NLRP14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NLRP14
Entrez Gene ID	338323
Full Name	NLR family pyrin domain containing 14
Synonyms	CLR11.2,GC-LRR,NALP14,NOD5,PAN8
General protein information	Preferred Names NLR family pyrin domain containing 14 Names NACHT, LRR and PYD domains-containing protein 14 NACHT, LRR and PYD containing protein 14 NACHT, leucine rich repeat and PYD containing 14 nucleotide-binding oligomerization domain protein 5 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008].
Disorder MIM:	609665

mRNA and Protein(s)

mRNA	Protein	Name
XM_011520044.1	XP_011518346.1	NACHT, LRR and PYD domains-containing protein 14 isoform X1
NM_176822.4	NP_789792.1	NACHT, LRR and PYD domains-containing protein 14
NM_176822.3	NP_789792.1	NACHT, LRR and PYD domains-containing protein 14

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NLRP14	XP_542482.3
Homo sapiens (human)	NLRP14	NP_789792.1
	NLRP14	XP_001107454.2
Pan troglodytes (chimpanzee)	NLRP14	XP_521822.2
Bos taurus (cattle)	NLRP14	XP_003587010.1
Mus musculus (house mouse)	Nlrp14	NP_001002894.2
Rattus norvegicus (Norway rat)	Nlrp14	XP_002728831.2

Gene Ontology
Bibliography

Related articles in PubMed

Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization.
Abe T, Lee A, Sitharam R, Kesner J, Rabadan R, Shapira SD
Immunity46(4)621-634(2017 04)

Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization.
Huber RG, Eibl C, Fuchs JE
Protein science : a publication of the Protein Society24(2)174-81(2015 Feb)

The genetics of NOD-like receptors in Crohn's disease.
Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP
Tissue antigens76(1)48-56(2010 Jul)

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Mart?n-Guerrero I, Colomer D, P?rez-Alvarez S, Reina O, Ardanaz MT, Jares P, Garc?a-Orad A, Pujana MA, Montserrat E, de Sanjos? S, Campo E
Cancer research68(24)10178-86(2008 Dec)

The NLR gene family: a standard nomenclature.
Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, Nunez G, Ogura Y, Otten LA, Philpott D, Reed JC, Reith W, Schreiber S, Steimle V, Ward PA
Immunity28(3)285-7(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that NLRP14 expression was rapidly downregulated after fertilization.
Title: Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization.

This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin domain fold.
Title: Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization.

Observational study of gene-disease association. (HuGE Navigator)
Title: The genetics of NOD-like receptors in Crohn's disease.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

The following NLRP14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NLRP14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07432	NM_176822.4 Latest version!	Homo sapiens NLR family pyrin domain containing 14 (NLRP14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
OHu79177	XM_011520044.1 Latest version!	Homo sapiens NLR family pyrin domain containing 14 (NLRP14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
View Old Accession Versions >>
OHu07432	NM_176822.3	Homo sapiens NLR family pyrin domain containing 14 (NLRP14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NLRP14 ( NM_176822.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_789792.1 Homo sapiens NLR family pyrin domain containing 14 (NLRP14), mRNA.

Price & Availability↑

CloneID	OHu07432
Clone ID Related Accession (Same CDS sequence)	NM_176822.4 , NM_176822.3
Accession Version	NM_176822.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC100875.3. On Dec 2, 2019 this sequence version replaced NM_176822.3. ##Evidence-Data-START## CDS exon combination :: BK001107.1, AY154469.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END##

