IGLL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IGLL1
Entrez Gene ID	3543
Full Name	immunoglobulin lambda like polypeptide 1
Synonyms	14.1,AGM2,CD179b,IGL1,IGL5,IGLJ14.1,IGLL,IGO,IGVPB,VPREB2
General protein information	Preferred Names immunoglobulin lambda like polypeptide 1 Names immunoglobulin lambda-like polypeptide 1 CD179 antigen-like family member B CD179b antigen Pre-B lymphocyte-specific protein-2 ig lambda-5 immunoglobulin omega polypeptide chain immunoglobulin-related 14.1 protein immunoglobulin-related protein 14.1 lambda5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.23
Summary	The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	146770
Disorder Html:	Agammaglobulinemia 2, 613500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_152855.3	NP_690594.1	immunoglobulin lambda-like polypeptide 1 isoform b precursor
XM_011530169.2	XP_011528471.1	immunoglobulin lambda-like polypeptide 1 isoform X1
NM_152855.2	NP_690594.1	immunoglobulin lambda-like polypeptide 1 isoform b precursor
NM_001369906.1	NP_001356835.1	immunoglobulin lambda-like polypeptide 1 isoform c
NM_020070.4	NP_064455.1	immunoglobulin lambda-like polypeptide 1 isoform a precursor
NM_020070.3	NP_064455.1	immunoglobulin lambda-like polypeptide 1 isoform a precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IGLL5	NP_001171597.1
Pan troglodytes (chimpanzee)	LOC100614342	XP_003953889.1
	LOC708665	XP_001097152.2
Mus musculus (house mouse)	Igll1	NP_001177254.1
Rattus norvegicus (Norway rat)	Igll1	NP_001177270.1
Canis lupus familiaris (dog)	LOC608238	XP_850294.1
Bos taurus (cattle)	LOC100847119	XP_005218337.1
Pan troglodytes (chimpanzee)	IGLL5	XP_003953892.1
Xenopus tropicalis (tropical clawed frog)	LOC101735033	XP_004911427.1
Homo sapiens (human)	IGLL1	NP_064455.1
Canis lupus familiaris (dog)	LOC607582	XP_849413.1
Canis lupus familiaris (dog)	LOC608248	XP_850308.1
Canis lupus familiaris (dog)	LOC486474	XP_543600.2

Gene Ontology
Bibliography

Related articles in PubMed

Autosomal recessive agammaglobulinemia associated with an IGLL1 gene missense mutation.
Gemayel KT, Litman GW, Sriaroon P
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology117(4)439-441(2016 Oct)

The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.
Chen D, Zheng J, Gerasimcik N, Lagerstedt K, Sj?gren H, Abrahamsson J, Fogelstrand L, M?rtensson IL
PloS one11(9)e0162638(2016)

The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study.
Kullo IJ, Shameer K, Jouni H, Lesnick TG, Pathak J, Chute CG, de Andrade M
Frontiers in genetics5166(2014)

Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.
Elantak L, Espeli M, Boned A, Bornet O, Bonzi J, Gauthier L, Feracci M, Roche P, Guerlesquin F, Schiff C
The Journal of biological chemistry287(53)44703-13(2012 Dec)

Meta-analysis of genome-wide association for migraine in six population-based European cohorts.
Ligthart L, de Vries B, Smith AV, Ikram MA, Amin N, Hottenga JJ, Koelewijn SC, Kattenberg VM, de Moor MH, Janssens AC, Aulchenko YS, Oostra BA, de Geus EJ, Smit JH, Zitman FG, Uitterlinden AG, Hofman A, Willemsen G, Nyholt DR, Montgomery GW, Terwindt GM, Gudnason V, Penninx BW, Breteler M, Ferrari MD, Launer LJ, van Duijn CM, van den Maagdenberg AM, Boomsma DI
European journal of human genetics : EJHG19(8)901-7(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the Title.
Title: Autosomal recessive agammaglobulinemia associated with an IGLL1 gene missense mutation.

Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia.
Title: The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.

Hhydrophobic residues from the lambda5-UR is crucial for the interaction with GAL1 and for pre-BCR clustering.
Title: Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.

The following IGLL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGLL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04419	NM_020070.4 Latest version!	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu55998	NM_152855.3 Latest version!	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu58377	NM_001369906.1 Latest version!	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu58377	XM_011530169.2 Latest version!	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu55998	NM_152855.2	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu04419	NM_020070.3	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IGLL1 ( NM_020070.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_064455.1 Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04419
Clone ID Related Accession (Same CDS sequence)	NM_020070.4 , NM_020070.3
Accession Version	NM_020070.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	immunoglobulin lambda-like polypeptide 1 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M27749.1 and BC030239.1. On Nov 23, 2018 this sequence version replaced NM_020070.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG388370.1, M27749.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330377.3/ ENSP00000329312.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTTC CTGCTCCAGC GCGGCTCCTG GACTGGCCCC 
AGGTGCTGGC CCCGGGGGTT TCAATCCAAG CATAACTCAG TGACGCATGT GTTTGGCAGC 
GGGACCCAGC TCACCGTTTT AAGTCAGCCC AAGGCCACCC CCTCGGTCAC TCTGTTCCCG 
CCGTCCTCTG AGGAGCTCCA AGCCAACAAG GCTACACTGG TGTGTCTCAT GAATGACTTT 
TATCCGGGAA TCTTGACGGT GACCTGGAAG GCAGATGGTA CCCCCATCAC CCAGGGCGTG 
GAGATGACCA CGCCCTCCAA ACAGAGCAAC AACAAGTACG CGGCCAGCAG CTACCTGAGC 
CTGACGCCCG AGCAGTGGAG GTCCCGCAGA AGCTACAGCT GCCAGGTCAT GCACGAAGGG 
AGCACCGTGG AGAAGACGGT GGCCCCTGCA GAATGTTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064455.1
CDS	101..742
Translation	MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSRSSLRSRWGRFLLQRGSWTGPRCWPRGFQSKHNSVTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPAECS

Target ORF information:

RefSeq Version	NM_020070.4
Organism	Homo sapiens(human)
Definition	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020070.4

ORF Insert Sequence:

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTTC CTGCTCCAGC GCGGCTCCTG GACTGGCCCC 
AGGTGCTGGC CCCGGGGGTT TCAATCCAAG CATAACTCAG TGACGCATGT GTTTGGCAGC 
GGGACCCAGC TCACCGTTTT AAGTCAGCCC AAGGCCACCC CCTCGGTCAC TCTGTTCCCG 
CCGTCCTCTG AGGAGCTCCA AGCCAACAAG GCTACACTGG TGTGTCTCAT GAATGACTTT 
TATCCGGGAA TCTTGACGGT GACCTGGAAG GCAGATGGTA CCCCCATCAC CCAGGGCGTG 
GAGATGACCA CGCCCTCCAA ACAGAGCAAC AACAAGTACG CGGCCAGCAG CTACCTGAGC 
CTGACGCCCG AGCAGTGGAG GTCCCGCAGA AGCTACAGCT GCCAGGTCAT GCACGAAGGG 
AGCACCGTGG AGAAGACGGT GGCCCCTGCA GAATGTTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGLL1 ( NM_020070.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_064455.1 Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04419
Clone ID Related Accession (Same CDS sequence)	NM_020070.4 , NM_020070.3
Accession Version	NM_020070.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	immunoglobulin lambda-like polypeptide 1 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M27749.1 and BC030239.1. On Jun 13, 2012 this sequence version replaced NM_020070.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG388370.1, BG259298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTTC CTGCTCCAGC GCGGCTCCTG GACTGGCCCC 
AGGTGCTGGC CCCGGGGGTT TCAATCCAAG CATAACTCAG TGACGCATGT GTTTGGCAGC 
GGGACCCAGC TCACCGTTTT AAGTCAGCCC AAGGCCACCC CCTCGGTCAC TCTGTTCCCG 
CCGTCCTCTG AGGAGCTCCA AGCCAACAAG GCTACACTGG TGTGTCTCAT GAATGACTTT 
TATCCGGGAA TCTTGACGGT GACCTGGAAG GCAGATGGTA CCCCCATCAC CCAGGGCGTG 
GAGATGACCA CGCCCTCCAA ACAGAGCAAC AACAAGTACG CGGCCAGCAG CTACCTGAGC 
CTGACGCCCG AGCAGTGGAG GTCCCGCAGA AGCTACAGCT GCCAGGTCAT GCACGAAGGG 
AGCACCGTGG AGAAGACGGT GGCCCCTGCA GAATGTTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064455.1
CDS	119..760
Translation	MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSRSSLRSRWGRFLLQRGSWTGPRCWPRGFQSKHNSVTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPAECS

