IFNA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNA2
Entrez Gene ID	3440
Full Name	interferon alpha 2
Synonyms	IFN-alphaA,IFNA,IFNA2B,INFA2
General protein information	Preferred Names interferon alpha 2 Names interferon alpha-2 IFN-alpha-2 alpha-2a interferon interferon alpha 2a interferon alpha 2b interferon alpha A leIF A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Summary	This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011].
Disorder MIM:	147562

mRNA and Protein(s)

mRNA	Protein	Name
NM_000605.4	NP_000596.2	interferon alpha-2 precursor
NM_000605.3	NP_000596.2	interferon alpha-2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IFNA2	XP_528568.1
Homo sapiens (human)	IFNA2	NP_000596.2
	IFNA2	NP_001129266.1

Gene Ontology
Bibliography

Related articles in PubMed

Interferon ?2 and interferon ? induce the degranulation independent production of VEGF-A and IL-1 receptor antagonist and other mediators from human mast cells.
Oldford SA, Salsman SP, Portales-Cervantes L, Alyazidi R, Anderson R, Haidl ID, Marshall JS
Immunity, inflammation and disease(2017 Dec)

IFNA2 p.Ala120Thr impairs the inhibitory activity of Interferon-?2 against the hepatitis B virus through altering its binding to the receptor.
Chen C, Zhu X, Xu W, Yang F, Zhang G, Wu L, Zheng Y, Gao Z, Xie C, Peng L
Antiviral research14711-18(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interferon-alpha-induced CD100 expression on naive CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction.
Title: Interferon-?-induced CD100 on na?ve CD8

Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function on exposure to IFN-alpha2a and IFN-gamma.
Title: Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma.

The variant models of the hIFNalpha-2b displayed structural and conformational changes that signified that changes to hIFNalpha-2b may be a risk factor in addition to other known factors associated with onset/progression of female breast carcinoma.
Title: Mutations in Human Interferon ?2b Gene and Potential as Risk Factor Associated with Female Breast Cancer.

All the tested TLRAs induced greater infant IFN-alpha2 production compared to newborn and adult blood. In contrast, CpG induced greater IFN-gamma, IL-1beta, IL-4, IL-12p40, IL-10 and CXCL8 in newborn than in infant and adult blood.
Title: In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.

Report biased expression of human interferon alpha-2b and Escherichia coli methionine amino peptidase genes under control of single promoter in E. coli.
Title: Biased expression, under the control of single promoter, of human interferon ?-2b and Escherichia coli methionine amino peptidase genes in E. coli, irrespective of their distance from the promoter.

The following IFNA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24434	NM_000605.4 Latest version!	Homo sapiens interferon alpha 2 (IFNA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24434	NM_000605.3	Homo sapiens interferon alpha 2 (IFNA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNA2 ( NM_000605.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000596.2 Homo sapiens interferon alpha 2 (IFNA2), mRNA.

Price & Availability↑

CloneID	OHu24434
Clone ID Related Accession (Same CDS sequence)	NM_000605.4 , NM_000605.3
Accession Version	NM_000605.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	interferon alpha-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL353732.14 and BC104163.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_000605.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and experimental data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1163658.305173.1, V00549.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380206.4/ ENSP00000369554.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTTGA CCTTTGCTTT ACTGGTGGCC CTCCTGGTGC TCAGCTGCAA GTCAAGCTGC 
TCTGTGGGCT GTGATCTGCC TCAAACCCAC AGCCTGGGTA GCAGGAGGAC CTTGATGCTC 
CTGGCACAGA TGAGGAGAAT CTCTCTTTTC TCCTGCTTGA AGGACAGACA TGACTTTGGA 
TTTCCCCAGG AGGAGTTTGG CAACCAGTTC CAAAAGGCTG AAACCATCCC TGTCCTCCAT 
GAGATGATCC AGCAGATCTT CAATCTCTTC AGCACAAAGG ACTCATCTGC TGCTTGGGAT 
GAGACCCTCC TAGACAAATT CTACACTGAA CTCTACCAGC AGCTGAATGA CCTGGAAGCC 
TGTGTGATAC AGGGGGTGGG GGTGACAGAG ACTCCCCTGA TGAAGGAGGA CTCCATTCTG 
GCTGTGAGGA AATACTTCCA AAGAATCACT CTCTATCTGA AAGAGAAGAA ATACAGCCCT 
TGTGCCTGGG AGGTTGTCAG AGCAGAAATC ATGAGATCTT TTTCTTTGTC AACAAACTTG 
CAAGAAAGTT TAAGAAGTAA GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000596.2
CDS	70..636
Translation	MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE

Target ORF information:

RefSeq Version	NM_000605.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon alpha 2 (IFNA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000605.4

ORF Insert Sequence:

