NEXMIF cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEXMIF
Entrez Gene ID	340533
Full Name	neurite extension and migration factor
Synonyms	KIAA2022,KIDLIA,MRX98,XPN
General protein information	Preferred Names neurite extension and migration factor Names neurite extension and migration factor XLMR protein related to neurite extension XLMR-related protein, neurite extension
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq13.3
Summary	An inversion on the X chromosome which disrupts this gene and a G-protein coupled purinergic receptor gene located in the pseudoautosomal region of the X chromosome has been linked to X linked cognitive disability.[provided by RefSeq, Mar 2009].
Disorder MIM:	300524
Disorder Html:	Mental retardation, X-linked 98, 300912 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008537.3	NP_001008537.1	neurite extension and migration factor
NM_001008537.2	NP_001008537.1	neurite extension and migration factor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KIAA2022	XP_005641565.1
Gallus gallus (chicken)	KIAA2022	XP_420300.4
Danio rerio (zebrafish)	LOC796115	XP_005157233.1
Xenopus tropicalis (tropical clawed frog)	kiaa2022	XP_002931872.2
	LOC703920	XP_001096699.1
Bos taurus (cattle)	KIAA2022	XP_002700021.2
Mus musculus (house mouse)	C77370	NP_001070822.2
Rattus norvegicus (Norway rat)	RGD1561931	XP_006257215.1
Homo sapiens (human)	KIAA2022	NP_001008537.1
Pan troglodytes (chimpanzee)	KIAA2022	XP_521141.3

Gene Ontology
Bibliography

Related articles in PubMed

De novo loss of function mutations in KIAA2022 are associated with epilepsy and neurodevelopmental delay in females.
Webster R, Cho MT, Retterer K, Millan F, Nowak C, Douglas J, Ahmad A, Raymond GV, Johnson MR, Pujol A, Begtrup A, McKnight D, Devinsky O, Chung WK
Clinical genetics91(5)756-763(2017 May)

De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy.
de Lange IM, Helbig KL, Weckhuysen S, M?ller RS, Velinov M, Dolzhanskaya N, Marsh E, Helbig I, Devinsky O, Tang S, Mefford HC, Myers CT, van Paesschen W, Striano P, van Gassen K, van Kempen M, de Kovel CG, Piard J, Minassian BA, Nezarati MM, Pessoa A, Jacquette A, Maher B, Balestrini S, Sisodiya S, Warde MT, De St Martin A, Chelly J, , van 't Slot R, Van Maldergem L, Brilstra EH, Koeleman BP
Journal of medical genetics53(12)850-858(2016 Dec)

The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and ?-Catenin Signaling.
Gilbert J, Man HY
eNeuro3(5)(2016 Sep-Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Heterozygous loss of KIAA2022 expression is a cause of intellectual disability in females. Compared with its hemizygous male counterpart, the heterozygous female disease has less severe intellectual disability, but is more often associated with a severe and intractable myoclonic epilepsy.
Title: De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy.

Two unrelated patients with X-linked intellectual disability found having the KIAA2022 mutation phenotype.
Title: Delineation of the KIAA2022 mutation phenotype: two patients with X-linked intellectual disability and distinctive features.

Xpn regulates cell-cell and cell-matrix adhesion and cellular migration by regulating the expression of adhesion molecules
Title: XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration.

study describes 3 new families with likely pathogenic mutations of KIAA2022 and further defined clinical and genetic phenotypes; role of KIAA2022 in neuronal development, together with the clinical features of patients observed, provides evidence that KIAA2022 is essential for proper brain development
Title: Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth.

disrupted in X-linked mental retardation
Title: Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males.

The following NEXMIF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEXMIF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22432	NM_001008537.3 Latest version!	Homo sapiens neurite extension and migration factor (NEXMIF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$579.50-$811.30 $1159.00
View Old Accession Versions >>
OHu22432	NM_001008537.2	Homo sapiens neurite extension and migration factor (NEXMIF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$579.50-$811.30 $1159.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEXMIF ( NM_001008537.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008537.1 Homo sapiens neurite extension and migration factor (NEXMIF), mRNA.

