IGFALS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IGFALS
Entrez Gene ID	3483
Full Name	insulin like growth factor binding protein acid labile subunit
Synonyms	ACLSD,ALS
General protein information	Preferred Names insulin like growth factor binding protein acid labile subunit Names insulin-like growth factor-binding protein complex acid labile subunit insulin-like growth factor binding protein complex acid labile chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Disorder MIM:	601489
Disorder Html:	Acid-labile subunit, deficiency of, 615961 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004970.3	NP_004961.1	insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor
NM_004970.2	NP_004961.1	insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor
NM_001146006.1	NP_001139478.1	insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor
NM_001146006.2	NP_001139478.1	insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IGFALS	XP_547189.4
Mus musculus (house mouse)	Igfals	NP_032366.2
Pan troglodytes (chimpanzee)	IGFALS	XP_001172738.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007061	XP_565143.2
Gallus gallus (chicken)	IGFALS	XP_004945462.1
Xenopus tropicalis (tropical clawed frog)	igfals	XP_002940278.1
Homo sapiens (human)	IGFALS	NP_001139478.1
Rattus norvegicus (Norway rat)	Igfals	NP_445781.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007059	XP_001688062.1
	LOC722493	XP_002802399.1
Bos taurus (cattle)	IGFALS	NP_001069431.1
Danio rerio (zebrafish)	si:ch211-66h3.1	XP_003198203.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007060	XP_565144.3

Gene Ontology
Bibliography

Related articles in PubMed

Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms.
Rotwein P
The Journal of biological chemistry292(22)9252-9261(2017 06)

Clinical and biochemical characteristics and bone mineral density of homozygous, compound heterozygous and heterozygous carriers of three novel
I??k E, Haliloglu B, van Doorn J, Demirbilek H, Scheltinga SA, Losekoot M, Wit JM
European journal of endocrinology176(6)657-667(2017 Jun)

Assessment of pathogenicity of natural IGFALS gene variants by in silico bioinformatics tools and in?vitro functional studies.
Martucci LC, Guti?rrez ML, Karabatas LM, Scaglia PA, Rey RA, Domen? HM, Jasper HG, Domen? S
Molecular and cellular endocrinology42919-28(2016 07)

[Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues].
Li GL, Niu LL, Liu HF, Guo JZ
Yi chuan = Hereditas37(12)1185-93(2015 12)

IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration.
H?gler W, Martin DD, Crabtree N, Nightingale P, Tomlinson J, Metherell L, Rosenfeld R, Hwa V, Rose S, Walker J, Shaw N, Barrett T, Frystyk J
The Journal of clinical endocrinology and metabolism99(4)E703-12(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Previously characterized disease-causing mutations in IGF2, IGF1R, IGF2R, or IGFALS all were found in the general population but with allele frequencies of <1:30,000.
Title: Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms.

To the known phenotype of ACLSD (i.e. short stature, reduced serum levels of IGF-I and ALS, extremely low serum IGFBP-3 and disturbed ternary complex formation), the study adds reduced birth weight, head circumference and serum IGF-II.
Title: Clinical and biochemical characteristics and bone mineral density of homozygous, compound heterozygous and heterozygous carriers of three novel

The aim of this study was to evaluate the potential pathogenicity of eleven IGFALS variants.
Title: Assessment of pathogenicity of natural IGFALS gene variants by in silico bioinformatics tools and in?vitro functional studies.

Mutations in the IGFALS and low expression level of IGFALS proteins lead to growth and development retardation. [Review]
Title: [Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues].

These gene dosage effects demonstrate that one functional IGFALS allele is insufficient to maintain normal ALS levels, endocrine IGF-I action, full growth potential, muscle size, and periosteal expansion.
Title: IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration.

