HOXA6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXA6
Entrez Gene ID	3203
Full Name	homeobox A6
Synonyms	HOX1,HOX1.2,HOX1B
General protein information	Preferred Names homeobox A6 Names homeobox protein Hox-A6 homeo box 1B homeo box A6 homeobox protein HOXA6 homeobox protein Hox-1B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p15.2
Summary	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008].
Disorder MIM:	142951

mRNA and Protein(s)

mRNA	Protein	Name
NM_024014.4	NP_076919.1	homeobox protein Hox-A6
NM_024014.3	NP_076919.1	homeobox protein Hox-A6

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HOXA6	XP_003586029.1
Rattus norvegicus (Norway rat)	Hoxa6	NP_001178016.1
Rattus norvegicus (Norway rat)	LOC100911511	XP_003752227.1
Pan troglodytes (chimpanzee)	HOXA6	XP_003318413.1
	HOXA6	XP_001092459.1
Gallus gallus (chicken)	HOXA6	NP_001026158.1
Gallus gallus (chicken)	LOC100857163	XP_003640784.1
Gallus gallus (chicken)	LOC100858434	XP_003640748.2
Canis lupus familiaris (dog)	HOXA6	XP_854141.1
Mus musculus (house mouse)	Hoxa6	NP_034584.1
Rattus norvegicus (Norway rat)	LOC100909604	XP_003749802.1
Homo sapiens (human)	HOXA6	NP_076919.1
Xenopus tropicalis (tropical clawed frog)	hoxa6	XP_002933441.2

Gene Ontology
Bibliography

Related articles in PubMed

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy.
Dickson GJ, Liberante FG, Kettyle LM, O'Hagan KA, Finnegan DP, Bullinger L, Geerts D, McMullin MF, Lappin TR, Mills KI, Thompson A
Haematologica98(8)1216-25(2013 Aug)

DNA methylation in the malignant transformation of meningiomas.
Gao F, Shi L, Russin J, Zeng L, Chang X, He S, Chen TC, Giannotta SL, Weisenberger DJ, Zada G, Mack WJ, Wang K
PloS one8(1)e54114(2013)

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research24(12)2039-49(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HOXA6 is a signature gene involved in cell growth and sensitivity to chemotherapy in acute myeloid leukemia cells.
Title: HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy.

Data indicate that genes with hypermethylated CpG islands in malignant meningiomas, such as HOXA6 and HOXA9, tend to coincide with the binding sites of polycomb repressive complexes (PRC) in early developmental stage.
Title: DNA methylation in the malignant transformation of meningiomas.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Enforced overexpression of HOXA6 or HOXA9 in FDCP-Mix resulted in increased proliferation and colony formation but had negligible effect on differentiation in early multipotential and later committed precursor cells
Title: Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal.

The following HOXA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55592	NM_024014.4 Latest version!	Homo sapiens homeobox A6 (HOXA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55592	NM_024014.3	Homo sapiens homeobox A6 (HOXA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXA6 ( NM_024014.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_076919.1 Homo sapiens homeobox A6 (HOXA6), mRNA.