Price & Availability↑

CloneID	OHu22432
Clone ID Related Accession (Same CDS sequence)	NM_001008537.3 , NM_001008537.2
Accession Version	NM_001008537.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	neurite extension and migration factor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA776009.1, AY563507.1, AL139395.7 and AI167637.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001008537.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY563507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152798, SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000055682.12/ ENSP00000055682.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATAACC AACAAGATAA GGCTATTGTT GCCTCAGCCA ACGGAGAAAA CACTCTGATT 
AATGGGGTCA AAGAAAATGA CTCAGAGGAC CAGGATGTGG CAATGAAGTC ATTTGCAGCT 
CTAGAAGCTG CTGCACCTAT CCAGCCTACA CCGGTGGCAC AAAAAGAGAC CCTGATGTAT 
CCCAGAGGTC TCCTGCCTCT ACCCTCTAAG AAGCCCTGTA TGCAGAGCCC GCCCTCTCCT 
TTGGGCCTGA TTGAAGCACC CGAACATGCT GCTAATAGTG CTTCTGTGAA TGCCATCTCC 
CTCACATCTG GCATTGCAAA AGGCCTGAAC ACATGGTCAC TTCCCAATGA ATGTGAGAAA 
GCTCCATTTG CCATAATGGA GCCTGCAGGC ATGTCAGCTC TGAATGGGGA CTGTCTCATG 
CAGCCAAGTC GGACTTGCTT AGGCTGCTTC ATGGAATCCA AGGATGCAGT AGATCCTGAG 
CCAGGGATCA GTCTGAAAGT TGGTGATCTA AATAGGGATT ATGAAACGTG TGCAGTCTCT 
GATATAGGGA TTCAGTGTAT TAATGCTGGA GAAAATATGA AATATGGAGA GCAGCTGCTC 
TCAGACCAGC TCCTAGGCTT CCCCCTGCAT AAGTCAAGGG CAGGAGACAG ACGAGAAACT 
GAGAAACCTG ACATTGACTT GGAGGATCCG GCTCAGAAAA GCTATTATGA GGCATTACTG 
TTAGACAAGT GCAATACAGA AGAAGCTTTG CTTGCAAATT CCAATCAGGA TTGGGGTTAC 
TTCGAGACTT TTATTAGTGA AAGTAAGATT GAACTGCTTG ACCTCTGTTC CAAAAATGAG 
CTGTCTGTCA ACCTATTCTC TGAAGAAGAT GTGGATAACT ACATGTTTGA TGATGATGAA 
TCAACACTAG GCAGTGATGT CTGCTCCCTG AAAATTCGAT ATGAATCCTT TCAGGACAAT 
GTTCGAGACA AGACTACTCT TTTGATGCAG GAAGATGCCC AATTCAACTT TTTTCCCAGC 
GTCTTTACTA CCTGCCCCAA GCGAGAGTCT AAGAGTGGGG CCCTGAAGCA GAGCAGTGAT 
TTTTCCCAAT TCAAGGTCCC TGATGTGAGC ATCATCTGGG GGGAGGAAGA TAAAAACTTG 
GACAAGAAGA AAGGCAAAGA GGAAGGACAG GAAGACAAAG GTGTAGAGAA GAAAGATGGA 
AAGGATAATG GAGAAAAGCC TGCCTTAAAT AAACCATGCA GTGGGACTGA AGTAGAGCAA 
CTTAAGAATC CAAAGCAGGG CCATCTTGCT AATTCCCTGG AGACATCAGG GAGTTTCAGT 
GATGATAGTT CCTTCATTGA GATCTCATAT GATGCTATGG GTGAGATCAA GGACTGTAGT 
CGCTATATGG CTCGGGACAC TAATTCTGGC AGCTCCTCCT CCCAACAGAA CTATGGGCTG 
CGAGCCAAGA GAAAAGTCAG ATACAGTGAA GATTATCTAT ATGATGTTGA CTCACTAGAG 
GGTGAAAAAG TAAATGAGAG GAAGGAATGG CTGCCAGTTG GTTCCAAAGA GGAAGATGAT 
GATGAATGGT GTCCCAAAAA GAGAAGAAAA GTAACCCGTA AGGAGCCCCC TGTTATTATC 
AAATATATCA TCATTAATCG CTTTAAAGGT GAGAAGAACA TGCTGGTGAA GTTGGGTAAG 
GTGGATGCCA GTGAGACAAC AGTGAATTTG AGTGAGAATC AGCTCAACAA ATATGCCAAG 
CTGGCACCCT TGAAAGGCTT CTGGCAAAAG AAGAAGAAGC AGAGAAACAC CAACACGGAC 
TCCATCAAGA CACCTTTTTC CCAAAAGCAA AGCTTTGAAC CAGGTAGCTT TGAGGTGTCA 
TTTCTGCCAC CTGCTCGCAA ACGAAAATCT AAACTTGGCA ACAGGCACAG GATTCAAAGA 
ATCCCATCCA TTGAAATTTC AGCAAGTAGT AAACAGATTT CATTATGTAA TGATCAGAGG 
CACGCTAGTA ATCATAAAGA AGATGGAGGC CTAAAAGGTA CACTGAAGTC AGCACCTCTG 
GGTGCTCCTA GCTGTGCAAA TGGATCACAT TTAAATGACA TCACAGGCCC TGACTCAGTG 
AAAGTCAAAG CCCAAGACAC AGAGTTTAAG GGGCCAGAGA GGAAAGTGCT CAATAAAATC 
AAATTTAAAA GTGAAGCTAG GTTAAAATCT AAGAAAGTCA AAGCTGCTGG GCAAGAAAGC 
AAGCCAATTG TTCAAATGAG CCCTCTCTTG GAAAACCAAT CCTCAAAGGC TAATTTAAAG 
AATGAAGTTA TTCCTGGGAC ATCAAACAGT TCCCGTCTAT CTGAATTTCA TGAGGCAAAG 
GCTGCTAAGA GTTCCACTTT TCTACCAACG ACATGCTCTT CTGAAATGCC TTTATCATCT 
GCTAATGTTA CCACTAATAT ACCTGTTATC CCGGGAGGGT ATCTGCAGAC ATTGTTAGAT 
GCTTCTGACT TGTCAAATAA CACTAGTATC TCATACTTCA GCCACCATTC TCCAGAGCAA 
AATGAAGGCA GCCTCACTCA AACCGAAAAA TCATTTGTAC CCCTCCAGCC TACCCAGGAC 
TGTGTGCTCA CCTCATCCTC TGACTCTGAG CTGCAGCAGT CATCTCATAA CTTCAAAATG 
GAATCAAGCA ACTATAGAAA TGTGTGGCCC AACAAGGCTA CTTCTGGCAC CCAGGAATTC 