ATGGCAGATT CATCATCATC TTCTTTCTTT CCTGATTTTG GGCTGCTATT GTATTTGGAG 
GAGCTAAACA AAGAGGAATT AAATACATTC AAGTTATTCC TAAAGGAGAC CATGGAACCT 
GAGCATGGCC TGACACCCTG GAATGAAGTG AAGAAGGCCA GGCGGGAGGA CCTGGCCAAT 
TTGATGAAGA AATATTATCC AGGAGAGAAA GCCTGGAGTG TGTCTCTCAA AATCTTTGGC 
AAGATGAACC TGAAGGATCT GTGTGAGAGA GCGAAAGAAG AGATCAACTG GTCGGCCCAG 
ACTATAGGAC CAGATGATGC CAAGGCTGGA GAGACACAAG AAGATCAGGA GGCAGTGCTG 
GGTGATGGAA CAGAATACAG AAATAGAATA AAGGAAAAAT TTTGCATCAC TTGGGACAAG 
AAGTCTTTGG CTGGAAAGCC TGAAGATTTC CATCATGGAA TTGCAGAGAA AGATAGAAAA 
CTGTTGGAAC ACTTGTTCGA TGTGGATGTC AAAACCGGTG CACAGCCACA GATCGTGGTG 
CTTCAGGGAG CTGCTGGAGT TGGGAAAACA ACCTTGGTGA GAAAGGCAAT GTTAGATTGG 
GCAGAGGGCA GTCTCTACCA GCAGAGGTTT AAGTATGTTT TTTATCTCAA TGGGAGAGAA 
ATTAACCAGC TGAAAGAGAG AAGCTTTGCT CAATTGATAT CAAAGGACTG GCCCAGCACA 
GAAGGCCCCA TTGAAGAAAT CATGTACCAG CCAAGTAGCC TCTTGTTTAT TATTGACAGT 
TTCGATGAAC TGAACTTTGC CTTTGAAGAA CCTGAGTTTG CACTGTGCGA AGACTGGACC 
CAAGAACACC CAGTGTCCTT CCTCATGAGT AGTTTGCTGA GGAAAGTGAT GCTCCCTGAG 
GCATCCTTAT TGGTGACAAC AAGACTCACA ACTTCTAAGA GACTAAAGCA GTTGTTGAAG 
AATCACCATT ATGTAGAGCT ACTAGGAATG TCTGAGGATG CAAGAGAGGA GTATATTTAC 
CAGTTTTTTG AAGATAAGAG GTGGGCCATG AAAGTATTCA GTTCACTAAA AAGCAATGAG 
ATGCTGTTTA GCATGTGCCA AGTCCCCCTA GTGTGCTGGG CCGCTTGTAC TTGTCTGAAG 
CAGCAAATGG AGAAGGGTGG TGATGTCACA TTGACCTGCC AAACAACCAC AGCTCTGTTT 
ACCTGCTATA TTTCTAGCTT GTTCACACCA GTAGATGGAG GCTCTCCTAG TCTACCCAAC 
CAAGCCCAGC TGAGAAGACT GTGCCAAGTC GCTGCCAAAG GAATATGGAC TATGACTTAC 
GTGTTTTACA GAGAAAATCT CAGAAGGCTT GGGTTAACTC AATCTGATGT CTCTAGTTTT 
ATGGACAGCA ATATTATTCA GAAGGACGCA GAGTATGAAA ACTGCTATGT GTTCACCCAC 
CTTCATGTTC AGGAGTTTTT TGCAGCTATG TTCTATATGT TGAAAGGCAG TTGGGAAGCT 
GGGAACCCTT CCTGCCAGCC TTTTGAAGAT TTGAAGTCAT TACTTCAAAG CACAAGTTAT 
AAAGACCCCC ATTTGACACA GATGAAGTGC TTTTTGTTTG GCCTTTTGAA TGAAGATCGA 
GTAAAACAAC TGGAGAGGAC TTTTAACTGT AAAATGTCAC TGAAGATAAA ATCAAAGTTA 
CTTCAGTGTA TGGAAGTATT AGGAAACAGT GACTATTCTC CATCACAGCT GGGATTTCTG 
GAGTTGTTTC ACTGTCTGTA TGAGACTCAA GATAAAGCGT TTATAAGCCA GGCAATGAGA 
TGTTTCCCAA AGGTTGCCAT TAATATTTGT GAGAAAATAC ATTTGCTTGT ATCTTCTTTC 
TGCCTTAAGC ACTGCCGGTG TTTGCGGACC ATCAGGCTGT CTGTAACTGT GGTATTTGAG 
AAGAAGATAT TAAAAACAAG CCTCCCAACT AACACTTGGG ATGGTGATCG CATTACTCAC 
TGTTGGCAAG ATCTCTGTTC TGTGCTTCAT ACAAATGAAC ACTTGAGAGA ATTGGACCTG 
TACCATAGCA ACCTTGATAA ATCAGCAATG AATATCCTGC ATCATGAACT AAGGCACCCA 
AACTGTAAAC TACAAAAGCT ACTGTTGAAA TTTATCACTT TCCCTGATGG TTGTCAGGAT 
ATCTCTACTT CTTTGATTCA TAACAAGAAT CTGATGCATC TTGACCTAAA AGGGAGTGAT 
ATAGGGGATA ATGGAGTAAA GTCATTGTGT GAGGCCTTGA AACACCCAGA GTGTAAACTA 
CAGACTCTCA GGCTGGAATC TTGCAACCTA ACTGTATTTT GTTGTCTAAA TATATCTAAT 
GCTCTCATCA GAAGCCAGAG CCTGATATTT CTGAATCTGT CAACCAATAA TCTGTTGGAT 
GATGGAGTGC AGCTTTTGTG TGAGGCCTTA AGACATCCAA AGTGTTATCT AGAGAGACTG 
TCCTTAGAAA GCTGTGGTCT CACAGAGGCT GGCTGTGAGT ATCTTTCTTT GGCTCTCATC 
AGCAATAAAA GACTGACACA TTTGTGCTTG GCAGACAATG TCTTGGGTGA TGGTGGAGTA 
AAGCTTATGA GTGATGCCCT GCAACATGCA CAATGTACTC TGAAGAGCCT TGTGCTGAGG 
CGTTGCCATT TCACTTCACT TAGCAGTGAA TATCTGTCAA CTTCTCTTCT ACACAACAAG 
AGCCTGACGC ATCTGGATCT AGGATCAAAC TGGCTACAAG ACAATGGAGT GAAGCTTCTG 
TGTGATGTCT TTCGGCATCC AAGCTGTAAT CTTCAGGACT TGGAATTGAT GGGCTGTGTT 
CTCACTAATG CATGTTGTCT GGATCTGGCT TCTGTTATTT TGAATAACCC AAACCTGAGG 
AGCCTGGACC TTGGGAACAA CGATTTGCAG GATGATGGAG TGAAAATTCT GTGTGATGCT 
TTGAGATATC CAAACTGTAA CATTCAGAGG CTCGGGTTGG AATACTGTGG TTTGACATCT 
CTCTGCTGTC AAGATCTCTC CTCTGCTCTT ATCTGCAACA AAAGACTGAT AAAAATGAAT 
CTGACACAGA ATACCTTAGG ATATGAAGGA ATTGTGAAGT TATATAAAGT CTTGAAGTCT 
CCTAAGTGTA AACTACAAGT TCTAGGGTTG TGCAAAGAGG CATTTGATGA GGAAGCCCAG 
AAGCTGCTGG AAGCTGTGGG AGTTAGCAAT CCACACTTAA TCATTAAGCC AGATTGTAAC 
TATCATAATG AAGAAGATGT GTCTTGGTGG TGGTGTTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789792.1
CDS	314..3595
Translation	MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCNYHNEEDVSWWWCF

Target ORF information:

RefSeq Version	NM_176822.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 14 (NLRP14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176822.4

ORF Insert Sequence:

ATGGCAGATT CATCATCATC TTCTTTCTTT CCTGATTTTG GGCTGCTATT GTATTTGGAG 
GAGCTAAACA AAGAGGAATT AAATACATTC AAGTTATTCC TAAAGGAGAC CATGGAACCT 
GAGCATGGCC TGACACCCTG GAATGAAGTG AAGAAGGCCA GGCGGGAGGA CCTGGCCAAT 
TTGATGAAGA AATATTATCC AGGAGAGAAA GCCTGGAGTG TGTCTCTCAA AATCTTTGGC 
AAGATGAACC TGAAGGATCT GTGTGAGAGA GCGAAAGAAG AGATCAACTG GTCGGCCCAG 
ACTATAGGAC CAGATGATGC CAAGGCTGGA GAGACACAAG AAGATCAGGA GGCAGTGCTG 
GGTGATGGAA CAGAATACAG AAATAGAATA AAGGAAAAAT TTTGCATCAC TTGGGACAAG 
AAGTCTTTGG CTGGAAAGCC TGAAGATTTC CATCATGGAA TTGCAGAGAA AGATAGAAAA 
CTGTTGGAAC ACTTGTTCGA TGTGGATGTC AAAACCGGTG CACAGCCACA GATCGTGGTG 
CTTCAGGGAG CTGCTGGAGT TGGGAAAACA ACCTTGGTGA GAAAGGCAAT GTTAGATTGG 
GCAGAGGGCA GTCTCTACCA GCAGAGGTTT AAGTATGTTT TTTATCTCAA TGGGAGAGAA 
ATTAACCAGC TGAAAGAGAG AAGCTTTGCT CAATTGATAT CAAAGGACTG GCCCAGCACA 
GAAGGCCCCA TTGAAGAAAT CATGTACCAG CCAAGTAGCC TCTTGTTTAT TATTGACAGT 
TTCGATGAAC TGAACTTTGC CTTTGAAGAA CCTGAGTTTG CACTGTGCGA AGACTGGACC 
CAAGAACACC CAGTGTCCTT CCTCATGAGT AGTTTGCTGA GGAAAGTGAT GCTCCCTGAG 
GCATCCTTAT TGGTGACAAC AAGACTCACA ACTTCTAAGA GACTAAAGCA GTTGTTGAAG 
AATCACCATT ATGTAGAGCT ACTAGGAATG TCTGAGGATG CAAGAGAGGA GTATATTTAC 
CAGTTTTTTG AAGATAAGAG GTGGGCCATG AAAGTATTCA GTTCACTAAA AAGCAATGAG 
ATGCTGTTTA GCATGTGCCA AGTCCCCCTA GTGTGCTGGG CCGCTTGTAC TTGTCTGAAG 
CAGCAAATGG AGAAGGGTGG TGATGTCACA TTGACCTGCC AAACAACCAC AGCTCTGTTT 
ACCTGCTATA TTTCTAGCTT GTTCACACCA GTAGATGGAG GCTCTCCTAG TCTACCCAAC 
CAAGCCCAGC TGAGAAGACT GTGCCAAGTC GCTGCCAAAG GAATATGGAC TATGACTTAC 
GTGTTTTACA GAGAAAATCT CAGAAGGCTT GGGTTAACTC AATCTGATGT CTCTAGTTTT 
ATGGACAGCA ATATTATTCA GAAGGACGCA GAGTATGAAA ACTGCTATGT GTTCACCCAC 
CTTCATGTTC AGGAGTTTTT TGCAGCTATG TTCTATATGT TGAAAGGCAG TTGGGAAGCT 
GGGAACCCTT CCTGCCAGCC TTTTGAAGAT TTGAAGTCAT TACTTCAAAG CACAAGTTAT 
AAAGACCCCC ATTTGACACA GATGAAGTGC TTTTTGTTTG GCCTTTTGAA TGAAGATCGA 
GTAAAACAAC TGGAGAGGAC TTTTAACTGT AAAATGTCAC TGAAGATAAA ATCAAAGTTA 
CTTCAGTGTA TGGAAGTATT AGGAAACAGT GACTATTCTC CATCACAGCT GGGATTTCTG 
GAGTTGTTTC ACTGTCTGTA TGAGACTCAA GATAAAGCGT TTATAAGCCA GGCAATGAGA 
TGTTTCCCAA AGGTTGCCAT TAATATTTGT GAGAAAATAC ATTTGCTTGT ATCTTCTTTC 
TGCCTTAAGC ACTGCCGGTG TTTGCGGACC ATCAGGCTGT CTGTAACTGT GGTATTTGAG 
AAGAAGATAT TAAAAACAAG CCTCCCAACT AACACTTGGG ATGGTGATCG CATTACTCAC 
TGTTGGCAAG ATCTCTGTTC TGTGCTTCAT ACAAATGAAC ACTTGAGAGA ATTGGACCTG 
TACCATAGCA ACCTTGATAA ATCAGCAATG AATATCCTGC ATCATGAACT AAGGCACCCA 
AACTGTAAAC TACAAAAGCT ACTGTTGAAA TTTATCACTT TCCCTGATGG TTGTCAGGAT 
ATCTCTACTT CTTTGATTCA TAACAAGAAT CTGATGCATC TTGACCTAAA AGGGAGTGAT 
ATAGGGGATA ATGGAGTAAA GTCATTGTGT GAGGCCTTGA AACACCCAGA GTGTAAACTA 
CAGACTCTCA GGCTGGAATC TTGCAACCTA ACTGTATTTT GTTGTCTAAA TATATCTAAT 
GCTCTCATCA GAAGCCAGAG CCTGATATTT CTGAATCTGT CAACCAATAA TCTGTTGGAT 
GATGGAGTGC AGCTTTTGTG TGAGGCCTTA AGACATCCAA AGTGTTATCT AGAGAGACTG 
TCCTTAGAAA GCTGTGGTCT CACAGAGGCT GGCTGTGAGT ATCTTTCTTT GGCTCTCATC 
AGCAATAAAA GACTGACACA TTTGTGCTTG GCAGACAATG TCTTGGGTGA TGGTGGAGTA 
AAGCTTATGA GTGATGCCCT GCAACATGCA CAATGTACTC TGAAGAGCCT TGTGCTGAGG 
CGTTGCCATT TCACTTCACT TAGCAGTGAA TATCTGTCAA CTTCTCTTCT ACACAACAAG 
AGCCTGACGC ATCTGGATCT AGGATCAAAC TGGCTACAAG ACAATGGAGT GAAGCTTCTG 
TGTGATGTCT TTCGGCATCC AAGCTGTAAT CTTCAGGACT TGGAATTGAT GGGCTGTGTT 
CTCACTAATG CATGTTGTCT GGATCTGGCT TCTGTTATTT TGAATAACCC AAACCTGAGG 
AGCCTGGACC TTGGGAACAA CGATTTGCAG GATGATGGAG TGAAAATTCT GTGTGATGCT 
TTGAGATATC CAAACTGTAA CATTCAGAGG CTCGGGTTGG AATACTGTGG TTTGACATCT 
CTCTGCTGTC AAGATCTCTC CTCTGCTCTT ATCTGCAACA AAAGACTGAT AAAAATGAAT 
CTGACACAGA ATACCTTAGG ATATGAAGGA ATTGTGAAGT TATATAAAGT CTTGAAGTCT 
CCTAAGTGTA AACTACAAGT TCTAGGGTTG TGCAAAGAGG CATTTGATGA GGAAGCCCAG 
AAGCTGCTGG AAGCTGTGGG AGTTAGCAAT CCACACTTAA TCATTAAGCC AGATTGTAAC 
TATCATAATG AAGAAGATGT GTCTTGGTGG TGGTGTTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP14 ( NM_176822.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_789792.1 Homo sapiens NLR family pyrin domain containing 14 (NLRP14), mRNA.

