HTR1D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTR1D
Entrez Gene ID	3352
Full Name	5-hydroxytryptamine receptor 1D
Synonyms	5-HT1D,HT1DA,HTR1DA,HTRL,RDC4
General protein information	Preferred Names 5-hydroxytryptamine receptor 1D Names 5-hydroxytryptamine receptor 1D 5-HT-1D 5-HT-1D-alpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled serotonin 1D alpha receptor serotonin receptor 1D
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.12
Disorder MIM:	182133

mRNA and Protein(s)

mRNA	Protein	Name
NM_000864.4	NP_000855.1	5-hydroxytryptamine receptor 1D

Pathways from BioSystems

Homologies

	HTR1D	XP_001102386.1
Canis lupus familiaris (dog)	HTR1D	NP_001003280.1
Caenorhabditis elegans (roundworm)	tyra-3	NP_001024805.1
Homo sapiens (human)	HTR1D	NP_000855.1
Pan troglodytes (chimpanzee)	HTR1D	XP_524604.1
Drosophila melanogaster (fruit fly)	Oct-TyrR	NP_524419.2
Xenopus tropicalis (tropical clawed frog)	htr1d	XP_002938881.2
Rattus norvegicus (Norway rat)	Htr1d	NP_036984.1
Gallus gallus (chicken)	HTR1D	XP_003642607.1
Bos taurus (cattle)	HTR1D	XP_005203375.1
Mus musculus (house mouse)	Htr1d	NP_001272412.1
Danio rerio (zebrafish)	htr1bd	NP_001139158.1
Anopheles gambiae (African malaria mosquito)	GPRTYR	XP_312420.3

Gene Ontology
Bibliography

Related articles in PubMed

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
Bennet H, Balhuizen A, Medina A, Dekker Nitert M, Ottosson Laakso E, Ess?n S, Sp?gel P, Storm P, Krus U, Wierup N, Fex M
Peptides71113-20(2015 Sep)

5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/?-catenin/MMP-7 signaling pathway.
Sui H, Xu H, Ji Q, Liu X, Zhou L, Song H, Zhou X, Xu Y, Chen Z, Cai J, Ji G, Li Q
Oncotarget6(28)25975-87(2015 Sep)

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
Gurbuz N, Ashour AA, Alpay SN, Ozpolat B
PloS one9(9)e110067(2014)

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
Gurbuz N, Ashour AA, Alpay SN, Ozpolat B
PloS one9(8)e105245(2014)

Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus.
Thompson MD, Noble-Topham S, Percy ME, Andrade DM, Ebers GC
Neuroreport23(1)45-8(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non- diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D
Title: Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

Data show that 5-hydroxytryptamine receptor (5-HT1DR) played an important role in cell invasion via Axin1/beta-catenin/matrix metalloproteinase 7 (MMP-7) pathway.
Title: 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/?-catenin/MMP-7 signaling pathway.

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
Title: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.

5-HT1B- and 5-HT1D-mediated signaling play an important role in the regulation of the proliferative and invasive phenotype of pancreatic cancer cells.
Title: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.

study identified the presence of genetic association at chromosome 1p36 with migraine with aura (P=0.045, Bonferroni corrected): the locus encoding the 5HT(1D) receptor gene
Title: Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus.

The following HTR1D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTR1D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24313	NM_000864.4 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 1D (HTR1D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTR1D ( NM_000864.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000855.1 Homo sapiens 5-hydroxytryptamine receptor 1D (HTR1D), mRNA.

Price & Availability↑

CloneID	OHu24313
Clone ID Related Accession (Same CDS sequence)	NM_000864.4
Accession Version	NM_000864.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 1D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC007720.2, M81589.1 and AL049576.19. On May 8, 2008 this sequence version replaced NM_000864.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC007720.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCCAC TGAACCAGTC AGCAGAAGGC CTTCCCCAGG AGGCCTCCAA CAGATCCCTG 
AATGCCACAG AAACCTCAGA GGCTTGGGAT CCCAGGACCC TCCAGGCGCT CAAGATCTCC 
CTTGCCGTGG TCCTTTCCGT CATCACACTG GCCACAGTCC TCTCCAATGC CTTTGTACTC 
ACCACCATCT TACTCACCAG GAAGCTCCAC ACCCCTGCCA ACTACCTGAT TGGCTCCCTG 
GCCACCACCG ACCTCTTGGT TTCCATCTTG GTAATGCCCA TCAGCATCGC CTATACCATC 
ACCCACACCT GGAACTTTGG CCAAATCTTG TGTGACATCT GGCTGTCCTC TGACATCACG 
TGCTGCACAG CCTCCATCCT GCATCTCTGT GTCATTGCTC TGGACAGGTA CTGGGCAATC 
ACAGATGCCC TGGAATACAG TAAACGCAGG ACGGCTGGCC ACGCGGCCAC CATGATCGCC 
ATTGTCTGGG CCATCTCCAT CTGCATCTCC ATCCCCCCGC TCTTCTGGCG GCAGGCCAAG 
GCCCAGGAGG AGATGTCGGA CTGTCTGGTG AACACCTCTC AGATCTCCTA CACCATCTAC 
TCCACCTGTG GGGCCTTCTA CATTCCCTCG GTGTTGCTCA TCATCCTATA TGGCCGGATC 
TACCGGGCTG CCCGGAACCG CATCCTGAAT CCACCCTCAC TCTATGGGAA GCGCTTCACC 
ACGGCCCACC TCATCACAGG CTCTGCCGGG TCCTCGCTCT GCTCGCTCAA CTCCAGCCTC 
CATGAGGGGC ACTCGCACTC GGCTGGCTCC CCTCTCTTTT TCAACCACGT GAAAATCAAG 
CTTGCTGACA GTGCCCTGGA ACGCAAGAGG ATTTCTGCTG CTCGAGAAAG GAAAGCCACT 
AAAATCCTGG GCATCATTCT GGGGGCCTTT ATCATCTGCT GGCTGCCCTT CTTCGTGGTG 
TCTCTGGTCC TCCCCATCTG CCGGGACTCC TGCTGGATCC ACCCGGCGCT CTTTGACTTC 
TTCACCTGGC TAGGCTATTT AAACTCCCTC ATCAATCCAA TAATCTACAC TGTGTTTAAT 
GAAGAGTTTC GGCAAGCTTT TCAGAAAATT GTCCCTTTCC GGAAGGCCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000855.1
CDS	511..1644
Translation	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS

Target ORF information:

RefSeq Version	NM_000864.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 1D (HTR1D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000864.4

ORF Insert Sequence:

ATGTCCCCAC TGAACCAGTC AGCAGAAGGC CTTCCCCAGG AGGCCTCCAA CAGATCCCTG 
AATGCCACAG AAACCTCAGA GGCTTGGGAT CCCAGGACCC TCCAGGCGCT CAAGATCTCC 
CTTGCCGTGG TCCTTTCCGT CATCACACTG GCCACAGTCC TCTCCAATGC CTTTGTACTC 
ACCACCATCT TACTCACCAG GAAGCTCCAC ACCCCTGCCA ACTACCTGAT TGGCTCCCTG 
GCCACCACCG ACCTCTTGGT TTCCATCTTG GTAATGCCCA TCAGCATCGC CTATACCATC 
ACCCACACCT GGAACTTTGG CCAAATCTTG TGTGACATCT GGCTGTCCTC TGACATCACG 
TGCTGCACAG CCTCCATCCT GCATCTCTGT GTCATTGCTC TGGACAGGTA CTGGGCAATC 
ACAGATGCCC TGGAATACAG TAAACGCAGG ACGGCTGGCC ACGCGGCCAC CATGATCGCC 
ATTGTCTGGG CCATCTCCAT CTGCATCTCC ATCCCCCCGC TCTTCTGGCG GCAGGCCAAG 
GCCCAGGAGG AGATGTCGGA CTGTCTGGTG AACACCTCTC AGATCTCCTA CACCATCTAC 
TCCACCTGTG GGGCCTTCTA CATTCCCTCG GTGTTGCTCA TCATCCTATA TGGCCGGATC 
TACCGGGCTG CCCGGAACCG CATCCTGAAT CCACCCTCAC TCTATGGGAA GCGCTTCACC 
ACGGCCCACC TCATCACAGG CTCTGCCGGG TCCTCGCTCT GCTCGCTCAA CTCCAGCCTC 
CATGAGGGGC ACTCGCACTC GGCTGGCTCC CCTCTCTTTT TCAACCACGT GAAAATCAAG 
CTTGCTGACA GTGCCCTGGA ACGCAAGAGG ATTTCTGCTG CTCGAGAAAG GAAAGCCACT 
AAAATCCTGG GCATCATTCT GGGGGCCTTT ATCATCTGCT GGCTGCCCTT CTTCGTGGTG 
TCTCTGGTCC TCCCCATCTG CCGGGACTCC TGCTGGATCC ACCCGGCGCT CTTTGACTTC 
TTCACCTGGC TAGGCTATTT AAACTCCCTC ATCAATCCAA TAATCTACAC TGTGTTTAAT 
GAAGAGTTTC GGCAAGCTTT TCAGAAAATT GTCCCTTTCC GGAAGGCCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
Peptides71113-20(2015 Sep)
Bennet H,Balhuizen A,Medina A,Dekker Nitert M,Ottosson Laakso E,Ess?n S,Sp?gel P,Storm P,Krus U,Wierup N,Fex M

5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/?-catenin/MMP-7 signaling pathway.
Oncotarget6(28)25975-87(2015 Sep)
Sui H,Xu H,Ji Q,Liu X,Zhou L,Song H,Zhou X,Xu Y,Chen Z,Cai J,Ji G,Li Q

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
PloS one9(9)e110067(2014)
Gurbuz N,Ashour AA,Alpay SN,Ozpolat B

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
PloS one9(8)e105245(2014)
Gurbuz N,Ashour AA,Alpay SN,Ozpolat B

Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus.
Neuroreport23(1)45-8(2012 Jan)
Thompson MD,Noble-Topham S,Percy ME,Andrade DM,Ebers GC

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

HTR1D cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報