Gene Symbol | IRF8 |
Entrez Gene ID | 3394 |
Full Name | interferon regulatory factor 8 |
Synonyms | H-ICSBP,ICSBP,ICSBP1,IMD32A,IMD32B,IRF-8 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Immunodeficiency 32A, mycobacteriosis, autosomal dominant, 614893 (3); Immunodeficiency 32B, monocyte and dendritic cell deficiency, autosomal recessive, 614894 (3) |