTGG CCGGCCAGCC CGAGGCCCTG 
AGCGCCCAGT GCCCACTGGG GCAAAGGTGC CTGGAGAAGG CCCCAGGCCA GTGTCTGCGA 
CCACCCTGTG AGGCCTGGGG GGAGTGCGGC GCAGAAGAGC CACCGAGCAC CCCCTGCCTG 
CCACGCTCCG GCCACCTGGA CAATAACTGT GCCCGCCTCA CCTTGCATTT CAACCGTGAC 
CACGTGCCCC AGGGCACCAC GGTGGGCGCC ATTTGCTCCG GGATCCGCTC CCTGCCAGCC 
ACAAGGGCTG TGGCACGGGA CCGCCTGCTG GTGTTGCTTT GCGACCGGGC GTCCTCGGGG 
GCCAGTGCTG TGGAGGTGGC CGTGTCCTTC AGCCCTGCCA GGGACCTGCC TGACAGCAGC 
CTGATCCAGG GCGCGGCCCA CGCCATCGTG GCCGCCATCA CCCAGCGGGG GAACAGCTCA 
CTGCTCCTGG CTGTCACCGA GGTCAAGGTG GAGACGGTTG TTACGGGCGG CTCTTCCACA 
GGTCTGCTGG TGCCTGTGCT GTGTGGTGCC TTCAGCGTGC TGTGGCTGGC GTGCGTGGTC 
CTGTGCGTGT GGTGGACACG CAAGCGCAGG AAAGAGCGGG AGAGGAGCCG GCTGCCGCGG 
GAGGAGAGCG CCAACAACCA GTGGGCCCCG CTCAACCCCA TCCGCAACCC CATTGAGCGG 
CCGGGGGGCC ACAAGGACGT GCTCTACCAG TGCAAGAACT TCACGCCGCC GCCGCGCAGG 
GCGGACGAGG CGCTGCCCGG GCCGGCCGGC CACGCGGCCG TCAGGGAGGA TGAGGAGGAC 
GAGGATCTGG GCCGCGGTGA GGAGGACTCC CTGGAGGCGG AGAAGTTCCT CTCACACAAA 
TTCACCAAAG ATCCTGGCCG CTCGCCGGGG AGGCCGGCCC ACTGGGCCTC AGGCCCCAAA 
GTGGACAACC GCGCGGTCAG GAGCATCAAT GAGGCCCGCT ACGCCGGCAA GGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002217.3
CDS	405..4121
Translation	MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE

Target ORF information:

RefSeq Version	NM_002226.4
Organism	Homo sapiens(human)
Definition	Homo sapiens jagged 2 (JAG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002226.4

ORF Insert Sequence:

ATGCGGGCGC AGGGCCGGGG GCGCCTTCCC CGGCGGCTGC TGCTGCTGCT GGCGCTCTGG 
GTGCAGGCGG CGCGGCCCAT GGGCTATTTC GAGCTGCAGC TGAGCGCGCT GCGGAACGTG 
AACGGGGAGC TGCTGAGCGG CGCCTGCTGT GACGGCGACG GCCGGACAAC GCGCGCGGGG 
GGCTGCGGCC ACGACGAGTG CGACACGTAC GTGCGCGTGT GCCTTAAGGA GTACCAGGCC 
AAGGTGACGC CCACGGGGCC CTGCAGCTAC GGCCACGGCG CCACGCCCGT GCTGGGCGGC 
AACTCCTTCT ACCTGCCGCC GGCGGGCGCT GCGGGGGACC GAGCGCGGGC GCGGGCCCGG 
GCCGGCGGCG ACCAGGACCC GGGCCTCGTC GTCATCCCCT TCCAGTTCGC CTGGCCGCGC 
TCCTTTACCC TCATCGTGGA GGCCTGGGAC TGGGACAACG ATACCACCCC GAATGAGGAG 
CTGCTGATCG AGCGAGTGTC GCATGCCGGC ATGATCAACC CGGAGGACCG CTGGAAGAGC 
CTGCACTTCA GCGGCCACGT GGCGCACCTG GAGCTGCAGA TCCGCGTGCG CTGCGACGAG 
AACTACTACA GCGCCACTTG CAACAAGTTC TGCCGGCCCC GCAACGACTT TTTCGGCCAC 
TACACCTGCG ACCAGTACGG CAACAAGGCC TGCATGGACG GCTGGATGGG CAAGGAGTGC 
AAGGAAGCTG TGTGTAAACA AGGGTGTAAT TTGCTCCACG GGGGATGCAC CGTGCCTGGG 
GAGTGCAGGT GCAGCTACGG CTGGCAAGGG AGGTTCTGCG ATGAGTGTGT CCCCTACCCC 
GGCTGCGTGC ATGGCAGTTG TGTGGAGCCC TGGCAGTGCA ACTGTGAGAC CAACTGGGGC 
GGCCTGCTCT GTGACAAAGA CCTGAACTAC TGTGGCAGCC ACCACCCCTG CACCAACGGA 
GGCACGTGCA TCAACGCCGA GCCTGACCAG TACCGCTGCA CCTGCCCTGA CGGCTACTCG 
GGCAGGAACT GTGAGAAGGC TGAGCACGCC TGCACCTCCA ACCCGTGTGC CAACGGGGGC 
TCTTGCCATG AGGTGCCGTC CGGCTTCGAA TGCCACTGCC CATCGGGCTG GAGCGGGCCC 
ACCTGTGCCC TTGACATCGA TGAGTGTGCT TCGAACCCGT GTGCGGCCGG TGGCACCTGT 
GTGGACCAGG TGGACGGCTT TGAGTGCATC TGCCCCGAGC AGTGGGTGGG GGCCACCTGC 
CAGCTGGACG CCAATGAGTG TGAAGGGAAG CCATGCCTTA ACGCTTTTTC TTGCAAAAAC 
CTGATTGGCG GCTATTACTG TGATTGCATC CCGGGCTGGA AGGGCATCAA CTGCCATATC 
AACGTCAACG ACTGTCGCGG GCAGTGTCAG CATGGGGGCA CCTGCAAGGA CCTGGTGAAC 
GGGTACCAGT GTGTGTGCCC ACGGGGCTTC GGAGGCCGGC ATTGCGAGCT GGAACGAGAC 
GAGTGTGCCA GCAGCCCCTG CCACAGCGGC GGCCTCTGCG AGGACCTGGC CGACGGCTTC 
CACTGCCACT GCCCCCAGGG CTTCTCCGGG CCTCTCTGTG AGGTGGATGT CGACCTTTGT 
GAGCCAAGCC CCTGCCGGAA CGGCGCTCGC TGCTATAACC TGGAGGGTGA CTATTACTGC 
GCCTGCCCTG ATGACTTTGG TGGCAAGAAC TGCTCCGTGC CCCGCGAGCC GTGCCCTGGC 
GGGGCCTGCA GAGTGATCGA TGGCTGCGGG TCAGACGCGG GGCCTGGGAT GCCTGGCACA 
GCAGCCTCCG GCGTGTGTGG CCCCCATGGA CGCTGCGTCA GCCAGCCAGG GGGCAACTTT 
TCCTGCATCT GTGACAGTGG CTTTACTGGC ACCTACTGCC ATGAGAACAT TGACGACTGC 
CTGGGCCAGC CCTGCCGCAA TGGGGGCACA TGCATCGATG AGGTGGACGC CTTCCGCTGC 
TTCTGCCCCA GCGGCTGGGA GGGCGAGCTC TGCGACACCA ATCCCAACGA CTGCCTTCCC 
GATCCCTGCC ACAGCCGCGG CCGCTGCTAC GACCTGGTCA ATGACTTCTA CTGTGCGTGC 
GACGACGGCT GGAAGGGCAA GACCTGCCAC TCACGCGAGT TCCAGTGCGA TGCCTACACC 
