CCDC39 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCDC39
Entrez Gene ID	339829
Full Name	coiled-coil domain containing 39
Synonyms	CILD14,FAP59
General protein information	Preferred Names coiled-coil domain containing 39 Names coiled-coil domain-containing protein 39
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q26.33
Summary	The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat. Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14). [provided by RefSeq, Jul 2011].
Disorder MIM:	613798
Disorder Html:	Ciliary dyskinesia, primary, 14, 613807 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_181426.1	NP_852091.1	coiled-coil domain-containing protein 39
NM_181426.2	NP_852091.1	coiled-coil domain-containing protein 39

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CCDC39	NP_001192985.1
Gallus gallus (chicken)	CCDC39	XP_422777.3
Xenopus tropicalis (tropical clawed frog)	ccdc39	NP_001072342.1
Canis lupus familiaris (dog)	CCDC39	XP_545213.3
Rattus norvegicus (Norway rat)	Ccdc39	NP_001101137.1
Danio rerio (zebrafish)	ccdc39	XP_682709.6
Homo sapiens (human)	CCDC39	NP_852091.1
Pan troglodytes (chimpanzee)	CCDC39	XP_003310174.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001293	XP_321854.5
Mus musculus (house mouse)	Ccdc39	NP_080498.1
Drosophila melanogaster (fruit fly)	CG17387	NP_649495.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.
Jeanson L, Thomas L, Copin B, Coste A, Sermet-Gaudelus I, Dastot-Le Moal F, Duquesnoy P, Montantin G, Collot N, Tissier S, Papon JF, Clement A, Louis B, Escudier E, Amselem S, Legendre M
Human mutation37(8)776-85(2016 08)

Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex.
Olbrich H, Cremers C, Loges NT, Werner C, Nielsen KG, Marthin JK, Philipsen M, Wallmeier J, Pennekamp P, Menchen T, Edelbusch C, Dougherty GW, Schwartz O, Thiele H, Altm?ller J, Rommelmann F, Omran H
American journal of human genetics97(4)546-54(2015 Oct)

Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype.
Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, Leigh MW
American journal of respiratory and critical care medicine191(3)316-24(2015 Feb)

Biological insights from 108 schizophrenia-associated genetic loci.

Nature511(7510)421-7(2014 Jul)

Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE, Daniels ML, Noone PG, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A, Dixit A, O'Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD, , Chung EM, Shoemark A, Knowles MR, Omran H, Mitchison HM
Human mutation34(3)462-72(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lung disease was worse in those with IDA/CA/MTD ultrastructural defects, most of whom had biallelic mutations in ccdc39.
Title: Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype.

This study shows that CCDC39 and CCDC40 mutations are the major cause of Primary ciliary dyskinesia in patients with the previously termed "radial spoke defect".
Title: Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.

Aiming to delineate the CCDC39/CCDC40 mutation spectrum and associated phenotypes, a large cohort of patients with IDA defects were screened. Biallelic CCDC39 or CCDC40 mutations were identified in 30/34 unrelated families with IDA defects.
Title: Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesia.

Functional analyses indicated that CCDC39 localizes to ciliary axonemes and is essential for assembly of inner dynein arms and the dynein regulatory complex.
Title: CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following CCDC39 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCDC39 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18891	NM_181426.2 Latest version!	Homo sapiens coiled-coil domain containing 39 (CCDC39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
View Old Accession Versions >>
OHu18891	NM_181426.1	Homo sapiens coiled-coil domain containing 39 (CCDC39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCDC39 ( NM_181426.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_852091.1 Homo sapiens coiled-coil domain containing 39 (CCDC39), mRNA.