Price & Availability↑

CloneID	OHu55592
Clone ID Related Accession (Same CDS sequence)	NM_024014.4 , NM_024014.3
Accession Version	NM_024014.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	homeobox protein Hox-A6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC104915.1 and AC004080.2. On May 17, 2019 this sequence version replaced NM_024014.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC104915.1, EL736261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222728.3/ ENSP00000222728.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGTTCCT ATTTTGTGAA TCCCACTTTC CCCGGGAGCC TTCCCAGCGG CCAGGACTCC 
TTCTTGGGCC AGCTGCCCCT CTACCAGGCT GGCTATGACG CGCTGAGGCC CTTCCCGGCC 
TCGTACGGGG CGTCGAGTCT CCCGGACAAG ACGTACACCT CACCTTGTTT CTACCAACAG 
TCCAACTCGG TCCTGGCCTG CAACCGGGCG TCCTACGAGT ACGGGGCCTC GTGTTTCTAT 
TCTGATAAGG ACCTCAGTGG CGCCTCGCCC TCGGGCAGTG GCAAGCAGAG GGGCCCCGGG 
GACTACCTGC ACTTTTCTCC CGAGCAGCAG TACAAACCCG ACAGCAGCAG CGGGCAGGGC 
AAAGCACTCC ATGACGAAGG CGCCGACCGG AAGTACACGA GCCCGGTTTA CCCTTGGATG 
CAGCGGATGA ACTCCTGCGC GGGTGCTGTG TATGGGAGCC ATGGGCGCCG AGGCCGCCAG 
ACCTACACGC GCTACCAGAC ACTGGAGCTG GAGAAGGAGT TCCACTTCAA CCGCTACCTG 
ACACGGCGCC GCCGCATCGA GATCGCCAAC GCGCTCTGCC TCACCGAGCG CCAGATCAAG 
ATCTGGTTCC AGAACCGCCG CATGAAGTGG AAAAAGGAAA ACAAGCTCAT CAATTCCACG 
CAGCCCAGCG GGGAGGACTC AGAGGCAAAG GCGGGCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076919.1
CDS	26..727
Translation	MSSYFVNPTFPGSLPSGQDSFLGQLPLYQAGYDALRPFPASYGASSLPDKTYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGSGKQRGPGDYLHFSPEQQYKPDSSSGQGKALHDEGADRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSGEDSEAKAGE

Target ORF information:

RefSeq Version	NM_024014.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox A6 (HOXA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024014.4

ORF Insert Sequence:

ATGAGTTCCT ATTTTGTGAA TCCCACTTTC CCCGGGAGCC TTCCCAGCGG CCAGGACTCC 
TTCTTGGGCC AGCTGCCCCT CTACCAGGCT GGCTATGACG CGCTGAGGCC CTTCCCGGCC 
TCGTACGGGG CGTCGAGTCT CCCGGACAAG ACGTACACCT CACCTTGTTT CTACCAACAG 
TCCAACTCGG TCCTGGCCTG CAACCGGGCG TCCTACGAGT ACGGGGCCTC GTGTTTCTAT 
TCTGATAAGG ACCTCAGTGG CGCCTCGCCC TCGGGCAGTG GCAAGCAGAG GGGCCCCGGG 
GACTACCTGC ACTTTTCTCC CGAGCAGCAG TACAAACCCG ACAGCAGCAG CGGGCAGGGC 
AAAGCACTCC ATGACGAAGG CGCCGACCGG AAGTACACGA GCCCGGTTTA CCCTTGGATG 
CAGCGGATGA ACTCCTGCGC GGGTGCTGTG TATGGGAGCC ATGGGCGCCG AGGCCGCCAG 
ACCTACACGC GCTACCAGAC ACTGGAGCTG GAGAAGGAGT TCCACTTCAA CCGCTACCTG 
ACACGGCGCC GCCGCATCGA GATCGCCAAC GCGCTCTGCC TCACCGAGCG CCAGATCAAG 
ATCTGGTTCC AGAACCGCCG CATGAAGTGG AAAAAGGAAA ACAAGCTCAT CAATTCCACG 
CAGCCCAGCG GGGAGGACTC AGAGGCAAAG GCGGGCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXA6 ( NM_024014.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_076919.1 Homo sapiens homeobox A6 (HOXA6), mRNA.