ATGGCCTTGA CCTTTGCTTT ACTGGTGGCC CTCCTGGTGC TCAGCTGCAA GTCAAGCTGC 
TCTGTGGGCT GTGATCTGCC TCAAACCCAC AGCCTGGGTA GCAGGAGGAC CTTGATGCTC 
CTGGCACAGA TGAGGAGAAT CTCTCTTTTC TCCTGCTTGA AGGACAGACA TGACTTTGGA 
TTTCCCCAGG AGGAGTTTGG CAACCAGTTC CAAAAGGCTG AAACCATCCC TGTCCTCCAT 
GAGATGATCC AGCAGATCTT CAATCTCTTC AGCACAAAGG ACTCATCTGC TGCTTGGGAT 
GAGACCCTCC TAGACAAATT CTACACTGAA CTCTACCAGC AGCTGAATGA CCTGGAAGCC 
TGTGTGATAC AGGGGGTGGG GGTGACAGAG ACTCCCCTGA TGAAGGAGGA CTCCATTCTG 
GCTGTGAGGA AATACTTCCA AAGAATCACT CTCTATCTGA AAGAGAAGAA ATACAGCCCT 
TGTGCCTGGG AGGTTGTCAG AGCAGAAATC ATGAGATCTT TTTCTTTGTC AACAAACTTG 
CAAGAAAGTT TAAGAAGTAA GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNA2 ( NM_000605.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000596.2 Homo sapiens interferon alpha 2 (IFNA2), mRNA.

Price & Availability↑

CloneID	OHu24434
Clone ID Related Accession (Same CDS sequence)	NM_000605.4 , NM_000605.3
Accession Version	NM_000605.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	interferon alpha-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL353732.14 and BC104163.1. This sequence is a reference standard in the RefSeqGene project. On Oct 11, 2008 this sequence version replaced NM_000605.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and experimental data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCCTTGA CCTTTGCTTT ACTGGTGGCC CTCCTGGTGC TCAGCTGCAA GTCAAGCTGC 
TCTGTGGGCT GTGATCTGCC TCAAACCCAC AGCCTGGGTA GCAGGAGGAC CTTGATGCTC 
CTGGCACAGA TGAGGAGAAT CTCTCTTTTC TCCTGCTTGA AGGACAGACA TGACTTTGGA 
TTTCCCCAGG AGGAGTTTGG CAACCAGTTC CAAAAGGCTG AAACCATCCC TGTCCTCCAT 
GAGATGATCC AGCAGATCTT CAATCTCTTC AGCACAAAGG ACTCATCTGC TGCTTGGGAT 
GAGACCCTCC TAGACAAATT CTACACTGAA CTCTACCAGC AGCTGAATGA CCTGGAAGCC 
TGTGTGATAC AGGGGGTGGG GGTGACAGAG ACTCCCCTGA TGAAGGAGGA CTCCATTCTG 
GCTGTGAGGA AATACTTCCA AAGAATCACT CTCTATCTGA AAGAGAAGAA ATACAGCCCT 
TGTGCCTGGG AGGTTGTCAG AGCAGAAATC ATGAGATCTT TTTCTTTGTC AACAAACTTG 
CAAGAAAGTT TAAGAAGTAA GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000596.2
CDS	69..635
Translation	MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE

Target ORF information:

RefSeq Version	NM_000605.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon alpha 2 (IFNA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000605.3

ORF Insert Sequence:

ATGGCCTTGA CCTTTGCTTT ACTGGTGGCC CTCCTGGTGC TCAGCTGCAA GTCAAGCTGC 
TCTGTGGGCT GTGATCTGCC TCAAACCCAC AGCCTGGGTA GCAGGAGGAC CTTGATGCTC 
CTGGCACAGA TGAGGAGAAT CTCTCTTTTC TCCTGCTTGA AGGACAGACA TGACTTTGGA 
TTTCCCCAGG AGGAGTTTGG CAACCAGTTC CAAAAGGCTG AAACCATCCC TGTCCTCCAT 
GAGATGATCC AGCAGATCTT CAATCTCTTC AGCACAAAGG ACTCATCTGC TGCTTGGGAT 
GAGACCCTCC TAGACAAATT CTACACTGAA CTCTACCAGC AGCTGAATGA CCTGGAAGCC 
TGTGTGATAC AGGGGGTGGG GGTGACAGAG ACTCCCCTGA TGAAGGAGGA CTCCATTCTG 
GCTGTGAGGA AATACTTCCA AAGAATCACT CTCTATCTGA AAGAGAAGAA ATACAGCCCT 
TGTGCCTGGG AGGTTGTCAG AGCAGAAATC ATGAGATCTT TTTCTTTGTC AACAAACTTG 
CAAGAAAGTT TAAGAAGTAA GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interferon ?2 and interferon ? induce the degranulation independent production of VEGF-A and IL-1 receptor antagonist and other mediators from human mast cells.
Immunity, inflammation and disease(2017 Dec)
Oldford SA,Salsman SP,Portales-Cervantes L,Alyazidi R,Anderson R,Haidl ID,Marshall JS

IFNA2 p.Ala120Thr impairs the inhibitory activity of Interferon-?2 against the hepatitis B virus through altering its binding to the receptor.
Antiviral research14711-18(2017 Nov)
Chen C,Zhu X,Xu W,Yang F,Zhang G,Wu L,Zheng Y,Gao Z,Xie C,Peng L

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IFNA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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