Price & Availability↑

CloneID	OHu18891
Clone ID Related Accession (Same CDS sequence)	NM_181426.1 , NM_181426.2
Accession Version	NM_181426.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2826bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 39
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC399927.1, AL122120.1 and BG205877.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304270.1, SRR1803615.176119.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTAGCG AATTCCTGGC TGAGCTGCAC TGGGAGGATG GGTTCGCCAT CCCGGTGGCG 
AACGAGGAGA ACAAGCTACT GGAAGATCAG TTGTCAAAGC TGAAGGATGA AAGAGCAAGC 
TTGCAAGATG AGTTACGTGA GTATGAAGAG CGAATTAATT CTATGACTTC TCACTTCAAA 
AATGTTAAGC AAGAGCTCTC AATTACACAG TCTCTTTGCA AAGCAAGGGA GCGTGAGACT 
GAAAGTGAAG AACATTTTAA GGCCATTGCT CAAAGAGAAT TGGGACGAGT GAAAGATGAA 
ATTCAACGGC TGGAAAATGA GATGGCTTCA ATACTGGAAA AGAAAAGTGA TAAAGAAAAT 
GGCATATTTA AAGCCACTCA AAAATTGGAT GGTTTGAAAT GTCAAATGAA CTGGGACCAG 
CAAGCATTGG AGGCCTGGTT AGAAGAATCA GCTCATAAAG ATAGTGATGC TCTCACTCTC 
CAGAAGTATG CACAACAAGA TGATAATAAA ATCAGGGCAC TGACTCTGCA ATTAGAAAGA 
CTAACTTTGG AATGTAATCA GAAAAGAAAG ATACTTGACA ACGAACTTAC AGAGACTATA 
AGCGCACAGT TAGAATTGGA TAAAGCAGCA CAAGATTTTC GTAAGATTCA TAATGAAAGA 
CAAGAACTCA TTAAACAATG GGAGAACACA ATAGAACAGA TGCAGAAGAG GGATGGAGAC 
ATAGATAACT GTGCTTTGGA ATTAGCAAGG ATAAAGCAGG AAACGAGAGA AAAAGAAAAT 
TTGGTTAAAG AAAAGATCAA GTTTTTGGAA AGTGAGATTG GGAATAACAC AGAGTTTGAG 
AAAAGAATTT CTGTGGCTGA TCGTAAACTT TTAAAATGTA GAACGGCATA TCAGGACCAT 
GAAACTAGTA GAATTCAGCT GAAGGGTGAG CTGGATTCTT TAAAAGCCAC TGTGAATAGA 
ACTTCCAGTG ATTTAGAAGC TCTGAGGAAA AATATTTCCA AGATAAAGAA GGACATTCAT 
GAAGAAACAG CAAGGTTACA AAAAACTAAA AATCATAATG AGATAATACA AACAAAATTA 
AAGGAGATAA CTGAGAAAAC CATGTCTGTA GAAGAGAAAG CTACTAATTT GGAAGATATG 
CTAAAGGAGG AGGAAAAAGA TGTGAAGGAA GTAGATGTTC AACTGAACCT CATAAAAGGT 
GTGCTGTTTA AGAAAGCTCA GGAGTTACAG ACTGAGACAA TGAAAGAAAA AGCTGTTTTA 