The following IGFALS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGFALS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22278	NM_004970.3 Latest version!	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu31932	NM_001146006.2 Latest version!	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu22278	NM_004970.2	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu31932	NM_001146006.1	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IGFALS ( NM_004970.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004961.1 Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22278
Clone ID Related Accession (Same CDS sequence)	NM_004970.3 , NM_004970.2
Accession Version	NM_004970.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1818bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025681.1 and AC012180.6. On Nov 30, 2019 this sequence version replaced NM_004970.2. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025681.1, M86826.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTGA GGAAAGGAGG CCTGGCCCTG GCGCTGCTGC TGCTGTCCTG GGTGGCACTG 
GGCCCCCGCA GCCTGGAGGG AGCAGACCCC GGAACGCCGG GGGAAGCCGA GGGCCCAGCG 
TGCCCGGCCG CCTGTGTCTG CAGCTACGAT GACGACGCGG ATGAGCTCAG CGTCTTCTGC 
AGCTCCAGGA ACCTCACGCG CCTGCCTGAT GGAGTCCCGG GCGGCACCCA AGCCCTGTGG 
CTGGACGGCA ACAACCTCTC GTCCGTCCCC CCGGCAGCCT TCCAGAACCT CTCCAGCCTG 
GGCTTCCTCA ACCTGCAGGG CGGCCAGCTG GGCAGCCTGG AGCCACAGGC GCTGCTGGGC 
CTAGAGAACC TGTGCCACCT GCACCTGGAG CGGAACCAGC TGCGCAGCCT GGCACTCGGC 
ACGTTTGCAC ACACGCCCGC GCTGGCCTCG CTCGGCCTCA GCAACAACCG TCTGAGCAGG 
CTGGAGGACG GGCTCTTCGA GGGCCTCGGC AGCCTCTGGG ACCTCAACCT CGGCTGGAAT 
AGCCTGGCGG TGCTCCCCGA TGCGGCGTTC CGCGGCCTGG GCAGCCTGCG CGAGCTGGTG 
CTGGCGGGCA ACAGGCTGGC CTACCTGCAG CCCGCGCTCT TCAGCGGCCT GGCCGAGCTC 
CGGGAGCTGG ACCTGAGCAG GAACGCGCTG CGGGCCATCA AGGCAAACGT GTTCGTGCAG 
CTGCCCCGGC TCCAGAAACT CTACCTGGAC CGCAACCTCA TCGCTGCCGT GGCCCCGGGC 
GCCTTCCTGG GCCTGAAGGC GCTGCGATGG CTGGACCTGT CCCACAACCG CGTGGCTGGC 
CTCCTGGAGG ACACGTTCCC CGGTCTGCTG GGCCTGCGTG TGCTGCGGCT GTCCCACAAC 
GCCATCGCCA GCCTGCGGCC CCGCACCTTC AAGGACCTGC ACTTCCTGGA GGAGCTGCAG 
CTGGGCCACA ACCGCATCCG GCAGCTGGCT GAGCGCAGCT TTGAGGGCCT GGGGCAGCTT 
GAGGTGCTCA CGCTAGACCA CAACCAGCTC CAGGAGGTCA AGGCGGGCGC TTTCCTCGGC 
CTCACCAACG TGGCGGTCAT GAACCTCTCT GGGAACTGTC TCCGGAACCT TCCGGAGCAG 
GTGTTCCGGG GCCTGGGCAA GCTGCACAGC CTGCACCTGG AGGGCAGCTG CCTGGGACGC 
ATCCGCCCGC ACACCTTCAC CGGCCTCTCG GGGCTCCGCC GACTCTTCCT CAAGGACAAC 
GGCCTCGTGG GCATTGAGGA GCAGAGCCTG TGGGGGCTGG CGGAGCTGCT GGAGCTCGAC 
CTGACCTCCA ACCAGCTCAC GCACCTGCCC CACCGCCTCT TCCAGGGCCT GGGCAAGCTG 
GAGTACCTGC TGCTCTCCCG CAACCGCCTG GCAGAGCTGC CGGCGGACGC CCTGGGCCCC 
CTGCAGCGGG CCTTCTGGCT GGACGTCTCG CACAACCGCC TGGAGGCATT GCCCAACAGC 
CTCTTGGCAC CACTGGGGCG GCTGCGCTAC CTCAGCCTCA GGAACAACTC ACTGCGGACC 
TTCACGCCGC AGCCCCCGGG CCTGGAGCGC CTGTGGCTGG AGGGTAACCC CTGGGACTGT 
GGCTGCCCTC TCAAGGCGCT GCGGGACTTC GCCCTGCAGA ACCCCAGTGC TGTGCCCCGC 
TTCGTCCAGG CCATCTGTGA GGGGGACGAT TGCCAGCCGC CCGCGTACAC CTACAACAAC 
ATCACCTGTG CCAGCCCGCC CGAGGTCGTG GGGCTCGACC TGCGGGACCT CAGCGAGGCC 
CACTTTGCTC CCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004961.1
CDS	54..1871
Translation	MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC

Target ORF information:

RefSeq Version	NM_004970.3
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004970.3

ORF Insert Sequence:

ATGGCCCTGA GGAAAGGAGG CCTGGCCCTG GCGCTGCTGC TGCTGTCCTG GGTGGCACTG 
GGCCCCCGCA GCCTGGAGGG AGCAGACCCC GGAACGCCGG GGGAAGCCGA GGGCCCAGCG 
TGCCCGGCCG CCTGTGTCTG CAGCTACGAT GACGACGCGG ATGAGCTCAG CGTCTTCTGC 
AGCTCCAGGA ACCTCACGCG CCTGCCTGAT GGAGTCCCGG GCGGCACCCA AGCCCTGTGG 
CTGGACGGCA ACAACCTCTC GTCCGTCCCC CCGGCAGCCT TCCAGAACCT CTCCAGCCTG 
GGCTTCCTCA ACCTGCAGGG CGGCCAGCTG GGCAGCCTGG AGCCACAGGC GCTGCTGGGC 
CTAGAGAACC TGTGCCACCT GCACCTGGAG CGGAACCAGC TGCGCAGCCT GGCACTCGGC 
ACGTTTGCAC ACACGCCCGC GCTGGCCTCG CTCGGCCTCA GCAACAACCG TCTGAGCAGG 
CTGGAGGACG GGCTCTTCGA GGGCCTCGGC AGCCTCTGGG ACCTCAACCT CGGCTGGAAT 
AGCCTGGCGG TGCTCCCCGA TGCGGCGTTC CGCGGCCTGG GCAGCCTGCG CGAGCTGGTG 
CTGGCGGGCA ACAGGCTGGC CTACCTGCAG CCCGCGCTCT TCAGCGGCCT GGCCGAGCTC 
CGGGAGCTGG ACCTGAGCAG GAACGCGCTG CGGGCCATCA AGGCAAACGT GTTCGTGCAG 
CTGCCCCGGC TCCAGAAACT CTACCTGGAC CGCAACCTCA TCGCTGCCGT GGCCCCGGGC 
GCCTTCCTGG GCCTGAAGGC GCTGCGATGG CTGGACCTGT CCCACAACCG CGTGGCTGGC 
CTCCTGGAGG ACACGTTCCC CGGTCTGCTG GGCCTGCGTG TGCTGCGGCT GTCCCACAAC 
GCCATCGCCA GCCTGCGGCC CCGCACCTTC AAGGACCTGC ACTTCCTGGA GGAGCTGCAG 
CTGGGCCACA ACCGCATCCG GCAGCTGGCT GAGCGCAGCT TTGAGGGCCT GGGGCAGCTT 
GAGGTGCTCA CGCTAGACCA CAACCAGCTC CAGGAGGTCA AGGCGGGCGC TTTCCTCGGC 
CTCACCAACG TGGCGGTCAT GAACCTCTCT GGGAACTGTC TCCGGAACCT TCCGGAGCAG 
GTGTTCCGGG GCCTGGGCAA GCTGCACAGC CTGCACCTGG AGGGCAGCTG CCTGGGACGC 
ATCCGCCCGC ACACCTTCAC CGGCCTCTCG GGGCTCCGCC GACTCTTCCT CAAGGACAAC 
GGCCTCGTGG GCATTGAGGA GCAGAGCCTG TGGGGGCTGG CGGAGCTGCT GGAGCTCGAC 
CTGACCTCCA ACCAGCTCAC GCACCTGCCC CACCGCCTCT TCCAGGGCCT GGGCAAGCTG 
GAGTACCTGC TGCTCTCCCG CAACCGCCTG GCAGAGCTGC CGGCGGACGC CCTGGGCCCC 
CTGCAGCGGG CCTTCTGGCT GGACGTCTCG CACAACCGCC TGGAGGCATT GCCCAACAGC 
CTCTTGGCAC CACTGGGGCG GCTGCGCTAC CTCAGCCTCA GGAACAACTC ACTGCGGACC 
TTCACGCCGC AGCCCCCGGG CCTGGAGCGC CTGTGGCTGG AGGGTAACCC CTGGGACTGT 
GGCTGCCCTC TCAAGGCGCT GCGGGACTTC GCCCTGCAGA ACCCCAGTGC TGTGCCCCGC 
TTCGTCCAGG CCATCTGTGA GGGGGACGAT TGCCAGCCGC CCGCGTACAC CTACAACAAC 
ATCACCTGTG CCAGCCCGCC CGAGGTCGTG GGGCTCGACC TGCGGGACCT CAGCGAGGCC 
CACTTTGCTC CCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGFALS ( NM_004970.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004961.1 Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22278
Clone ID Related Accession (Same CDS sequence)	NM_004970.3 , NM_004970.2
Accession Version	NM_004970.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1818bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025681.1 and AC012180.6. This sequence is a reference standard in the RefSeqGene project. On Mar 24, 2009 this sequence version replaced NM_004970.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025681.1, M86826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTGA GGAAAGGAGG CCTGGCCCTG GCGCTGCTGC TGCTGTCCTG GGTGGCACTG 
GGCCCCCGCA GCCTGGAGGG AGCAGACCCC GGAACGCCGG GGGAAGCCGA GGGCCCAGCG 
TGCCCGGCCG CCTGTGTCTG CAGCTACGAT GACGACGCGG ATGAGCTCAG CGTCTTCTGC 
AGCTCCAGGA ACCTCACGCG CCTGCCTGAT GGAGTCCCGG GCGGCACCCA AGCCCTGTGG 
CTGGACGGCA ACAACCTCTC GTCCGTCCCC CCGGCAGCCT TCCAGAACCT CTCCAGCCTG 
GGCTTCCTCA ACCTGCAGGG CGGCCAGCTG GGCAGCCTGG AGCCACAGGC GCTGCTGGGC 
CTAGAGAACC TGTGCCACCT GCACCTGGAG CGGAACCAGC TGCGCAGCCT GGCACTCGGC 
ACGTTTGCAC ACACGCCCGC GCTGGCCTCG CTCGGCCTCA GCAACAACCG TCTGAGCAGG 
CTGGAGGACG GGCTCTTCGA GGGCCTCGGC AGCCTCTGGG ACCTCAACCT CGGCTGGAAT 
AGCCTGGCGG TGCTCCCCGA TGCGGCGTTC CGCGGCCTGG GCAGCCTGCG CGAGCTGGTG 
CTGGCGGGCA ACAGGCTGGC CTACCTGCAG CCCGCGCTCT TCAGCGGCCT GGCCGAGCTC 
CGGGAGCTGG ACCTGAGCAG GAACGCGCTG CGGGCCATCA AGGCAAACGT GTTCGTGCAG 
CTGCCCCGGC TCCAGAAACT CTACCTGGAC CGCAACCTCA TCGCTGCCGT GGCCCCGGGC 
GCCTTCCTGG GCCTGAAGGC GCTGCGATGG CTGGACCTGT CCCACAACCG CGTGGCTGGC 
CTCCTGGAGG ACACGTTCCC CGGTCTGCTG GGCCTGCGTG TGCTGCGGCT GTCCCACAAC 
GCCATCGCCA GCCTGCGGCC CCGCACCTTC AAGGACCTGC ACTTCCTGGA GGAGCTGCAG 
CTGGGCCACA ACCGCATCCG GCAGCTGGCT GAGCGCAGCT TTGAGGGCCT GGGGCAGCTT 
GAGGTGCTCA CGCTAGACCA CAACCAGCTC CAGGAGGTCA AGGCGGGCGC TTTCCTCGGC 
CTCACCAACG TGGCGGTCAT GAACCTCTCT GGGAACTGTC TCCGGAACCT TCCGGAGCAG 
GTGTTCCGGG GCCTGGGCAA GCTGCACAGC CTGCACCTGG AGGGCAGCTG CCTGGGACGC 
ATCCGCCCGC ACACCTTCAC CGGCCTCTCG GGGCTCCGCC GACTCTTCCT CAAGGACAAC 
GGCCTCGTGG GCATTGAGGA GCAGAGCCTG TGGGGGCTGG CGGAGCTGCT GGAGCTCGAC 
CTGACCTCCA ACCAGCTCAC GCACCTGCCC CACCGCCTCT TCCAGGGCCT GGGCAAGCTG 
GAGTACCTGC TGCTCTCCCG CAACCGCCTG GCAGAGCTGC CGGCGGACGC CCTGGGCCCC 
CTGCAGCGGG CCTTCTGGCT GGACGTCTCG CACAACCGCC TGGAGGCATT GCCCAACAGC 
CTCTTGGCAC CACTGGGGCG GCTGCGCTAC CTCAGCCTCA GGAACAACTC ACTGCGGACC 
TTCACGCCGC AGCCCCCGGG CCTGGAGCGC CTGTGGCTGG AGGGTAACCC CTGGGACTGT 
GGCTGCCCTC TCAAGGCGCT GCGGGACTTC GCCCTGCAGA ACCCCAGTGC TGTGCCCCGC 
TTCGTCCAGG CCATCTGTGA GGGGGACGAT TGCCAGCCGC CCGCGTACAC CTACAACAAC 
ATCACCTGTG CCAGCCCGCC CGAGGTCGTG GGGCTCGACC TGCGGGACCT CAGCGAGGCC 
CACTTTGCTC CCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004961.1
CDS	82..1899
Translation	MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC

Target ORF information:

RefSeq Version	NM_004970.2
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004970.2

ORF Insert Sequence:

ATGGCCCTGA GGAAAGGAGG CCTGGCCCTG GCGCTGCTGC TGCTGTCCTG GGTGGCACTG 
GGCCCCCGCA GCCTGGAGGG AGCAGACCCC GGAACGCCGG GGGAAGCCGA GGGCCCAGCG 
TGCCCGGCCG CCTGTGTCTG CAGCTACGAT GACGACGCGG ATGAGCTCAG CGTCTTCTGC 
AGCTCCAGGA ACCTCACGCG CCTGCCTGAT GGAGTCCCGG GCGGCACCCA AGCCCTGTGG 
CTGGACGGCA ACAACCTCTC GTCCGTCCCC CCGGCAGCCT TCCAGAACCT CTCCAGCCTG 
GGCTTCCTCA ACCTGCAGGG CGGCCAGCTG GGCAGCCTGG AGCCACAGGC GCTGCTGGGC 
CTAGAGAACC TGTGCCACCT GCACCTGGAG CGGAACCAGC TGCGCAGCCT GGCACTCGGC 
ACGTTTGCAC ACACGCCCGC GCTGGCCTCG CTCGGCCTCA GCAACAACCG TCTGAGCAGG 
CTGGAGGACG GGCTCTTCGA GGGCCTCGGC AGCCTCTGGG ACCTCAACCT CGGCTGGAAT 
AGCCTGGCGG TGCTCCCCGA TGCGGCGTTC CGCGGCCTGG GCAGCCTGCG CGAGCTGGTG 
CTGGCGGGCA ACAGGCTGGC CTACCTGCAG CCCGCGCTCT TCAGCGGCCT GGCCGAGCTC 
CGGGAGCTGG ACCTGAGCAG GAACGCGCTG CGGGCCATCA AGGCAAACGT GTTCGTGCAG 
CTGCCCCGGC TCCAGAAACT CTACCTGGAC CGCAACCTCA TCGCTGCCGT GGCCCCGGGC 
GCCTTCCTGG GCCTGAAGGC GCTGCGATGG CTGGACCTGT CCCACAACCG CGTGGCTGGC 
CTCCTGGAGG ACACGTTCCC CGGTCTGCTG GGCCTGCGTG TGCTGCGGCT GTCCCACAAC 
GCCATCGCCA GCCTGCGGCC CCGCACCTTC AAGGACCTGC ACTTCCTGGA GGAGCTGCAG 
CTGGGCCACA ACCGCATCCG GCAGCTGGCT GAGCGCAGCT TTGAGGGCCT GGGGCAGCTT 
GAGGTGCTCA CGCTAGACCA CAACCAGCTC CAGGAGGTCA AGGCGGGCGC TTTCCTCGGC 
CTCACCAACG TGGCGGTCAT GAACCTCTCT GGGAACTGTC TCCGGAACCT TCCGGAGCAG 
GTGTTCCGGG GCCTGGGCAA GCTGCACAGC CTGCACCTGG AGGGCAGCTG CCTGGGACGC 
ATCCGCCCGC ACACCTTCAC CGGCCTCTCG GGGCTCCGCC GACTCTTCCT CAAGGACAAC 
GGCCTCGTGG GCATTGAGGA GCAGAGCCTG TGGGGGCTGG CGGAGCTGCT GGAGCTCGAC 
CTGACCTCCA ACCAGCTCAC GCACCTGCCC CACCGCCTCT TCCAGGGCCT GGGCAAGCTG 
GAGTACCTGC TGCTCTCCCG CAACCGCCTG GCAGAGCTGC CGGCGGACGC CCTGGGCCCC 
CTGCAGCGGG CCTTCTGGCT GGACGTCTCG CACAACCGCC TGGAGGCATT GCCCAACAGC 
CTCTTGGCAC CACTGGGGCG GCTGCGCTAC CTCAGCCTCA GGAACAACTC ACTGCGGACC 
TTCACGCCGC AGCCCCCGGG CCTGGAGCGC CTGTGGCTGG AGGGTAACCC CTGGGACTGT 
GGCTGCCCTC TCAAGGCGCT GCGGGACTTC GCCCTGCAGA ACCCCAGTGC TGTGCCCCGC 
TTCGTCCAGG CCATCTGTGA GGGGGACGAT TGCCAGCCGC CCGCGTACAC CTACAACAAC 
ATCACCTGTG CCAGCCCGCC CGAGGTCGTG GGGCTCGACC TGCGGGACCT CAGCGAGGCC 
CACTTTGCTC CCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGFALS ( NM_001146006.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139478.1 Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 1, mRNA.