ATGGCTGAAG TCTCAAGGGA GATAGCCCCA ACCCAATCCA GTGAATTTGG AGCCTCCCAA 
GTAGTCTCCA TGGAAAATAA CCTCACACCT ACAACATACA ATCCAATCTG TCTCAATAGT 
GGTGGCAGTA ATTGCAACAA GGTCCTGTAT GACTCCATGC AAGATACCCA ACTCCCATCT 
GATGACTCTT ACCAATTATG TCACTTTAAT AATGGAGAGA TCTGCTTTCC TTTCCAGCAG 
GGGCCAGTCA ATATGGATGA TGGTCGGCTC TTTAGCTTTG ATTCAATGGC CCCACTCTCT 
GTCAGCTCAA GTAATTATTG CTCCTTAAGC TTGAAGTCCT GTGAAAAGGA TGGCGATGAT 
GATATCACTG ATGACTTCCT GGCCCATTGC AGCCCTAAGC TGGTGATCCA GCAAAGCATT 
GATGAGATAG CACCACTAAA GGAGTCCACT GACCTCCTGG ATATATCCAA CTTCACCCCT 
GACAAATTCC GCCACTCTTC CCTTTCAGAG ATGTCCCCAC CGGACACCCC TAGTCTTTCC 
CCTCAAATTA CCAGATGTGA GAGTATGAAG ACACTAGGAA CACTAAAGGG GTTCCAAGAG 
GGTGTCCCAG GACCATTGGA CAGTGTGGAA AAAATCAAGT GGGACTGCAG TACCCTTTCA 
CGGCAGGTCC AAATGGAGGA TGGATTTACT TTAAATAATC ACCAGTTTCA GTTCCATATG 
TTCAATGATG AGGATTCTGT CAGCCTGCTC CAAAAAAACC CTTGCCTGTC AACATTTAAT 
GATCCATCTG GTCAAATTAG TACCAACAAC AAAGTGTCAA AATCAAGAAA GAAAAGTTCA 
CCCAGCAAGA GTGGGGCTAT GAACCAAAGC TCTTCTCAGA AAAACACCAG GAAAAAATCC 
CTCAAAGGTA ACAACAAGGG GATTGAAAAA CCACCTGGCA AAAACTCCCG CCAGGTCCCT 
AAGTCCACAA AGAAAGGGAA ATACATGGCT GCCATCAATG GAGAGAAAAT GCAAATTGGC 
ATTGGCCGTG GGGGAAGCCA AACCAACACC ATATCCTCCA CTGGGAAGAC ATTGGCTGAA 
TGTATCCAAC ATGGTGGCCC TATGGCCTCT ATGAAGATGC CAAGTCAAAA GGGACTTTCT 
GGAGATTGGG CCTTGGGGAA GGAGAGCAGC CCAGGCTGGA GTGATATGAG CATGGGCACC 
AACACCAACA GCCTTCTGGA TGATGACCAA CGGGAATTTC AGGAGCCTTC CTATATCTTG 
TCCAACATTG CCTCTGGTAT GGCAGATGTG CAGAGATTCA TGATGGCCTC CATAGAGCCC 
CTTTGGGAAC CCATGGAGCA CCATGGGGAT CCCAACATAT TCTACTCCCC TGAGTCCAAT 
AGTCTAAAAT TAAAAACCCT CAAAATATTG GCTGGGACAC CACAGGAGTC TAAGAAAAAG 
ATCAACAGTG GGTCCCAAGG AGCCACTAAG AATCACAGGT CAATCAAGGG TGTGAGCAAA 
AGCAATGGGA AAACAGCAAT AGGTGATCCT GGTCGTGCAA ACATGCCTGG TTATAACGAG 
GACTCTCGCT CTACCTTCTT TGATAAAAAG TATAGTAACA TGAGCACTTT AGGCAATAAC 
GGACCGACAC ACAAAAAGTT GTATCGTCAC AAATCCAGCT CCAAGGCCCT GAGAGATGAG 
AAATGTAAGG GAAAGCACAT GGAGCGAGAA CAGGTCCACA AGGATGAGTC TGGGACAGCT 
TCTTTTGAAA AACTGAGGGA TTCCGACTAC AATCTCCTAA AAGCAGAAAC AACCTTTTGG 
GTTTTACCTG TGTTTGAAGA AGAGACTCGC ATTTTCCAGA AAGACATTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008537.1
CDS	618..5168
Translation	MDNQQDKAIVASANGENTLINGVKENDSEDQDVAMKSFAALEAAAPIQPTPVAQKETLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGIAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDAVDPEPGISLKVGDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRRETEKPDIDLEDPAQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKSGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEDKGVEKKDGKDNGEKPALNKPCSGTEVEQLKNPKQGHLANSLETSGSFSDDSSFIEISYDAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPVGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGKVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNTNTDSIKTPFSQKQSFEPGSFEVSFLPPARKRKSKLGNRHRIQRIPSIEISASSKQISLCNDQRHASNHKEDGGLKGTLKSAPLGAPSCANGSHLNDITGPDSVKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKVKAAGQESKPIVQMSPLLENQSSKANLKNEVIPGTSNSSRLSEFHEAKAAKSSTFLPTTCSSEMPLSSANVTTNIPVIPGGYLQTLLDASDLSNNTSISYFSHHSPEQNEGSLTQTEKSFVPLQPTQDCVLTSSSDSELQQSSHNFKMESSNYRNVWPNKATSGTQEFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNCNKVLYDSMQDTQLPSDDSYQLCHFNNGEICFPFQQGPVNMDDGRLFSFDSMAPLSVSSSNYCSLSLKSCEKDGDDDITDDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEMSPPDTPSLSPQITRCESMKTLGTLKGFQEGVPGPLDSVEKIKWDCSTLSRQVQMEDGFTLNNHQFQFHMFNDEDSVSLLQKNPCLSTFNDPSGQISTNNKVSKSRKKSSPSKSGAMNQSSSQKNTRKKSLKGNNKGIEKPPGKNSRQVPKSTKKGKYMAAINGEKMQIGIGRGGSQTNTISSTGKTLAECIQHGGPMASMKMPSQKGLSGDWALGKESSPGWSDMSMGTNTNSLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKINSGSQGATKNHRSIKGVSKSNGKTAIGDPGRANMPGYNEDSRSTFFDKKYSNMSTLGNNGPTHKKLYRHKSSSKALRDEKCKGKHMEREQVHKDESGTASFEKLRDSDYNLLKAETTFWVLPVFEEETRIFQKDI