TCAGAAATTG AAGGAACTCG TTCCTCTCTG AAACATCTCA ACCATCAGTT ACAAAAACTG 
GATTTTGAAA CCTTGAAGCA GCAAGAAATT ATGTACAGCC AGGATTTTCA CATTCAACAA 
GTGGAACGGA GAATGTCACG GTTAAAGGGA GAAATTAATT CAGAAGAAAA ACAAGCGCTT 
GAAGCAAAAA TTGTTGAACT TAGGAAGTCT TTGGAAGAGA AAAAATCTAC ATGTGGCCTT 
TTGGAAACAC AGATCAAGAA GCTTCATAAT GATCTTTATT TTATCAAGAA GGCACATAGT 
AAAAACAGTG ATGAAAAACA GTCCCTTATG ACCAAAATAA ATGAACTAAA CCTTTTCATC 
GACAGATCAG AGAAAGAACT TGATAAAGCC AAAGGTTTTA AGCAGGATTT GATGATAGAG 
GACAATCTTT TAAAACTTGA AGTTAAGCGT ACTCGAGAAA TGCTTCACAG TAAGGCAGAA 
GAAGTTCTTT CCCTAGAAAA AAGAAAACAG CAATTATACA CAGCAATGGA AGAGCGAACT 
GAAGAAATCA AGGTTCATAA AACAATGCTT GCGTCACAAA TAAGATATGT TGATCAAGAA 
CGGGAAAACA TAAGCACTGA GTTTCGCGAG CGGCTAAGTA AAATTGAGAA GCTGAAGAAT 
AGATATGAAA TTCTGACTGT TGTTATGCTG CCTCCTGAAG GAGAAGAGGA GAAAACACAG 
GCCTATTATG TAATAAAGGC TGCTCAAGAA AAAGAAGAAC TTCAAAGGGA AGGTGACTGT 
TTGGATGCCA AGATCAACAA AGCTGAAAAA GAAATCTACG CTCTAGAAAA TACCCTTCAA 
GTGCTGAACA GCTGTAACAA CAATTATAAG CAATCTTTTA AAAAAGTGAC TCCATCTAGT 
GATGAGTATG AGCTAAAAAT TCAACTAGAA GAACAAAAAA GAGCTGTTGA TGAAAAATAC 
AGATACAAAC AAAGACAAAT CAGAGAACTT CAAGAAGACA TCCAGAGCAT GGAAAATACA 
TTAGATGTTA TAGAACATTT GGCAAATAAT GTTAAAGAAA AGTTATCAGA GAAGCAGGCT 
TATTCATTTC AACTAAGTAA AGAAACGGAG GAGCAGAAGC CAAAATTAGA AAGAGTGACC 
AAACAGTGTG CAAAACTCAC AAAGGAAATC CGTCTTTTGA AAGACACAAA AGATGAAACA 
ATGGAAGAAC AAGACATCAA ACTTCGTGAA ATGAAACAGT TTCACAAAGT TATTGATGAA 
ATGTTAGTTG ATATCATAGA AGAAAATACT GAGATCCGTA TTATCCTTCA AACATACTTT 
CAACAGAGTG GGTTAGAACT ACCTACAGCT AGCACAAAAG GCAGTCGTCA GAGCTCTAGA 
TCTCCTTCAC ATACTTCACT ATCAGCAAGG TCATCTAGGA GTACAAGTAC ATCTACTTCT 
CAGTCTTCAA TTAAAGTACT GGAGCTTAAA TTCCCGGCCT CCTCTTCACT AGTAGGCAGC 
CCTTCTAGGC CATCTAGTGC TAGTAGTAGC TCTAGTAATG TTAAGAGCAA AAAGAGCAGC 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852091.1
CDS	116..2941
Translation	MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK

Target ORF information:

RefSeq Version	NM_181426.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 39 (CCDC39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181426.1

ORF Insert Sequence:

ATGAGTAGCG AATTCCTGGC TGAGCTGCAC TGGGAGGATG GGTTCGCCAT CCCGGTGGCG 
AACGAGGAGA ACAAGCTACT GGAAGATCAG TTGTCAAAGC TGAAGGATGA AAGAGCAAGC 
TTGCAAGATG AGTTACGTGA GTATGAAGAG CGAATTAATT CTATGACTTC TCACTTCAAA 
AATGTTAAGC AAGAGCTCTC AATTACACAG TCTCTTTGCA AAGCAAGGGA GCGTGAGACT 
GAAAGTGAAG AACATTTTAA GGCCATTGCT CAAAGAGAAT TGGGACGAGT GAAAGATGAA 
ATTCAACGGC TGGAAAATGA GATGGCTTCA ATACTGGAAA AGAAAAGTGA TAAAGAAAAT 
GGCATATTTA AAGCCACTCA AAAATTGGAT GGTTTGAAAT GTCAAATGAA CTGGGACCAG 
CAAGCATTGG AGGCCTGGTT AGAAGAATCA GCTCATAAAG ATAGTGATGC TCTCACTCTC 
CAGAAGTATG CACAACAAGA TGATAATAAA ATCAGGGCAC TGACTCTGCA ATTAGAAAGA 
CTAACTTTGG AATGTAATCA GAAAAGAAAG ATACTTGACA ACGAACTTAC AGAGACTATA 
AGCGCACAGT TAGAATTGGA TAAAGCAGCA CAAGATTTTC GTAAGATTCA TAATGAAAGA 
CAAGAACTCA TTAAACAATG GGAGAACACA ATAGAACAGA TGCAGAAGAG GGATGGAGAC 
ATAGATAACT GTGCTTTGGA ATTAGCAAGG ATAAAGCAGG AAACGAGAGA AAAAGAAAAT 
TTGGTTAAAG AAAAGATCAA GTTTTTGGAA AGTGAGATTG GGAATAACAC AGAGTTTGAG 
AAAAGAATTT CTGTGGCTGA TCGTAAACTT TTAAAATGTA GAACGGCATA TCAGGACCAT 
GAAACTAGTA GAATTCAGCT GAAGGGTGAG CTGGATTCTT TAAAAGCCAC TGTGAATAGA 
ACTTCCAGTG ATTTAGAAGC TCTGAGGAAA AATATTTCCA AGATAAAGAA GGACATTCAT 
GAAGAAACAG CAAGGTTACA AAAAACTAAA AATCATAATG AGATAATACA AACAAAATTA 
AAGGAGATAA CTGAGAAAAC CATGTCTGTA GAAGAGAAAG CTACTAATTT GGAAGATATG 
CTAAAGGAGG AGGAAAAAGA TGTGAAGGAA GTAGATGTTC AACTGAACCT CATAAAAGGT 
GTGCTGTTTA AGAAAGCTCA GGAGTTACAG ACTGAGACAA TGAAAGAAAA AGCTGTTTTA 
TCAGAAATTG AAGGAACTCG TTCCTCTCTG AAACATCTCA ACCATCAGTT ACAAAAACTG 
GATTTTGAAA CCTTGAAGCA GCAAGAAATT ATGTACAGCC AGGATTTTCA CATTCAACAA 
GTGGAACGGA GAATGTCACG GTTAAAGGGA GAAATTAATT CAGAAGAAAA ACAAGCGCTT 
GAAGCAAAAA TTGTTGAACT TAGGAAGTCT TTGGAAGAGA AAAAATCTAC ATGTGGCCTT 
TTGGAAACAC AGATCAAGAA GCTTCATAAT GATCTTTATT TTATCAAGAA GGCACATAGT 
AAAAACAGTG ATGAAAAACA GTCCCTTATG ACCAAAATAA ATGAACTAAA CCTTTTCATC 
GACAGATCAG AGAAAGAACT TGATAAAGCC AAAGGTTTTA AGCAGGATTT GATGATAGAG 
GACAATCTTT TAAAACTTGA AGTTAAGCGT ACTCGAGAAA TGCTTCACAG TAAGGCAGAA 
GAAGTTCTTT CCCTAGAAAA AAGAAAACAG CAATTATACA CAGCAATGGA AGAGCGAACT 
GAAGAAATCA AGGTTCATAA AACAATGCTT GCGTCACAAA TAAGATATGT TGATCAAGAA 
CGGGAAAACA TAAGCACTGA GTTTCGCGAG CGGCTAAGTA AAATTGAGAA GCTGAAGAAT 
AGATATGAAA TTCTGACTGT TGTTATGCTG CCTCCTGAAG GAGAAGAGGA GAAAACACAG 
GCCTATTATG TAATAAAGGC TGCTCAAGAA AAAGAAGAAC TTCAAAGGGA AGGTGACTGT 
TTGGATGCCA AGATCAACAA AGCTGAAAAA GAAATCTACG CTCTAGAAAA TACCCTTCAA 
GTGCTGAACA GCTGTAACAA CAATTATAAG CAATCTTTTA AAAAAGTGAC TCCATCTAGT 
GATGAGTATG AGCTAAAAAT TCAACTAGAA GAACAAAAAA GAGCTGTTGA TGAAAAATAC 
AGATACAAAC AAAGACAAAT CAGAGAACTT CAAGAAGACA TCCAGAGCAT GGAAAATACA 
TTAGATGTTA TAGAACATTT GGCAAATAAT GTTAAAGAAA AGTTATCAGA GAAGCAGGCT 
TATTCATTTC AACTAAGTAA AGAAACGGAG GAGCAGAAGC CAAAATTAGA AAGAGTGACC 
AAACAGTGTG CAAAACTCAC AAAGGAAATC CGTCTTTTGA AAGACACAAA AGATGAAACA 
ATGGAAGAAC AAGACATCAA ACTTCGTGAA ATGAAACAGT TTCACAAAGT TATTGATGAA 
ATGTTAGTTG ATATCATAGA AGAAAATACT GAGATCCGTA TTATCCTTCA AACATACTTT 
CAACAGAGTG GGTTAGAACT ACCTACAGCT AGCACAAAAG GCAGTCGTCA GAGCTCTAGA 
TCTCCTTCAC ATACTTCACT ATCAGCAAGG TCATCTAGGA GTACAAGTAC ATCTACTTCT 
CAGTCTTCAA TTAAAGTACT GGAGCTTAAA TTCCCGGCCT CCTCTTCACT AGTAGGCAGC 
CCTTCTAGGC CATCTAGTGC TAGTAGTAGC TCTAGTAATG TTAAGAGCAA AAAGAGCAGC 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC39 ( NM_181426.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_852091.1 Homo sapiens coiled-coil domain containing 39 (CCDC39), mRNA.

