SLC6A18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC6A18
Entrez Gene ID	348932
Full Name	solute carrier family 6 member 18
Synonyms	Xtrp2
General protein information	Preferred Names solute carrier family 6 member 18 Names sodium-dependent neutral amino acid transporter B(0)AT3 sodium channel-like protein sodium- and chloride-dependent transporter XTRP2 solute carrier family 6 (neurotransmitter transporter), member 18 solute carrier family 6 (neutral amino acid transporter), member 18 system B(0) neutral amino acid transporter AT3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p15.33
Summary	The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010].
Disorder MIM:	610300

mRNA and Protein(s)

mRNA	Protein	Name
NM_182632.3	NP_872438.2	inactive sodium-dependent neutral amino acid transporter B(0)AT3
NM_182632.2	NP_872438.2	sodium-dependent neutral amino acid transporter B(0)AT3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC6A18	XP_535804.3
Rattus norvegicus (Norway rat)	Slc6a18	NP_058859.1
Danio rerio (zebrafish)	slc6a18	NP_001108369.1
Homo sapiens (human)	SLC6A18	NP_872438.2
Pan troglodytes (chimpanzee)	SLC6A18	XP_517609.3
Drosophila melanogaster (fruit fly)	CG10804	NP_726868.1
	SLC6A18	XP_001119131.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000637	XP_311164.5
Mus musculus (house mouse)	Slc6a18	NP_001035782.1
Gallus gallus (chicken)	LOC100858092	XP_003640835.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
Fairweather SJ, Br?er A, Subramanian N, Tumer E, Cheng Q, Schmoll D, O'Mara ML, Br?er S
The Journal of biological chemistry290(40)24308-25(2015 Oct)

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Wolpin BM, Rizzato C, Kraft P, Kooperberg C, Petersen GM, Wang Z, Arslan AA, Beane-Freeman L, Bracci PM, Buring J, Canzian F, Duell EJ, Gallinger S, Giles GG, Goodman GE, Goodman PJ, Jacobs EJ, Kamineni A, Klein AP, Kolonel LN, Kulke MH, Li D, Malats N, Olson SH, Risch HA, Sesso HD, Visvanathan K, White E, Zheng W, Abnet CC, Albanes D, Andreotti G, Austin MA, Barfield R, Basso D, Berndt SI, Boutron-Ruault MC, Brotzman M, B?chler MW, Bueno-de-Mesquita HB, Bugert P, Burdette L, Campa D, Caporaso NE, Capurso G, Chung C, Cotterchio M, Costello E, Elena J, Funel N, Gaziano JM, Giese NA, Giovannucci EL, Goggins M, Gorman MJ, Gross M, Haiman CA, Hassan M, Helzlsouer KJ, Henderson BE, Holly EA, Hu N, Hunter DJ, Innocenti F, Jenab M, Kaaks R, Key TJ, Khaw KT, Klein EA, Kogevinas M, Krogh V, Kupcinskas J, Kurtz RC, LaCroix A, Landi MT, Landi S, Le Marchand L, Mambrini A, Mannisto S, Milne RL, Nakamura Y, Oberg AL, Owzar K, Patel AV, Peeters PH, Peters U, Pezzilli R, Piepoli A, Porta M, Real FX, Riboli E, Rothman N, Scarpa A, Shu XO, Silverman DT, Soucek P, Sund M, Talar-Wojnarowska R, Taylor PR, Theodoropoulos GE, Thornquist M, Tj?nneland A, Tobias GS, Trichopoulos D, Vodicka P, Wactawski-Wende J, Wentzensen N, Wu C, Yu H, Yu K, Zeleniuch-Jacquotte A, Hoover R, Hartge P, Fuchs C, Chanock SJ, Stolzenberg-Solomon RS, Amundadottir LT
Nature genetics46(9)994-1000(2014 Sep)

Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.
Friedman E, Moran DS, Ben-Avraham D, Yanovich R, Atzmon G
Genetics research96e004(2014)

Association study: SLC6A18 gene and myocardial infarction.
Matsumoto K, Shimodaira M, Nakagawa T, Nakayama T, Nakazato T, Izumi Y, Soma M, Matsumoto K, Sato N, Aoi N
Clinical biochemistry44(10-11)789-94(2011 Jul)

Genetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, Garc?a-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tard?n A, Carrato A, Garc?a-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N,
European urology57(2)283-92(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutations in SLC6A18 gene is associated with stress fracture.
Title: Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.