TGCAGCAACG GTGGCACCTG CTACGACAGC GGCGACACCT TCCGCTGCGC CTGCCCCCCC 
GGCTGGAAGG GCAGCACCTG CGCCGTCGCC AAGAACAGCA GCTGCCTGCC CAACCCCTGT 
GTGAATGGTG GCACCTGCGT GGGCAGCGGG GCCTCCTTCT CCTGCATCTG CCGGGACGGC 
TGGGAGGGTC GTACTTGCAC TCACAATACC AACGACTGCA ACCCTCTGCC TTGCTACAAT 
GGTGGCATCT GTGTTGACGG CGTCAACTGG TTCCGCTGCG AGTGTGCACC TGGCTTCGCG 
GGGCCTGACT GCCGCATCAA CATCGACGAG TGCCAGTCCT CGCCCTGTGC CTACGGGGCC 
ACGTGTGTGG ATGAGATCAA CGGGTATCGC TGTAGCTGCC CACCCGGCCG AGCCGGCCCC 
CGGTGCCAGG AAGTGATCGG GTTCGGGAGA TCCTGCTGGT CCCGGGGCAC TCCGTTCCCA 
CACGGAAGCT CCTGGGTGGA AGACTGCAAC AGCTGCCGCT GCCTGGATGG CCGCCGTGAC 
TGCAGCAAGG TGTGGTGCGG ATGGAAGCCT TGTCTGCTGG CCGGCCAGCC CGAGGCCCTG 
AGCGCCCAGT GCCCACTGGG GCAAAGGTGC CTGGAGAAGG CCCCAGGCCA GTGTCTGCGA 
CCACCCTGTG AGGCCTGGGG GGAGTGCGGC GCAGAAGAGC CACCGAGCAC CCCCTGCCTG 
CCACGCTCCG GCCACCTGGA CAATAACTGT GCCCGCCTCA CCTTGCATTT CAACCGTGAC 
CACGTGCCCC AGGGCACCAC GGTGGGCGCC ATTTGCTCCG GGATCCGCTC CCTGCCAGCC 
ACAAGGGCTG TGGCACGGGA CCGCCTGCTG GTGTTGCTTT GCGACCGGGC GTCCTCGGGG 
GCCAGTGCTG TGGAGGTGGC CGTGTCCTTC AGCCCTGCCA GGGACCTGCC TGACAGCAGC 
CTGATCCAGG GCGCGGCCCA CGCCATCGTG GCCGCCATCA CCCAGCGGGG GAACAGCTCA 
CTGCTCCTGG CTGTCACCGA GGTCAAGGTG GAGACGGTTG TTACGGGCGG CTCTTCCACA 
GGTCTGCTGG TGCCTGTGCT GTGTGGTGCC TTCAGCGTGC TGTGGCTGGC GTGCGTGGTC 
CTGTGCGTGT GGTGGACACG CAAGCGCAGG AAAGAGCGGG AGAGGAGCCG GCTGCCGCGG 
GAGGAGAGCG CCAACAACCA GTGGGCCCCG CTCAACCCCA TCCGCAACCC CATTGAGCGG 
CCGGGGGGCC ACAAGGACGT GCTCTACCAG TGCAAGAACT TCACGCCGCC GCCGCGCAGG 
GCGGACGAGG CGCTGCCCGG GCCGGCCGGC CACGCGGCCG TCAGGGAGGA TGAGGAGGAC 
GAGGATCTGG GCCGCGGTGA GGAGGACTCC CTGGAGGCGG AGAAGTTCCT CTCACACAAA 
TTCACCAAAG ATCCTGGCCG CTCGCCGGGG AGGCCGGCCC ACTGGGCCTC AGGCCCCAAA 
GTGGACAACC GCGCGGTCAG GAGCATCAAT GAGGCCCGCT ACGCCGGCAA GGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.
The Journal of allergy and clinical immunology140(4)1079-1089(2017 Oct)
Tindemans I,Lukkes M,de Bruijn MJW,Li BWS,van Nimwegen M,Amsen D,KleinJan A,Hendriks RW

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
The EMBO journal36(15)2204-2215(2017 08)
Suckling RJ,Korona B,Whiteman P,Chillakuri C,Holt L,Handford PA,Lea SM

Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells.
Scientific reports514284(2015 Sep)
Xishan Z,Bin Z,Haiyue Z,Xiaowei D,Jingwen B,Guojun Z

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JAG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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