Price & Availability↑

CloneID	OHu18891
Clone ID Related Accession (Same CDS sequence)	NM_181426.1 , NM_181426.2
Accession Version	NM_181426.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2826bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 39
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC399927.1, AL122120.1 and BG205877.1. This sequence is a reference standard in the RefSeqGene project. On Jun 30, 2018 this sequence version replaced NM_181426.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304270.1, SRR1803615.176119.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000476379.6/ ENSP00000417960.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTAGCG AATTCCTGGC TGAGCTGCAC TGGGAGGATG GGTTCGCCAT CCCGGTGGCG 
AACGAGGAGA ACAAGCTACT GGAAGATCAG TTGTCAAAGC TGAAGGATGA AAGAGCAAGC 
TTGCAAGATG AGTTACGTGA GTATGAAGAG CGAATTAATT CTATGACTTC TCACTTCAAA 
AATGTTAAGC AAGAGCTCTC AATTACACAG TCTCTTTGCA AAGCAAGGGA GCGTGAGACT 
GAAAGTGAAG AACATTTTAA GGCCATTGCT CAAAGAGAAT TGGGACGAGT GAAAGATGAA 
ATTCAACGGC TGGAAAATGA GATGGCTTCA ATACTGGAAA AGAAAAGTGA TAAAGAAAAT 
GGCATATTTA AAGCCACTCA AAAATTGGAT GGTTTGAAAT GTCAAATGAA CTGGGACCAG 
CAAGCATTGG AGGCCTGGTT AGAAGAATCA GCTCATAAAG ATAGTGATGC TCTCACTCTC 
CAGAAGTATG CACAACAAGA TGATAATAAA ATCAGGGCAC TGACTCTGCA ATTAGAAAGA 
CTAACTTTGG AATGTAATCA GAAAAGAAAG ATACTTGACA ACGAACTTAC AGAGACTATA 
AGCGCACAGT TAGAATTGGA TAAAGCAGCA CAAGATTTTC GTAAGATTCA TAATGAAAGA 
CAAGAACTCA TTAAACAATG GGAGAACACA ATAGAACAGA TGCAGAAGAG GGATGGAGAC 
ATAGATAACT GTGCTTTGGA ATTAGCAAGG ATAAAGCAGG AAACGAGAGA AAAAGAAAAT 
TTGGTTAAAG AAAAGATCAA GTTTTTGGAA AGTGAGATTG GGAATAACAC AGAGTTTGAG 
AAAAGAATTT CTGTGGCTGA TCGTAAACTT TTAAAATGTA GAACGGCATA TCAGGACCAT 
GAAACTAGTA GAATTCAGCT GAAGGGTGAG CTGGATTCTT TAAAAGCCAC TGTGAATAGA 
ACTTCCAGTG ATTTAGAAGC TCTGAGGAAA AATATTTCCA AGATAAAGAA GGACATTCAT 
GAAGAAACAG CAAGGTTACA AAAAACTAAA AATCATAATG AGATAATACA AACAAAATTA 
AAGGAGATAA CTGAGAAAAC CATGTCTGTA GAAGAGAAAG CTACTAATTT GGAAGATATG 
CTAAAGGAGG AGGAAAAAGA TGTGAAGGAA GTAGATGTTC AACTGAACCT CATAAAAGGT 
GTGCTGTTTA AGAAAGCTCA GGAGTTACAG ACTGAGACAA TGAAAGAAAA AGCTGTTTTA 