These results suggest that SLC6A18 or neighboring genes are associated with increased susceptibility to myocardial infarction.
Title: Association study: SLC6A18 gene and myocardial infarction.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility to distinct bladder cancer subphenotypes.

Observational study of gene-disease association. (HuGE Navigator)
Title: Analysis of VNTRs in the solute carrier family 6, member 18 (SLC6A18) and lack of association with hypertension.

Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
Title: A nonsense polymorphism (Y319X) of the solute carrier family 6 member 18 (SLC6A18) gene is not associated with hypertension and blood pressure in Japanese.

The following SLC6A18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC6A18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31360	NM_182632.3 Latest version!	Homo sapiens solute carrier family 6 member 18 (SLC6A18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
View Old Accession Versions >>
OHu31360	NM_182632.2	Homo sapiens solute carrier family 6 member 18 (SLC6A18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC6A18 ( NM_182632.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_872438.2 Homo sapiens solute carrier family 6 member 18 (SLC6A18), mRNA.

Price & Availability↑

CloneID	OHu31360
Clone ID Related Accession (Same CDS sequence)	NM_182632.3 , NM_182632.2
Accession Version	NM_182632.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1887bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	inactive sodium-dependent neutral amino acid transporter B(0)AT3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK055798.1 and BC056757.1. On Nov 23, 2018 this sequence version replaced NM_182632.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056757.1, AK055798.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000324642.4/ ENSP00000323549.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCATG CCCCAGAACC GGACCCGGCC GCCTGCGACC TCGGGGATGA GAGGCCCAAG 
TGGGACAACA AGGCCCAGTA CCTCCTGAGC TGCACTGGGT TTGCCGTGGG ACTGGGGAAC 
ATTTGGCGGT TCCCATACCT GTGCCAGACC TATGGAGGAG GGGCCTTCCT CATCCCCTAC 
