NACA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NACA2
Entrez Gene ID	342538
Full Name	nascent polypeptide associated complex alpha subunit 2
Synonyms	ANAC,NACAL
General protein information	Preferred Names nascent polypeptide associated complex alpha subunit 2 Names nascent polypeptide-associated complex subunit alpha-2 IgE autoantigen alpha-nascent polypeptide-associated complex alpha-NAC protein hom s 2.01 protein nascent polypeptide-associated complex, alpha polypeptide, 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q23.2
Disorder MIM:	609274

mRNA and Protein(s)

mRNA	Protein	Name
NM_199290.3	NP_954984.1	nascent polypeptide-associated complex subunit alpha-2
NM_199290.4	NP_954984.1	nascent polypeptide-associated complex subunit alpha-2

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	Y65B4BR.5	NP_871846.1
Homo sapiens (human)	NACA2	NP_954984.1
Pan troglodytes (chimpanzee)	NACA2	XP_511608.1
Xenopus tropicalis (tropical clawed frog)	naca.2	NP_001007513.1
Oryza sativa (rice)	Os03g0121700	NP_001048795.1
Oryza sativa (rice)	Os01g0698900	NP_001172523.1

Gene Ontology
Bibliography

Related articles in PubMed

The human skin-associated autoantigen ?-NAC activates monocytes and dendritic cells via TLR-2 and primes an IL-12-dependent Th1 response.
Hradetzky S, Balaji H, Roesner LM, Heratizadeh A, Mittermann I, Valenta R, Werfel T
The Journal of investigative dermatology133(9)2289-92(2013 Sep)

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF
BMC medical genetics1196(2010 Jun)

Many sequence variants affecting diversity of adult human height.
Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, Sulem P, Thorlacius S, Gylfason A, Steinberg S, Helgadottir A, Ingason A, Steinthorsdottir V, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Pedersen O, Aben KK, Witjes JA, Swinkels DW, den Heijer M, Franke B, Verbeek AL, Becker DM, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Gulcher J, Kiemeney LA, Kong A, Thorsteinsdottir U, Stefansson K
Nature genetics40(5)609-15(2008 May)

Emergence of young human genes after a burst of retroposition in primates.
Marques AC, Dupanloup I, Vinckenbosch N, Reymond A, Kaessmann H
PLoS biology3(11)e357(2005 Nov)

Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.
Mossabeb R, Seiberler S, Mittermann I, Reininger R, Spitzauer S, Natter S, Verdino P, Keller W, Kraft D, Valenta R
The Journal of investigative dermatology119(4)820-9(2002 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alpha-nac is a potent inducer of a Th1 response via IL12 and TLR2.
Title: The human skin-associated autoantigen ?-NAC activates monocytes and dendritic cells via TLR-2 and primes an IL-12-dependent Th1 response.

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

The following NACA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NACA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13606	NM_199290.4 Latest version!	Homo sapiens nascent polypeptide associated complex subunit alpha 2 (NACA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13606	NM_199290.3	Homo sapiens nascent polypeptide associated complex subunit alpha 2 (NACA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NACA2 ( NM_199290.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_954984.1 Homo sapiens nascent polypeptide associated complex subunit alpha 2 (NACA2), mRNA.

Price & Availability↑

CloneID	OHu13606
Clone ID Related Accession (Same CDS sequence)	NM_199290.3 , NM_199290.4
Accession Version	NM_199290.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	nascent polypeptide-associated complex subunit alpha-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC062710.1. On Sep 23, 2009 this sequence version replaced NM_199290.2. ##Evidence-Data-START## Transcript is intronless :: BC062710.1, BM542278.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGGCG AAGCCACAGA AACCGTCCCT GCTACAGAGC AGGAGTTGCC GCAGTCCCAG 
GCTGAGACAG GGTCTGGAAC AGCATCTGAT AGTGGTGAAT CAGTACCAGG GATTGAAGAA 
CAGGATTCCA CCCAGACCAC CACACAAAAA GCCTGGCTGG TGGCAGCAGC TGAAATTGAT 
GAAGAACCAG TCGGTAAAGC AAAACAGAGT CGGAGTGAAA AGAGGGCACG GAAGGCTATG 
TCCAAACTGG GTCTTCTACA GGTTACAGGA GTTACTAGAG TCACTATCTG GAAATCTAAG 
AATATCCTCT TTGTCATCAC AAAACTGGAC GTCTACAAGA GCCCTGCTTC GGATGCCTAC 
ATAGTTTTTG GGGAAGCCAA GATCCAAGAT TTATCTCAGC AAGCACAACT AGCAGCTGCG 
GAGAAATTCA GAGTTCAAGG TGAAGCTGTC GGAAACATTC AAGAAAACAC ACAGACTCCA 
ACTGTACAAG AGGAGAGTGA AGAGGAAGAG GTCGATGAAA CAGGTGTAGA AGTTAAAGAC 
GTGAAATTGG TCATGTCACA AGCAAATGTG TCGAGAGCAA AGGCAGTCCG AGCTCTGAAG 
AACAACAGTA ATGATATTGT AAATGCGATT ATGGAATTAA CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954984.1
CDS	23..670
Translation	MPGEATETVPATEQELPQSQAETGSGTASDSGESVPGIEEQDSTQTTTQKAWLVAAAEIDEEPVGKAKQSRSEKRARKAMSKLGLLQVTGVTRVTIWKSKNILFVITKLDVYKSPASDAYIVFGEAKIQDLSQQAQLAAAEKFRVQGEAVGNIQENTQTPTVQEESEEEEVDETGVEVKDVKLVMSQANVSRAKAVRALKNNSNDIVNAIMELTV