Price & Availability↑

CloneID	OHu07432
Clone ID Related Accession (Same CDS sequence)	NM_176822.4 , NM_176822.3
Accession Version	NM_176822.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB226777.1 and BK001107.1. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2006 this sequence version replaced NM_176822.2. ##Evidence-Data-START## CDS exon combination :: BK001107.1, AY154469.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END##

ATGGCAGATT CATCATCATC TTCTTTCTTT CCTGATTTTG GGCTGCTATT GTATTTGGAG 
GAGCTAAACA AAGAGGAATT AAATACATTC AAGTTATTCC TAAAGGAGAC CATGGAACCT 
GAGCATGGCC TGACACCCTG GAATGAAGTG AAGAAGGCCA GGCGGGAGGA CCTGGCCAAT 
TTGATGAAGA AATATTATCC AGGAGAGAAA GCCTGGAGTG TGTCTCTCAA AATCTTTGGC 
AAGATGAACC TGAAGGATCT GTGTGAGAGA GCGAAAGAAG AGATCAACTG GTCGGCCCAG 
ACTATAGGAC CAGATGATGC CAAGGCTGGA GAGACACAAG AAGATCAGGA GGCAGTGCTG 
GGTGATGGAA CAGAATACAG AAATAGAATA AAGGAAAAAT TTTGCATCAC TTGGGACAAG 
AAGTCTTTGG CTGGAAAGCC TGAAGATTTC CATCATGGAA TTGCAGAGAA AGATAGAAAA 
CTGTTGGAAC ACTTGTTCGA TGTGGATGTC AAAACCGGTG CACAGCCACA GATCGTGGTG 
CTTCAGGGAG CTGCTGGAGT TGGGAAAACA ACCTTGGTGA GAAAGGCAAT GTTAGATTGG 
GCAGAGGGCA GTCTCTACCA GCAGAGGTTT AAGTATGTTT TTTATCTCAA TGGGAGAGAA 
ATTAACCAGC TGAAAGAGAG AAGCTTTGCT CAATTGATAT CAAAGGACTG GCCCAGCACA 
GAAGGCCCCA TTGAAGAAAT CATGTACCAG CCAAGTAGCC TCTTGTTTAT TATTGACAGT 
TTCGATGAAC TGAACTTTGC CTTTGAAGAA CCTGAGTTTG CACTGTGCGA AGACTGGACC 
CAAGAACACC CAGTGTCCTT CCTCATGAGT AGTTTGCTGA GGAAAGTGAT GCTCCCTGAG 
GCATCCTTAT TGGTGACAAC AAGACTCACA ACTTCTAAGA GACTAAAGCA GTTGTTGAAG 
AATCACCATT ATGTAGAGCT ACTAGGAATG TCTGAGGATG CAAGAGAGGA GTATATTTAC 
CAGTTTTTTG AAGATAAGAG GTGGGCCATG AAAGTATTCA GTTCACTAAA AAGCAATGAG 
ATGCTGTTTA GCATGTGCCA AGTCCCCCTA GTGTGCTGGG CCGCTTGTAC TTGTCTGAAG 
CAGCAAATGG AGAAGGGTGG TGATGTCACA TTGACCTGCC AAACAACCAC AGCTCTGTTT 
ACCTGCTATA TTTCTAGCTT GTTCACACCA GTAGATGGAG GCTCTCCTAG TCTACCCAAC 
CAAGCCCAGC TGAGAAGACT GTGCCAAGTC GCTGCCAAAG GAATATGGAC TATGACTTAC 
GTGTTTTACA GAGAAAATCT CAGAAGGCTT GGGTTAACTC AATCTGATGT CTCTAGTTTT 
ATGGACAGCA ATATTATTCA GAAGGACGCA GAGTATGAAA ACTGCTATGT GTTCACCCAC 
CTTCATGTTC AGGAGTTTTT TGCAGCTATG TTCTATATGT TGAAAGGCAG TTGGGAAGCT 
GGGAACCCTT CCTGCCAGCC TTTTGAAGAT TTGAAGTCAT TACTTCAAAG CACAAGTTAT 
AAAGACCCCC ATTTGACACA GATGAAGTGC TTTTTGTTTG GCCTTTTGAA TGAAGATCGA 
GTAAAACAAC TGGAGAGGAC TTTTAACTGT AAAATGTCAC TGAAGATAAA ATCAAAGTTA 
CTTCAGTGTA TGGAAGTATT AGGAAACAGT GACTATTCTC CATCACAGCT GGGATTTCTG 
GAGTTGTTTC ACTGTCTGTA TGAGACTCAA GATAAAGCGT TTATAAGCCA GGCAATGAGA 
TGTTTCCCAA AGGTTGCCAT TAATATTTGT GAGAAAATAC ATTTGCTTGT ATCTTCTTTC 
TGCCTTAAGC ACTGCCGGTG TTTGCGGACC ATCAGGCTGT CTGTAACTGT GGTATTTGAG 
AAGAAGATAT TAAAAACAAG CCTCCCAACT AACACTTGGG ATGGTGATCG CATTACTCAC 
TGTTGGCAAG ATCTCTGTTC TGTGCTTCAT ACAAATGAAC ACTTGAGAGA ATTGGACCTG 
TACCATAGCA ACCTTGATAA ATCAGCAATG AATATCCTGC ATCATGAACT AAGGCACCCA 
AACTGTAAAC TACAAAAGCT ACTGTTGAAA TTTATCACTT TCCCTGATGG TTGTCAGGAT 
ATCTCTACTT CTTTGATTCA TAACAAGAAT CTGATGCATC TTGACCTAAA AGGGAGTGAT 
ATAGGGGATA ATGGAGTAAA GTCATTGTGT GAGGCCTTGA AACACCCAGA GTGTAAACTA 
CAGACTCTCA GGCTGGAATC TTGCAACCTA ACTGTATTTT GTTGTCTAAA TATATCTAAT 
GCTCTCATCA GAAGCCAGAG CCTGATATTT CTGAATCTGT CAACCAATAA TCTGTTGGAT 
GATGGAGTGC AGCTTTTGTG TGAGGCCTTA AGACATCCAA AGTGTTATCT AGAGAGACTG 
TCCTTAGAAA GCTGTGGTCT CACAGAGGCT GGCTGTGAGT ATCTTTCTTT GGCTCTCATC 
AGCAATAAAA GACTGACACA TTTGTGCTTG GCAGACAATG TCTTGGGTGA TGGTGGAGTA 
AAGCTTATGA GTGATGCCCT GCAACATGCA CAATGTACTC TGAAGAGCCT TGTGCTGAGG 
CGTTGCCATT TCACTTCACT TAGCAGTGAA TATCTGTCAA CTTCTCTTCT ACACAACAAG 
AGCCTGACGC ATCTGGATCT AGGATCAAAC TGGCTACAAG ACAATGGAGT GAAGCTTCTG 
TGTGATGTCT TTCGGCATCC AAGCTGTAAT CTTCAGGACT TGGAATTGAT GGGCTGTGTT 
CTCACTAATG CATGTTGTCT GGATCTGGCT TCTGTTATTT TGAATAACCC AAACCTGAGG 
AGCCTGGACC TTGGGAACAA CGATTTGCAG GATGATGGAG TGAAAATTCT GTGTGATGCT 
TTGAGATATC CAAACTGTAA CATTCAGAGG CTCGGGTTGG AATACTGTGG TTTGACATCT 
CTCTGCTGTC AAGATCTCTC CTCTGCTCTT ATCTGCAACA AAAGACTGAT AAAAATGAAT 
CTGACACAGA ATACCTTAGG ATATGAAGGA ATTGTGAAGT TATATAAAGT CTTGAAGTCT 
CCTAAGTGTA AACTACAAGT TCTAGGGTTG TGCAAAGAGG CATTTGATGA GGAAGCCCAG 
AAGCTGCTGG AAGCTGTGGG AGTTAGCAAT CCACACTTAA TCATTAAGCC AGATTGTAAC 
TATCATAATG AAGAAGATGT GTCTTGGTGG TGGTGTTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789792.1
CDS	324..3605
Translation	MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCNYHNEEDVSWWWCF

Target ORF information:

RefSeq Version	NM_176822.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 14 (NLRP14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176822.3

ORF Insert Sequence:

ATGGCAGATT CATCATCATC TTCTTTCTTT CCTGATTTTG GGCTGCTATT GTATTTGGAG 
GAGCTAAACA AAGAGGAATT AAATACATTC AAGTTATTCC TAAAGGAGAC CATGGAACCT 
GAGCATGGCC TGACACCCTG GAATGAAGTG AAGAAGGCCA GGCGGGAGGA CCTGGCCAAT 
TTGATGAAGA AATATTATCC AGGAGAGAAA GCCTGGAGTG TGTCTCTCAA AATCTTTGGC 
AAGATGAACC TGAAGGATCT GTGTGAGAGA GCGAAAGAAG AGATCAACTG GTCGGCCCAG 
ACTATAGGAC CAGATGATGC CAAGGCTGGA GAGACACAAG AAGATCAGGA GGCAGTGCTG 
GGTGATGGAA CAGAATACAG AAATAGAATA AAGGAAAAAT TTTGCATCAC TTGGGACAAG 
AAGTCTTTGG CTGGAAAGCC TGAAGATTTC CATCATGGAA TTGCAGAGAA AGATAGAAAA 
CTGTTGGAAC ACTTGTTCGA TGTGGATGTC AAAACCGGTG CACAGCCACA GATCGTGGTG 
CTTCAGGGAG CTGCTGGAGT TGGGAAAACA ACCTTGGTGA GAAAGGCAAT GTTAGATTGG 
GCAGAGGGCA GTCTCTACCA GCAGAGGTTT AAGTATGTTT TTTATCTCAA TGGGAGAGAA 
ATTAACCAGC TGAAAGAGAG AAGCTTTGCT CAATTGATAT CAAAGGACTG GCCCAGCACA 
GAAGGCCCCA TTGAAGAAAT CATGTACCAG CCAAGTAGCC TCTTGTTTAT TATTGACAGT 
TTCGATGAAC TGAACTTTGC CTTTGAAGAA CCTGAGTTTG CACTGTGCGA AGACTGGACC 
CAAGAACACC CAGTGTCCTT CCTCATGAGT AGTTTGCTGA GGAAAGTGAT GCTCCCTGAG 
GCATCCTTAT TGGTGACAAC AAGACTCACA ACTTCTAAGA GACTAAAGCA GTTGTTGAAG 
AATCACCATT ATGTAGAGCT ACTAGGAATG TCTGAGGATG CAAGAGAGGA GTATATTTAC 
CAGTTTTTTG AAGATAAGAG GTGGGCCATG AAAGTATTCA GTTCACTAAA AAGCAATGAG 
ATGCTGTTTA GCATGTGCCA AGTCCCCCTA GTGTGCTGGG CCGCTTGTAC TTGTCTGAAG 
CAGCAAATGG AGAAGGGTGG TGATGTCACA TTGACCTGCC AAACAACCAC AGCTCTGTTT 
ACCTGCTATA TTTCTAGCTT GTTCACACCA GTAGATGGAG GCTCTCCTAG TCTACCCAAC 
CAAGCCCAGC TGAGAAGACT GTGCCAAGTC GCTGCCAAAG GAATATGGAC TATGACTTAC 
GTGTTTTACA GAGAAAATCT CAGAAGGCTT GGGTTAACTC AATCTGATGT CTCTAGTTTT 
ATGGACAGCA ATATTATTCA GAAGGACGCA GAGTATGAAA ACTGCTATGT GTTCACCCAC 
CTTCATGTTC AGGAGTTTTT TGCAGCTATG TTCTATATGT TGAAAGGCAG TTGGGAAGCT 
GGGAACCCTT CCTGCCAGCC TTTTGAAGAT TTGAAGTCAT TACTTCAAAG CACAAGTTAT 
AAAGACCCCC ATTTGACACA GATGAAGTGC TTTTTGTTTG GCCTTTTGAA TGAAGATCGA 
GTAAAACAAC TGGAGAGGAC TTTTAACTGT AAAATGTCAC TGAAGATAAA ATCAAAGTTA 
CTTCAGTGTA TGGAAGTATT AGGAAACAGT GACTATTCTC CATCACAGCT GGGATTTCTG 
GAGTTGTTTC ACTGTCTGTA TGAGACTCAA GATAAAGCGT TTATAAGCCA GGCAATGAGA 
TGTTTCCCAA AGGTTGCCAT TAATATTTGT GAGAAAATAC ATTTGCTTGT ATCTTCTTTC 
TGCCTTAAGC ACTGCCGGTG TTTGCGGACC ATCAGGCTGT CTGTAACTGT GGTATTTGAG 
AAGAAGATAT TAAAAACAAG CCTCCCAACT AACACTTGGG ATGGTGATCG CATTACTCAC 
TGTTGGCAAG ATCTCTGTTC TGTGCTTCAT ACAAATGAAC ACTTGAGAGA ATTGGACCTG 
TACCATAGCA ACCTTGATAA ATCAGCAATG AATATCCTGC ATCATGAACT AAGGCACCCA 
AACTGTAAAC TACAAAAGCT ACTGTTGAAA TTTATCACTT TCCCTGATGG TTGTCAGGAT 
ATCTCTACTT CTTTGATTCA TAACAAGAAT CTGATGCATC TTGACCTAAA AGGGAGTGAT 
ATAGGGGATA ATGGAGTAAA GTCATTGTGT GAGGCCTTGA AACACCCAGA GTGTAAACTA 
CAGACTCTCA GGCTGGAATC TTGCAACCTA ACTGTATTTT GTTGTCTAAA TATATCTAAT 
GCTCTCATCA GAAGCCAGAG CCTGATATTT CTGAATCTGT CAACCAATAA TCTGTTGGAT 
GATGGAGTGC AGCTTTTGTG TGAGGCCTTA AGACATCCAA AGTGTTATCT AGAGAGACTG 
TCCTTAGAAA GCTGTGGTCT CACAGAGGCT GGCTGTGAGT ATCTTTCTTT GGCTCTCATC 
AGCAATAAAA GACTGACACA TTTGTGCTTG GCAGACAATG TCTTGGGTGA TGGTGGAGTA 
AAGCTTATGA GTGATGCCCT GCAACATGCA CAATGTACTC TGAAGAGCCT TGTGCTGAGG 
CGTTGCCATT TCACTTCACT TAGCAGTGAA TATCTGTCAA CTTCTCTTCT ACACAACAAG 
AGCCTGACGC ATCTGGATCT AGGATCAAAC TGGCTACAAG ACAATGGAGT GAAGCTTCTG 
TGTGATGTCT TTCGGCATCC AAGCTGTAAT CTTCAGGACT TGGAATTGAT GGGCTGTGTT 
CTCACTAATG CATGTTGTCT GGATCTGGCT TCTGTTATTT TGAATAACCC AAACCTGAGG 
AGCCTGGACC TTGGGAACAA CGATTTGCAG GATGATGGAG TGAAAATTCT GTGTGATGCT 
TTGAGATATC CAAACTGTAA CATTCAGAGG CTCGGGTTGG AATACTGTGG TTTGACATCT 
CTCTGCTGTC AAGATCTCTC CTCTGCTCTT ATCTGCAACA AAAGACTGAT AAAAATGAAT 
CTGACACAGA ATACCTTAGG ATATGAAGGA ATTGTGAAGT TATATAAAGT CTTGAAGTCT 
CCTAAGTGTA AACTACAAGT TCTAGGGTTG TGCAAAGAGG CATTTGATGA GGAAGCCCAG 
AAGCTGCTGG AAGCTGTGGG AGTTAGCAAT CCACACTTAA TCATTAAGCC AGATTGTAAC 
TATCATAATG AAGAAGATGT GTCTTGGTGG TGGTGTTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP14 ( XM_011520044.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518346.1 Homo sapiens NLR family pyrin domain containing 14 (NLRP14), transcript variant X1, mRNA.

