HOXD12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXD12
Entrez Gene ID	3238
Full Name	homeobox D12
Synonyms	HOX4H
General protein information	Preferred Names homeobox D12 Names homeobox protein Hox-D12 Hox-4.7, mouse, homolog of homeo box D12 homeobox protein Hox-4H
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	142988

mRNA and Protein(s)

mRNA	Protein	Name
NM_021193.3	NP_067016.3	homeobox protein Hox-D12
NM_021193.4	NP_067016.3	homeobox protein Hox-D12

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HOXD12	XP_515926.1
Bos taurus (cattle)	HOXD12	NP_001192800.1
Homo sapiens (human)	HOXD12	NP_067016.3
Canis lupus familiaris (dog)	HOXD12	XP_545535.1
Rattus norvegicus (Norway rat)	Hoxd12	NP_001178832.1
Gallus gallus (chicken)	HOXD12	NP_990580.1
	HOXD12	XP_002799016.1
Danio rerio (zebrafish)	hoxd12a	NP_001119958.1
Mus musculus (house mouse)	Hoxd12	NP_032300.2

Gene Ontology
Bibliography

Related articles in PubMed

Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length.
Sugie Y, Sugie H, Fukuda T, Osawa J
Brain & development32(5)356-61(2010 May)

A region of the human HOXD cluster that confers polycomb-group responsiveness.
Woo CJ, Kharchenko PV, Daheron L, Park PJ, Kingston RE
Cell140(1)99-110(2010 Jan)

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research24(12)2039-49(2009 Dec)

Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
Ester AR, Weymouth KS, Burt A, Wise CA, Scott A, Gurnett CA, Dobbs MB, Blanton SH, Hecht JT
American journal of medical genetics. Part A149A(12)2745-52(2009 Dec)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length.

In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease sensitivity as hESCs differentiate.
Title: A region of the human HOXD cluster that confers polycomb-group responsiveness.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.

Data show that HOXD12 are important susceptible genes of idiopathic congenital talipes equinovarus.
Title: [Analysis of association between 5' HOXD gene and idiopathic congenital talipes equinovarus].

The following HOXD12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXD12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31952	NM_021193.4 Latest version!	Homo sapiens homeobox D12 (HOXD12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu31952	NM_021193.3	Homo sapiens homeobox D12 (HOXD12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXD12 ( NM_021193.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_067016.3 Homo sapiens homeobox D12 (HOXD12), mRNA.

Price & Availability↑

CloneID	OHu31952
Clone ID Related Accession (Same CDS sequence)	NM_021193.3 , NM_021193.4
Accession Version	NM_021193.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009336.13. On Jul 17, 2019 this sequence version replaced NM_021193.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG031716.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTGTGAGC GCAGTCTCTA CAGAGCGGGC TATGTGGGCT CGCTTCTGAA TCTGCAGTCG 
CCAGACTCTT TCTACTTCTC CAACCTGAGG CCGAATGGCG GCCAGTTGGC CGCGCTTCCC 
CCTATCTCCT ACCCGCGCGG CGCGCTGCCC TGGGCCGCCA CGCCCGCCTC CTGCGCCCCC 
GCGCAGCCTG CGGGCGCCAC TGCCTTCGGC GGCTTCTCGC AGCCCTACCT GGCTGGCTCC 
GGGCCTCTCG GCCTGCAGCC CCCAACAGCC AAAGACGGAC CCGAAGAGCA GGCTAAGTTC 
TATGCGCCCG AAGCGGCCGC TGGGCCAGAG GAGCGCGGTC GTACCCGGCC GTCCTTCGCC 
CCCGAGTCTA GCCTGGCTCC TGCAGTGGCT GCTCTCAAAG CGGCCAAGTA TGACTACGCT 
GGTGTGGGTC GTGCCACGCC GGGCTCCACG ACCCTGCTCC AGGGGGCTCC CTGCGCCCCT 
GGCTTCAAGG ACGACACCAA GGGCCCGCTC AACTTGAACA TGACAGTGCA GGCGGCGGGC 
GTTGCCTCTT GCCTGCGACC TTCACTGCCC GACGGCCTGC CGTGGGGGGC GGCCCCGGGG 
AGGGCCCGCA AGAAGCGGAA ACCCTACACG AAGCAGCAGA TTGCGGAGTT GGAGAACGAA 
TTCCTCGTCA ACGAATTCAT CAACAGGCAG AAACGCAAGG AATTGTCCAA TAGGCTGAAC 
CTCAGCGACC AGCAAGTCAA AATCTGGTTC CAGAACAGGC GTATGAAGAA GAAGCGCGTG 
GTGCTTCGGG AGCAGGCGCT GGCGCTCTAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067016.3
CDS	8..820
Translation	MCERSLYRAGYVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAPAQPAGATAFGGFSQPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPEERGRTRPSFAPESSLAPAVAALKAAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDTKGPLNLNMTVQAAGVASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVLREQALALY

Target ORF information:

RefSeq Version	NM_021193.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D12 (HOXD12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021193.4

ORF Insert Sequence:

ATGTGTGAGC GCAGTCTCTA CAGAGCGGGC TATGTGGGCT CGCTTCTGAA TCTGCAGTCG 
CCAGACTCTT TCTACTTCTC CAACCTGAGG CCGAATGGCG GCCAGTTGGC CGCGCTTCCC 
CCTATCTCCT ACCCGCGCGG CGCGCTGCCC TGGGCCGCCA CGCCCGCCTC CTGCGCCCCC 
GCGCAGCCTG CGGGCGCCAC TGCCTTCGGC GGCTTCTCGC AGCCCTACCT GGCTGGCTCC 
GGGCCTCTCG GCCTGCAGCC CCCAACAGCC AAAGACGGAC CCGAAGAGCA GGCTAAGTTC 
TATGCGCCCG AAGCGGCCGC TGGGCCAGAG GAGCGCGGTC GTACCCGGCC GTCCTTCGCC 
CCCGAGTCTA GCCTGGCTCC TGCAGTGGCT GCTCTCAAAG CGGCCAAGTA TGACTACGCT 
GGTGTGGGTC GTGCCACGCC GGGCTCCACG ACCCTGCTCC AGGGGGCTCC CTGCGCCCCT 
GGCTTCAAGG ACGACACCAA GGGCCCGCTC AACTTGAACA TGACAGTGCA GGCGGCGGGC 
GTTGCCTCTT GCCTGCGACC TTCACTGCCC GACGGCCTGC CGTGGGGGGC GGCCCCGGGG 
AGGGCCCGCA AGAAGCGGAA ACCCTACACG AAGCAGCAGA TTGCGGAGTT GGAGAACGAA 
TTCCTCGTCA ACGAATTCAT CAACAGGCAG AAACGCAAGG AATTGTCCAA TAGGCTGAAC 
CTCAGCGACC AGCAAGTCAA AATCTGGTTC CAGAACAGGC GTATGAAGAA GAAGCGCGTG 
GTGCTTCGGG AGCAGGCGCT GGCGCTCTAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXD12 ( NM_021193.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_067016.3 Homo sapiens homeobox D12 (HOXD12), mRNA.

Price & Availability↑

CloneID	OHu31952
Clone ID Related Accession (Same CDS sequence)	NM_021193.3 , NM_021193.4
Accession Version	NM_021193.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	homeobox protein Hox-D12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069088.1 and BG031716.1. On Jul 22, 2008 this sequence version replaced NM_021193.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG031716.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2156266 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTGTGAGC GCAGTCTCTA CAGAGCGGGC TATGTGGGCT CGCTTCTGAA TCTGCAGTCG 
CCAGACTCTT TCTACTTCTC CAACCTGAGG CCGAATGGCG GCCAGTTGGC CGCGCTTCCC 
CCTATCTCCT ACCCGCGCGG CGCGCTGCCC TGGGCCGCCA CGCCCGCCTC CTGCGCCCCC 
GCGCAGCCTG CGGGCGCCAC TGCCTTCGGC GGCTTCTCGC AGCCCTACCT GGCTGGCTCC 
GGGCCTCTCG GCCTGCAGCC CCCAACAGCC AAAGACGGAC CCGAAGAGCA GGCTAAGTTC 
TATGCGCCCG AAGCGGCCGC TGGGCCAGAG GAGCGCGGTC GTACCCGGCC GTCCTTCGCC 
CCCGAGTCTA GCCTGGCTCC TGCAGTGGCT GCTCTCAAAG CGGCCAAGTA TGACTACGCT 
GGTGTGGGTC GTGCCACGCC GGGCTCCACG ACCCTGCTCC AGGGGGCTCC CTGCGCCCCT 
GGCTTCAAGG ACGACACCAA GGGCCCGCTC AACTTGAACA TGACAGTGCA GGCGGCGGGC 
GTTGCCTCTT GCCTGCGACC TTCACTGCCC GACGGCCTGC CGTGGGGGGC GGCCCCGGGG 
AGGGCCCGCA AGAAGCGGAA ACCCTACACG AAGCAGCAGA TTGCGGAGTT GGAGAACGAA 
TTCCTCGTCA ACGAATTCAT CAACAGGCAG AAACGCAAGG AATTGTCCAA TAGGCTGAAC 
CTCAGCGACC AGCAAGTCAA AATCTGGTTC CAGAACAGGC GTATGAAGAA GAAGCGCGTG 
GTGCTTCGGG AGCAGGCGCT GGCGCTCTAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067016.3
CDS	1..813
Translation	MCERSLYRAGYVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAPAQPAGATAFGGFSQPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPEERGRTRPSFAPESSLAPAVAALKAAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDTKGPLNLNMTVQAAGVASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVLREQALALY

Target ORF information:

RefSeq Version	NM_021193.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox D12 (HOXD12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021193.3

ORF Insert Sequence:

ATGTGTGAGC GCAGTCTCTA CAGAGCGGGC TATGTGGGCT CGCTTCTGAA TCTGCAGTCG 
CCAGACTCTT TCTACTTCTC CAACCTGAGG CCGAATGGCG GCCAGTTGGC CGCGCTTCCC 
CCTATCTCCT ACCCGCGCGG CGCGCTGCCC TGGGCCGCCA CGCCCGCCTC CTGCGCCCCC 
GCGCAGCCTG CGGGCGCCAC TGCCTTCGGC GGCTTCTCGC AGCCCTACCT GGCTGGCTCC 
GGGCCTCTCG GCCTGCAGCC CCCAACAGCC AAAGACGGAC CCGAAGAGCA GGCTAAGTTC 
TATGCGCCCG AAGCGGCCGC TGGGCCAGAG GAGCGCGGTC GTACCCGGCC GTCCTTCGCC 
CCCGAGTCTA GCCTGGCTCC TGCAGTGGCT GCTCTCAAAG CGGCCAAGTA TGACTACGCT 
GGTGTGGGTC GTGCCACGCC GGGCTCCACG ACCCTGCTCC AGGGGGCTCC CTGCGCCCCT 
GGCTTCAAGG ACGACACCAA GGGCCCGCTC AACTTGAACA TGACAGTGCA GGCGGCGGGC 
GTTGCCTCTT GCCTGCGACC TTCACTGCCC GACGGCCTGC CGTGGGGGGC GGCCCCGGGG 
AGGGCCCGCA AGAAGCGGAA ACCCTACACG AAGCAGCAGA TTGCGGAGTT GGAGAACGAA 
TTCCTCGTCA ACGAATTCAT CAACAGGCAG AAACGCAAGG AATTGTCCAA TAGGCTGAAC 
CTCAGCGACC AGCAAGTCAA AATCTGGTTC CAGAACAGGC GTATGAAGAA GAAGCGCGTG 
GTGCTTCGGG AGCAGGCGCT GGCGCTCTAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length.
Brain & development32(5)356-61(2010 May)
Sugie Y,Sugie H,Fukuda T,Osawa J

A region of the human HOXD cluster that confers polycomb-group responsiveness.
Cell140(1)99-110(2010 Jan)
Woo CJ,Kharchenko PV,Daheron L,Park PJ,Kingston RE

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research24(12)2039-49(2009 Dec)
Yerges LM,Klei L,Cauley JA,Roeder K,Kammerer CM,Moffett SP,Ensrud KE,Nestlerode CS,Marshall LM,Hoffman AR,Lewis C,Lang TF,Barrett-Connor E,Ferrell RE,Orwoll ES,Zmuda JM,

Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
American journal of medical genetics. Part A149A(12)2745-52(2009 Dec)
Ester AR,Weymouth KS,Burt A,Wise CA,Scott A,Gurnett CA,Dobbs MB,Blanton SH,Hecht JT

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

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HOXD12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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