OSTN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OSTN
Entrez Gene ID	344901
Full Name	osteocrin
Synonyms	MUSCLIN
General protein information	Preferred Names osteocrin Names osteocrin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q28
Disorder MIM:	610280

mRNA and Protein(s)

mRNA	Protein	Name
XM_017006303.1	XP_016861792.1	osteocrin isoform X1
XM_005247428.3	XP_005247485.1	osteocrin isoform X1
NM_198184.1	NP_937827.1	osteocrin precursor
XM_017006303.2	XP_016861792.1	osteocrin isoform X1
NM_198184.2	NP_937827.1	osteocrin precursor

Pathways from BioSystems

Homologies

	OSTN	XP_001094278.1
Pan troglodytes (chimpanzee)	OSTN	XP_001144666.2
Bos taurus (cattle)	OSTN	NP_001092405.1
Homo sapiens (human)	OSTN	NP_937827.1
Mus musculus (house mouse)	Ostn	NP_932780.1
Gallus gallus (chicken)	OSTN	NP_001092078.1
Canis lupus familiaris (dog)	OSTN	XP_850347.2
Danio rerio (zebrafish)	LOC100333936	XP_002664707.1
Xenopus tropicalis (tropical clawed frog)	ostn	XP_002934095.2
Rattus norvegicus (Norway rat)	Ostn	NP_997495.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients.
Chen WJ, Liu Y, Sui YB, Zhang B, Zhang XH, Yin XH
Diabetes & vascular disease research14(2)116-121(2017 03)

Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME
Nature539(7628)242-247(2016 11)

Musclin is an activity-stimulated myokine that enhances physical endurance.
Subbotina E, Sierra A, Zhu Z, Gao Z, Koganti SR, Reyes S, Stepniak E, Walsh SA, Acevedo MR, Perez-Terzic CM, Hodgson-Zingman DM, Zingman LV
Proceedings of the National Academy of Sciences of the United States of America112(52)16042-7(2015 Dec)

Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
Moffatt P, Thomas G, Sellin K, Bessette MC, Lafreni?re F, Akhouayri O, St-Arnaud R, Lanct?t C
The Journal of biological chemistry282(50)36454-62(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus.
Title: Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients.

findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates
Title: Evolution of Osteocrin as an activity-regulated factor in the primate brain.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells.
Title: Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.

Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide.
Title: Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.

The following OSTN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OSTN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31299	NM_198184.2 Latest version!	Homo sapiens osteocrin (OSTN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31299	XM_005247428.3 Latest version!	Homo sapiens osteocrin (OSTN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31299	XM_017006303.2 Latest version!	Homo sapiens osteocrin (OSTN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31299	XM_017006303.1	Homo sapiens osteocrin (OSTN), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31299	NM_198184.1	Homo sapiens osteocrin (OSTN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OSTN ( NM_198184.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_937827.1 Homo sapiens osteocrin (OSTN), mRNA.

Price & Availability↑

CloneID	OHu31299
Clone ID Related Accession (Same CDS sequence)	XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2
Accession Version	NM_198184.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	osteocrin precursor
Comment

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937827.1
Translation	MLDWRLASAHFILAVTLTLWSSGKVLSVDVTTTEAFDSGVIDVQSTPTVREEKSATDLTAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPMDRIGRNRLSNSRG

Target ORF information:

RefSeq Version	NM_198184.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens osteocrin (OSTN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198184.1

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OSTN ( NM_198184.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_937827.1 Homo sapiens osteocrin (OSTN), mRNA.