GTCATCGCGC TGGTCTTCGA GGGGATCCCC ATTTTCCACG TCGAGCTCGC CATCGGCCAG 
CGGCTGCGGA AGGGCAGCGT CGGCGTGTGG ACGGCCATCT CCCCGTACCT CAGTGGAGTA 
GGGCTGGGCT GTGTCACGCT GTCCTTCCTG ATCAGCCTGT ACTACAACAC CATCGTGGCG 
TGGGTGCTGT GGTACCTCCT CAACTCCTTC CAGCACCCGC TGCCCTGGAG CTCCTGCCCA 
CCGGACCTCA ACAGAACAGG GTTTGTGGAG GAGTGCCAGG GCAGCAGCGC CGTGAGCTAC 
TTCTGGTACC GGCAGACACT GAACATCACA GCCGACATCA ATGACAGTGG CTCCATCCAG 
TGGTGGCTGC TCATCTGCTT GGCAGCCTCC TGGGCAGTCG TGTACATGTG TGTCATCAGG 
GGCATTGAGA CTACAGGGAA GGTGATTTAC TTCACAGCTT TGTTCCCTTA CCTGGTCCTG 
ACCATCTTTC TCATCAGAGG GCTGACCCTG CCAGGGGCAA CAAAAGGACT CATCTACTTG 
TTCACTCCCA ACATGCACAT TCTCCAGAAC CCCCGGGTGT GGCTGGACGC AGCCACCCAG 
ATATTCTTCT CTCTGTCCCT GGCCTTCGGA GGACACATCG CTTTTGCAAG TTACAACTCG 
CCCAGGAATG ACTGCCAGAA GGATGCGGTG GTCATCGCCC TGGTCAACAG GATGACCTCC 
CTGTACGCGT CCATCGCTGT CTTCTCTGTC CTGGGGTTCA AAGCAACTAA TGACTACGAG 
CACTGCCTGG ACAGAAACAT CCTCAGCCTC ATCAACGACT TTGACTTCCC AGAGCAGAGC 
ATCTCCAGGG ACGACTACCC AGCCGTCCTC ATGCACCTGA ACGCCACCTG GCCCAAGAGG 
GTGGCCCAGC TCCCCCTGAA GGCCTGCCTC CTGGAAGACT TTCTGGATAA GAGTGCCTCG 
GGCCCGGGCC TGGCCTTCGT CGTCTTCACG GAGACCGACC TCCACATGCC GGGGGCTCCT 
GTGTGGGCCA TGCTCTTCTT CGGGATGCTG TTCACCTTGG GGCTATCGAC CATGTTCGGG 
ACCGTGGAGG CGGTCATCAC ACCCCTGCTG GACGTGGGGG TCCTGCCTAG ATGGGTCCCC 
AAGGAGGCCC TGACTGGGCT GGTCTGCCTG GTCTGCTTCC TCTCCGCCAC CTGCTTCACG 
CTGCAGTCTG GGAACTACTG GCTGGAGATT TTCGACAATT TTGCCGCTTC CCCGAACCTG 
CTCATGTTGG CCTTTCTCGA GGTTGTGGGT GTCGTTTATG TTTATGGAAT GAAACGGTTC 
TGCGATGACA TTGCGTGGAT GACCGGGAGG CGGCCCAGCC CCTACTGGCG GCTGACCTGG 
AGGGTGGTCA GTCCCCTGCT GCTGACCATC TTTGTGGCTT ACATCATCCT CCTGTTCTGG 
AAGCCACTGA GATACAAGGC CTGGAACCCC AAATACGAGC TGTTCCCCTC GCGTCAGGAG 
AAGCTCTACC CGGGCTGGGC GCGCGCCGCC TGTGTGCTGC TGTCCTTGCT GCCCGTGCTG 
TGGGTCCCGG TGGCCGCGCT TGCTCAGCTG CTCACCCGGC GGAGGCGGAC GTGGAGGGAC 
AGGGACGCGC GCCCAGACAC GGACATGCGC CCGGACACGG ACACGCGCCC AGACACGGAC 
ATGCGCCCGG ACACGGACAT GCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_872438.2
CDS	98..1984
Translation	MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRDRDARPDTDMRPDTDTRPDTDMRPDTDMR