Price & Availability↑

CloneID	OHu55592
Clone ID Related Accession (Same CDS sequence)	NM_024014.4 , NM_024014.3
Accession Version	NM_024014.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-13
Organism	Homo sapiens(human)
Product	homeobox protein Hox-A6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC104915.1. On Jun 3, 2011 this sequence version replaced NM_024014.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC104915.1, BC069497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTCCT ATTTTGTGAA TCCCACTTTC CCCGGGAGCC TTCCCAGCGG CCAGGACTCC 
TTCTTGGGCC AGCTGCCCCT CTACCAGGCT GGCTATGACG CGCTGAGGCC CTTCCCGGCC 
TCGTACGGGG CGTCGAGTCT CCCGGACAAG ACGTACACCT CACCTTGTTT CTACCAACAG 
TCCAACTCGG TCCTGGCCTG CAACCGGGCG TCCTACGAGT ACGGGGCCTC GTGTTTCTAT 
TCTGATAAGG ACCTCAGTGG CGCCTCGCCC TCGGGCAGTG GCAAGCAGAG GGGCCCCGGG 
GACTACCTGC ACTTTTCTCC CGAGCAGCAG TACAAACCCG ACAGCAGCAG CGGGCAGGGC 
AAAGCACTCC ATGACGAAGG CGCCGACCGG AAGTACACGA GCCCGGTTTA CCCTTGGATG 
CAGCGGATGA ACTCCTGCGC GGGTGCTGTG TATGGGAGCC ATGGGCGCCG AGGCCGCCAG 
ACCTACACGC GCTACCAGAC ACTGGAGCTG GAGAAGGAGT TCCACTTCAA CCGCTACCTG 
ACACGGCGCC GCCGCATCGA GATCGCCAAC GCGCTCTGCC TCACCGAGCG CCAGATCAAG 
ATCTGGTTCC AGAACCGCCG CATGAAGTGG AAAAAGGAAA ACAAGCTCAT CAATTCCACG 
CAGCCCAGCG GGGAGGACTC AGAGGCAAAG GCGGGCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076919.1
CDS	26..727
Translation	MSSYFVNPTFPGSLPSGQDSFLGQLPLYQAGYDALRPFPASYGASSLPDKTYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGSGKQRGPGDYLHFSPEQQYKPDSSSGQGKALHDEGADRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSGEDSEAKAGE

Target ORF information:

RefSeq Version	NM_024014.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox A6 (HOXA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024014.3

ORF Insert Sequence:

ATGAGTTCCT ATTTTGTGAA TCCCACTTTC CCCGGGAGCC TTCCCAGCGG CCAGGACTCC 
TTCTTGGGCC AGCTGCCCCT CTACCAGGCT GGCTATGACG CGCTGAGGCC CTTCCCGGCC 
TCGTACGGGG CGTCGAGTCT CCCGGACAAG ACGTACACCT CACCTTGTTT CTACCAACAG 
TCCAACTCGG TCCTGGCCTG CAACCGGGCG TCCTACGAGT ACGGGGCCTC GTGTTTCTAT 
TCTGATAAGG ACCTCAGTGG CGCCTCGCCC TCGGGCAGTG GCAAGCAGAG GGGCCCCGGG 
GACTACCTGC ACTTTTCTCC CGAGCAGCAG TACAAACCCG ACAGCAGCAG CGGGCAGGGC 
AAAGCACTCC ATGACGAAGG CGCCGACCGG AAGTACACGA GCCCGGTTTA CCCTTGGATG 
CAGCGGATGA ACTCCTGCGC GGGTGCTGTG TATGGGAGCC ATGGGCGCCG AGGCCGCCAG 
ACCTACACGC GCTACCAGAC ACTGGAGCTG GAGAAGGAGT TCCACTTCAA CCGCTACCTG 
ACACGGCGCC GCCGCATCGA GATCGCCAAC GCGCTCTGCC TCACCGAGCG CCAGATCAAG 
ATCTGGTTCC AGAACCGCCG CATGAAGTGG AAAAAGGAAA ACAAGCTCAT CAATTCCACG 
CAGCCCAGCG GGGAGGACTC AGAGGCAAAG GCGGGCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy.
Haematologica98(8)1216-25(2013 Aug)
Dickson GJ,Liberante FG,Kettyle LM,O'Hagan KA,Finnegan DP,Bullinger L,Geerts D,McMullin MF,Lappin TR,Mills KI,Thompson A

DNA methylation in the malignant transformation of meningiomas.
PloS one8(1)e54114(2013)
Gao F,Shi L,Russin J,Zeng L,Chang X,He S,Chen TC,Giannotta SL,Weisenberger DJ,Zada G,Mack WJ,Wang K

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research24(12)2039-49(2009 Dec)
Yerges LM,Klei L,Cauley JA,Roeder K,Kammerer CM,Moffett SP,Ensrud KE,Nestlerode CS,Marshall LM,Hoffman AR,Lewis C,Lang TF,Barrett-Connor E,Ferrell RE,Orwoll ES,Zmuda JM,

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HOXA6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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