TCAGAAATTG AAGGAACTCG TTCCTCTCTG AAACATCTCA ACCATCAGTT ACAAAAACTG 
GATTTTGAAA CCTTGAAGCA GCAAGAAATT ATGTACAGCC AGGATTTTCA CATTCAACAA 
GTGGAACGGA GAATGTCACG GTTAAAGGGA GAAATTAATT CAGAAGAAAA ACAAGCGCTT 
GAAGCAAAAA TTGTTGAACT TAGGAAGTCT TTGGAAGAGA AAAAATCTAC ATGTGGCCTT 
TTGGAAACAC AGATCAAGAA GCTTCATAAT GATCTTTATT TTATCAAGAA GGCACATAGT 
AAAAACAGTG ATGAAAAACA GTCCCTTATG ACCAAAATAA ATGAACTAAA CCTTTTCATC 
GACAGATCAG AGAAAGAACT TGATAAAGCC AAAGGTTTTA AGCAGGATTT GATGATAGAG 
GACAATCTTT TAAAACTTGA AGTTAAGCGT ACTCGAGAAA TGCTTCACAG TAAGGCAGAA 
GAAGTTCTTT CCCTAGAAAA AAGAAAACAG CAATTATACA CAGCAATGGA AGAGCGAACT 
GAAGAAATCA AGGTTCATAA AACAATGCTT GCGTCACAAA TAAGATATGT TGATCAAGAA 
CGGGAAAACA TAAGCACTGA GTTTCGCGAG CGGCTAAGTA AAATTGAGAA GCTGAAGAAT 
AGATATGAAA TTCTGACTGT TGTTATGCTG CCTCCTGAAG GAGAAGAGGA GAAAACACAG 
GCCTATTATG TAATAAAGGC TGCTCAAGAA AAAGAAGAAC TTCAAAGGGA AGGTGACTGT 
TTGGATGCCA AGATCAACAA AGCTGAAAAA GAAATCTACG CTCTAGAAAA TACCCTTCAA 
GTGCTGAACA GCTGTAACAA CAATTATAAG CAATCTTTTA AAAAAGTGAC TCCATCTAGT 
GATGAGTATG AGCTAAAAAT TCAACTAGAA GAACAAAAAA GAGCTGTTGA TGAAAAATAC 
AGATACAAAC AAAGACAAAT CAGAGAACTT CAAGAAGACA TCCAGAGCAT GGAAAATACA 
TTAGATGTTA TAGAACATTT GGCAAATAAT GTTAAAGAAA AGTTATCAGA GAAGCAGGCT 
TATTCATTTC AACTAAGTAA AGAAACGGAG GAGCAGAAGC CAAAATTAGA AAGAGTGACC 
AAACAGTGTG CAAAACTCAC AAAGGAAATC CGTCTTTTGA AAGACACAAA AGATGAAACA 
ATGGAAGAAC AAGACATCAA ACTTCGTGAA ATGAAACAGT TTCACAAAGT TATTGATGAA 
ATGTTAGTTG ATATCATAGA AGAAAATACT GAGATCCGTA TTATCCTTCA AACATACTTT 
CAACAGAGTG GGTTAGAACT ACCTACAGCT AGCACAAAAG GCAGTCGTCA GAGCTCTAGA 
TCTCCTTCAC ATACTTCACT ATCAGCAAGG TCATCTAGGA GTACAAGTAC ATCTACTTCT 
CAGTCTTCAA TTAAAGTACT GGAGCTTAAA TTCCCGGCCT CCTCTTCACT AGTAGGCAGC 
CCTTCTAGGC CATCTAGTGC TAGTAGTAGC TCTAGTAATG TTAAGAGCAA AAAGAGCAGC 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852091.1
CDS	110..2935
Translation	MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK

Target ORF information:

RefSeq Version	NM_181426.2
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 39 (CCDC39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181426.2

ORF Insert Sequence:

ATGAGTAGCG AATTCCTGGC TGAGCTGCAC TGGGAGGATG GGTTCGCCAT CCCGGTGGCG 
AACGAGGAGA ACAAGCTACT GGAAGATCAG TTGTCAAAGC TGAAGGATGA AAGAGCAAGC 
TTGCAAGATG AGTTACGTGA GTATGAAGAG CGAATTAATT CTATGACTTC TCACTTCAAA 
AATGTTAAGC AAGAGCTCTC AATTACACAG TCTCTTTGCA AAGCAAGGGA GCGTGAGACT 
GAAAGTGAAG AACATTTTAA GGCCATTGCT CAAAGAGAAT TGGGACGAGT GAAAGATGAA 
ATTCAACGGC TGGAAAATGA GATGGCTTCA ATACTGGAAA AGAAAAGTGA TAAAGAAAAT 
GGCATATTTA AAGCCACTCA AAAATTGGAT GGTTTGAAAT GTCAAATGAA CTGGGACCAG 
CAAGCATTGG AGGCCTGGTT AGAAGAATCA GCTCATAAAG ATAGTGATGC TCTCACTCTC 
CAGAAGTATG CACAACAAGA TGATAATAAA ATCAGGGCAC TGACTCTGCA ATTAGAAAGA 
CTAACTTTGG AATGTAATCA GAAAAGAAAG ATACTTGACA ACGAACTTAC AGAGACTATA 
AGCGCACAGT TAGAATTGGA TAAAGCAGCA CAAGATTTTC GTAAGATTCA TAATGAAAGA 
CAAGAACTCA TTAAACAATG GGAGAACACA ATAGAACAGA TGCAGAAGAG GGATGGAGAC 
ATAGATAACT GTGCTTTGGA ATTAGCAAGG ATAAAGCAGG AAACGAGAGA AAAAGAAAAT 
TTGGTTAAAG AAAAGATCAA GTTTTTGGAA AGTGAGATTG GGAATAACAC AGAGTTTGAG 
AAAAGAATTT CTGTGGCTGA TCGTAAACTT TTAAAATGTA GAACGGCATA TCAGGACCAT 
GAAACTAGTA GAATTCAGCT GAAGGGTGAG CTGGATTCTT TAAAAGCCAC TGTGAATAGA 
ACTTCCAGTG ATTTAGAAGC TCTGAGGAAA AATATTTCCA AGATAAAGAA GGACATTCAT 
GAAGAAACAG CAAGGTTACA AAAAACTAAA AATCATAATG AGATAATACA AACAAAATTA 
AAGGAGATAA CTGAGAAAAC CATGTCTGTA GAAGAGAAAG CTACTAATTT GGAAGATATG 
CTAAAGGAGG AGGAAAAAGA TGTGAAGGAA GTAGATGTTC AACTGAACCT CATAAAAGGT 
GTGCTGTTTA AGAAAGCTCA GGAGTTACAG ACTGAGACAA TGAAAGAAAA AGCTGTTTTA 
TCAGAAATTG AAGGAACTCG TTCCTCTCTG AAACATCTCA ACCATCAGTT ACAAAAACTG 
GATTTTGAAA CCTTGAAGCA GCAAGAAATT ATGTACAGCC AGGATTTTCA CATTCAACAA 
GTGGAACGGA GAATGTCACG GTTAAAGGGA GAAATTAATT CAGAAGAAAA ACAAGCGCTT 
GAAGCAAAAA TTGTTGAACT TAGGAAGTCT TTGGAAGAGA AAAAATCTAC ATGTGGCCTT 
TTGGAAACAC AGATCAAGAA GCTTCATAAT GATCTTTATT TTATCAAGAA GGCACATAGT 
AAAAACAGTG ATGAAAAACA GTCCCTTATG ACCAAAATAA ATGAACTAAA CCTTTTCATC 
GACAGATCAG AGAAAGAACT TGATAAAGCC AAAGGTTTTA AGCAGGATTT GATGATAGAG 
GACAATCTTT TAAAACTTGA AGTTAAGCGT ACTCGAGAAA TGCTTCACAG TAAGGCAGAA 
GAAGTTCTTT CCCTAGAAAA AAGAAAACAG CAATTATACA CAGCAATGGA AGAGCGAACT 
GAAGAAATCA AGGTTCATAA AACAATGCTT GCGTCACAAA TAAGATATGT TGATCAAGAA 
CGGGAAAACA TAAGCACTGA GTTTCGCGAG CGGCTAAGTA AAATTGAGAA GCTGAAGAAT 
AGATATGAAA TTCTGACTGT TGTTATGCTG CCTCCTGAAG GAGAAGAGGA GAAAACACAG 
GCCTATTATG TAATAAAGGC TGCTCAAGAA AAAGAAGAAC TTCAAAGGGA AGGTGACTGT 
TTGGATGCCA AGATCAACAA AGCTGAAAAA GAAATCTACG CTCTAGAAAA TACCCTTCAA 
GTGCTGAACA GCTGTAACAA CAATTATAAG CAATCTTTTA AAAAAGTGAC TCCATCTAGT 
GATGAGTATG AGCTAAAAAT TCAACTAGAA GAACAAAAAA GAGCTGTTGA TGAAAAATAC 
AGATACAAAC AAAGACAAAT CAGAGAACTT CAAGAAGACA TCCAGAGCAT GGAAAATACA 
TTAGATGTTA TAGAACATTT GGCAAATAAT GTTAAAGAAA AGTTATCAGA GAAGCAGGCT 
TATTCATTTC AACTAAGTAA AGAAACGGAG GAGCAGAAGC CAAAATTAGA AAGAGTGACC 
AAACAGTGTG CAAAACTCAC AAAGGAAATC CGTCTTTTGA AAGACACAAA AGATGAAACA 
ATGGAAGAAC AAGACATCAA ACTTCGTGAA ATGAAACAGT TTCACAAAGT TATTGATGAA 
ATGTTAGTTG ATATCATAGA AGAAAATACT GAGATCCGTA TTATCCTTCA AACATACTTT 
CAACAGAGTG GGTTAGAACT ACCTACAGCT AGCACAAAAG GCAGTCGTCA GAGCTCTAGA 
TCTCCTTCAC ATACTTCACT ATCAGCAAGG TCATCTAGGA GTACAAGTAC ATCTACTTCT 
CAGTCTTCAA TTAAAGTACT GGAGCTTAAA TTCCCGGCCT CCTCTTCACT AGTAGGCAGC 
CCTTCTAGGC CATCTAGTGC TAGTAGTAGC TCTAGTAATG TTAAGAGCAA AAAGAGCAGC 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.
Human mutation37(8)776-85(2016 08)
Jeanson L,Thomas L,Copin B,Coste A,Sermet-Gaudelus I,Dastot-Le Moal F,Duquesnoy P,Montantin G,Collot N,Tissier S,Papon JF,Clement A,Louis B,Escudier E,Amselem S,Legendre M

Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex.
American journal of human genetics97(4)546-54(2015 Oct)
Olbrich H,Cremers C,Loges NT,Werner C,Nielsen KG,Marthin JK,Philipsen M,Wallmeier J,Pennekamp P,Menchen T,Edelbusch C,Dougherty GW,Schwartz O,Thiele H,Altm?ller J,Rommelmann F,Omran H

Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype.
American journal of respiratory and critical care medicine191(3)316-24(2015 Feb)
Davis SD,Ferkol TW,Rosenfeld M,Lee HS,Dell SD,Sagel SD,Milla C,Zariwala MA,Pittman JE,Shapiro AJ,Carson JL,Krischer JP,Hazucha MJ,Cooper ML,Knowles MR,Leigh MW

Biological insights from 108 schizophrenia-associated genetic loci.
Nature511(7510)421-7(2014 Jul)

Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
Human mutation34(3)462-72(2013 Mar)
Antony D,Becker-Heck A,Zariwala MA,Schmidts M,Onoufriadis A,Forouhan M,Wilson R,Taylor-Cox T,Dewar A,Jackson C,Goggin P,Loges NT,Olbrich H,Jaspers M,Jorissen M,Leigh MW,Wolf WE,Daniels ML,Noone PG,Ferkol TW,Sagel SD,Rosenfeld M,Rutman A,Dixit A,O'Callaghan C,Lucas JS,Hogg C,Scambler PJ,Emes RD,,Chung EM,Shoemark A,Knowles MR,Omran H,Mitchison HM

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CCDC39 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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