Target ORF information:

RefSeq Version	NM_182632.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 18 (SLC6A18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182632.3

ORF Insert Sequence:

ATGGCTCATG CCCCAGAACC GGACCCGGCC GCCTGCGACC TCGGGGATGA GAGGCCCAAG 
TGGGACAACA AGGCCCAGTA CCTCCTGAGC TGCACTGGGT TTGCCGTGGG ACTGGGGAAC 
ATTTGGCGGT TCCCATACCT GTGCCAGACC TATGGAGGAG GGGCCTTCCT CATCCCCTAC 
GTCATCGCGC TGGTCTTCGA GGGGATCCCC ATTTTCCACG TCGAGCTCGC CATCGGCCAG 
CGGCTGCGGA AGGGCAGCGT CGGCGTGTGG ACGGCCATCT CCCCGTACCT CAGTGGAGTA 
GGGCTGGGCT GTGTCACGCT GTCCTTCCTG ATCAGCCTGT ACTACAACAC CATCGTGGCG 
TGGGTGCTGT GGTACCTCCT CAACTCCTTC CAGCACCCGC TGCCCTGGAG CTCCTGCCCA 
CCGGACCTCA ACAGAACAGG GTTTGTGGAG GAGTGCCAGG GCAGCAGCGC CGTGAGCTAC 
TTCTGGTACC GGCAGACACT GAACATCACA GCCGACATCA ATGACAGTGG CTCCATCCAG 
TGGTGGCTGC TCATCTGCTT GGCAGCCTCC TGGGCAGTCG TGTACATGTG TGTCATCAGG 
GGCATTGAGA CTACAGGGAA GGTGATTTAC TTCACAGCTT TGTTCCCTTA CCTGGTCCTG 
ACCATCTTTC TCATCAGAGG GCTGACCCTG CCAGGGGCAA CAAAAGGACT CATCTACTTG 
TTCACTCCCA ACATGCACAT TCTCCAGAAC CCCCGGGTGT GGCTGGACGC AGCCACCCAG 
ATATTCTTCT CTCTGTCCCT GGCCTTCGGA GGACACATCG CTTTTGCAAG TTACAACTCG 
CCCAGGAATG ACTGCCAGAA GGATGCGGTG GTCATCGCCC TGGTCAACAG GATGACCTCC 
CTGTACGCGT CCATCGCTGT CTTCTCTGTC CTGGGGTTCA AAGCAACTAA TGACTACGAG 
CACTGCCTGG ACAGAAACAT CCTCAGCCTC ATCAACGACT TTGACTTCCC AGAGCAGAGC 
ATCTCCAGGG ACGACTACCC AGCCGTCCTC ATGCACCTGA ACGCCACCTG GCCCAAGAGG 
GTGGCCCAGC TCCCCCTGAA GGCCTGCCTC CTGGAAGACT TTCTGGATAA GAGTGCCTCG 
GGCCCGGGCC TGGCCTTCGT CGTCTTCACG GAGACCGACC TCCACATGCC GGGGGCTCCT 
GTGTGGGCCA TGCTCTTCTT CGGGATGCTG TTCACCTTGG GGCTATCGAC CATGTTCGGG 
ACCGTGGAGG CGGTCATCAC ACCCCTGCTG GACGTGGGGG TCCTGCCTAG ATGGGTCCCC 
AAGGAGGCCC TGACTGGGCT GGTCTGCCTG GTCTGCTTCC TCTCCGCCAC CTGCTTCACG 
CTGCAGTCTG GGAACTACTG GCTGGAGATT TTCGACAATT TTGCCGCTTC CCCGAACCTG 
CTCATGTTGG CCTTTCTCGA GGTTGTGGGT GTCGTTTATG TTTATGGAAT GAAACGGTTC 
TGCGATGACA TTGCGTGGAT GACCGGGAGG CGGCCCAGCC CCTACTGGCG GCTGACCTGG 
AGGGTGGTCA GTCCCCTGCT GCTGACCATC TTTGTGGCTT ACATCATCCT CCTGTTCTGG 
AAGCCACTGA GATACAAGGC CTGGAACCCC AAATACGAGC TGTTCCCCTC GCGTCAGGAG 
AAGCTCTACC CGGGCTGGGC GCGCGCCGCC TGTGTGCTGC TGTCCTTGCT GCCCGTGCTG 
TGGGTCCCGG TGGCCGCGCT TGCTCAGCTG CTCACCCGGC GGAGGCGGAC GTGGAGGGAC 
AGGGACGCGC GCCCAGACAC GGACATGCGC CCGGACACGG ACACGCGCCC AGACACGGAC 
ATGCGCCCGG ACACGGACAT GCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC6A18 ( NM_182632.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_872438.2 Homo sapiens solute carrier family 6 member 18 (SLC6A18), mRNA.

