HSPB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSPB2
Entrez Gene ID	3316
Full Name	heat shock protein family B (small) member 2
Synonyms	HSP27,Hs.78846,LOH11CR1K,MKBP
General protein information	Preferred Names heat shock protein family B (small) member 2 Names heat shock protein beta-2 DMPK-binding protein heat shock 27kDa protein 2 heat-shock protein beta-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.1
Summary	The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012].
Disorder MIM:	602179

mRNA and Protein(s)

mRNA	Protein	Name
NM_001541.3	NP_001532.1	heat shock protein beta-2
NM_001541.4	NP_001532.1	heat shock protein beta-2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Hspb2	NP_569115.1
Homo sapiens (human)	HSPB2	NP_001532.1
Canis lupus familiaris (dog)	HSPB2	XP_854111.1
Mus musculus (house mouse)	Hspb2	NP_077761.3
Danio rerio (zebrafish)	hspb2	NP_001017744.1
Xenopus tropicalis (tropical clawed frog)	hspb2	XP_002932983.1
	HSPB2	XP_002799806.1
Bos taurus (cattle)	HSPB2	NP_001091850.1
Gallus gallus (chicken)	HSPB2	NP_001001527.1

Gene Ontology
Bibliography

Related articles in PubMed

Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.
Morelli FF, Verbeek DS, Bertacchini J, Vinet J, Mediani L, Marmiroli S, Cenacchi G, Nasi M, De Biasi S, Brunsting JF, Lammerding J, Pegoraro E, Angelini C, Tupler R, Alberti S, Carra S
Cell reports20(9)2100-2115(2017 Aug)

An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.
Morelli FF, Mediani L, Heldens L, Bertacchini J, Bigi I, Carr? AD, Vinet J, Carra S
Cell stress & chaperones22(4)531-540(2017 Jul)

Potential role of heat-shock proteins in giant cell tumors.
Chen JT, Younusi A, Cao L, Tian Z, Zhou YJ, Song XH
Genetics and molecular research : GMR14(4)19144-54(2015 Dec)

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Kipper S, Hamad S, Caly L, Avrahami D, Bacharach E, Jans DA, Gerber D, Bajorek M
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
Grose JH, Langston K, Wang X, Squires S, Mustafi SB, Hayes W, Neubert J, Fischer SK, Fasano M, Saunders GM, Dai Q, Christians E, Lewandowski ED, Ping P, Benjamin IJ
PloS one10(10)e0133994(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Three of the differentially expressed heat-schock proteins, HSP90A, HSPB1, and HSPB2, are up-regulated in giant cell tumor of bone patients.
Title: Potential role of heat-shock proteins in giant cell tumors.

HspB2 has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis
Title: Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.

Results suggest a limited function of alphaB-crystallin and HSP27 in preventing abnormal tau protein deposition in glial cells and neurons; in addition, the expression of alphaB-crystallin phosphorylated at Ser59 may act as a protective factor in glial cells.
Title: ?B-crystallin and HSP27 in glial cells in tauopathies.

These findings provide novel insights into the role of p53 as a regulator of bidirectional gene pair HspB2/alpha B-crystallin-mediated ROS and the Warburg effect
Title: As a novel p53 direct target, bidirectional gene HspB2/?B-crystallin regulates the ROS level and Warburg effect.

Study shows that HspB2 oligomers exchange subunits.
Title: HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects.

The following HSPB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19365	NM_001541.4 Latest version!	Homo sapiens heat shock protein family B (small) member 2 (HSPB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19365	NM_001541.3	Homo sapiens heat shock protein family B (small) member 2 (HSPB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSPB2 ( NM_001541.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001532.1 Homo sapiens heat shock protein family B (small) member 2 (HSPB2), mRNA.

Price & Availability↑

CloneID	OHu19365
Clone ID Related Accession (Same CDS sequence)	NM_001541.3 , NM_001541.4
Accession Version	NM_001541.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	heat shock protein beta-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB096250.1 and AI131288.1. This sequence is a reference standard in the RefSeqGene project. On Oct 31, 2008 this sequence version replaced NM_001541.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279845.598.1, AB096250.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGCC GCTCAGTGCC ACATGCCCAC CCGGCCACCG CCGAGTACGA ATTTGCCAAC 
CCGAGCCGCC TGGGTGAGCA GCGCTTCGGA GAAGGCCTCC TGCCAGAAGA GATCCTGACC 
CCCACACTCT ACCATGGCTA CTATGTCCGG CCTCGGGCCG CCCCAGCTGG GGAGGGCAGC 
AGGGCAGGGG CCTCCGAGCT TAGGCTCAGT GAGGGCAAGT TCCAGGCATT TCTGGATGTG 
AGCCACTTTA CCCCAGACGA GGTGACTGTG AGGACTGTGG ATAACCTGCT GGAGGTGTCT 
GCCCGGCACC CCCAGCGCCT GGACCGCCAC GGCTTCGTGT CCCGAGAGTT CTGCCGCACC 
TATGTCCTGC CTGCTGATGT CGACCCCTGG CGAGTCCGAG CTGCTCTCTC CCATGATGGC 
ATCTTAAACC TGGAAGCACC TCGGGGTGGC CGACATTTGG ACACAGAGGT CAATGAGGTC 
TACATCTCCC TGCTCCCTGC GCCTCCTGAT CCAGAGGAAG AGGAGGAGGC AGCCATAGTT 
GAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001532.1
CDS	95..643
Translation	MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIVEP

Target ORF information:

RefSeq Version	NM_001541.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family B (small) member 2 (HSPB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001541.3

ORF Insert Sequence:

ATGTCGGGCC GCTCAGTGCC ACATGCCCAC CCGGCCACCG CCGAGTACGA ATTTGCCAAC 
CCGAGCCGCC TGGGTGAGCA GCGCTTCGGA GAAGGCCTCC TGCCAGAAGA GATCCTGACC 
CCCACACTCT ACCATGGCTA CTATGTCCGG CCTCGGGCCG CCCCAGCTGG GGAGGGCAGC 
AGGGCAGGGG CCTCCGAGCT TAGGCTCAGT GAGGGCAAGT TCCAGGCATT TCTGGATGTG 
AGCCACTTTA CCCCAGACGA GGTGACTGTG AGGACTGTGG ATAACCTGCT GGAGGTGTCT 
GCCCGGCACC CCCAGCGCCT GGACCGCCAC GGCTTCGTGT CCCGAGAGTT CTGCCGCACC 
TATGTCCTGC CTGCTGATGT CGACCCCTGG CGAGTCCGAG CTGCTCTCTC CCATGATGGC 
ATCTTAAACC TGGAAGCACC TCGGGGTGGC CGACATTTGG ACACAGAGGT CAATGAGGTC 
TACATCTCCC TGCTCCCTGC GCCTCCTGAT CCAGAGGAAG AGGAGGAGGC AGCCATAGTT 
GAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPB2 ( NM_001541.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001532.1 Homo sapiens heat shock protein family B (small) member 2 (HSPB2), mRNA.

Price & Availability↑

CloneID	OHu19365
Clone ID Related Accession (Same CDS sequence)	NM_001541.3 , NM_001541.4
Accession Version	NM_001541.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	heat shock protein beta-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000907.6, AB096250.1 and AI131288.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001541.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.254719.1, AB096250.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304298.4/ ENSP00000302476.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGGCC GCTCAGTGCC ACATGCCCAC CCGGCCACCG CCGAGTACGA ATTTGCCAAC 
CCGAGCCGCC TGGGTGAGCA GCGCTTCGGA GAAGGCCTCC TGCCAGAAGA GATCCTGACC 
CCCACACTCT ACCATGGCTA CTATGTCCGG CCTCGGGCCG CCCCAGCTGG GGAGGGCAGC 
AGGGCAGGGG CCTCCGAGCT TAGGCTCAGT GAGGGCAAGT TCCAGGCATT TCTGGATGTG 
AGCCACTTTA CCCCAGACGA GGTGACTGTG AGGACTGTGG ATAACCTGCT GGAGGTGTCT 
GCCCGGCACC CCCAGCGCCT GGACCGCCAC GGCTTCGTGT CCCGAGAGTT CTGCCGCACC 
TATGTCCTGC CTGCTGATGT CGACCCCTGG CGAGTCCGAG CTGCTCTCTC CCATGATGGC 
ATCTTAAACC TGGAAGCACC TCGGGGTGGC CGACATTTGG ACACAGAGGT CAATGAGGTC 
TACATCTCCC TGCTCCCTGC GCCTCCTGAT CCAGAGGAAG AGGAGGAGGC AGCCATAGTT 
GAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001532.1
CDS	97..645
Translation	MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIVEP

Target ORF information:

RefSeq Version	NM_001541.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family B (small) member 2 (HSPB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001541.4

ORF Insert Sequence:

ATGTCGGGCC GCTCAGTGCC ACATGCCCAC CCGGCCACCG CCGAGTACGA ATTTGCCAAC 
CCGAGCCGCC TGGGTGAGCA GCGCTTCGGA GAAGGCCTCC TGCCAGAAGA GATCCTGACC 
CCCACACTCT ACCATGGCTA CTATGTCCGG CCTCGGGCCG CCCCAGCTGG GGAGGGCAGC 
AGGGCAGGGG CCTCCGAGCT TAGGCTCAGT GAGGGCAAGT TCCAGGCATT TCTGGATGTG 
AGCCACTTTA CCCCAGACGA GGTGACTGTG AGGACTGTGG ATAACCTGCT GGAGGTGTCT 
GCCCGGCACC CCCAGCGCCT GGACCGCCAC GGCTTCGTGT CCCGAGAGTT CTGCCGCACC 
TATGTCCTGC CTGCTGATGT CGACCCCTGG CGAGTCCGAG CTGCTCTCTC CCATGATGGC 
ATCTTAAACC TGGAAGCACC TCGGGGTGGC CGACATTTGG ACACAGAGGT CAATGAGGTC 
TACATCTCCC TGCTCCCTGC GCCTCCTGAT CCAGAGGAAG AGGAGGAGGC AGCCATAGTT 
GAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.
Cell reports20(9)2100-2115(2017 Aug)
Morelli FF,Verbeek DS,Bertacchini J,Vinet J,Mediani L,Marmiroli S,Cenacchi G,Nasi M,De Biasi S,Brunsting JF,Lammerding J,Pegoraro E,Angelini C,Tupler R,Alberti S,Carra S

An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.
Cell stress & chaperones22(4)531-540(2017 Jul)
Morelli FF,Mediani L,Heldens L,Bertacchini J,Bigi I,Carr? AD,Vinet J,Carra S

Potential role of heat-shock proteins in giant cell tumors.
Genetics and molecular research : GMR14(4)19144-54(2015 Dec)
Chen JT,Younusi A,Cao L,Tian Z,Zhou YJ,Song XH

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)
Kipper S,Hamad S,Caly L,Avrahami D,Bacharach E,Jans DA,Gerber D,Bajorek M

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
PloS one10(10)e0133994(2015)
Grose JH,Langston K,Wang X,Squires S,Mustafi SB,Hayes W,Neubert J,Fischer SK,Fasano M,Saunders GM,Dai Q,Christians E,Lewandowski ED,Ping P,Benjamin IJ

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HSPB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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