Target ORF information:

RefSeq Version	NM_199290.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nascent polypeptide associated complex subunit alpha 2 (NACA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199290.3

ORF Insert Sequence:

ATGCCGGGCG AAGCCACAGA AACCGTCCCT GCTACAGAGC AGGAGTTGCC GCAGTCCCAG 
GCTGAGACAG GGTCTGGAAC AGCATCTGAT AGTGGTGAAT CAGTACCAGG GATTGAAGAA 
CAGGATTCCA CCCAGACCAC CACACAAAAA GCCTGGCTGG TGGCAGCAGC TGAAATTGAT 
GAAGAACCAG TCGGTAAAGC AAAACAGAGT CGGAGTGAAA AGAGGGCACG GAAGGCTATG 
TCCAAACTGG GTCTTCTACA GGTTACAGGA GTTACTAGAG TCACTATCTG GAAATCTAAG 
AATATCCTCT TTGTCATCAC AAAACTGGAC GTCTACAAGA GCCCTGCTTC GGATGCCTAC 
ATAGTTTTTG GGGAAGCCAA GATCCAAGAT TTATCTCAGC AAGCACAACT AGCAGCTGCG 
GAGAAATTCA GAGTTCAAGG TGAAGCTGTC GGAAACATTC AAGAAAACAC ACAGACTCCA 
ACTGTACAAG AGGAGAGTGA AGAGGAAGAG GTCGATGAAA CAGGTGTAGA AGTTAAAGAC 
GTGAAATTGG TCATGTCACA AGCAAATGTG TCGAGAGCAA AGGCAGTCCG AGCTCTGAAG 
AACAACAGTA ATGATATTGT AAATGCGATT ATGGAATTAA CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NACA2 ( NM_199290.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_954984.1 Homo sapiens nascent polypeptide associated complex subunit alpha 2 (NACA2), mRNA.

Price & Availability↑

CloneID	OHu13606
Clone ID Related Accession (Same CDS sequence)	NM_199290.3 , NM_199290.4
Accession Version	NM_199290.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	nascent polypeptide-associated complex subunit alpha-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC002994.3 and BC062710.1. On May 17, 2019 this sequence version replaced NM_199290.3. ##Evidence-Data-START## Transcript is intronless :: SRR5189652.156963.1, SRR5189661.12344.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000521764.3/ ENSP00000427802.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGGGCG AAGCCACAGA AACCGTCCCT GCTACAGAGC AGGAGTTGCC GCAGTCCCAG 
GCTGAGACAG GGTCTGGAAC AGCATCTGAT AGTGGTGAAT CAGTACCAGG GATTGAAGAA 
CAGGATTCCA CCCAGACCAC CACACAAAAA GCCTGGCTGG TGGCAGCAGC TGAAATTGAT 
GAAGAACCAG TCGGTAAAGC AAAACAGAGT CGGAGTGAAA AGAGGGCACG GAAGGCTATG 
TCCAAACTGG GTCTTCTACA GGTTACAGGA GTTACTAGAG TCACTATCTG GAAATCTAAG 
AATATCCTCT TTGTCATCAC AAAACTGGAC GTCTACAAGA GCCCTGCTTC GGATGCCTAC 
ATAGTTTTTG GGGAAGCCAA GATCCAAGAT TTATCTCAGC AAGCACAACT AGCAGCTGCG 
GAGAAATTCA GAGTTCAAGG TGAAGCTGTC GGAAACATTC AAGAAAACAC ACAGACTCCA 
ACTGTACAAG AGGAGAGTGA AGAGGAAGAG GTCGATGAAA CAGGTGTAGA AGTTAAAGAC 
GTGAAATTGG TCATGTCACA AGCAAATGTG TCGAGAGCAA AGGCAGTCCG AGCTCTGAAG 
AACAACAGTA ATGATATTGT AAATGCGATT ATGGAATTAA CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954984.1
CDS	40..687
Translation	MPGEATETVPATEQELPQSQAETGSGTASDSGESVPGIEEQDSTQTTTQKAWLVAAAEIDEEPVGKAKQSRSEKRARKAMSKLGLLQVTGVTRVTIWKSKNILFVITKLDVYKSPASDAYIVFGEAKIQDLSQQAQLAAAEKFRVQGEAVGNIQENTQTPTVQEESEEEEVDETGVEVKDVKLVMSQANVSRAKAVRALKNNSNDIVNAIMELTV