Price & Availability↑

CloneID	OHu31360
Clone ID Related Accession (Same CDS sequence)	NM_182632.3 , NM_182632.2
Accession Version	NM_182632.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1887bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sodium-dependent neutral amino acid transporter B(0)AT3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK055798.1 and BC056757.1. On Jul 10, 2008 this sequence version replaced NM_182632.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055798.1, BC056757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCATG CCCCAGAACC GGACCCGGCC GCCTGCGACC TCGGGGATGA GAGGCCCAAG 
TGGGACAACA AGGCCCAGTA CCTCCTGAGC TGCACTGGGT TTGCCGTGGG ACTGGGGAAC 
ATTTGGCGGT TCCCATACCT GTGCCAGACC TATGGAGGAG GGGCCTTCCT CATCCCCTAC 
GTCATCGCGC TGGTCTTCGA GGGGATCCCC ATTTTCCACG TCGAGCTCGC CATCGGCCAG 
CGGCTGCGGA AGGGCAGCGT CGGCGTGTGG ACGGCCATCT CCCCGTACCT CAGTGGAGTA 
GGGCTGGGCT GTGTCACGCT GTCCTTCCTG ATCAGCCTGT ACTACAACAC CATCGTGGCG 
TGGGTGCTGT GGTACCTCCT CAACTCCTTC CAGCACCCGC TGCCCTGGAG CTCCTGCCCA 
CCGGACCTCA ACAGAACAGG GTTTGTGGAG GAGTGCCAGG GCAGCAGCGC CGTGAGCTAC 
TTCTGGTACC GGCAGACACT GAACATCACA GCCGACATCA ATGACAGTGG CTCCATCCAG 
TGGTGGCTGC TCATCTGCTT GGCAGCCTCC TGGGCAGTCG TGTACATGTG TGTCATCAGG 
GGCATTGAGA CTACAGGGAA GGTGATTTAC TTCACAGCTT TGTTCCCTTA CCTGGTCCTG 
ACCATCTTTC TCATCAGAGG GCTGACCCTG CCAGGGGCAA CAAAAGGACT CATCTACTTG 
TTCACTCCCA ACATGCACAT TCTCCAGAAC CCCCGGGTGT GGCTGGACGC AGCCACCCAG 
ATATTCTTCT CTCTGTCCCT GGCCTTCGGA GGACACATCG CTTTTGCAAG TTACAACTCG 
CCCAGGAATG ACTGCCAGAA GGATGCGGTG GTCATCGCCC TGGTCAACAG GATGACCTCC 
CTGTACGCGT CCATCGCTGT CTTCTCTGTC CTGGGGTTCA AAGCAACTAA TGACTACGAG 
CACTGCCTGG ACAGAAACAT CCTCAGCCTC ATCAACGACT TTGACTTCCC AGAGCAGAGC 
ATCTCCAGGG ACGACTACCC AGCCGTCCTC ATGCACCTGA ACGCCACCTG GCCCAAGAGG 
GTGGCCCAGC TCCCCCTGAA GGCCTGCCTC CTGGAAGACT TTCTGGATAA GAGTGCCTCG 
GGCCCGGGCC TGGCCTTCGT CGTCTTCACG GAGACCGACC TCCACATGCC GGGGGCTCCT 
GTGTGGGCCA TGCTCTTCTT CGGGATGCTG TTCACCTTGG GGCTATCGAC CATGTTCGGG 
ACCGTGGAGG CGGTCATCAC ACCCCTGCTG GACGTGGGGG TCCTGCCTAG ATGGGTCCCC 
AAGGAGGCCC TGACTGGGCT GGTCTGCCTG GTCTGCTTCC TCTCCGCCAC CTGCTTCACG 
CTGCAGTCTG GGAACTACTG GCTGGAGATT TTCGACAATT TTGCCGCTTC CCCGAACCTG 
CTCATGTTGG CCTTTCTCGA GGTTGTGGGT GTCGTTTATG TTTATGGAAT GAAACGGTTC 
TGCGATGACA TTGCGTGGAT GACCGGGAGG CGGCCCAGCC CCTACTGGCG GCTGACCTGG 
AGGGTGGTCA GTCCCCTGCT GCTGACCATC TTTGTGGCTT ACATCATCCT CCTGTTCTGG 
AAGCCACTGA GATACAAGGC CTGGAACCCC AAATACGAGC TGTTCCCCTC GCGTCAGGAG 
AAGCTCTACC CGGGCTGGGC GCGCGCCGCC TGTGTGCTGC TGTCCTTGCT GCCCGTGCTG 
TGGGTCCCGG TGGCCGCGCT TGCTCAGCTG CTCACCCGGC GGAGGCGGAC GTGGAGGGAC 
AGGGACGCGC GCCCAGACAC GGACATGCGC CCGGACACGG ACACGCGCCC AGACACGGAC 
ATGCGCCCGG ACACGGACAT GCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_872438.2
CDS	124..2010
Translation	MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRDRDARPDTDMRPDTDTRPDTDMRPDTDMR