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CloneID	OHu31932
Clone ID Related Accession (Same CDS sequence)	NM_001146006.1 , NM_001146006.2
Accession Version	NM_001146006.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025681.1, AK303146.1 and AC012180.6. On Jun 2, 2019 this sequence version replaced NM_001146006.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303146.1, DC405669.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTGA GGAAAGCGGG TGACCTCGAG CCTCAGTTCA CACCTGAGCG CCGCTTCCGG 
CTGTGCTGGT ATCAGGCTCA CTCGGGCAGA GCCCTCCTCG GGCCGCCTCC CCAAGCCTCT 
CCCCCCGCAG GAGGCCTGGC CCTGGCGCTG CTGCTGCTGT CCTGGGTGGC ACTGGGCCCC 
CGCAGCCTGG AGGGAGCAGA CCCCGGAACG CCGGGGGAAG CCGAGGGCCC AGCGTGCCCG 
GCCGCCTGTG TCTGCAGCTA CGATGACGAC GCGGATGAGC TCAGCGTCTT CTGCAGCTCC 
AGGAACCTCA CGCGCCTGCC TGATGGAGTC CCGGGCGGCA CCCAAGCCCT GTGGCTGGAC 
GGCAACAACC TCTCGTCCGT CCCCCCGGCA GCCTTCCAGA ACCTCTCCAG CCTGGGCTTC 
CTCAACCTGC AGGGCGGCCA GCTGGGCAGC CTGGAGCCAC AGGCGCTGCT GGGCCTAGAG 
AACCTGTGCC ACCTGCACCT GGAGCGGAAC CAGCTGCGCA GCCTGGCACT CGGCACGTTT 
GCACACACGC CCGCGCTGGC CTCGCTCGGC CTCAGCAACA ACCGTCTGAG CAGGCTGGAG 
GACGGGCTCT TCGAGGGCCT CGGCAGCCTC TGGGACCTCA ACCTCGGCTG GAATAGCCTG 
GCGGTGCTCC CCGATGCGGC GTTCCGCGGC CTGGGCAGCC TGCGCGAGCT GGTGCTGGCG 
GGCAACAGGC TGGCCTACCT GCAGCCCGCG CTCTTCAGCG GCCTGGCCGA GCTCCGGGAG 
CTGGACCTGA GCAGGAACGC GCTGCGGGCC ATCAAGGCAA ACGTGTTCGT GCAGCTGCCC 
CGGCTCCAGA AACTCTACCT GGACCGCAAC CTCATCGCTG CCGTGGCCCC GGGCGCCTTC 
CTGGGCCTGA AGGCGCTGCG ATGGCTGGAC CTGTCCCACA ACCGCGTGGC TGGCCTCCTG 
GAGGACACGT TCCCCGGTCT GCTGGGCCTG CGTGTGCTGC GGCTGTCCCA CAACGCCATC 
GCCAGCCTGC GGCCCCGCAC CTTCAAGGAC CTGCACTTCC TGGAGGAGCT GCAGCTGGGC 
CACAACCGCA TCCGGCAGCT GGCTGAGCGC AGCTTTGAGG GCCTGGGGCA GCTTGAGGTG 
CTCACGCTAG ACCACAACCA GCTCCAGGAG GTCAAGGCGG GCGCTTTCCT CGGCCTCACC 
AACGTGGCGG TCATGAACCT CTCTGGGAAC TGTCTCCGGA ACCTTCCGGA GCAGGTGTTC 
CGGGGCCTGG GCAAGCTGCA CAGCCTGCAC CTGGAGGGCA GCTGCCTGGG ACGCATCCGC 
CCGCACACCT TCACCGGCCT CTCGGGGCTC CGCCGACTCT TCCTCAAGGA CAACGGCCTC 
GTGGGCATTG AGGAGCAGAG CCTGTGGGGG CTGGCGGAGC TGCTGGAGCT CGACCTGACC 
TCCAACCAGC TCACGCACCT GCCCCACCGC CTCTTCCAGG GCCTGGGCAA GCTGGAGTAC 
CTGCTGCTCT CCCGCAACCG CCTGGCAGAG CTGCCGGCGG ACGCCCTGGG CCCCCTGCAG 
CGGGCCTTCT GGCTGGACGT CTCGCACAAC CGCCTGGAGG CATTGCCCAA CAGCCTCTTG 
GCACCACTGG GGCGGCTGCG CTACCTCAGC CTCAGGAACA ACTCACTGCG GACCTTCACG 
CCGCAGCCCC CGGGCCTGGA GCGCCTGTGG CTGGAGGGTA ACCCCTGGGA CTGTGGCTGC 
CCTCTCAAGG CGCTGCGGGA CTTCGCCCTG CAGAACCCCA GTGCTGTGCC CCGCTTCGTC 
CAGGCCATCT GTGAGGGGGA CGATTGCCAG CCGCCCGCGT ACACCTACAA CAACATCACC 
TGTGCCAGCC CGCCCGAGGT CGTGGGGCTC GACCTGCGGG ACCTCAGCGA GGCCCACTTT 
GCTCCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139478.1
CDS	54..1985
Translation	MALRKAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC

Target ORF information:

RefSeq Version	NM_001146006.2
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146006.2

ORF Insert Sequence:

ATGGCCCTGA GGAAAGCGGG TGACCTCGAG CCTCAGTTCA CACCTGAGCG CCGCTTCCGG 
CTGTGCTGGT ATCAGGCTCA CTCGGGCAGA GCCCTCCTCG GGCCGCCTCC CCAAGCCTCT 
CCCCCCGCAG GAGGCCTGGC CCTGGCGCTG CTGCTGCTGT CCTGGGTGGC ACTGGGCCCC 
CGCAGCCTGG AGGGAGCAGA CCCCGGAACG CCGGGGGAAG CCGAGGGCCC AGCGTGCCCG 
GCCGCCTGTG TCTGCAGCTA CGATGACGAC GCGGATGAGC TCAGCGTCTT CTGCAGCTCC 
AGGAACCTCA CGCGCCTGCC TGATGGAGTC CCGGGCGGCA CCCAAGCCCT GTGGCTGGAC 
GGCAACAACC TCTCGTCCGT CCCCCCGGCA GCCTTCCAGA ACCTCTCCAG CCTGGGCTTC 
CTCAACCTGC AGGGCGGCCA GCTGGGCAGC CTGGAGCCAC AGGCGCTGCT GGGCCTAGAG 
AACCTGTGCC ACCTGCACCT GGAGCGGAAC CAGCTGCGCA GCCTGGCACT CGGCACGTTT 
GCACACACGC CCGCGCTGGC CTCGCTCGGC CTCAGCAACA ACCGTCTGAG CAGGCTGGAG 
GACGGGCTCT TCGAGGGCCT CGGCAGCCTC TGGGACCTCA ACCTCGGCTG GAATAGCCTG 
GCGGTGCTCC CCGATGCGGC GTTCCGCGGC CTGGGCAGCC TGCGCGAGCT GGTGCTGGCG 
GGCAACAGGC TGGCCTACCT GCAGCCCGCG CTCTTCAGCG GCCTGGCCGA GCTCCGGGAG 
CTGGACCTGA GCAGGAACGC GCTGCGGGCC ATCAAGGCAA ACGTGTTCGT GCAGCTGCCC 
CGGCTCCAGA AACTCTACCT GGACCGCAAC CTCATCGCTG CCGTGGCCCC GGGCGCCTTC 
CTGGGCCTGA AGGCGCTGCG ATGGCTGGAC CTGTCCCACA ACCGCGTGGC TGGCCTCCTG 
GAGGACACGT TCCCCGGTCT GCTGGGCCTG CGTGTGCTGC GGCTGTCCCA CAACGCCATC 
GCCAGCCTGC GGCCCCGCAC CTTCAAGGAC CTGCACTTCC TGGAGGAGCT GCAGCTGGGC 
CACAACCGCA TCCGGCAGCT GGCTGAGCGC AGCTTTGAGG GCCTGGGGCA GCTTGAGGTG 
CTCACGCTAG ACCACAACCA GCTCCAGGAG GTCAAGGCGG GCGCTTTCCT CGGCCTCACC 
AACGTGGCGG TCATGAACCT CTCTGGGAAC TGTCTCCGGA ACCTTCCGGA GCAGGTGTTC 
CGGGGCCTGG GCAAGCTGCA CAGCCTGCAC CTGGAGGGCA GCTGCCTGGG ACGCATCCGC 
CCGCACACCT TCACCGGCCT CTCGGGGCTC CGCCGACTCT TCCTCAAGGA CAACGGCCTC 
GTGGGCATTG AGGAGCAGAG CCTGTGGGGG CTGGCGGAGC TGCTGGAGCT CGACCTGACC 
TCCAACCAGC TCACGCACCT GCCCCACCGC CTCTTCCAGG GCCTGGGCAA GCTGGAGTAC 
CTGCTGCTCT CCCGCAACCG CCTGGCAGAG CTGCCGGCGG ACGCCCTGGG CCCCCTGCAG 
CGGGCCTTCT GGCTGGACGT CTCGCACAAC CGCCTGGAGG CATTGCCCAA CAGCCTCTTG 
GCACCACTGG GGCGGCTGCG CTACCTCAGC CTCAGGAACA ACTCACTGCG GACCTTCACG 
CCGCAGCCCC CGGGCCTGGA GCGCCTGTGG CTGGAGGGTA ACCCCTGGGA CTGTGGCTGC 
CCTCTCAAGG CGCTGCGGGA CTTCGCCCTG CAGAACCCCA GTGCTGTGCC CCGCTTCGTC 
CAGGCCATCT GTGAGGGGGA CGATTGCCAG CCGCCCGCGT ACACCTACAA CAACATCACC 
TGTGCCAGCC CGCCCGAGGT CGTGGGGCTC GACCTGCGGG ACCTCAGCGA GGCCCACTTT 
GCTCCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGFALS ( NM_001146006.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139478.1 Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31932
Clone ID Related Accession (Same CDS sequence)	NM_001146006.1 , NM_001146006.2