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CloneID	OHu79177
Clone ID Related Accession (Same CDS sequence)	XM_011520044.1
Accession Version	XM_011520044.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3159bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGATT CATCATCATC TTCTTTCTTT CCTGATTTTG GGCTGCTATT GTATTTGGAG 
GAGCTAAACA AAGAGGAATT AAATACATTC AAGTTATTCC TAAAGGAGAC CATGGAACCT 
GAGCATGGCC TGACACCCTG GAATGAAGTG AAGAAGGCCA GGCGGGAGGA CCTGGCCAAT 
TTGATGAAGA AATATTATCC AGGAGAGAAA GCCTGGAGTG TGTCTCTCAA AATCTTTGGC 
AAGATGAACC TGAAGGATCT GTGTGAGAGA GCGAAAGAAG AGATCAACTG GTCGGCCCAG 
ACTATAGGAC CAGATGATGC CAAGGCTGGA GAGACACAAG AAGATCAGGA GGCAGTGCTG 
GGTGATGGAA CAGAATACAG AAATAGAATA AAGGAAAAAT TTTGCATCAC TTGGGACAAG 
AAGTCTTTGG CTGGAAAGCC TGAAGATTTC CATCATGGAA TTGCAGAGAA AGATAGAAAA 
CTGTTGGAAC ACTTGTTCGA TGTGGATGTC AAAACCGGTG CACAGCCACA GATCGTGGTG 
CTTCAGGGAG CTGCTGGAGT TGGGAAAACA ACCTTGGTGA GAAAGGCAAT GTTAGATTGG 
GCAGAGGGCA GTCTCTACCA GCAGAGGTTT AAGTATGTTT TTTATCTCAA TGGGAGAGAA 
ATTAACCAGC TGAAAGAGAG AAGCTTTGCT CAATTGATAT CAAAGGACTG GCCCAGCACA 
GAAGGCCCCA TTGAAGAAAT CATGTACCAG CCAAGTAGCC TCTTGTTTAT TATTGACAGT 
TTCGATGAAC TGAACTTTGC CTTTGAAGAA CCTGAGTTTG CACTGTGCGA AGACTGGACC 
CAAGAACACC CAGTGTCCTT CCTCATGAGT AGTTTGCTGA GGAAAGTGAT GCTCCCTGAG 
GCATCCTTAT TGGTGACAAC AAGACTCACA ACTTCTAAGA GACTAAAGCA GTTGTTGAAG 
AATCACCATT ATGTAGAGCT ACTAGGAATG TCTGAGGATG CAAGAGAGGA GTATATTTAC 
CAGTTTTTTG AAGATAAGAG GTGGGCCATG AAAGTATTCA GTTCACTAAA AAGCAATGAG 
ATGCTGTTTA GCATGTGCCA AGTCCCCCTA GTGTGCTGGG CCGCTTGTAC TTGTCTGAAG 
CAGCAAATGG AGAAGGGTGG TGATGTCACA TTGACCTGCC AAACAACCAC AGCTCTGTTT 
ACCTGCTATA TTTCTAGCTT GTTCACACCA GTAGATGGAG GCTCTCCTAG TCTACCCAAC 
CAAGCCCAGC TGAGAAGACT GTGCCAAGTC GCTGCCAAAG GAATATGGAC TATGACTTAC 
GTGTTTTACA GAGAAAATCT CAGAAGGCTT GGGTTAACTC AATCTGATGT CTCTAGTTTT 
ATGGACAGCA ATATTATTCA GAAGGACGCA GAGTATGAAA ACTGCTATGT GTTCACCCAC 
CTTCATGTTC AGGAGTTTTT TGCAGCTATG TTCTATATGT TGAAAGGCAG TTGGGAAGCT 
GGGAACCCTT CCTGCCAGCC TTTTGAAGAT TTGAAGTCAT TACTTCAAAG CACAAGTTAT 
AAAGACCCCC ATTTGACACA GATGAAGTGC TTTTTGTTTG GCCTTTTGAA TGAAGATCGA 
GTAAAACAAC TGGAGAGGAC TTTTAACTGT AAAATGTCAC TGAAGATAAA ATCAAAGTTA 
CTTCAGTGTA TGGAAGTATT AGGAAACAGT GACTATTCTC CATCACAGCT GGGATTTCTG 
GAGTTGTTTC ACTGTCTGTA TGAGACTCAA GATAAAGCGT TTATAAGCCA GGCAATGAGA 
TGTTTCCCAA AGGTTGCCAT TAATATTTGT GAGAAAATAC ATTTGCTTGT ATCTTCTTTC 
TGCCTTAAGC ACTGCCGGTG TTTGCGGACC ATCAGGCTGT CTGTAACTGT GGTATTTGAG 
AAGAAGATAT TAAAAACAAG CCTCCCAACT AACACTTGGG ATGGTGATCG CATTACTCAC 
TGTTGGCAAG ATCTCTGTTC TGTGCTTCAT ACAAATGAAC ACTTGAGAGA ATTGGACCTG 
TACCATAGCA ACCTTGATAA ATCAGCAATG AATATCCTGC ATCATGAACT AAGGCACCCA 
AACTGTAAAC TACAAAAGCT ACTGTTGAAA TTTATCACTT TCCCTGATGG TTGTCAGGAT 
ATCTCTACTT CTTTGATTCA TAACAAGAAT CTGATGCATC TTGACCTAAA AGGGAGTGAT 
ATAGGGGATA ATGGAGTAAA GTCATTGTGT GAGGCCTTGA AACACCCAGA GTGTAAACTA 
CAGACTCTCA GCTTAGAAAG CTGTGGTCTC ACAGAGGCTG GCTGTGAGTA TCTTTCTTTG 
GCTCTCATCA GCAATAAAAG ACTGACACAT TTGTGCTTGG CAGACAATGT CTTGGGTGAT 
GGTGGAGTAA AGCTTATGAG TGATGCCCTG CAACATGCAC AATGTACTCT GAAGAGCCTT 
GTGCTGAGGC GTTGCCATTT CACTTCACTT AGCAGTGAAT ATCTGTCAAC TTCTCTTCTA 
CACAACAAGA GCCTGACGCA TCTGGATCTA GGATCAAACT GGCTACAAGA CAATGGAGTG 
AAGCTTCTGT GTGATGTCTT TCGGCATCCA AGCTGTAATC TTCAGGACTT GGAATTGATG 
GGCTGTGTTC TCACTAATGC ATGTTGTCTG GATCTGGCTT CTGTTATTTT GAATAACCCA 
AACCTGAGGA GCCTGGACCT TGGGAACAAC GATTTGCAGG ATGATGGAGT GAAAATTCTG 
TGTGATGCTT TGAGATATCC AAACTGTAAC ATTCAGAGGC TCGGGTTGGA ATACTGTGGT 
TTGACATCTC TCTGCTGTCA AGATCTCTCC TCTGCTCTTA TCTGCAACAA AAGACTGATA 
AAAATGAATC TGACACAGAA TACCTTAGGA TATGAAGGAA TTGTGAAGTT ATATAAAGTC 
TTGAAGTCTC CTAAGTGTAA ACTACAAGTT CTAGGGAGGC CATTGAAGCC GTTAAGACCG 
GGTCAGGTGA ACAGGAAGTT AAAGACTGAA AAGGAGACAC AAAACTGCCG ACTTTCCCGA 
CGGCGAATTG GCCCTCTGGA AACAGCCGAC CAATCACAGG CAGCAGGGGC GCGCCCTGCA 
GCGGGGCTCC GGCTGCGGTT CCGTGGACTC GGCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518346.1
CDS	347..3505
Translation	MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGRPLKPLRPGQVNRKLKTEKETQNCRLSRRRIGPLETADQSQAAGARPAAGLRLRFRGLGD