Target ORF information:

RefSeq Version	NM_182632.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 18 (SLC6A18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182632.2

ORF Insert Sequence:

ATGGCTCATG CCCCAGAACC GGACCCGGCC GCCTGCGACC TCGGGGATGA GAGGCCCAAG 
TGGGACAACA AGGCCCAGTA CCTCCTGAGC TGCACTGGGT TTGCCGTGGG ACTGGGGAAC 
ATTTGGCGGT TCCCATACCT GTGCCAGACC TATGGAGGAG GGGCCTTCCT CATCCCCTAC 
GTCATCGCGC TGGTCTTCGA GGGGATCCCC ATTTTCCACG TCGAGCTCGC CATCGGCCAG 
CGGCTGCGGA AGGGCAGCGT CGGCGTGTGG ACGGCCATCT CCCCGTACCT CAGTGGAGTA 
GGGCTGGGCT GTGTCACGCT GTCCTTCCTG ATCAGCCTGT ACTACAACAC CATCGTGGCG 
TGGGTGCTGT GGTACCTCCT CAACTCCTTC CAGCACCCGC TGCCCTGGAG CTCCTGCCCA 
CCGGACCTCA ACAGAACAGG GTTTGTGGAG GAGTGCCAGG GCAGCAGCGC CGTGAGCTAC 
TTCTGGTACC GGCAGACACT GAACATCACA GCCGACATCA ATGACAGTGG CTCCATCCAG 
TGGTGGCTGC TCATCTGCTT GGCAGCCTCC TGGGCAGTCG TGTACATGTG TGTCATCAGG 
GGCATTGAGA CTACAGGGAA GGTGATTTAC TTCACAGCTT TGTTCCCTTA CCTGGTCCTG 
ACCATCTTTC TCATCAGAGG GCTGACCCTG CCAGGGGCAA CAAAAGGACT CATCTACTTG 
TTCACTCCCA ACATGCACAT TCTCCAGAAC CCCCGGGTGT GGCTGGACGC AGCCACCCAG 
ATATTCTTCT CTCTGTCCCT GGCCTTCGGA GGACACATCG CTTTTGCAAG TTACAACTCG 
CCCAGGAATG ACTGCCAGAA GGATGCGGTG GTCATCGCCC TGGTCAACAG GATGACCTCC 
CTGTACGCGT CCATCGCTGT CTTCTCTGTC CTGGGGTTCA AAGCAACTAA TGACTACGAG 
CACTGCCTGG ACAGAAACAT CCTCAGCCTC ATCAACGACT TTGACTTCCC AGAGCAGAGC 
ATCTCCAGGG ACGACTACCC AGCCGTCCTC ATGCACCTGA ACGCCACCTG GCCCAAGAGG 
GTGGCCCAGC TCCCCCTGAA GGCCTGCCTC CTGGAAGACT TTCTGGATAA GAGTGCCTCG 
GGCCCGGGCC TGGCCTTCGT CGTCTTCACG GAGACCGACC TCCACATGCC GGGGGCTCCT 
GTGTGGGCCA TGCTCTTCTT CGGGATGCTG TTCACCTTGG GGCTATCGAC CATGTTCGGG 
ACCGTGGAGG CGGTCATCAC ACCCCTGCTG GACGTGGGGG TCCTGCCTAG ATGGGTCCCC 
AAGGAGGCCC TGACTGGGCT GGTCTGCCTG GTCTGCTTCC TCTCCGCCAC CTGCTTCACG 
CTGCAGTCTG GGAACTACTG GCTGGAGATT TTCGACAATT TTGCCGCTTC CCCGAACCTG 
CTCATGTTGG CCTTTCTCGA GGTTGTGGGT GTCGTTTATG TTTATGGAAT GAAACGGTTC 
TGCGATGACA TTGCGTGGAT GACCGGGAGG CGGCCCAGCC CCTACTGGCG GCTGACCTGG 
AGGGTGGTCA GTCCCCTGCT GCTGACCATC TTTGTGGCTT ACATCATCCT CCTGTTCTGG 
AAGCCACTGA GATACAAGGC CTGGAACCCC AAATACGAGC TGTTCCCCTC GCGTCAGGAG 
AAGCTCTACC CGGGCTGGGC GCGCGCCGCC TGTGTGCTGC TGTCCTTGCT GCCCGTGCTG 
TGGGTCCCGG TGGCCGCGCT TGCTCAGCTG CTCACCCGGC GGAGGCGGAC GTGGAGGGAC 
AGGGACGCGC GCCCAGACAC GGACATGCGC CCGGACACGG ACACGCGCCC AGACACGGAC 
ATGCGCCCGG ACACGGACAT GCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
The Journal of biological chemistry290(40)24308-25(2015 Oct)
Fairweather SJ,Br?er A,Subramanian N,Tumer E,Cheng Q,Schmoll D,O'Mara ML,Br?er S

