HOXB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXB2
Entrez Gene ID	3212
Full Name	homeobox B2
Synonyms	HOX2,HOX2H,Hox-2.8,K8
General protein information	Preferred Names homeobox B2 Names homeobox protein Hox-B2 K8 home protein homeo box 2H homeo box B2 homeobox protein Hox-2.8 homeobox protein Hox-2H
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008].
Disorder MIM:	142967

mRNA and Protein(s)

mRNA	Protein	Name
XM_005257275.4	XP_005257332.1	homeobox protein Hox-B2 isoform X1
NM_002145.3	NP_002136.1	homeobox protein Hox-B2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HOXB2	XP_003642840.1
Xenopus tropicalis (tropical clawed frog)	hoxb2	XP_002938064.2
Homo sapiens (human)	HOXB2	NP_002136.1
Pan troglodytes (chimpanzee)	HOXB2	XP_001173066.1
Canis lupus familiaris (dog)	HOXB2	XP_851108.1
Bos taurus (cattle)	HOXB2	NP_001178264.1
Rattus norvegicus (Norway rat)	Hoxb2	XP_002727852.1
Mus musculus (house mouse)	Hoxb2	NP_598793.2
Danio rerio (zebrafish)	hoxb2a	NP_571191.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of HOXB2 and HOXB3 in acute myeloid leukemia.
Lindblad O, Chougule RA, Moharram SA, Kabir NN, Sun J, Kazi JU, R?nnstrand L
Biochemical and biophysical research communications467(4)742-7(2015 Nov)

Increased expression of HOXB2 and HOXB13 proteins is associated with HPV infection and cervical cancer progression.
Gonzalez-Herrera A, Salgado-Bernabe M, Velazquez-Velazquez C, Salcedo-Vargas M, Andrade-Manzano A, Avila-Moreno F, Pina-Sanchez P
Asian Pacific journal of cancer prevention : APJCP16(4)1349-53(2015)

DNA-binding specificities of human transcription factors.
Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J
Cell152(1-2)327-39(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HOXB2 and HOXB3 act as tumor suppressors in acute myeloid leukemia patients carrying the FLT3 protein mutations.
Title: The role of HOXB2 and HOXB3 in acute myeloid leukemia.

Increased expression of HOXB2 protein is associated with HPV infection and cervical cancer progression.
Title: Increased expression of HOXB2 and HOXB13 proteins is associated with HPV infection and cervical cancer progression.

HOXB2 acts as a negative tumor growth regulator, decreasing proliferation in mammary adenocarcinoma tumors.
Title: A functional in vivo screen for regulators of tumor progression identifies HOXB2 as a regulator of tumor growth in breast cancer.

Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation.
Title: HoxB2, HoxB4 and Alx4 genes are downregulated in the cadmium-induced omphalocele in the chick model.

Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

The following HOXB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30190	NM_002145.3 Latest version!	Homo sapiens homeobox B2 (HOXB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu50329	XM_005257275.4 Latest version!	Homo sapiens homeobox B2 (HOXB2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXB2 ( NM_002145.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002136.1 Homo sapiens homeobox B2 (HOXB2), mRNA.

Price & Availability↑

CloneID	OHu30190
Clone ID Related Accession (Same CDS sequence)	NM_002145.3
Accession Version	NM_002145.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	homeobox protein Hox-B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC103702.3, X16665.1 and BC038968.1. On Jan 6, 2006 this sequence version replaced NM_002145.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.557633.1, X16665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATTTTG AATTTGAGAG GGAGATTGGG TTTATAAACA GCCAGCCGTC GCTCGCCGAG 
TGTCTGACTT CCTTCCCCGC TGTCTTGGAG ACATTTCAAA CTTCATCAAT CAAGGAGTCG 
ACATTAATTC CTCCTCCTCC TCCTTTCGAG CAAACCTTCC CCAGCCTCCA GCCCGGCGCC 
TCCACCCTTC AGAGACCCAG GAGCCAAAAG CGAGCCGAAG ATGGGCCTGC TCTGCCGCCG 
CCACCGCCGC CGCCACTCCC CGCTGCCCCC CCGGCCCCCG AGTTCCCTTG GATGAAAGAG 
AAGAAATCCG CCAAGAAACC CAGCCAATCC GCCACGTCTC CTTCTCCGGC CGCCTCCGCC 
GTTCCGGCCT CCGGGGTCGG ATCGCCTGCA GATGGCCTGG GACTGCCGGA GGCTGGTGGC 
GGCGGGGCGC GCAGGCTGCG CACGGCTTAC ACCAACACGC AGCTGCTGGA ACTGGAGAAG 
GAATTCCACT TTAATAAGTA CCTGTGCCGG CCACGCCGCG TCGAGATCGC GGCCTTGCTG 
GACCTCACCG AAAGGCAGGT CAAAGTCTGG TTTCAGAACC GGCGCATGAA GCACAAGCGG 
CAGACGCAGC ACCGAGAGCC GCCGGATGGG GAGCCTGCCT GCCCGGGAGC CCTGGAGGAC 
ATCTGCGACC CTGCCGAGGA ACCCGCGGCC AGCCCGGGCG GCCCCTCCGC CTCGCGGGCG 
GCGTGGGAAG CCTGCTGTCA CCCGCCGGAG GTGGTGCCGG GGGCCTTAAG CGCGGACCCC 
CGGCCTTTAG CCGTTCGCTT AGAGGGCGCA GGCGCGTCGA GTCCCGGCTG CGCGCTGCGC 
GGGGCCGGCG GGCTGGAGCC CGGGCCATTG CCAGAAGACG TCTTCTCGGG GCGCCAGGAT 
TCACCTTTCC TTCCCGACCT CAACTTCTTC GCGGCCGACT CCTGTCTCCA GCTATCCGGA 
GGCCTCTCCC CTAGCCTACA GGGTTCTCTC GACAGCCCGG TCCCTTTTTC CGAGGAAGAG 
CTGGATTTTT TCACCAGTAC GCTCTGTGCC ATCGACCTGC AGTTTCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002136.1
CDS	121..1191
Translation	MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRAAWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQDSPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP

Target ORF information:

RefSeq Version	NM_002145.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox B2 (HOXB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002145.3

ORF Insert Sequence:

ATGAATTTTG AATTTGAGAG GGAGATTGGG TTTATAAACA GCCAGCCGTC GCTCGCCGAG 
TGTCTGACTT CCTTCCCCGC TGTCTTGGAG ACATTTCAAA CTTCATCAAT CAAGGAGTCG 
ACATTAATTC CTCCTCCTCC TCCTTTCGAG CAAACCTTCC CCAGCCTCCA GCCCGGCGCC 
TCCACCCTTC AGAGACCCAG GAGCCAAAAG CGAGCCGAAG ATGGGCCTGC TCTGCCGCCG 
CCACCGCCGC CGCCACTCCC CGCTGCCCCC CCGGCCCCCG AGTTCCCTTG GATGAAAGAG 
AAGAAATCCG CCAAGAAACC CAGCCAATCC GCCACGTCTC CTTCTCCGGC CGCCTCCGCC 
GTTCCGGCCT CCGGGGTCGG ATCGCCTGCA GATGGCCTGG GACTGCCGGA GGCTGGTGGC 
GGCGGGGCGC GCAGGCTGCG CACGGCTTAC ACCAACACGC AGCTGCTGGA ACTGGAGAAG 
GAATTCCACT TTAATAAGTA CCTGTGCCGG CCACGCCGCG TCGAGATCGC GGCCTTGCTG 
GACCTCACCG AAAGGCAGGT CAAAGTCTGG TTTCAGAACC GGCGCATGAA GCACAAGCGG 
CAGACGCAGC ACCGAGAGCC GCCGGATGGG GAGCCTGCCT GCCCGGGAGC CCTGGAGGAC 
ATCTGCGACC CTGCCGAGGA ACCCGCGGCC AGCCCGGGCG GCCCCTCCGC CTCGCGGGCG 
GCGTGGGAAG CCTGCTGTCA CCCGCCGGAG GTGGTGCCGG GGGCCTTAAG CGCGGACCCC 
CGGCCTTTAG CCGTTCGCTT AGAGGGCGCA GGCGCGTCGA GTCCCGGCTG CGCGCTGCGC 
GGGGCCGGCG GGCTGGAGCC CGGGCCATTG CCAGAAGACG TCTTCTCGGG GCGCCAGGAT 
TCACCTTTCC TTCCCGACCT CAACTTCTTC GCGGCCGACT CCTGTCTCCA GCTATCCGGA 
GGCCTCTCCC CTAGCCTACA GGGTTCTCTC GACAGCCCGG TCCCTTTTTC CGAGGAAGAG 
CTGGATTTTT TCACCAGTAC GCTCTGTGCC ATCGACCTGC AGTTTCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXB2 ( XM_005257275.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005257332.1 Homo sapiens homeobox B2 (HOXB2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu50329
Clone ID Related Accession (Same CDS sequence)	XM_005257275.4
Accession Version	XM_005257275.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	homeobox protein Hox-B2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005257275.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTTGCC CTGACCCGGG CCGGGGCTGT AGACTAGAGA GGGAGAGAAG AAAACCCAAA 
AGCAATGGCC TGGGACTGCC GGAGGCTGGT GGCGGCGGGG CGCGCAGGCT GCGCACGGCT 
TACACCAACA CGCAGCTGCT GGAACTGGAG AAGGAATTCC ACTTTAATAA GTACCTGTGC 
CGGCCACGCC GCGTCGAGAT CGCGGCCTTG CTGGACCTCA CCGAAAGGCA GGTCAAAGTC 
TGGTTTCAGA ACCGGCGCAT GAAGCACAAG CGGCAGACGC AGCACCGAGA GCCGCCGGAT 
GGGGAGCCTG CCTGCCCGGG AGCCCTGGAG GACATCTGCG ACCCTGCCGA GGAACCCGCG 
GCCAGCCCGG GCGGCCCCTC CGCCTCGCGG GCGGCGTGGG AAGCCTGCTG TCACCCGCCG 
GAGGTGGTGC CGGGGGCCTT AAGCGCGGAC CCCCGGCCTT TAGCCGTTCG CTTAGAGGGC 
GCAGGCGCGT CGAGTCCCGG CTGCGCGCTG CGCGGGGCCG GCGGGCTGGA GCCCGGGCCA 
TTGCCAGAAG ACGTCTTCTC GGGGCGCCAG GATTCACCTT TCCTTCCCGA CCTCAACTTC 
TTCGCGGCCG ACTCCTGTCT CCAGCTATCC GGAGGCCTCT CCCCTAGCCT ACAGGGTTCT 
CTCGACAGCC CGGTCCCTTT TTCCGAGGAA GAGCTGGATT TTTTCACCAG TACGCTCTGT 
GCCATCGACC TGCAGTTTCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005257332.1
CDS	17..760
Translation	MLCPDPGRGCRLERERRKPKSNGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRAAWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQDSPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP

Target ORF information:

RefSeq Version	XM_005257275.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox B2 (HOXB2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005257275.4

ORF Insert Sequence:

ATGCTTTGCC CTGACCCGGG CCGGGGCTGT AGACTAGAGA GGGAGAGAAG AAAACCCAAA 
AGCAATGGCC TGGGACTGCC GGAGGCTGGT GGCGGCGGGG CGCGCAGGCT GCGCACGGCT 
TACACCAACA CGCAGCTGCT GGAACTGGAG AAGGAATTCC ACTTTAATAA GTACCTGTGC 
CGGCCACGCC GCGTCGAGAT CGCGGCCTTG CTGGACCTCA CCGAAAGGCA GGTCAAAGTC 
TGGTTTCAGA ACCGGCGCAT GAAGCACAAG CGGCAGACGC AGCACCGAGA GCCGCCGGAT 
GGGGAGCCTG CCTGCCCGGG AGCCCTGGAG GACATCTGCG ACCCTGCCGA GGAACCCGCG 
GCCAGCCCGG GCGGCCCCTC CGCCTCGCGG GCGGCGTGGG AAGCCTGCTG TCACCCGCCG 
GAGGTGGTGC CGGGGGCCTT AAGCGCGGAC CCCCGGCCTT TAGCCGTTCG CTTAGAGGGC 
GCAGGCGCGT CGAGTCCCGG CTGCGCGCTG CGCGGGGCCG GCGGGCTGGA GCCCGGGCCA 
TTGCCAGAAG ACGTCTTCTC GGGGCGCCAG GATTCACCTT TCCTTCCCGA CCTCAACTTC 
TTCGCGGCCG ACTCCTGTCT CCAGCTATCC GGAGGCCTCT CCCCTAGCCT ACAGGGTTCT 
CTCGACAGCC CGGTCCCTTT TTCCGAGGAA GAGCTGGATT TTTTCACCAG TACGCTCTGT 
GCCATCGACC TGCAGTTTCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of HOXB2 and HOXB3 in acute myeloid leukemia.
Biochemical and biophysical research communications467(4)742-7(2015 Nov)
Lindblad O,Chougule RA,Moharram SA,Kabir NN,Sun J,Kazi JU,R?nnstrand L

Increased expression of HOXB2 and HOXB13 proteins is associated with HPV infection and cervical cancer progression.
Asian Pacific journal of cancer prevention : APJCP16(4)1349-53(2015)
Gonzalez-Herrera A,Salgado-Bernabe M,Velazquez-Velazquez C,Salcedo-Vargas M,Andrade-Manzano A,Avila-Moreno F,Pina-Sanchez P

DNA-binding specificities of human transcription factors.
Cell152(1-2)327-39(2013 Jan)
Jolma A,Yan J,Whitington T,Toivonen J,Nitta KR,Rastas P,Morgunova E,Enge M,Taipale M,Wei G,Palin K,Vaquerizas JM,Vincentelli R,Luscombe NM,Hughes TR,Lemaire P,Ukkonen E,Kivioja T,Taipale J

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HOXB2 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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