HOXC13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXC13
Entrez Gene ID	3229
Full Name	homeobox C13
Synonyms	ECTD9,HOX3,HOX3G
General protein information	Preferred Names homeobox C13 Names homeobox protein Hox-C13 NUP98/HOXC13 homeo box 3G homeobox protein Hox-3G
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008].
Disorder MIM:	142976
Disorder Html:	Ectodermal dysplasia 9, hair/nail type, 614931 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_017410.2	NP_059106.2	homeobox protein Hox-C13
NM_017410.3	NP_059106.2	homeobox protein Hox-C13

Pathways from BioSystems

Homologies

Homo sapiens (human)	HOXC13	NP_059106.2
	HOXC13	XP_001107932.1
Rattus norvegicus (Norway rat)	Hoxc13	XP_235695.3
Danio rerio (zebrafish)	hoxc13a	NP_571618.1
Pan troglodytes (chimpanzee)	HOXC13	XP_522408.2
Bos taurus (cattle)	HOXC13	NP_001076959.1
Mus musculus (house mouse)	Hoxc13	NP_034594.1
Xenopus tropicalis (tropical clawed frog)	LOC100487255	XP_002936691.1
Canis lupus familiaris (dog)	HOXC13	XP_856807.2

Gene Ontology
Bibliography

Related articles in PubMed

An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction.
Humbatova A, Maroofian R, Romano MT, Tafazzoli A, Behnam M, Dilaver N, Nouri N, Salehi M, Wolf S, Frank J, Kokordelis P, Betz RC
The British journal of dermatology(2017 Dec)

HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription of CASP3.
Luo J, Wang Z, Huang J, Yao Y, Sun Q, Wang J, Shen Y, Xu L, Ren B
Cancer science(2017 Nov)

Autosomal recessive transmission of a rare HOXC13 variant causes pure hair and nail ectodermal dysplasia.
Mehmood S, Raza SI, Van Bokhoven H, Ahmad W
Clinical and experimental dermatology42(5)585-589(2017 Jul)

A novel mutation in homeobox DNA binding domain of HOXC13 gene underlies pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family.
Khan AK, Muhammad N, Aziz A, Khan SA, Shah K, Nasir A, Khan MA, Khan S
BMC medical genetics18(1)42(2017 04)

Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9.
Han K, Liang L, Li L, Ouyang Z, Zhao B, Wang Q, Liu Z, Zhao Y, Ren X, Jiang F, Lai C, Wang K, Yan S, Huang L, Guo L, Zeng K, Lai L, Fan N
Human molecular genetics26(1)184-191(2017 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel missense mutation (c.929A > C) in HOXC13 gene associated with pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family.
Title: A novel mutation in homeobox DNA binding domain of HOXC13 gene underlies pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family.

Mutations in Hoxc13 is associated with ectodermal dysplasia-9.
Title: Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9.

The microdeletions share a minimal non-coding region overlap upstream of HOXC13, with variable phenotypes depending upon HOXC13, HOXC12 or thIdentification of 5' HOXC microdeletions highlights the importance of transcriptional regulators in the aetiology of severe lower limb malformations and will improve their diagnosis and managemente HOTAIR lncRNA inclusion.
Title: Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.

YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes.
Title: YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues.

In conclusion, our data show a deregulation of the HOXC13 marker in welldifferentiated and dedifferentiated LPSs, possibly related to 12q13-15 chromosomal amplification.
Title: Hyperexpression of HOXC13, located in the 12q13 chromosomal region, in well?differentiated and dedifferentiated human liposarcomas.

The following HOXC13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXC13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25402	NM_017410.3 Latest version!	Homo sapiens homeobox C13 (HOXC13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu25402	NM_017410.2	Homo sapiens homeobox C13 (HOXC13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXC13 ( NM_017410.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_059106.2 Homo sapiens homeobox C13 (HOXC13), mRNA.