Target ORF information:

RefSeq Version	XM_011520044.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 14 (NLRP14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520044.1

ORF Insert Sequence:

ATGGCAGATT CATCATCATC TTCTTTCTTT CCTGATTTTG GGCTGCTATT GTATTTGGAG 
GAGCTAAACA AAGAGGAATT AAATACATTC AAGTTATTCC TAAAGGAGAC CATGGAACCT 
GAGCATGGCC TGACACCCTG GAATGAAGTG AAGAAGGCCA GGCGGGAGGA CCTGGCCAAT 
TTGATGAAGA AATATTATCC AGGAGAGAAA GCCTGGAGTG TGTCTCTCAA AATCTTTGGC 
AAGATGAACC TGAAGGATCT GTGTGAGAGA GCGAAAGAAG AGATCAACTG GTCGGCCCAG 
ACTATAGGAC CAGATGATGC CAAGGCTGGA GAGACACAAG AAGATCAGGA GGCAGTGCTG 
GGTGATGGAA CAGAATACAG AAATAGAATA AAGGAAAAAT TTTGCATCAC TTGGGACAAG 
AAGTCTTTGG CTGGAAAGCC TGAAGATTTC CATCATGGAA TTGCAGAGAA AGATAGAAAA 
CTGTTGGAAC ACTTGTTCGA TGTGGATGTC AAAACCGGTG CACAGCCACA GATCGTGGTG 
CTTCAGGGAG CTGCTGGAGT TGGGAAAACA ACCTTGGTGA GAAAGGCAAT GTTAGATTGG 
GCAGAGGGCA GTCTCTACCA GCAGAGGTTT AAGTATGTTT TTTATCTCAA TGGGAGAGAA 
ATTAACCAGC TGAAAGAGAG AAGCTTTGCT CAATTGATAT CAAAGGACTG GCCCAGCACA 
GAAGGCCCCA TTGAAGAAAT CATGTACCAG CCAAGTAGCC TCTTGTTTAT TATTGACAGT 
TTCGATGAAC TGAACTTTGC CTTTGAAGAA CCTGAGTTTG CACTGTGCGA AGACTGGACC 
CAAGAACACC CAGTGTCCTT CCTCATGAGT AGTTTGCTGA GGAAAGTGAT GCTCCCTGAG 
GCATCCTTAT TGGTGACAAC AAGACTCACA ACTTCTAAGA GACTAAAGCA GTTGTTGAAG 
AATCACCATT ATGTAGAGCT ACTAGGAATG TCTGAGGATG CAAGAGAGGA GTATATTTAC 
CAGTTTTTTG AAGATAAGAG GTGGGCCATG AAAGTATTCA GTTCACTAAA AAGCAATGAG 
ATGCTGTTTA GCATGTGCCA AGTCCCCCTA GTGTGCTGGG CCGCTTGTAC TTGTCTGAAG 
CAGCAAATGG AGAAGGGTGG TGATGTCACA TTGACCTGCC AAACAACCAC AGCTCTGTTT 
ACCTGCTATA TTTCTAGCTT GTTCACACCA GTAGATGGAG GCTCTCCTAG TCTACCCAAC 
CAAGCCCAGC TGAGAAGACT GTGCCAAGTC GCTGCCAAAG GAATATGGAC TATGACTTAC 
GTGTTTTACA GAGAAAATCT CAGAAGGCTT GGGTTAACTC AATCTGATGT CTCTAGTTTT 
ATGGACAGCA ATATTATTCA GAAGGACGCA GAGTATGAAA ACTGCTATGT GTTCACCCAC 
CTTCATGTTC AGGAGTTTTT TGCAGCTATG TTCTATATGT TGAAAGGCAG TTGGGAAGCT 
GGGAACCCTT CCTGCCAGCC TTTTGAAGAT TTGAAGTCAT TACTTCAAAG CACAAGTTAT 
AAAGACCCCC ATTTGACACA GATGAAGTGC TTTTTGTTTG GCCTTTTGAA TGAAGATCGA 
GTAAAACAAC TGGAGAGGAC TTTTAACTGT AAAATGTCAC TGAAGATAAA ATCAAAGTTA 
CTTCAGTGTA TGGAAGTATT AGGAAACAGT GACTATTCTC CATCACAGCT GGGATTTCTG 
GAGTTGTTTC ACTGTCTGTA TGAGACTCAA GATAAAGCGT TTATAAGCCA GGCAATGAGA 
TGTTTCCCAA AGGTTGCCAT TAATATTTGT GAGAAAATAC ATTTGCTTGT ATCTTCTTTC 
TGCCTTAAGC ACTGCCGGTG TTTGCGGACC ATCAGGCTGT CTGTAACTGT GGTATTTGAG 
AAGAAGATAT TAAAAACAAG CCTCCCAACT AACACTTGGG ATGGTGATCG CATTACTCAC 
TGTTGGCAAG ATCTCTGTTC TGTGCTTCAT ACAAATGAAC ACTTGAGAGA ATTGGACCTG 