Target ORF information:

RefSeq Version	NM_001008537.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neurite extension and migration factor (NEXMIF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008537.3

ORF Insert Sequence:

ATGGATAACC AACAAGATAA GGCTATTGTT GCCTCAGCCA ACGGAGAAAA CACTCTGATT 
AATGGGGTCA AAGAAAATGA CTCAGAGGAC CAGGATGTGG CAATGAAGTC ATTTGCAGCT 
CTAGAAGCTG CTGCACCTAT CCAGCCTACA CCGGTGGCAC AAAAAGAGAC CCTGATGTAT 
CCCAGAGGTC TCCTGCCTCT ACCCTCTAAG AAGCCCTGTA TGCAGAGCCC GCCCTCTCCT 
TTGGGCCTGA TTGAAGCACC CGAACATGCT GCTAATAGTG CTTCTGTGAA TGCCATCTCC 
CTCACATCTG GCATTGCAAA AGGCCTGAAC ACATGGTCAC TTCCCAATGA ATGTGAGAAA 
GCTCCATTTG CCATAATGGA GCCTGCAGGC ATGTCAGCTC TGAATGGGGA CTGTCTCATG 
CAGCCAAGTC GGACTTGCTT AGGCTGCTTC ATGGAATCCA AGGATGCAGT AGATCCTGAG 
CCAGGGATCA GTCTGAAAGT TGGTGATCTA AATAGGGATT ATGAAACGTG TGCAGTCTCT 
GATATAGGGA TTCAGTGTAT TAATGCTGGA GAAAATATGA AATATGGAGA GCAGCTGCTC 
TCAGACCAGC TCCTAGGCTT CCCCCTGCAT AAGTCAAGGG CAGGAGACAG ACGAGAAACT 
GAGAAACCTG ACATTGACTT GGAGGATCCG GCTCAGAAAA GCTATTATGA GGCATTACTG 
TTAGACAAGT GCAATACAGA AGAAGCTTTG CTTGCAAATT CCAATCAGGA TTGGGGTTAC 
TTCGAGACTT TTATTAGTGA AAGTAAGATT GAACTGCTTG ACCTCTGTTC CAAAAATGAG 
CTGTCTGTCA ACCTATTCTC TGAAGAAGAT GTGGATAACT ACATGTTTGA TGATGATGAA 
TCAACACTAG GCAGTGATGT CTGCTCCCTG AAAATTCGAT ATGAATCCTT TCAGGACAAT 
GTTCGAGACA AGACTACTCT TTTGATGCAG GAAGATGCCC AATTCAACTT TTTTCCCAGC 
GTCTTTACTA CCTGCCCCAA GCGAGAGTCT AAGAGTGGGG CCCTGAAGCA GAGCAGTGAT 
TTTTCCCAAT TCAAGGTCCC TGATGTGAGC ATCATCTGGG GGGAGGAAGA TAAAAACTTG 
GACAAGAAGA AAGGCAAAGA GGAAGGACAG GAAGACAAAG GTGTAGAGAA GAAAGATGGA 
AAGGATAATG GAGAAAAGCC TGCCTTAAAT AAACCATGCA GTGGGACTGA AGTAGAGCAA 
CTTAAGAATC CAAAGCAGGG CCATCTTGCT AATTCCCTGG AGACATCAGG GAGTTTCAGT 
GATGATAGTT CCTTCATTGA GATCTCATAT GATGCTATGG GTGAGATCAA GGACTGTAGT 
CGCTATATGG CTCGGGACAC TAATTCTGGC AGCTCCTCCT CCCAACAGAA CTATGGGCTG 
CGAGCCAAGA GAAAAGTCAG ATACAGTGAA GATTATCTAT ATGATGTTGA CTCACTAGAG 
GGTGAAAAAG TAAATGAGAG GAAGGAATGG CTGCCAGTTG GTTCCAAAGA GGAAGATGAT 
GATGAATGGT GTCCCAAAAA GAGAAGAAAA GTAACCCGTA AGGAGCCCCC TGTTATTATC 
AAATATATCA TCATTAATCG CTTTAAAGGT GAGAAGAACA TGCTGGTGAA GTTGGGTAAG 
GTGGATGCCA GTGAGACAAC AGTGAATTTG AGTGAGAATC AGCTCAACAA ATATGCCAAG 
CTGGCACCCT TGAAAGGCTT CTGGCAAAAG AAGAAGAAGC AGAGAAACAC CAACACGGAC 
TCCATCAAGA CACCTTTTTC CCAAAAGCAA AGCTTTGAAC CAGGTAGCTT TGAGGTGTCA 
TTTCTGCCAC CTGCTCGCAA ACGAAAATCT AAACTTGGCA ACAGGCACAG GATTCAAAGA 
ATCCCATCCA TTGAAATTTC AGCAAGTAGT AAACAGATTT CATTATGTAA TGATCAGAGG 
CACGCTAGTA ATCATAAAGA AGATGGAGGC CTAAAAGGTA CACTGAAGTC AGCACCTCTG 
GGTGCTCCTA GCTGTGCAAA TGGATCACAT TTAAATGACA TCACAGGCCC TGACTCAGTG 
AAAGTCAAAG CCCAAGACAC AGAGTTTAAG GGGCCAGAGA GGAAAGTGCT CAATAAAATC 
AAATTTAAAA GTGAAGCTAG GTTAAAATCT AAGAAAGTCA AAGCTGCTGG GCAAGAAAGC 
AAGCCAATTG TTCAAATGAG CCCTCTCTTG GAAAACCAAT CCTCAAAGGC TAATTTAAAG 
AATGAAGTTA TTCCTGGGAC ATCAAACAGT TCCCGTCTAT CTGAATTTCA TGAGGCAAAG 
GCTGCTAAGA GTTCCACTTT TCTACCAACG ACATGCTCTT CTGAAATGCC TTTATCATCT 
GCTAATGTTA CCACTAATAT ACCTGTTATC CCGGGAGGGT ATCTGCAGAC ATTGTTAGAT 
GCTTCTGACT TGTCAAATAA CACTAGTATC TCATACTTCA GCCACCATTC TCCAGAGCAA 
AATGAAGGCA GCCTCACTCA AACCGAAAAA TCATTTGTAC CCCTCCAGCC TACCCAGGAC 
TGTGTGCTCA CCTCATCCTC TGACTCTGAG CTGCAGCAGT CATCTCATAA CTTCAAAATG 
GAATCAAGCA ACTATAGAAA TGTGTGGCCC AACAAGGCTA CTTCTGGCAC CCAGGAATTC 
ATGGCTGAAG TCTCAAGGGA GATAGCCCCA ACCCAATCCA GTGAATTTGG AGCCTCCCAA 
GTAGTCTCCA TGGAAAATAA CCTCACACCT ACAACATACA ATCCAATCTG TCTCAATAGT 
GGTGGCAGTA ATTGCAACAA GGTCCTGTAT GACTCCATGC AAGATACCCA ACTCCCATCT 
GATGACTCTT ACCAATTATG TCACTTTAAT AATGGAGAGA TCTGCTTTCC TTTCCAGCAG 
GGGCCAGTCA ATATGGATGA TGGTCGGCTC TTTAGCTTTG ATTCAATGGC CCCACTCTCT 
GTCAGCTCAA GTAATTATTG CTCCTTAAGC TTGAAGTCCT GTGAAAAGGA TGGCGATGAT 
GATATCACTG ATGACTTCCT GGCCCATTGC AGCCCTAAGC TGGTGATCCA GCAAAGCATT 
GATGAGATAG CACCACTAAA GGAGTCCACT GACCTCCTGG ATATATCCAA CTTCACCCCT 
GACAAATTCC GCCACTCTTC CCTTTCAGAG ATGTCCCCAC CGGACACCCC TAGTCTTTCC 
CCTCAAATTA CCAGATGTGA GAGTATGAAG ACACTAGGAA CACTAAAGGG GTTCCAAGAG 
GGTGTCCCAG GACCATTGGA CAGTGTGGAA AAAATCAAGT GGGACTGCAG TACCCTTTCA 
CGGCAGGTCC AAATGGAGGA TGGATTTACT TTAAATAATC ACCAGTTTCA GTTCCATATG 
TTCAATGATG AGGATTCTGT CAGCCTGCTC CAAAAAAACC CTTGCCTGTC AACATTTAAT 
GATCCATCTG GTCAAATTAG TACCAACAAC AAAGTGTCAA AATCAAGAAA GAAAAGTTCA 
CCCAGCAAGA GTGGGGCTAT GAACCAAAGC TCTTCTCAGA AAAACACCAG GAAAAAATCC 
CTCAAAGGTA ACAACAAGGG GATTGAAAAA CCACCTGGCA AAAACTCCCG CCAGGTCCCT 
AAGTCCACAA AGAAAGGGAA ATACATGGCT GCCATCAATG GAGAGAAAAT GCAAATTGGC 
ATTGGCCGTG GGGGAAGCCA AACCAACACC ATATCCTCCA CTGGGAAGAC ATTGGCTGAA 
TGTATCCAAC ATGGTGGCCC TATGGCCTCT ATGAAGATGC CAAGTCAAAA GGGACTTTCT 
GGAGATTGGG CCTTGGGGAA GGAGAGCAGC CCAGGCTGGA GTGATATGAG CATGGGCACC 
AACACCAACA GCCTTCTGGA TGATGACCAA CGGGAATTTC AGGAGCCTTC CTATATCTTG 
TCCAACATTG CCTCTGGTAT GGCAGATGTG CAGAGATTCA TGATGGCCTC CATAGAGCCC 
CTTTGGGAAC CCATGGAGCA CCATGGGGAT CCCAACATAT TCTACTCCCC TGAGTCCAAT 
AGTCTAAAAT TAAAAACCCT CAAAATATTG GCTGGGACAC CACAGGAGTC TAAGAAAAAG 
ATCAACAGTG GGTCCCAAGG AGCCACTAAG AATCACAGGT CAATCAAGGG TGTGAGCAAA 
AGCAATGGGA AAACAGCAAT AGGTGATCCT GGTCGTGCAA ACATGCCTGG TTATAACGAG 
GACTCTCGCT CTACCTTCTT TGATAAAAAG TATAGTAACA TGAGCACTTT AGGCAATAAC 
GGACCGACAC ACAAAAAGTT GTATCGTCAC AAATCCAGCT CCAAGGCCCT GAGAGATGAG 
AAATGTAAGG GAAAGCACAT GGAGCGAGAA CAGGTCCACA AGGATGAGTC TGGGACAGCT 
TCTTTTGAAA AACTGAGGGA TTCCGACTAC AATCTCCTAA AAGCAGAAAC AACCTTTTGG 
GTTTTACCTG TGTTTGAAGA AGAGACTCGC ATTTTCCAGA AAGACATTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NEXMIF ( NM_001008537.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008537.1 Homo sapiens neurite extension and migration factor (NEXMIF), mRNA.