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Nature genetics46(9)994-1000(2014 Sep)
Wolpin BM,Rizzato C,Kraft P,Kooperberg C,Petersen GM,Wang Z,Arslan AA,Beane-Freeman L,Bracci PM,Buring J,Canzian F,Duell EJ,Gallinger S,Giles GG,Goodman GE,Goodman PJ,Jacobs EJ,Kamineni A,Klein AP,Kolonel LN,Kulke MH,Li D,Malats N,Olson SH,Risch HA,Sesso HD,Visvanathan K,White E,Zheng W,Abnet CC,Albanes D,Andreotti G,Austin MA,Barfield R,Basso D,Berndt SI,Boutron-Ruault MC,Brotzman M,B?chler MW,Bueno-de-Mesquita HB,Bugert P,Burdette L,Campa D,Caporaso NE,Capurso G,Chung C,Cotterchio M,Costello E,Elena J,Funel N,Gaziano JM,Giese NA,Giovannucci EL,Goggins M,Gorman MJ,Gross M,Haiman CA,Hassan M,Helzlsouer KJ,Henderson BE,Holly EA,Hu N,Hunter DJ,Innocenti F,Jenab M,Kaaks R,Key TJ,Khaw KT,Klein EA,Kogevinas M,Krogh V,Kupcinskas J,Kurtz RC,LaCroix A,Landi MT,Landi S,Le Marchand L,Mambrini A,Mannisto S,Milne RL,Nakamura Y,Oberg AL,Owzar K,Patel AV,Peeters PH,Peters U,Pezzilli R,Piepoli A,Porta M,Real FX,Riboli E,Rothman N,Scarpa A,Shu XO,Silverman DT,Soucek P,Sund M,Talar-Wojnarowska R,Taylor PR,Theodoropoulos GE,Thornquist M,Tj?nneland A,Tobias GS,Trichopoulos D,Vodicka P,Wactawski-Wende J,Wentzensen N,Wu C,Yu H,Yu K,Zeleniuch-Jacquotte A,Hoover R,Hartge P,Fuchs C,Chanock SJ,Stolzenberg-Solomon RS,Amundadottir LT

Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.
Genetics research96e004(2014)
Friedman E,Moran DS,Ben-Avraham D,Yanovich R,Atzmon G

Association study: SLC6A18 gene and myocardial infarction.
Clinical biochemistry44(10-11)789-94(2011 Jul)
Matsumoto K,Shimodaira M,Nakagawa T,Nakayama T,Nakazato T,Izumi Y,Soma M,Matsumoto K,Sato N,Aoi N

Genetic susceptibility to distinct bladder cancer subphenotypes.
European urology57(2)283-92(2010 Feb)
Guey LT,Garc?a-Closas M,Murta-Nascimento C,Lloreta J,Palencia L,Kogevinas M,Rothman N,Vellalta G,Calle ML,Marenne G,Tard?n A,Carrato A,Garc?a-Closas R,Serra C,Silverman DT,Chanock S,Real FX,Malats N,

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SLC6A18 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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