Price & Availability↑

CloneID	OHu25402
Clone ID Related Accession (Same CDS sequence)	NM_017410.2 , NM_017410.3
Accession Version	NM_017410.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF255676.1, AF263466.2, BU158600.1, BC090850.1 and AA722686.1. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2002 this sequence version replaced NM_017410.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF255676.1, AK024027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGACTT CGCTGCTCCT GCATCCACGC TGGCCGGAGA GCCTTATGTA CGTCTATGAG 
GACAGCGCGG CGGAGAGCGG CATCGGCGGC GGCGGCGGAG GAGGAGGCGG CGGCACGGGC 
GGAGCGGGGG GTGGCTGCAG CGGAGCGAGC CCCGGCAAAG CCCCGAGCAT GGATGGTCTG 
GGCAGCAGCT GCCCGGCCAG CCACTGCCGC GACCTGCTTC CGCACCCCGT GCTGGGCCGC 
CCGCCGGCTC CCCTGGGCGC CCCTCAGGGC GCCGTCTATA CGGACATCCC GGCCCCGGAG 
GCGGCGCGCC AGTGTGCCCC GCCGCCCGCA CCCCCCACCT CGTCCAGCGC CACCCTGGGC 
TACGGCTACC CCTTCGGGGG CAGCTACTAC GGCTGCCGCC TGTCGCACAA CGTGAACCTG 
CAGCAGAAGC CTTGCGCCTA CCACCCGGGC GATAAATACC CGGAGCCGTC GGGCGCCCTG 
CCCGGTGACG ACCTGTCCTC TAGGGCCAAG GAGTTCGCCT TCTACCCCAG CTTCGCCAGC 
TCCTACCAGG CGATGCCCGG CTACCTGGAC GTGTCGGTGG TGCCCGGGAT CAGCGGGCAC 
CCGGAGCCGC GTCACGACGC CCTCATCCCC GTCGAAGGCT ACCAGCACTG GGCTCTCTCC 
AATGGCTGGG ACAGTCAGGT GTACTGCTCC AAGGAGCAGT CGCAGTCCGC CCACCTCTGG 
AAGTCTCCCT TCCCAGACGT GGTTCCCCTG CAGCCCGAGG TGAGCAGCTA CCGGCGCGGG 
CGCAAGAAAC GCGTGCCCTA CACTAAGGTG CAGCTGAAGG AGCTAGAGAA GGAATACGCG 
GCTAGCAAGT TCATCACCAA AGAGAAGCGC CGGCGCATCT CCGCCACCAC GAACCTCTCT 
GAGCGCCAGG TAACCATCTG GTTCCAGAAC CGGCGGGTCA AAGAGAAGAA GGTGGTCAGC 
AAATCGAAAG CGCCTCATCT CCACTCCACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059106.2
CDS	116..1108
Translation	MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST

Target ORF information:

RefSeq Version	NM_017410.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C13 (HOXC13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017410.2

ORF Insert Sequence:

ATGACGACTT CGCTGCTCCT GCATCCACGC TGGCCGGAGA GCCTTATGTA CGTCTATGAG 
GACAGCGCGG CGGAGAGCGG CATCGGCGGC GGCGGCGGAG GAGGAGGCGG CGGCACGGGC 
GGAGCGGGGG GTGGCTGCAG CGGAGCGAGC CCCGGCAAAG CCCCGAGCAT GGATGGTCTG 
GGCAGCAGCT GCCCGGCCAG CCACTGCCGC GACCTGCTTC CGCACCCCGT GCTGGGCCGC 
CCGCCGGCTC CCCTGGGCGC CCCTCAGGGC GCCGTCTATA CGGACATCCC GGCCCCGGAG 
GCGGCGCGCC AGTGTGCCCC GCCGCCCGCA CCCCCCACCT CGTCCAGCGC CACCCTGGGC 
TACGGCTACC CCTTCGGGGG CAGCTACTAC GGCTGCCGCC TGTCGCACAA CGTGAACCTG 
CAGCAGAAGC CTTGCGCCTA CCACCCGGGC GATAAATACC CGGAGCCGTC GGGCGCCCTG 
CCCGGTGACG ACCTGTCCTC TAGGGCCAAG GAGTTCGCCT TCTACCCCAG CTTCGCCAGC 
TCCTACCAGG CGATGCCCGG CTACCTGGAC GTGTCGGTGG TGCCCGGGAT CAGCGGGCAC 
CCGGAGCCGC GTCACGACGC CCTCATCCCC GTCGAAGGCT ACCAGCACTG GGCTCTCTCC 
AATGGCTGGG ACAGTCAGGT GTACTGCTCC AAGGAGCAGT CGCAGTCCGC CCACCTCTGG 
AAGTCTCCCT TCCCAGACGT GGTTCCCCTG CAGCCCGAGG TGAGCAGCTA CCGGCGCGGG 
CGCAAGAAAC GCGTGCCCTA CACTAAGGTG CAGCTGAAGG AGCTAGAGAA GGAATACGCG 
GCTAGCAAGT TCATCACCAA AGAGAAGCGC CGGCGCATCT CCGCCACCAC GAACCTCTCT 
GAGCGCCAGG TAACCATCTG GTTCCAGAAC CGGCGGGTCA AAGAGAAGAA GGTGGTCAGC 
AAATCGAAAG CGCCTCATCT CCACTCCACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXC13 ( NM_017410.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_059106.2 Homo sapiens homeobox C13 (HOXC13), mRNA.

Price & Availability↑

CloneID	OHu25402
Clone ID Related Accession (Same CDS sequence)	NM_017410.2 , NM_017410.3
Accession Version	NM_017410.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF255676.1, AF263466.2, BU158600.1, BC090850.1 and AA722686.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_017410.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC090850.1, SRR5189658.196826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243056.5/ ENSP00000243056.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGACTT CGCTGCTCCT GCATCCACGC TGGCCGGAGA GCCTTATGTA CGTCTATGAG 
GACAGCGCGG CGGAGAGCGG CATCGGCGGC GGCGGCGGAG GAGGAGGCGG CGGCACGGGC 
GGAGCGGGGG GTGGCTGCAG CGGAGCGAGC CCCGGCAAAG CCCCGAGCAT GGATGGTCTG 
GGCAGCAGCT GCCCGGCCAG CCACTGCCGC GACCTGCTTC CGCACCCCGT GCTGGGCCGC 
CCGCCGGCTC CCCTGGGCGC CCCTCAGGGC GCCGTCTATA CGGACATCCC GGCCCCGGAG 
GCGGCGCGCC AGTGTGCCCC GCCGCCCGCA CCCCCCACCT CGTCCAGCGC CACCCTGGGC 
TACGGCTACC CCTTCGGGGG CAGCTACTAC GGCTGCCGCC TGTCGCACAA CGTGAACCTG 
CAGCAGAAGC CTTGCGCCTA CCACCCGGGC GATAAATACC CGGAGCCGTC GGGCGCCCTG 
CCCGGTGACG ACCTGTCCTC TAGGGCCAAG GAGTTCGCCT TCTACCCCAG CTTCGCCAGC 
TCCTACCAGG CGATGCCCGG CTACCTGGAC GTGTCGGTGG TGCCCGGGAT CAGCGGGCAC 
CCGGAGCCGC GTCACGACGC CCTCATCCCC GTCGAAGGCT ACCAGCACTG GGCTCTCTCC 
AATGGCTGGG ACAGTCAGGT GTACTGCTCC AAGGAGCAGT CGCAGTCCGC CCACCTCTGG 
AAGTCTCCCT TCCCAGACGT GGTTCCCCTG CAGCCCGAGG TGAGCAGCTA CCGGCGCGGG 
CGCAAGAAAC GCGTGCCCTA CACTAAGGTG CAGCTGAAGG AGCTAGAGAA GGAATACGCG 
GCTAGCAAGT TCATCACCAA AGAGAAGCGC CGGCGCATCT CCGCCACCAC GAACCTCTCT 
GAGCGCCAGG TAACCATCTG GTTCCAGAAC CGGCGGGTCA AAGAGAAGAA GGTGGTCAGC 
AAATCGAAAG CGCCTCATCT CCACTCCACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059106.2
CDS	77..1069
Translation	MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST

Target ORF information:

RefSeq Version	NM_017410.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C13 (HOXC13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017410.3

ORF Insert Sequence:

ATGACGACTT CGCTGCTCCT GCATCCACGC TGGCCGGAGA GCCTTATGTA CGTCTATGAG 
GACAGCGCGG CGGAGAGCGG CATCGGCGGC GGCGGCGGAG GAGGAGGCGG CGGCACGGGC 
GGAGCGGGGG GTGGCTGCAG CGGAGCGAGC CCCGGCAAAG CCCCGAGCAT GGATGGTCTG 
GGCAGCAGCT GCCCGGCCAG CCACTGCCGC GACCTGCTTC CGCACCCCGT GCTGGGCCGC 
CCGCCGGCTC CCCTGGGCGC CCCTCAGGGC GCCGTCTATA CGGACATCCC GGCCCCGGAG 
GCGGCGCGCC AGTGTGCCCC GCCGCCCGCA CCCCCCACCT CGTCCAGCGC CACCCTGGGC 
TACGGCTACC CCTTCGGGGG CAGCTACTAC GGCTGCCGCC TGTCGCACAA CGTGAACCTG 
CAGCAGAAGC CTTGCGCCTA CCACCCGGGC GATAAATACC CGGAGCCGTC GGGCGCCCTG 
CCCGGTGACG ACCTGTCCTC TAGGGCCAAG GAGTTCGCCT TCTACCCCAG CTTCGCCAGC 
TCCTACCAGG CGATGCCCGG CTACCTGGAC GTGTCGGTGG TGCCCGGGAT CAGCGGGCAC 
CCGGAGCCGC GTCACGACGC CCTCATCCCC GTCGAAGGCT ACCAGCACTG GGCTCTCTCC 
AATGGCTGGG ACAGTCAGGT GTACTGCTCC AAGGAGCAGT CGCAGTCCGC CCACCTCTGG 
AAGTCTCCCT TCCCAGACGT GGTTCCCCTG CAGCCCGAGG TGAGCAGCTA CCGGCGCGGG 
CGCAAGAAAC GCGTGCCCTA CACTAAGGTG CAGCTGAAGG AGCTAGAGAA GGAATACGCG 
GCTAGCAAGT TCATCACCAA AGAGAAGCGC CGGCGCATCT CCGCCACCAC GAACCTCTCT 
GAGCGCCAGG TAACCATCTG GTTCCAGAAC CGGCGGGTCA AAGAGAAGAA GGTGGTCAGC 
AAATCGAAAG CGCCTCATCT CCACTCCACC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction.
The British journal of dermatology(2017 Dec)
Humbatova A,Maroofian R,Romano MT,Tafazzoli A,Behnam M,Dilaver N,Nouri N,Salehi M,Wolf S,Frank J,Kokordelis P,Betz RC

HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription of CASP3.
Cancer science(2017 Nov)
Luo J,Wang Z,Huang J,Yao Y,Sun Q,Wang J,Shen Y,Xu L,Ren B

Autosomal recessive transmission of a rare HOXC13 variant causes pure hair and nail ectodermal dysplasia.
Clinical and experimental dermatology42(5)585-589(2017 Jul)
Mehmood S,Raza SI,Van Bokhoven H,Ahmad W

A novel mutation in homeobox DNA binding domain of HOXC13 gene underlies pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family.
BMC medical genetics18(1)42(2017 04)
Khan AK,Muhammad N,Aziz A,Khan SA,Shah K,Nasir A,Khan MA,Khan S

Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9.
Human molecular genetics26(1)184-191(2017 01)
Han K,Liang L,Li L,Ouyang Z,Zhao B,Wang Q,Liu Z,Zhao Y,Ren X,Jiang F,Lai C,Wang K,Yan S,Huang L,Guo L,Zeng K,Lai L,Fan N

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HOXC13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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