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CloneID	OHu22432
Clone ID Related Accession (Same CDS sequence)	NM_001008537.3 , NM_001008537.2
Accession Version	NM_001008537.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	neurite extension and migration factor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA776009.1, AY563507.1, AL139395.7 and AI167637.1. This sequence is a reference standard in the RefSeqGene project. On Mar 23, 2009 this sequence version replaced NM_001008537.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY563507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152798, SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAACC AACAAGATAA GGCTATTGTT GCCTCAGCCA ACGGAGAAAA CACTCTGATT 
AATGGGGTCA AAGAAAATGA CTCAGAGGAC CAGGATGTGG CAATGAAGTC ATTTGCAGCT 
CTAGAAGCTG CTGCACCTAT CCAGCCTACA CCGGTGGCAC AAAAAGAGAC CCTGATGTAT 
CCCAGAGGTC TCCTGCCTCT ACCCTCTAAG AAGCCCTGTA TGCAGAGCCC GCCCTCTCCT 
TTGGGCCTGA TTGAAGCACC CGAACATGCT GCTAATAGTG CTTCTGTGAA TGCCATCTCC 
CTCACATCTG GCATTGCAAA AGGCCTGAAC ACATGGTCAC TTCCCAATGA ATGTGAGAAA 
GCTCCATTTG CCATAATGGA GCCTGCAGGC ATGTCAGCTC TGAATGGGGA CTGTCTCATG 
CAGCCAAGTC GGACTTGCTT AGGCTGCTTC ATGGAATCCA AGGATGCAGT AGATCCTGAG 
CCAGGGATCA GTCTGAAAGT TGGTGATCTA AATAGGGATT ATGAAACGTG TGCAGTCTCT 
GATATAGGGA TTCAGTGTAT TAATGCTGGA GAAAATATGA AATATGGAGA GCAGCTGCTC 
TCAGACCAGC TCCTAGGCTT CCCCCTGCAT AAGTCAAGGG CAGGAGACAG ACGAGAAACT 
GAGAAACCTG ACATTGACTT GGAGGATCCG GCTCAGAAAA GCTATTATGA GGCATTACTG 
TTAGACAAGT GCAATACAGA AGAAGCTTTG CTTGCAAATT CCAATCAGGA TTGGGGTTAC 
TTCGAGACTT TTATTAGTGA AAGTAAGATT GAACTGCTTG ACCTCTGTTC CAAAAATGAG 
CTGTCTGTCA ACCTATTCTC TGAAGAAGAT GTGGATAACT ACATGTTTGA TGATGATGAA 
TCAACACTAG GCAGTGATGT CTGCTCCCTG AAAATTCGAT ATGAATCCTT TCAGGACAAT 
GTTCGAGACA AGACTACTCT TTTGATGCAG GAAGATGCCC AATTCAACTT TTTTCCCAGC 
GTCTTTACTA CCTGCCCCAA GCGAGAGTCT AAGAGTGGGG CCCTGAAGCA GAGCAGTGAT 
TTTTCCCAAT TCAAGGTCCC TGATGTGAGC ATCATCTGGG GGGAGGAAGA TAAAAACTTG 
GACAAGAAGA AAGGCAAAGA GGAAGGACAG GAAGACAAAG GTGTAGAGAA GAAAGATGGA 
AAGGATAATG GAGAAAAGCC TGCCTTAAAT AAACCATGCA GTGGGACTGA AGTAGAGCAA 
CTTAAGAATC CAAAGCAGGG CCATCTTGCT AATTCCCTGG AGACATCAGG GAGTTTCAGT 
GATGATAGTT CCTTCATTGA GATCTCATAT GATGCTATGG GTGAGATCAA GGACTGTAGT 
CGCTATATGG CTCGGGACAC TAATTCTGGC AGCTCCTCCT CCCAACAGAA CTATGGGCTG 
CGAGCCAAGA GAAAAGTCAG ATACAGTGAA GATTATCTAT ATGATGTTGA CTCACTAGAG 
GGTGAAAAAG TAAATGAGAG GAAGGAATGG CTGCCAGTTG GTTCCAAAGA GGAAGATGAT 
GATGAATGGT GTCCCAAAAA GAGAAGAAAA GTAACCCGTA AGGAGCCCCC TGTTATTATC 
AAATATATCA TCATTAATCG CTTTAAAGGT GAGAAGAACA TGCTGGTGAA GTTGGGTAAG 
GTGGATGCCA GTGAGACAAC AGTGAATTTG AGTGAGAATC AGCTCAACAA ATATGCCAAG 
CTGGCACCCT TGAAAGGCTT CTGGCAAAAG AAGAAGAAGC AGAGAAACAC CAACACGGAC 
TCCATCAAGA CACCTTTTTC CCAAAAGCAA AGCTTTGAAC CAGGTAGCTT TGAGGTGTCA 
TTTCTGCCAC CTGCTCGCAA ACGAAAATCT AAACTTGGCA ACAGGCACAG GATTCAAAGA 
ATCCCATCCA TTGAAATTTC AGCAAGTAGT AAACAGATTT CATTATGTAA TGATCAGAGG 
CACGCTAGTA ATCATAAAGA AGATGGAGGC CTAAAAGGTA CACTGAAGTC AGCACCTCTG 
GGTGCTCCTA GCTGTGCAAA TGGATCACAT TTAAATGACA TCACAGGCCC TGACTCAGTG 
AAAGTCAAAG CCCAAGACAC AGAGTTTAAG GGGCCAGAGA GGAAAGTGCT CAATAAAATC 
AAATTTAAAA GTGAAGCTAG GTTAAAATCT AAGAAAGTCA AAGCTGCTGG GCAAGAAAGC 
AAGCCAATTG TTCAAATGAG CCCTCTCTTG GAAAACCAAT CCTCAAAGGC TAATTTAAAG 
AATGAAGTTA TTCCTGGGAC ATCAAACAGT TCCCGTCTAT CTGAATTTCA TGAGGCAAAG 
GCTGCTAAGA GTTCCACTTT TCTACCAACG ACATGCTCTT CTGAAATGCC TTTATCATCT 
GCTAATGTTA CCACTAATAT ACCTGTTATC CCGGGAGGGT ATCTGCAGAC ATTGTTAGAT 
GCTTCTGACT TGTCAAATAA CACTAGTATC TCATACTTCA GCCACCATTC TCCAGAGCAA 
AATGAAGGCA GCCTCACTCA AACCGAAAAA TCATTTGTAC CCCTCCAGCC TACCCAGGAC 
TGTGTGCTCA CCTCATCCTC TGACTCTGAG CTGCAGCAGT CATCTCATAA CTTCAAAATG 
GAATCAAGCA ACTATAGAAA TGTGTGGCCC AACAAGGCTA CTTCTGGCAC CCAGGAATTC 