Target ORF information:

RefSeq Version	NM_199290.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nascent polypeptide associated complex subunit alpha 2 (NACA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199290.4

ORF Insert Sequence:

ATGCCGGGCG AAGCCACAGA AACCGTCCCT GCTACAGAGC AGGAGTTGCC GCAGTCCCAG 
GCTGAGACAG GGTCTGGAAC AGCATCTGAT AGTGGTGAAT CAGTACCAGG GATTGAAGAA 
CAGGATTCCA CCCAGACCAC CACACAAAAA GCCTGGCTGG TGGCAGCAGC TGAAATTGAT 
GAAGAACCAG TCGGTAAAGC AAAACAGAGT CGGAGTGAAA AGAGGGCACG GAAGGCTATG 
TCCAAACTGG GTCTTCTACA GGTTACAGGA GTTACTAGAG TCACTATCTG GAAATCTAAG 
AATATCCTCT TTGTCATCAC AAAACTGGAC GTCTACAAGA GCCCTGCTTC GGATGCCTAC 
ATAGTTTTTG GGGAAGCCAA GATCCAAGAT TTATCTCAGC AAGCACAACT AGCAGCTGCG 
GAGAAATTCA GAGTTCAAGG TGAAGCTGTC GGAAACATTC AAGAAAACAC ACAGACTCCA 
ACTGTACAAG AGGAGAGTGA AGAGGAAGAG GTCGATGAAA CAGGTGTAGA AGTTAAAGAC 
GTGAAATTGG TCATGTCACA AGCAAATGTG TCGAGAGCAA AGGCAGTCCG AGCTCTGAAG 
AACAACAGTA ATGATATTGT AAATGCGATT ATGGAATTAA CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The human skin-associated autoantigen ?-NAC activates monocytes and dendritic cells via TLR-2 and primes an IL-12-dependent Th1 response.
The Journal of investigative dermatology133(9)2289-92(2013 Sep)
Hradetzky S,Balaji H,Roesner LM,Heratizadeh A,Mittermann I,Valenta R,Werfel T

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
BMC medical genetics1196(2010 Jun)
Zhao J,Li M,Bradfield JP,Zhang H,Mentch FD,Wang K,Sleiman PM,Kim CE,Glessner JT,Hou C,Keating BJ,Thomas KA,Garris ML,Deliard S,Frackelton EC,Otieno FG,Chiavacci RM,Berkowitz RI,Hakonarson H,Grant SF

Many sequence variants affecting diversity of adult human height.
Nature genetics40(5)609-15(2008 May)
Gudbjartsson DF,Walters GB,Thorleifsson G,Stefansson H,Halldorsson BV,Zusmanovich P,Sulem P,Thorlacius S,Gylfason A,Steinberg S,Helgadottir A,Ingason A,Steinthorsdottir V,Olafsdottir EJ,Olafsdottir GH,Jonsson T,Borch-Johnsen K,Hansen T,Andersen G,Jorgensen T,Pedersen O,Aben KK,Witjes JA,Swinkels DW,den Heijer M,Franke B,Verbeek AL,Becker DM,Yanek LR,Becker LC,Tryggvadottir L,Rafnar T,Gulcher J,Kiemeney LA,Kong A,Thorsteinsdottir U,Stefansson K

Emergence of young human genes after a burst of retroposition in primates.
PLoS biology3(11)e357(2005 Nov)
Marques AC,Dupanloup I,Vinckenbosch N,Reymond A,Kaessmann H

Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.
The Journal of investigative dermatology119(4)820-9(2002 Oct)
Mossabeb R,Seiberler S,Mittermann I,Reininger R,Spitzauer S,Natter S,Verdino P,Keller W,Kraft D,Valenta R

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NACA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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