TACCATAGCA ACCTTGATAA ATCAGCAATG AATATCCTGC ATCATGAACT AAGGCACCCA 
AACTGTAAAC TACAAAAGCT ACTGTTGAAA TTTATCACTT TCCCTGATGG TTGTCAGGAT 
ATCTCTACTT CTTTGATTCA TAACAAGAAT CTGATGCATC TTGACCTAAA AGGGAGTGAT 
ATAGGGGATA ATGGAGTAAA GTCATTGTGT GAGGCCTTGA AACACCCAGA GTGTAAACTA 
CAGACTCTCA GCTTAGAAAG CTGTGGTCTC ACAGAGGCTG GCTGTGAGTA TCTTTCTTTG 
GCTCTCATCA GCAATAAAAG ACTGACACAT TTGTGCTTGG CAGACAATGT CTTGGGTGAT 
GGTGGAGTAA AGCTTATGAG TGATGCCCTG CAACATGCAC AATGTACTCT GAAGAGCCTT 
GTGCTGAGGC GTTGCCATTT CACTTCACTT AGCAGTGAAT ATCTGTCAAC TTCTCTTCTA 
CACAACAAGA GCCTGACGCA TCTGGATCTA GGATCAAACT GGCTACAAGA CAATGGAGTG 
AAGCTTCTGT GTGATGTCTT TCGGCATCCA AGCTGTAATC TTCAGGACTT GGAATTGATG 
GGCTGTGTTC TCACTAATGC ATGTTGTCTG GATCTGGCTT CTGTTATTTT GAATAACCCA 
AACCTGAGGA GCCTGGACCT TGGGAACAAC GATTTGCAGG ATGATGGAGT GAAAATTCTG 
TGTGATGCTT TGAGATATCC AAACTGTAAC ATTCAGAGGC TCGGGTTGGA ATACTGTGGT 
TTGACATCTC TCTGCTGTCA AGATCTCTCC TCTGCTCTTA TCTGCAACAA AAGACTGATA 
AAAATGAATC TGACACAGAA TACCTTAGGA TATGAAGGAA TTGTGAAGTT ATATAAAGTC 
TTGAAGTCTC CTAAGTGTAA ACTACAAGTT CTAGGGAGGC CATTGAAGCC GTTAAGACCG 
GGTCAGGTGA ACAGGAAGTT AAAGACTGAA AAGGAGACAC AAAACTGCCG ACTTTCCCGA 
CGGCGAATTG GCCCTCTGGA AACAGCCGAC CAATCACAGG CAGCAGGGGC GCGCCCTGCA 
GCGGGGCTCC GGCTGCGGTT CCGTGGACTC GGCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization.
Immunity46(4)621-634(2017 04)
Abe T,Lee A,Sitharam R,Kesner J,Rabadan R,Shapira SD

Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization.
Protein science : a publication of the Protein Society24(2)174-81(2015 Feb)
Huber RG,Eibl C,Fuchs JE

The genetics of NOD-like receptors in Crohn's disease.
Tissue antigens76(1)48-56(2010 Jul)
Cummings JR,Cooney RM,Clarke G,Beckly J,Geremia A,Pathan S,Hancock L,Guo C,Cardon LR,Jewell DP

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Cancer research68(24)10178-86(2008 Dec)
Enjuanes A,Benavente Y,Bosch F,Mart?n-Guerrero I,Colomer D,P?rez-Alvarez S,Reina O,Ardanaz MT,Jares P,Garc?a-Orad A,Pujana MA,Montserrat E,de Sanjos? S,Campo E

The NLR gene family: a standard nomenclature.
Immunity28(3)285-7(2008 Mar)
Ting JP,Lovering RC,Alnemri ES,Bertin J,Boss JM,Davis BK,Flavell RA,Girardin SE,Godzik A,Harton JA,Hoffman HM,Hugot JP,Inohara N,Mackenzie A,Maltais LJ,Nunez G,Ogura Y,Otten LA,Philpott D,Reed JC,Reith W,Schreiber S,Steimle V,Ward PA

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NLRP14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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