Price & Availability↑

CloneID	OHu31299
Clone ID Related Accession (Same CDS sequence)	XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2
Accession Version	NM_198184.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	osteocrin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC126567.8 and AY398681.1. On or before Aug 24, 2016 this sequence version replaced XM_005247428.4, NM_198184.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.16739.1, SRR1660805.110908.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937827.1
CDS	68..469
Translation	MLDWRLASAHFILAVTLTLWSSGKVLSVDVTTTEAFDSGVIDVQSTPTVREEKSATDLTAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPMDRIGRNRLSNSRG

Target ORF information:

RefSeq Version	NM_198184.2
Organism	Homo sapiens(human)
Definition	Homo sapiens osteocrin (OSTN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198184.2

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OSTN ( XM_017006303.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861792.1 Homo sapiens osteocrin (OSTN), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu31299
Clone ID Related Accession (Same CDS sequence)	XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2
Accession Version	XM_017006303.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	osteocrin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861792.1
CDS	160..561
Translation	MLDWRLASAHFILAVTLTLWSSGKVLSVDVTTTEAFDSGVIDVQSTPTVREEKSATDLTAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPMDRIGRNRLSNSRG

Target ORF information:

RefSeq Version	XM_017006303.1
Organism	Homo sapiens(human)
Definition	Homo sapiens osteocrin (OSTN), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017006303.1

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OSTN ( XM_005247428.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005247485.1 Homo sapiens osteocrin (OSTN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu31299
Clone ID Related Accession (Same CDS sequence)	XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2
Accession Version	XM_005247428.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	osteocrin isoform X1
Comment

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005247485.1
Translation	MLDWRLASAHFILAVTLTLWSSGKVLSVDVTTTEAFDSGVIDVQSTPTVREEKSATDLTAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPMDRIGRNRLSNSRG

Target ORF information:

RefSeq Version	XM_005247428.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens osteocrin (OSTN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005247428.3

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OSTN ( XM_017006303.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861792.1 Homo sapiens osteocrin (OSTN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu31299
Clone ID Related Accession (Same CDS sequence)	XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2
Accession Version	XM_017006303.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	osteocrin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017006303.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861792.1
CDS	160..561
Translation	MLDWRLASAHFILAVTLTLWSSGKVLSVDVTTTEAFDSGVIDVQSTPTVREEKSATDLTAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPMDRIGRNRLSNSRG

Target ORF information:

RefSeq Version	XM_017006303.2
Organism	Homo sapiens(human)
Definition	Homo sapiens osteocrin (OSTN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017006303.2

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG 
AGCTCAGGAA AAGTCCTCTC AGTAGATGTA ACAACAACAG AGGCCTTTGA TTCTGGAGTC 
ATAGATGTGC AGTCAACACC CACAGTCAGG GAAGAGAAAT CAGCCACTGA CCTGACAGCA 
AAACTCTTGC TTCTTGATGA ATTGGTGTCC CTAGAAAATG ATGTGATTGA GACAAAGAAG 
AAAAGGAGTT TCTCTGGTTT TGGGTCTCCC CTTGACAGAC TCTCAGCTGG CTCTGTAGAT 
CACAAAGGTA AACAGAGGAA AGTAGTAGAT CATCCAAAAA GGCGATTTGG TATCCCCATG 
GATCGGATTG GTAGAAACCG GCTTTCAAAT TCCAGAGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients.
Diabetes & vascular disease research14(2)116-121(2017 03)
Chen WJ,Liu Y,Sui YB,Zhang B,Zhang XH,Yin XH

Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Nature539(7628)242-247(2016 11)
Ataman B,Boulting GL,Harmin DA,Yang MG,Baker-Salisbury M,Yap EL,Malik AN,Mei K,Rubin AA,Spiegel I,Durresi E,Sharma N,Hu LS,Pletikos M,Griffith EC,Partlow JN,Stevens CR,Adli M,Chahrour M,Sestan N,Walsh CA,Berezovskii VK,Livingstone MS,Greenberg ME

Musclin is an activity-stimulated myokine that enhances physical endurance.
Proceedings of the National Academy of Sciences of the United States of America112(52)16042-7(2015 Dec)
Subbotina E,Sierra A,Zhu Z,Gao Z,Koganti SR,Reyes S,Stepniak E,Walsh SA,Acevedo MR,Perez-Terzic CM,Hodgson-Zingman DM,Zingman LV

Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
The Journal of biological chemistry282(50)36454-62(2007 Dec)
Moffatt P,Thomas G,Sellin K,Bessette MC,Lafreni?re F,Akhouayri O,St-Arnaud R,Lanct?t C

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OSTN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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