Target ORF information:

RefSeq Version	NM_020070.3
Organism	Homo sapiens(human)
Definition	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020070.3

ORF Insert Sequence:

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTTC CTGCTCCAGC GCGGCTCCTG GACTGGCCCC 
AGGTGCTGGC CCCGGGGGTT TCAATCCAAG CATAACTCAG TGACGCATGT GTTTGGCAGC 
GGGACCCAGC TCACCGTTTT AAGTCAGCCC AAGGCCACCC CCTCGGTCAC TCTGTTCCCG 
CCGTCCTCTG AGGAGCTCCA AGCCAACAAG GCTACACTGG TGTGTCTCAT GAATGACTTT 
TATCCGGGAA TCTTGACGGT GACCTGGAAG GCAGATGGTA CCCCCATCAC CCAGGGCGTG 
GAGATGACCA CGCCCTCCAA ACAGAGCAAC AACAAGTACG CGGCCAGCAG CTACCTGAGC 
CTGACGCCCG AGCAGTGGAG GTCCCGCAGA AGCTACAGCT GCCAGGTCAT GCACGAAGGG 
AGCACCGTGG AGAAGACGGT GGCCCCTGCA GAATGTTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGLL1 ( NM_152855.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_690594.1 Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55998
Clone ID Related Accession (Same CDS sequence)	NM_152855.3 , NM_152855.2
Accession Version	NM_152855.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	immunoglobulin lambda-like polypeptide 1 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000345.1. On Apr 24, 2019 this sequence version replaced NM_152855.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030239.1, BG392623.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTCA GCCCAAGGCC ACCCCCTCGG TCACTCTGTT 
CCCGCCGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690594.1
CDS	101..355
Translation	MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSRSSLRSRWGRSAQGHPLGHSVPAVL

Target ORF information:

RefSeq Version	NM_152855.3
Organism	Homo sapiens(human)
Definition	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152855.3

ORF Insert Sequence:

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTCA GCCCAAGGCC ACCCCCTCGG TCACTCTGTT 
CCCGCCGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGLL1 ( NM_152855.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_690594.1 Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55998
Clone ID Related Accession (Same CDS sequence)	NM_152855.3 , NM_152855.2
Accession Version	NM_152855.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	immunoglobulin lambda-like polypeptide 1 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M27749.1 and BC030239.1. On Jun 13, 2012 this sequence version replaced NM_152855.1. Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, which causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030239.1, BG392623.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTCA GCCCAAGGCC ACCCCCTCGG TCACTCTGTT 
CCCGCCGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690594.1
CDS	119..373
Translation	MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSRSSLRSRWGRSAQGHPLGHSVPAVL

Target ORF information:

RefSeq Version	NM_152855.2
Organism	Homo sapiens(human)
Definition	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152855.2

ORF Insert Sequence:

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGGTCA GCCCAAGGCC ACCCCCTCGG TCACTCTGTT 
CCCGCCGTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGLL1 ( NM_001369906.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001356835.1 Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu58377
Clone ID Related Accession (Same CDS sequence)	XM_011530169.2 , NM_001369906.1
Accession Version	NM_001369906.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-07
Organism	Homo sapiens(human)
Product	immunoglobulin lambda-like polypeptide 1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000345.1. On Apr 24, 2019 this sequence version replaced XM_011530169.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DN998537.1, HY068682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGCAGG TTCCTGCTCC AGCGCGGCTC CTGGACTGGC 
CCCAGGTGCT GGCCCCGGGG GTTTCAATCC AAGCATAACT CAGTGACGCA TGTGTTTGGC 
AGCGGGACCC AGCTCACCGT TTTAAGTCAG CCCAAGGCCA CCCCCTCGGT CACTCTGTTC 
CCGCCGTCCT CTGAGGAGCT CCAAGCCAAC AAGGCTACAC TGGTGTGTCT CATGAATGAC 
TTTTATCCGG GAATCTTGAC GGTGACCTGG AAGGCAGATG GTACCCCCAT CACCCAGGGC 
GTGGAGATGA CCACGCCCTC CAAACAGAGC AACAACAAGT ACGCGGCCAG CAGCTACCTG 
AGCCTGACGC CCGAGCAGTG GAGGTCCCGC AGAAGCTACA GCTGCCAGGT CATGCACGAA 
GGGAGCACCG TGGAGAAGAC GGTGGCCCCT GCAGAATGTT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001356835.1
CDS	101..745
Translation	MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSRSSLRSRWGSRFLLQRGSWTGPRCWPRGFQSKHNSVTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPAECS

Target ORF information:

RefSeq Version	NM_001369906.1
Organism	Homo sapiens(human)
Definition	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001369906.1

ORF Insert Sequence:

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGCAGG TTCCTGCTCC AGCGCGGCTC CTGGACTGGC 
CCCAGGTGCT GGCCCCGGGG GTTTCAATCC AAGCATAACT CAGTGACGCA TGTGTTTGGC 
AGCGGGACCC AGCTCACCGT TTTAAGTCAG CCCAAGGCCA CCCCCTCGGT CACTCTGTTC 
CCGCCGTCCT CTGAGGAGCT CCAAGCCAAC AAGGCTACAC TGGTGTGTCT CATGAATGAC 
TTTTATCCGG GAATCTTGAC GGTGACCTGG AAGGCAGATG GTACCCCCAT CACCCAGGGC 
GTGGAGATGA CCACGCCCTC CAAACAGAGC AACAACAAGT ACGCGGCCAG CAGCTACCTG 
AGCCTGACGC CCGAGCAGTG GAGGTCCCGC AGAAGCTACA GCTGCCAGGT CATGCACGAA 
GGGAGCACCG TGGAGAAGAC GGTGGCCCCT GCAGAATGTT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGLL1 ( XM_011530169.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011528471.1 Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant X1, mRNA.

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CloneID	OHu58377
Clone ID Related Accession (Same CDS sequence)	XM_011530169.2 , NM_001369906.1
Accession Version	XM_011530169.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	immunoglobulin lambda-like polypeptide 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011530169.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGCAGG TTCCTGCTCC AGCGCGGCTC CTGGACTGGC 
CCCAGGTGCT GGCCCCGGGG GTTTCAATCC AAGCATAACT CAGTGACGCA TGTGTTTGGC 
AGCGGGACCC AGCTCACCGT TTTAAGTCAG CCCAAGGCCA CCCCCTCGGT CACTCTGTTC 
CCGCCGTCCT CTGAGGAGCT CCAAGCCAAC AAGGCTACAC TGGTGTGTCT CATGAATGAC 
TTTTATCCGG GAATCTTGAC GGTGACCTGG AAGGCAGATG GTACCCCCAT CACCCAGGGC 
GTGGAGATGA CCACGCCCTC CAAACAGAGC AACAACAAGT ACGCGGCCAG CAGCTACCTG 
AGCCTGACGC CCGAGCAGTG GAGGTCCCGC AGAAGCTACA GCTGCCAGGT CATGCACGAA 
GGGAGCACCG TGGAGAAGAC GGTGGCCCCT GCAGAATGTT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011528471.1
CDS	359..1003
Translation	MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSRSSLRSRWGSRFLLQRGSWTGPRCWPRGFQSKHNSVTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPAECS

Target ORF information:

RefSeq Version	XM_011530169.2
Organism	Homo sapiens(human)
Definition	Homo sapiens immunoglobulin lambda like polypeptide 1 (IGLL1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530169.2

ORF Insert Sequence:

ATGAGGCCAG GGACAGGCCA GGGGGGCCTT GAGGCCCCTG GTGAGCCAGG CCCCAACCTC 
AGGCAGCGCT GGCCCCTGCT GCTGCTGGGT CTGGCCGTGG TAACCCATGG CCTGCTGCGC 
CCAACAGCTG CATCGCAGAG CAGGGCCCTG GGCCCTGGAG CCCCTGGAGG AAGCAGCCGG 
TCCAGCCTGA GGAGCCGGTG GGGCAGCAGG TTCCTGCTCC AGCGCGGCTC CTGGACTGGC 
CCCAGGTGCT GGCCCCGGGG GTTTCAATCC AAGCATAACT CAGTGACGCA TGTGTTTGGC 
AGCGGGACCC AGCTCACCGT TTTAAGTCAG CCCAAGGCCA CCCCCTCGGT CACTCTGTTC 
CCGCCGTCCT CTGAGGAGCT CCAAGCCAAC AAGGCTACAC TGGTGTGTCT CATGAATGAC 
TTTTATCCGG GAATCTTGAC GGTGACCTGG AAGGCAGATG GTACCCCCAT CACCCAGGGC 
GTGGAGATGA CCACGCCCTC CAAACAGAGC AACAACAAGT ACGCGGCCAG CAGCTACCTG 
AGCCTGACGC CCGAGCAGTG GAGGTCCCGC AGAAGCTACA GCTGCCAGGT CATGCACGAA 
GGGAGCACCG TGGAGAAGAC GGTGGCCCCT GCAGAATGTT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autosomal recessive agammaglobulinemia associated with an IGLL1 gene missense mutation.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology117(4)439-441(2016 Oct)
Gemayel KT,Litman GW,Sriaroon P

The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.
PloS one11(9)e0162638(2016)
Chen D,Zheng J,Gerasimcik N,Lagerstedt K,Sj?gren H,Abrahamsson J,Fogelstrand L,M?rtensson IL

The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study.
Frontiers in genetics5166(2014)
Kullo IJ,Shameer K,Jouni H,Lesnick TG,Pathak J,Chute CG,de Andrade M

Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.
The Journal of biological chemistry287(53)44703-13(2012 Dec)
Elantak L,Espeli M,Boned A,Bornet O,Bonzi J,Gauthier L,Feracci M,Roche P,Guerlesquin F,Schiff C

Meta-analysis of genome-wide association for migraine in six population-based European cohorts.
European journal of human genetics : EJHG19(8)901-7(2011 Aug)
Ligthart L,de Vries B,Smith AV,Ikram MA,Amin N,Hottenga JJ,Koelewijn SC,Kattenberg VM,de Moor MH,Janssens AC,Aulchenko YS,Oostra BA,de Geus EJ,Smit JH,Zitman FG,Uitterlinden AG,Hofman A,Willemsen G,Nyholt DR,Montgomery GW,Terwindt GM,Gudnason V,Penninx BW,Breteler M,Ferrari MD,Launer LJ,van Duijn CM,van den Maagdenberg AM,Boomsma DI

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IGLL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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