ATGGCTGAAG TCTCAAGGGA GATAGCCCCA ACCCAATCCA GTGAATTTGG AGCCTCCCAA 
GTAGTCTCCA TGGAAAATAA CCTCACACCT ACAACATACA ATCCAATCTG TCTCAATAGT 
GGTGGCAGTA ATTGCAACAA GGTCCTGTAT GACTCCATGC AAGATACCCA ACTCCCATCT 
GATGACTCTT ACCAATTATG TCACTTTAAT AATGGAGAGA TCTGCTTTCC TTTCCAGCAG 
GGGCCAGTCA ATATGGATGA TGGTCGGCTC TTTAGCTTTG ATTCAATGGC CCCACTCTCT 
GTCAGCTCAA GTAATTATTG CTCCTTAAGC TTGAAGTCCT GTGAAAAGGA TGGCGATGAT 
GATATCACTG ATGACTTCCT GGCCCATTGC AGCCCTAAGC TGGTGATCCA GCAAAGCATT 
GATGAGATAG CACCACTAAA GGAGTCCACT GACCTCCTGG ATATATCCAA CTTCACCCCT 
GACAAATTCC GCCACTCTTC CCTTTCAGAG ATGTCCCCAC CGGACACCCC TAGTCTTTCC 
CCTCAAATTA CCAGATGTGA GAGTATGAAG ACACTAGGAA CACTAAAGGG GTTCCAAGAG 
GGTGTCCCAG GACCATTGGA CAGTGTGGAA AAAATCAAGT GGGACTGCAG TACCCTTTCA 
CGGCAGGTCC AAATGGAGGA TGGATTTACT TTAAATAATC ACCAGTTTCA GTTCCATATG 
TTCAATGATG AGGATTCTGT CAGCCTGCTC CAAAAAAACC CTTGCCTGTC AACATTTAAT 
GATCCATCTG GTCAAATTAG TACCAACAAC AAAGTGTCAA AATCAAGAAA GAAAAGTTCA 
CCCAGCAAGA GTGGGGCTAT GAACCAAAGC TCTTCTCAGA AAAACACCAG GAAAAAATCC 
CTCAAAGGTA ACAACAAGGG GATTGAAAAA CCACCTGGCA AAAACTCCCG CCAGGTCCCT 
AAGTCCACAA AGAAAGGGAA ATACATGGCT GCCATCAATG GAGAGAAAAT GCAAATTGGC 
ATTGGCCGTG GGGGAAGCCA AACCAACACC ATATCCTCCA CTGGGAAGAC ATTGGCTGAA 
TGTATCCAAC ATGGTGGCCC TATGGCCTCT ATGAAGATGC CAAGTCAAAA GGGACTTTCT 
GGAGATTGGG CCTTGGGGAA GGAGAGCAGC CCAGGCTGGA GTGATATGAG CATGGGCACC 
AACACCAACA GCCTTCTGGA TGATGACCAA CGGGAATTTC AGGAGCCTTC CTATATCTTG 
TCCAACATTG CCTCTGGTAT GGCAGATGTG CAGAGATTCA TGATGGCCTC CATAGAGCCC 
CTTTGGGAAC CCATGGAGCA CCATGGGGAT CCCAACATAT TCTACTCCCC TGAGTCCAAT 
AGTCTAAAAT TAAAAACCCT CAAAATATTG GCTGGGACAC CACAGGAGTC TAAGAAAAAG 
ATCAACAGTG GGTCCCAAGG AGCCACTAAG AATCACAGGT CAATCAAGGG TGTGAGCAAA 
AGCAATGGGA AAACAGCAAT AGGTGATCCT GGTCGTGCAA ACATGCCTGG TTATAACGAG 
GACTCTCGCT CTACCTTCTT TGATAAAAAG TATAGTAACA TGAGCACTTT AGGCAATAAC 
GGACCGACAC ACAAAAAGTT GTATCGTCAC AAATCCAGCT CCAAGGCCCT GAGAGATGAG 
AAATGTAAGG GAAAGCACAT GGAGCGAGAA CAGGTCCACA AGGATGAGTC TGGGACAGCT 
TCTTTTGAAA AACTGAGGGA TTCCGACTAC AATCTCCTAA AAGCAGAAAC AACCTTTTGG 
GTTTTACCTG TGTTTGAAGA AGAGACTCGC ATTTTCCAGA AAGACATTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008537.1
CDS	618..5168
Translation	MDNQQDKAIVASANGENTLINGVKENDSEDQDVAMKSFAALEAAAPIQPTPVAQKETLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGIAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDAVDPEPGISLKVGDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRRETEKPDIDLEDPAQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKSGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEDKGVEKKDGKDNGEKPALNKPCSGTEVEQLKNPKQGHLANSLETSGSFSDDSSFIEISYDAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPVGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGKVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNTNTDSIKTPFSQKQSFEPGSFEVSFLPPARKRKSKLGNRHRIQRIPSIEISASSKQISLCNDQRHASNHKEDGGLKGTLKSAPLGAPSCANGSHLNDITGPDSVKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKVKAAGQESKPIVQMSPLLENQSSKANLKNEVIPGTSNSSRLSEFHEAKAAKSSTFLPTTCSSEMPLSSANVTTNIPVIPGGYLQTLLDASDLSNNTSISYFSHHSPEQNEGSLTQTEKSFVPLQPTQDCVLTSSSDSELQQSSHNFKMESSNYRNVWPNKATSGTQEFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNCNKVLYDSMQDTQLPSDDSYQLCHFNNGEICFPFQQGPVNMDDGRLFSFDSMAPLSVSSSNYCSLSLKSCEKDGDDDITDDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEMSPPDTPSLSPQITRCESMKTLGTLKGFQEGVPGPLDSVEKIKWDCSTLSRQVQMEDGFTLNNHQFQFHMFNDEDSVSLLQKNPCLSTFNDPSGQISTNNKVSKSRKKSSPSKSGAMNQSSSQKNTRKKSLKGNNKGIEKPPGKNSRQVPKSTKKGKYMAAINGEKMQIGIGRGGSQTNTISSTGKTLAECIQHGGPMASMKMPSQKGLSGDWALGKESSPGWSDMSMGTNTNSLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKINSGSQGATKNHRSIKGVSKSNGKTAIGDPGRANMPGYNEDSRSTFFDKKYSNMSTLGNNGPTHKKLYRHKSSSKALRDEKCKGKHMEREQVHKDESGTASFEKLRDSDYNLLKAETTFWVLPVFEEETRIFQKDI

