IFNA10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNA10
Entrez Gene ID	3446
Full Name	interferon alpha 10
Synonyms	IFN-alphaC
General protein information	Preferred Names interferon alpha 10 Names interferon alpha-10 IFN-alpha-10 interferon alpha-6L interferon alpha-C leIF C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Summary	This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013].
Disorder MIM:	147577

mRNA and Protein(s)

mRNA	Protein	Name
NM_002171.2	NP_002162.1	interferon alpha-10 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IFNA4	XP_003312066.1
Homo sapiens (human)	IFNA10	NP_002162.1

Gene Ontology
Bibliography

Related articles in PubMed

Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.
Xiao CX, Xiao JJ, Xu HZ, Wang HH, Chen X, Liu YS, Li P, Shi Y, Nie YZ, Li S, Wu KC, Liu ZJ, Ren JL, Guleng B
Scientific reports510514(2015 May)

Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells.
Hillyer P, Raviv N, Gold DM, Dougherty D, Liu J, Johnson TR, Graham BS, Rabin RL
European journal of immunology43(12)3197-208(2013 Dec)

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM
Familial cancer9(4)625-33(2010 Dec)

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)

Cystic fibrosis conductance regulator, tumor necrosis factor, interferon alpha-10, interferon alpha-17, and interferon gamma genotyping as potential risk markers in pulmonary sarcoidosis pathogenesis in Greek patients.
Makrythanasis P, Tzetis M, Rapti A, Papatheodorou A, Tsipi M, Kitsiou S, Tsiamouri A, Poulou M, Roussos C, Kanavakis E
Genetic testing and molecular biomarkers14(4)577-84(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Heterozygous IFNA10 variants is a cause of impaired function and CD-susceptibility genes in Chinese individuals from multiple center based study.
Title: Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.

IFN-alpha8 and -alpha10 most potently enhanced expression of IFN-gamma, IL-2, and IL-4.
Title: Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.

We did not reproduce the associations previously noted with the TNF, IFNA10, IFNA17, and IFNG genes with pulmonary sarcoidosis.
Title: Cystic fibrosis conductance regulator, tumor necrosis factor, interferon alpha-10, interferon alpha-17, and interferon gamma genotyping as potential risk markers in pulmonary sarcoidosis pathogenesis in Greek patients.

The following IFNA10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNA10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu14292	NM_002171.2 Latest version!	Homo sapiens interferon alpha 10 (IFNA10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNA10 ( NM_002171.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002162.1 Homo sapiens interferon alpha 10 (IFNA10), mRNA.

Price & Availability↑

CloneID	OHu14292
Clone ID Related Accession (Same CDS sequence)	NM_002171.2
Accession Version	NM_002171.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	interferon alpha-10 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069409.1 and V00551.1. On Aug 31, 2013 this sequence version replaced NM_002171.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: V00551.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357374.2/ ENSP00000369566.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCTGT CCTTTTCTTT ACTTATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTAGGCT GTGATCTGCC TCAGACCCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGGACAAA TGGGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGATTTCCGA 
ATCCCCCAGG AGGAGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAG AGGACTCATC TGCTGCTTGG 
GAACAGAGCC TCCTAGAAAA ATTTTCCACT GAACTTTACC AGCAACTGAA TGACCTGGAA 
GCATGTGTGA TACAGGAGGT TGGGGTGGAA GAGACTCCCC TGATGAATGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT CCAAAGAATC ACTCTTTATC TAATAGAGAG GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCCTCTCGTT TTCAACAAAC 
TTGCAAAAAA GATTAAGGAG GAAGGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002162.1
CDS	47..616
Translation	MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLGQMGRISPFSCLKDRHDFRIPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLIERKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD

Target ORF information:

RefSeq Version	NM_002171.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon alpha 10 (IFNA10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002171.2

ORF Insert Sequence:

ATGGCCCTGT CCTTTTCTTT ACTTATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTAGGCT GTGATCTGCC TCAGACCCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGGACAAA TGGGAAGAAT CTCTCCTTTC TCCTGCCTGA AGGACAGACA TGATTTCCGA 
ATCCCCCAGG AGGAGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGTCCTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAG AGGACTCATC TGCTGCTTGG 
GAACAGAGCC TCCTAGAAAA ATTTTCCACT GAACTTTACC AGCAACTGAA TGACCTGGAA 
GCATGTGTGA TACAGGAGGT TGGGGTGGAA GAGACTCCCC TGATGAATGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT CCAAAGAATC ACTCTTTATC TAATAGAGAG GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCCTCTCGTT TTCAACAAAC 
TTGCAAAAAA GATTAAGGAG GAAGGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.
Scientific reports510514(2015 May)
Xiao CX,Xiao JJ,Xu HZ,Wang HH,Chen X,Liu YS,Li P,Shi Y,Nie YZ,Li S,Wu KC,Liu ZJ,Ren JL,Guleng B

Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells.
European journal of immunology43(12)3197-208(2013 Dec)
Hillyer P,Raviv N,Gold DM,Dougherty D,Liu J,Johnson TR,Graham BS,Rabin RL

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Familial cancer9(4)625-33(2010 Dec)
Yang XR,Liang X,Pfeiffer RM,Wheeler W,Maeder D,Burdette L,Yeager M,Chanock S,Tucker MA,Goldstein AM

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)
Silva LK,Blanton RE,Parrado AR,Melo PS,Morato VG,Reis EA,Dias JP,Castro JM,Vasconcelos PF,Goddard KA,Barreto ML,Reis MG,Teixeira MG

Cystic fibrosis conductance regulator, tumor necrosis factor, interferon alpha-10, interferon alpha-17, and interferon gamma genotyping as potential risk markers in pulmonary sarcoidosis pathogenesis in Greek patients.
Genetic testing and molecular biomarkers14(4)577-84(2010 Aug)
Makrythanasis P,Tzetis M,Rapti A,Papatheodorou A,Tsipi M,Kitsiou S,Tsiamouri A,Poulou M,Roussos C,Kanavakis E

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IFNA10 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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