Accession Version	NM_001146006.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025681.1, AK303146.1 and AC012180.6. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303146.1, DC405669.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTGA GGAAAGCGGG TGACCTCGAG CCTCAGTTCA CACCTGAGCG CCGCTTCCGG 
CTGTGCTGGT ATCAGGCTCA CTCGGGCAGA GCCCTCCTCG GGCCGCCTCC CCAAGCCTCT 
CCCCCCGCAG GAGGCCTGGC CCTGGCGCTG CTGCTGCTGT CCTGGGTGGC ACTGGGCCCC 
CGCAGCCTGG AGGGAGCAGA CCCCGGAACG CCGGGGGAAG CCGAGGGCCC AGCGTGCCCG 
GCCGCCTGTG TCTGCAGCTA CGATGACGAC GCGGATGAGC TCAGCGTCTT CTGCAGCTCC 
AGGAACCTCA CGCGCCTGCC TGATGGAGTC CCGGGCGGCA CCCAAGCCCT GTGGCTGGAC 
GGCAACAACC TCTCGTCCGT CCCCCCGGCA GCCTTCCAGA ACCTCTCCAG CCTGGGCTTC 
CTCAACCTGC AGGGCGGCCA GCTGGGCAGC CTGGAGCCAC AGGCGCTGCT GGGCCTAGAG 
AACCTGTGCC ACCTGCACCT GGAGCGGAAC CAGCTGCGCA GCCTGGCACT CGGCACGTTT 
GCACACACGC CCGCGCTGGC CTCGCTCGGC CTCAGCAACA ACCGTCTGAG CAGGCTGGAG 
GACGGGCTCT TCGAGGGCCT CGGCAGCCTC TGGGACCTCA ACCTCGGCTG GAATAGCCTG 
GCGGTGCTCC CCGATGCGGC GTTCCGCGGC CTGGGCAGCC TGCGCGAGCT GGTGCTGGCG 
GGCAACAGGC TGGCCTACCT GCAGCCCGCG CTCTTCAGCG GCCTGGCCGA GCTCCGGGAG 
CTGGACCTGA GCAGGAACGC GCTGCGGGCC ATCAAGGCAA ACGTGTTCGT GCAGCTGCCC 
CGGCTCCAGA AACTCTACCT GGACCGCAAC CTCATCGCTG CCGTGGCCCC GGGCGCCTTC 
CTGGGCCTGA AGGCGCTGCG ATGGCTGGAC CTGTCCCACA ACCGCGTGGC TGGCCTCCTG 
GAGGACACGT TCCCCGGTCT GCTGGGCCTG CGTGTGCTGC GGCTGTCCCA CAACGCCATC 
GCCAGCCTGC GGCCCCGCAC CTTCAAGGAC CTGCACTTCC TGGAGGAGCT GCAGCTGGGC 
CACAACCGCA TCCGGCAGCT GGCTGAGCGC AGCTTTGAGG GCCTGGGGCA GCTTGAGGTG 
CTCACGCTAG ACCACAACCA GCTCCAGGAG GTCAAGGCGG GCGCTTTCCT CGGCCTCACC 
AACGTGGCGG TCATGAACCT CTCTGGGAAC TGTCTCCGGA ACCTTCCGGA GCAGGTGTTC 
CGGGGCCTGG GCAAGCTGCA CAGCCTGCAC CTGGAGGGCA GCTGCCTGGG ACGCATCCGC 
CCGCACACCT TCACCGGCCT CTCGGGGCTC CGCCGACTCT TCCTCAAGGA CAACGGCCTC 
GTGGGCATTG AGGAGCAGAG CCTGTGGGGG CTGGCGGAGC TGCTGGAGCT CGACCTGACC 
TCCAACCAGC TCACGCACCT GCCCCACCGC CTCTTCCAGG GCCTGGGCAA GCTGGAGTAC 
CTGCTGCTCT CCCGCAACCG CCTGGCAGAG CTGCCGGCGG ACGCCCTGGG CCCCCTGCAG 
CGGGCCTTCT GGCTGGACGT CTCGCACAAC CGCCTGGAGG CATTGCCCAA CAGCCTCTTG 
GCACCACTGG GGCGGCTGCG CTACCTCAGC CTCAGGAACA ACTCACTGCG GACCTTCACG 
CCGCAGCCCC CGGGCCTGGA GCGCCTGTGG CTGGAGGGTA ACCCCTGGGA CTGTGGCTGC 
CCTCTCAAGG CGCTGCGGGA CTTCGCCCTG CAGAACCCCA GTGCTGTGCC CCGCTTCGTC 
CAGGCCATCT GTGAGGGGGA CGATTGCCAG CCGCCCGCGT ACACCTACAA CAACATCACC 
TGTGCCAGCC CGCCCGAGGT CGTGGGGCTC GACCTGCGGG ACCTCAGCGA GGCCCACTTT 
GCTCCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139478.1
CDS	82..2013
Translation	MALRKAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC

Target ORF information:

RefSeq Version	NM_001146006.1
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146006.1

ORF Insert Sequence:

ATGGCCCTGA GGAAAGCGGG TGACCTCGAG CCTCAGTTCA CACCTGAGCG CCGCTTCCGG 
CTGTGCTGGT ATCAGGCTCA CTCGGGCAGA GCCCTCCTCG GGCCGCCTCC CCAAGCCTCT 
CCCCCCGCAG GAGGCCTGGC CCTGGCGCTG CTGCTGCTGT CCTGGGTGGC ACTGGGCCCC 
CGCAGCCTGG AGGGAGCAGA CCCCGGAACG CCGGGGGAAG CCGAGGGCCC AGCGTGCCCG 
GCCGCCTGTG TCTGCAGCTA CGATGACGAC GCGGATGAGC TCAGCGTCTT CTGCAGCTCC 
AGGAACCTCA CGCGCCTGCC TGATGGAGTC CCGGGCGGCA CCCAAGCCCT GTGGCTGGAC 
GGCAACAACC TCTCGTCCGT CCCCCCGGCA GCCTTCCAGA ACCTCTCCAG CCTGGGCTTC 
CTCAACCTGC AGGGCGGCCA GCTGGGCAGC CTGGAGCCAC AGGCGCTGCT GGGCCTAGAG 
AACCTGTGCC ACCTGCACCT GGAGCGGAAC CAGCTGCGCA GCCTGGCACT CGGCACGTTT 
GCACACACGC CCGCGCTGGC CTCGCTCGGC CTCAGCAACA ACCGTCTGAG CAGGCTGGAG 
GACGGGCTCT TCGAGGGCCT CGGCAGCCTC TGGGACCTCA ACCTCGGCTG GAATAGCCTG 
GCGGTGCTCC CCGATGCGGC GTTCCGCGGC CTGGGCAGCC TGCGCGAGCT GGTGCTGGCG 
GGCAACAGGC TGGCCTACCT GCAGCCCGCG CTCTTCAGCG GCCTGGCCGA GCTCCGGGAG 
CTGGACCTGA GCAGGAACGC GCTGCGGGCC ATCAAGGCAA ACGTGTTCGT GCAGCTGCCC 
CGGCTCCAGA AACTCTACCT GGACCGCAAC CTCATCGCTG CCGTGGCCCC GGGCGCCTTC 
CTGGGCCTGA AGGCGCTGCG ATGGCTGGAC CTGTCCCACA ACCGCGTGGC TGGCCTCCTG 
GAGGACACGT TCCCCGGTCT GCTGGGCCTG CGTGTGCTGC GGCTGTCCCA CAACGCCATC 
GCCAGCCTGC GGCCCCGCAC CTTCAAGGAC CTGCACTTCC TGGAGGAGCT GCAGCTGGGC 
CACAACCGCA TCCGGCAGCT GGCTGAGCGC AGCTTTGAGG GCCTGGGGCA GCTTGAGGTG 
CTCACGCTAG ACCACAACCA GCTCCAGGAG GTCAAGGCGG GCGCTTTCCT CGGCCTCACC 
AACGTGGCGG TCATGAACCT CTCTGGGAAC TGTCTCCGGA ACCTTCCGGA GCAGGTGTTC 
CGGGGCCTGG GCAAGCTGCA CAGCCTGCAC CTGGAGGGCA GCTGCCTGGG ACGCATCCGC 
CCGCACACCT TCACCGGCCT CTCGGGGCTC CGCCGACTCT TCCTCAAGGA CAACGGCCTC 
GTGGGCATTG AGGAGCAGAG CCTGTGGGGG CTGGCGGAGC TGCTGGAGCT CGACCTGACC 
TCCAACCAGC TCACGCACCT GCCCCACCGC CTCTTCCAGG GCCTGGGCAA GCTGGAGTAC 
CTGCTGCTCT CCCGCAACCG CCTGGCAGAG CTGCCGGCGG ACGCCCTGGG CCCCCTGCAG 
CGGGCCTTCT GGCTGGACGT CTCGCACAAC CGCCTGGAGG CATTGCCCAA CAGCCTCTTG 
GCACCACTGG GGCGGCTGCG CTACCTCAGC CTCAGGAACA ACTCACTGCG GACCTTCACG 
CCGCAGCCCC CGGGCCTGGA GCGCCTGTGG CTGGAGGGTA ACCCCTGGGA CTGTGGCTGC 
CCTCTCAAGG CGCTGCGGGA CTTCGCCCTG CAGAACCCCA GTGCTGTGCC CCGCTTCGTC 
CAGGCCATCT GTGAGGGGGA CGATTGCCAG CCGCCCGCGT ACACCTACAA CAACATCACC 
TGTGCCAGCC CGCCCGAGGT CGTGGGGCTC GACCTGCGGG ACCTCAGCGA GGCCCACTTT 
GCTCCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms.
The Journal of biological chemistry292(22)9252-9261(2017 06)
Rotwein P

Clinical and biochemical characteristics and bone mineral density of homozygous, compound heterozygous and heterozygous carriers of three novel
European journal of endocrinology176(6)657-667(2017 Jun)
I??k E,Haliloglu B,van Doorn J,Demirbilek H,Scheltinga SA,Losekoot M,Wit JM

Assessment of pathogenicity of natural IGFALS gene variants by in silico bioinformatics tools and in?vitro functional studies.
Molecular and cellular endocrinology42919-28(2016 07)
Martucci LC,Guti?rrez ML,Karabatas LM,Scaglia PA,Rey RA,Domen? HM,Jasper HG,Domen? S

[Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues].
Yi chuan = Hereditas37(12)1185-93(2015 12)
Li GL,Niu LL,Liu HF,Guo JZ

IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration.
The Journal of clinical endocrinology and metabolism99(4)E703-12(2014 Apr)
H?gler W,Martin DD,Crabtree N,Nightingale P,Tomlinson J,Metherell L,Rosenfeld R,Hwa V,Rose S,Walker J,Shaw N,Barrett T,Frystyk J

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IGFALS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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