Target ORF information:

RefSeq Version	NM_001008537.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neurite extension and migration factor (NEXMIF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008537.2

ORF Insert Sequence:

ATGGATAACC AACAAGATAA GGCTATTGTT GCCTCAGCCA ACGGAGAAAA CACTCTGATT 
AATGGGGTCA AAGAAAATGA CTCAGAGGAC CAGGATGTGG CAATGAAGTC ATTTGCAGCT 
CTAGAAGCTG CTGCACCTAT CCAGCCTACA CCGGTGGCAC AAAAAGAGAC CCTGATGTAT 
CCCAGAGGTC TCCTGCCTCT ACCCTCTAAG AAGCCCTGTA TGCAGAGCCC GCCCTCTCCT 
TTGGGCCTGA TTGAAGCACC CGAACATGCT GCTAATAGTG CTTCTGTGAA TGCCATCTCC 
CTCACATCTG GCATTGCAAA AGGCCTGAAC ACATGGTCAC TTCCCAATGA ATGTGAGAAA 
GCTCCATTTG CCATAATGGA GCCTGCAGGC ATGTCAGCTC TGAATGGGGA CTGTCTCATG 
CAGCCAAGTC GGACTTGCTT AGGCTGCTTC ATGGAATCCA AGGATGCAGT AGATCCTGAG 
CCAGGGATCA GTCTGAAAGT TGGTGATCTA AATAGGGATT ATGAAACGTG TGCAGTCTCT 
GATATAGGGA TTCAGTGTAT TAATGCTGGA GAAAATATGA AATATGGAGA GCAGCTGCTC 
TCAGACCAGC TCCTAGGCTT CCCCCTGCAT AAGTCAAGGG CAGGAGACAG ACGAGAAACT 
GAGAAACCTG ACATTGACTT GGAGGATCCG GCTCAGAAAA GCTATTATGA GGCATTACTG 
TTAGACAAGT GCAATACAGA AGAAGCTTTG CTTGCAAATT CCAATCAGGA TTGGGGTTAC 
TTCGAGACTT TTATTAGTGA AAGTAAGATT GAACTGCTTG ACCTCTGTTC CAAAAATGAG 
CTGTCTGTCA ACCTATTCTC TGAAGAAGAT GTGGATAACT ACATGTTTGA TGATGATGAA 
TCAACACTAG GCAGTGATGT CTGCTCCCTG AAAATTCGAT ATGAATCCTT TCAGGACAAT 
GTTCGAGACA AGACTACTCT TTTGATGCAG GAAGATGCCC AATTCAACTT TTTTCCCAGC 
GTCTTTACTA CCTGCCCCAA GCGAGAGTCT AAGAGTGGGG CCCTGAAGCA GAGCAGTGAT 
TTTTCCCAAT TCAAGGTCCC TGATGTGAGC ATCATCTGGG GGGAGGAAGA TAAAAACTTG 
GACAAGAAGA AAGGCAAAGA GGAAGGACAG GAAGACAAAG GTGTAGAGAA GAAAGATGGA 
AAGGATAATG GAGAAAAGCC TGCCTTAAAT AAACCATGCA GTGGGACTGA AGTAGAGCAA 
CTTAAGAATC CAAAGCAGGG CCATCTTGCT AATTCCCTGG AGACATCAGG GAGTTTCAGT 
GATGATAGTT CCTTCATTGA GATCTCATAT GATGCTATGG GTGAGATCAA GGACTGTAGT 
CGCTATATGG CTCGGGACAC TAATTCTGGC AGCTCCTCCT CCCAACAGAA CTATGGGCTG 
CGAGCCAAGA GAAAAGTCAG ATACAGTGAA GATTATCTAT ATGATGTTGA CTCACTAGAG 
GGTGAAAAAG TAAATGAGAG GAAGGAATGG CTGCCAGTTG GTTCCAAAGA GGAAGATGAT 
GATGAATGGT GTCCCAAAAA GAGAAGAAAA GTAACCCGTA AGGAGCCCCC TGTTATTATC 
AAATATATCA TCATTAATCG CTTTAAAGGT GAGAAGAACA TGCTGGTGAA GTTGGGTAAG 
GTGGATGCCA GTGAGACAAC AGTGAATTTG AGTGAGAATC AGCTCAACAA ATATGCCAAG 
CTGGCACCCT TGAAAGGCTT CTGGCAAAAG AAGAAGAAGC AGAGAAACAC CAACACGGAC 
TCCATCAAGA CACCTTTTTC CCAAAAGCAA AGCTTTGAAC CAGGTAGCTT TGAGGTGTCA 
TTTCTGCCAC CTGCTCGCAA ACGAAAATCT AAACTTGGCA ACAGGCACAG GATTCAAAGA 
ATCCCATCCA TTGAAATTTC AGCAAGTAGT AAACAGATTT CATTATGTAA TGATCAGAGG 
CACGCTAGTA ATCATAAAGA AGATGGAGGC CTAAAAGGTA CACTGAAGTC AGCACCTCTG 
GGTGCTCCTA GCTGTGCAAA TGGATCACAT TTAAATGACA TCACAGGCCC TGACTCAGTG 
AAAGTCAAAG CCCAAGACAC AGAGTTTAAG GGGCCAGAGA GGAAAGTGCT CAATAAAATC 
AAATTTAAAA GTGAAGCTAG GTTAAAATCT AAGAAAGTCA AAGCTGCTGG GCAAGAAAGC 
AAGCCAATTG TTCAAATGAG CCCTCTCTTG GAAAACCAAT CCTCAAAGGC TAATTTAAAG 
AATGAAGTTA TTCCTGGGAC ATCAAACAGT TCCCGTCTAT CTGAATTTCA TGAGGCAAAG 
GCTGCTAAGA GTTCCACTTT TCTACCAACG ACATGCTCTT CTGAAATGCC TTTATCATCT 
GCTAATGTTA CCACTAATAT ACCTGTTATC CCGGGAGGGT ATCTGCAGAC ATTGTTAGAT 
GCTTCTGACT TGTCAAATAA CACTAGTATC TCATACTTCA GCCACCATTC TCCAGAGCAA 
AATGAAGGCA GCCTCACTCA AACCGAAAAA TCATTTGTAC CCCTCCAGCC TACCCAGGAC 
TGTGTGCTCA CCTCATCCTC TGACTCTGAG CTGCAGCAGT CATCTCATAA CTTCAAAATG 
