HSPE1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSPE1
Entrez Gene ID	3336
Full Name	heat shock protein family E (Hsp10) member 1
Synonyms	CPN10,EPF,GROES,HSP10
General protein information	Preferred Names heat shock protein family E (Hsp10) member 1 Names 10 kDa heat shock protein, mitochondrial 10 kDa chaperonin chaperonin 10 early-pregnancy factor heat shock 10kD protein 1 (chaperonin 10) heat shock 10kDa protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q33.1
Summary	This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011].
Disorder MIM:	600141

mRNA and Protein(s)

mRNA	Protein	Name
NM_002157.3	NP_002148.1	10 kDa heat shock protein, mitochondrial
NM_002157.2	NP_002148.1	10 kDa heat shock protein, mitochondrial

Pathways from BioSystems

Homologies

	LOC721815	XP_001118014.2
Rattus norvegicus (Norway rat)	Hspe1	NP_037098.1
Xenopus tropicalis (tropical clawed frog)	hspe1	NP_001006882.1
	LOC696316	XP_001084953.1
	LOC720015	XP_001114974.1
Canis lupus familiaris (dog)	HSPE1	XP_536017.2
Danio rerio (zebrafish)	hspe1	NP_571601.1
Kluyveromyces lactis	KLLA0E09307g	XP_454370.1
Schizosaccharomyces pombe (fission yeast)	hsp10	NP_588098.1
Neurospora crassa	NCU04334	XP_956315.1
Oryza sativa (rice)	Os07g0641700	NP_001060431.1
	HSPE1	XP_002799059.1
Bos taurus (cattle)	HSPE1	NP_776771.1
Mus musculus (house mouse)	Hspe1	NP_032329.1
Arabidopsis thaliana (thale cress)	CPN10	NP_563961.1
Arabidopsis thaliana (thale cress)	AT1G23100	NP_173723.1
Canis lupus familiaris (dog)	LOC609748	XP_852207.1
Caenorhabditis elegans (roundworm)	Y22D7AL.10	NP_497428.1
Magnaporthe oryzae (rice blast fungus)	MGG_13221	XP_003711926.1
Homo sapiens (human)	HSPE1	NP_002148.1
	LOC711695	XP_001100531.2
	LOC710026	XP_001105898.1
Saccharomyces cerevisiae (baker's yeast)	HSP10	NP_014663.1
Eremothecium gossypii	AGOS_AEL235W	NP_984626.2
Oryza sativa (rice)	Os03g0366000	NP_001050177.2

Gene Ontology
Bibliography

Related articles in PubMed

High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
Chu S, Wen Q, Qing Z, Luo J, Wang W, Chen L, Feng J, Xu L, Zang H, Fan S
Human pathology61173-180(2017 03)

Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
Fan W, Fan SS, Feng J, Xiao D, Fan S, Luo J
PloS one12(10)e0185563(2017)

miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
Pfeiffer D, Ro?manith E, Lang I, Falkenhagen D
PloS one12(6)e0179850(2017)

Early Pregnancy Factor Enhances the Generation and Function of CD4
Chen Q, Zhu X, Chen R, Liu J, Liu P, Hu A, Wu L, Hua H, Yuan H
The Tohoku journal of experimental medicine240(3)215-220(2016 11)

Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Hansen JJ, Bross P, Westergaard M, Nielsen MN, Eiberg H, B?rglum AD, Mogensen J, Kristiansen K, Bolund L, Gregersen N
Human genetics112(1)71-7(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in invasive ductal breast carcinoma.
Title: High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.

elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
Title: Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.

miR-146a, miR-146b, and miR-155 are exerting anti-inflammatory properties by down-regulating IL-6 and IL-8, and influencing the expression of HSP10 in the activated endothelium
Title: miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.

EPF induces the differentiation of regulatory T cells and increases their immunosuppressive activities.
Title: Early Pregnancy Factor Enhances the Generation and Function of CD4

Hsp10 and Hsp60 may be implicated in carcinogenesis from its very early steps in colorectal cancer.
Title: Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.

The following HSPE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17870	NM_002157.3 Latest version!	Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17870	NM_002157.2	Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSPE1 ( NM_002157.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002148.1 Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA.

Price & Availability↑

CloneID	OHu17870
Clone ID Related Accession (Same CDS sequence)	NM_002157.3 , NM_002157.2
Accession Version	NM_002157.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	10 kDa heat shock protein, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC023518.2 and BG188453.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002157.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.102397.1, SRR1163655.433354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000233893.10/ ENSP00000233893.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG 
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA 
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT 
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA 
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC 
GTAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002148.1
CDS	59..367
Translation	MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDGDILGKYVD

Target ORF information:

RefSeq Version	NM_002157.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002157.3

ORF Insert Sequence:

ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG 
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA 
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT 
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA 
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC 
GTAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPE1 ( NM_002157.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002148.1 Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA.

Price & Availability↑

CloneID	OHu17870
Clone ID Related Accession (Same CDS sequence)	NM_002157.3 , NM_002157.2
Accession Version	NM_002157.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	10 kDa heat shock protein, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN264788.1, BC023518.2 and BG188453.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2008 this sequence version replaced NM_002157.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.510550.1, SRR1660805.359481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG 
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA 
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT 
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA 
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC 
GTAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002148.1
CDS	441..749
Translation	MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDGDILGKYVD

Target ORF information:

RefSeq Version	NM_002157.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002157.2

ORF Insert Sequence:

ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG 
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA 
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT 
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA 
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC 
GTAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
Human pathology61173-180(2017 03)
Chu S,Wen Q,Qing Z,Luo J,Wang W,Chen L,Feng J,Xu L,Zang H,Fan S

Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
PloS one12(10)e0185563(2017)
Fan W,Fan SS,Feng J,Xiao D,Fan S,Luo J

miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
PloS one12(6)e0179850(2017)
Pfeiffer D,Ro?manith E,Lang I,Falkenhagen D

Early Pregnancy Factor Enhances the Generation and Function of CD4
The Tohoku journal of experimental medicine240(3)215-220(2016 11)
Chen Q,Zhu X,Chen R,Liu J,Liu P,Hu A,Wu L,Hua H,Yuan H

Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Human genetics112(1)71-7(2003 Jan)
Hansen JJ,Bross P,Westergaard M,Nielsen MN,Eiberg H,B?rglum AD,Mogensen J,Kristiansen K,Bolund L,Gregersen N

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HSPE1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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