H3C15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3C15
Entrez Gene ID	333932
Full Name	histone cluster 2 H3 family member a
Synonyms	H3/n,H3/o
General protein information	Preferred Names histone cluster 2 H3 family member a Names histone H3.2 histone 2, H3a histone H3/o histone cluster 2, H3a
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001005464.2	NP_001005464.1	histone H3.2
NM_001005464.3	NP_001005464.1	histone H3.2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC483172	XP_540290.2
Bos taurus (cattle)	LOC619141	XP_005204024.1
Gallus gallus (chicken)	LOC417953	XP_416193.2
Drosophila melanogaster (fruit fly)	His3:CG33815	NP_001027303.1
	LOC695573	XP_001083065.1
Rattus norvegicus (Norway rat)	LOC100359421	XP_002729690.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012573	XP_560604.5
Arabidopsis thaliana (thale cress)	AT1G13370	NP_172794.1
Homo sapiens (human)	HIST2H3A	NP_001005464.1
Mus musculus (house mouse)	Hist1h3f	NP_038576.1
Pan troglodytes (chimpanzee)	LOC100613592	XP_003314213.1
Danio rerio (zebrafish)	zgc:113983	NP_001020342.1
Xenopus tropicalis (tropical clawed frog)	LOC100487179	XP_004915673.1

Gene Ontology
Bibliography

Related articles in PubMed

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Huang H, Str?mme CB, Saredi G, H?dl M, Strandsby A, Gonz?lez-Aguilera C, Chen S, Groth A, Patel DJ
Nature structural & molecular biology22(8)618-26(2015 Aug)

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H
Biochemistry54(5)1171-9(2015 Feb)

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Els?sser SJ, Huang H, Lewis PW, Chin JW, Allis CD, Patel DJ
Nature491(7425)560-5(2012 Nov)

Functional characterization of a human histone gene cluster duplication.
Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS
Gene342(1)35-40(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulated by zinc and upregulated by docosahexaenoate in a neuroblastoma cell line.
Title: Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells.

histone H3 Lys(23) propionylation may provide a novel epigenetic regulatory mark for cell metabolism
Title: Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells.

These results suggest that Lysine 56 acetylation of Histone H3 is involved in the human core transcriptional network of pluripotency.
Title: Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.

the evolving role of histone H3 phosphorylation and demonstrate a direct, functional, and histone-modification-regulated association of SRp20 and ASF/SF2 with chromatin.
Title: Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation.

analysis of interactions between WDR5, the catalytic subunit, MLL, and the substrate, histone H3, of the MLL complex
Title: WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

The following H3C15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3C15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13909	NM_001005464.3 Latest version!	Homo sapiens H3 clustered histone 15 (H3C15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13909	NM_001005464.2	Homo sapiens histone cluster 2 H3 family member a (HIST2H3A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3C15 ( NM_001005464.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005464.1 Homo sapiens histone cluster 2 H3 family member a (HIST2H3A), mRNA.

Price & Availability↑

CloneID	OHu13909
Clone ID Related Accession (Same CDS sequence)	NM_001005464.2 , NM_001005464.3
Accession Version	NM_001005464.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	histone H3.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY648851.1. On Jun 2, 2006 this sequence version replaced NM_001005464.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGTA CTAAGCAGAC TGCTCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCCACCA AGGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT AGCCCTGCGG GAGATCCGGC GCTACCAGAA GTCCACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ACGCCAAGCG CGTGACCATT 
ATGCCCAAGG ACATCCAGCT GGCCCGCCGC ATCCGTGGAG AGCGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005464.1
CDS	37..447
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_001005464.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 2 H3 family member a (HIST2H3A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005464.2

ORF Insert Sequence:

ATGGCCCGTA CTAAGCAGAC TGCTCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCCACCA AGGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT AGCCCTGCGG GAGATCCGGC GCTACCAGAA GTCCACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ACGCCAAGCG CGTGACCATT 
ATGCCCAAGG ACATCCAGCT GGCCCGCCGC ATCCGTGGAG AGCGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3C15 ( NM_001005464.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005464.1 Homo sapiens H3 clustered histone 15 (H3C15), mRNA.

Price & Availability↑

CloneID	OHu13909
Clone ID Related Accession (Same CDS sequence)	NM_001005464.2 , NM_001005464.3
Accession Version	NM_001005464.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	histone H3.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC239868.2. On Dec 3, 2019 this sequence version replaced NM_001005464.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: HY085386.1, BE889837.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGTA CTAAGCAGAC TGCTCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCCACCA AGGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT AGCCCTGCGG GAGATCCGGC GCTACCAGAA GTCCACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ACGCCAAGCG CGTGACCATT 
ATGCCCAAGG ACATCCAGCT GGCCCGCCGC ATCCGTGGAG AGCGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005464.1
CDS	48..458
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_001005464.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 clustered histone 15 (H3C15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005464.3

ORF Insert Sequence:

ATGGCCCGTA CTAAGCAGAC TGCTCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCCACCA AGGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT AGCCCTGCGG GAGATCCGGC GCTACCAGAA GTCCACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ACGCCAAGCG CGTGACCATT 
ATGCCCAAGG ACATCCAGCT GGCCCGCCGC ATCCGTGGAG AGCGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Nature structural & molecular biology22(8)618-26(2015 Aug)
Huang H,Str?mme CB,Saredi G,H?dl M,Strandsby A,Gonz?lez-Aguilera C,Chen S,Groth A,Patel DJ

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Biochemistry54(5)1171-9(2015 Feb)
Kato D,Osakabe A,Tachiwana H,Tanaka H,Kurumizaka H

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Nature491(7425)560-5(2012 Nov)
Els?sser SJ,Huang H,Lewis PW,Chin JW,Allis CD,Patel DJ

Functional characterization of a human histone gene cluster duplication.
Gene342(1)35-40(2004 Nov)
Braastad CD,Hovhannisyan H,van Wijnen AJ,Stein JL,Stein GS

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H3C15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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