GAATCAAGCA ACTATAGAAA TGTGTGGCCC AACAAGGCTA CTTCTGGCAC CCAGGAATTC 
ATGGCTGAAG TCTCAAGGGA GATAGCCCCA ACCCAATCCA GTGAATTTGG AGCCTCCCAA 
GTAGTCTCCA TGGAAAATAA CCTCACACCT ACAACATACA ATCCAATCTG TCTCAATAGT 
GGTGGCAGTA ATTGCAACAA GGTCCTGTAT GACTCCATGC AAGATACCCA ACTCCCATCT 
GATGACTCTT ACCAATTATG TCACTTTAAT AATGGAGAGA TCTGCTTTCC TTTCCAGCAG 
GGGCCAGTCA ATATGGATGA TGGTCGGCTC TTTAGCTTTG ATTCAATGGC CCCACTCTCT 
GTCAGCTCAA GTAATTATTG CTCCTTAAGC TTGAAGTCCT GTGAAAAGGA TGGCGATGAT 
GATATCACTG ATGACTTCCT GGCCCATTGC AGCCCTAAGC TGGTGATCCA GCAAAGCATT 
GATGAGATAG CACCACTAAA GGAGTCCACT GACCTCCTGG ATATATCCAA CTTCACCCCT 
GACAAATTCC GCCACTCTTC CCTTTCAGAG ATGTCCCCAC CGGACACCCC TAGTCTTTCC 
CCTCAAATTA CCAGATGTGA GAGTATGAAG ACACTAGGAA CACTAAAGGG GTTCCAAGAG 
GGTGTCCCAG GACCATTGGA CAGTGTGGAA AAAATCAAGT GGGACTGCAG TACCCTTTCA 
CGGCAGGTCC AAATGGAGGA TGGATTTACT TTAAATAATC ACCAGTTTCA GTTCCATATG 
TTCAATGATG AGGATTCTGT CAGCCTGCTC CAAAAAAACC CTTGCCTGTC AACATTTAAT 
GATCCATCTG GTCAAATTAG TACCAACAAC AAAGTGTCAA AATCAAGAAA GAAAAGTTCA 
CCCAGCAAGA GTGGGGCTAT GAACCAAAGC TCTTCTCAGA AAAACACCAG GAAAAAATCC 
CTCAAAGGTA ACAACAAGGG GATTGAAAAA CCACCTGGCA AAAACTCCCG CCAGGTCCCT 
AAGTCCACAA AGAAAGGGAA ATACATGGCT GCCATCAATG GAGAGAAAAT GCAAATTGGC 
ATTGGCCGTG GGGGAAGCCA AACCAACACC ATATCCTCCA CTGGGAAGAC ATTGGCTGAA 
TGTATCCAAC ATGGTGGCCC TATGGCCTCT ATGAAGATGC CAAGTCAAAA GGGACTTTCT 
GGAGATTGGG CCTTGGGGAA GGAGAGCAGC CCAGGCTGGA GTGATATGAG CATGGGCACC 
AACACCAACA GCCTTCTGGA TGATGACCAA CGGGAATTTC AGGAGCCTTC CTATATCTTG 
TCCAACATTG CCTCTGGTAT GGCAGATGTG CAGAGATTCA TGATGGCCTC CATAGAGCCC 
CTTTGGGAAC CCATGGAGCA CCATGGGGAT CCCAACATAT TCTACTCCCC TGAGTCCAAT 
AGTCTAAAAT TAAAAACCCT CAAAATATTG GCTGGGACAC CACAGGAGTC TAAGAAAAAG 
ATCAACAGTG GGTCCCAAGG AGCCACTAAG AATCACAGGT CAATCAAGGG TGTGAGCAAA 
AGCAATGGGA AAACAGCAAT AGGTGATCCT GGTCGTGCAA ACATGCCTGG TTATAACGAG 
GACTCTCGCT CTACCTTCTT TGATAAAAAG TATAGTAACA TGAGCACTTT AGGCAATAAC 
GGACCGACAC ACAAAAAGTT GTATCGTCAC AAATCCAGCT CCAAGGCCCT GAGAGATGAG 
AAATGTAAGG GAAAGCACAT GGAGCGAGAA CAGGTCCACA AGGATGAGTC TGGGACAGCT 
TCTTTTGAAA AACTGAGGGA TTCCGACTAC AATCTCCTAA AAGCAGAAAC AACCTTTTGG 
GTTTTACCTG TGTTTGAAGA AGAGACTCGC ATTTTCCAGA AAGACATTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

De novo loss of function mutations in KIAA2022 are associated with epilepsy and neurodevelopmental delay in females.
Clinical genetics91(5)756-763(2017 May)
Webster R,Cho MT,Retterer K,Millan F,Nowak C,Douglas J,Ahmad A,Raymond GV,Johnson MR,Pujol A,Begtrup A,McKnight D,Devinsky O,Chung WK

De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy.
Journal of medical genetics53(12)850-858(2016 Dec)
de Lange IM,Helbig KL,Weckhuysen S,M?ller RS,Velinov M,Dolzhanskaya N,Marsh E,Helbig I,Devinsky O,Tang S,Mefford HC,Myers CT,van Paesschen W,Striano P,van Gassen K,van Kempen M,de Kovel CG,Piard J,Minassian BA,Nezarati MM,Pessoa A,Jacquette A,Maher B,Balestrini S,Sisodiya S,Warde MT,De St Martin A,Chelly J,,van 't Slot R,Van Maldergem L,Brilstra EH,Koeleman BP

The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and ?-Catenin Signaling.
eNeuro3(5)(2016 Sep-Oct)
Gilbert J,Man HY

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NEXMIF cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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