HNRNPH2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HNRNPH2
Entrez Gene ID	3188
Full Name	heterogeneous nuclear ribonucleoprotein H2
Synonyms	FTP3,HNRPH',HNRPH2,MRXSB,NRPH2,hnRNPH'
General protein information	Preferred Names heterogeneous nuclear ribonucleoprotein H2 Names heterogeneous nuclear ribonucleoprotein H2 FTP-3 heterogeneous nuclear ribonucleoprotein H-prime heterogeneous nuclear ribonucleoprotein H2 (H') hnRNP H' hnRNP H2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq22.1
Summary	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011].
Disorder MIM:	300610
Disorder Html:	Mental retardation, X-linked, syndromic, Bain type, 300986 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_019597.5	NP_062543.1	heterogeneous nuclear ribonucleoprotein H2
NM_001032393.2	NP_001027565.1	heterogeneous nuclear ribonucleoprotein H2
NM_019597.4	NP_062543.1	heterogeneous nuclear ribonucleoprotein H2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HNRNPH2	XP_862053.2
Mus musculus (house mouse)	Hnrnph2	NP_063921.1
Rattus norvegicus (Norway rat)	Hnrnph2	NP_001014041.1
Bos taurus (cattle)	HNRNPH2	NP_001069476.1
Homo sapiens (human)	HNRNPH2	NP_001027565.1
Pan troglodytes (chimpanzee)	HNRNPH2	NP_001233423.1
	HNRNPH2	XP_001093862.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Variants in HNRNPH2 on the X Chromosome Are Associated with a Neurodevelopmental Disorder in Females.
Bain JM, Cho MT, Telegrafi A, Wilson A, Brooks S, Botti C, Gowans G, Autullo LA, Krishnamurthy V, Willing MC, Toler TL, Ben-Zev B, Elpeleg O, Shen Y, Retterer K, Monaghan KG, Chung WK
American journal of human genetics99(3)728-734(2016 Sep)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrent? L, Mar JC
PLoS genetics11(8)e1005428(2015 Aug)

Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.
Rappe U, Schlechter T, Aschoff M, Hotz-Wagenblatt A, Hofmann I
The Journal of biological chemistry289(18)12421-34(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identification of six females from independent families with a common neurodevelopmental phenotype including developmental delay, intellectual disability, autism, hypotonia, and seizures, all with de novo predicted deleterious variants in the nuclear localization signal of Heterogeneous Nuclear Ribonucleoprotein H2, encoded by HNRNPH2, a gene located on the X chromosome
Title: Variants in HNRNPH2 on the X Chromosome Are Associated with a Neurodevelopmental Disorder in Females.

Data indicate that armadillo repeat protein ARVCF interacts with the splicing factors the splicing factor SRSF1 (SF2/ASF), the RNA helicase p68 (DDX5), and the heterogeneous nuclear ribonucleoprotein hnRNP H2.
Title: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.

altered function of hnRNP H1/H2 in tumor cells is a novel determinant of aberrant thymidine phosphorylase splicing thereby resulting in acquired chemoresistance to TP-activated fluoropyrimidine anticancer drugs.
Title: Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following HNRNPH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HNRNPH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10557	NM_001032393.2 Latest version!	Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu10557	NM_019597.5 Latest version!	Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu10557	NM_019597.4	Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HNRNPH2 ( NM_019597.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_062543.1 Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10557
Clone ID Related Accession (Same CDS sequence)	NM_019597.5 , NM_001032393.2 , NM_019597.4
Accession Version	NM_019597.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	heterogeneous nuclear ribonucleoprotein H2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA686966.1, U01923.1, AL035422.12 and AA758785.1. On Nov 23, 2018 this sequence version replaced NM_019597.4. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.2736.1, SRR3476690.550271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000316594.6/ ENSP00000361927.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGCTGA GCACGGAAGG CAGGGAGGGG TTCGTGGTGA AGGTCAGGGG CCTACCCTGG 
TCCTGCTCAG CCGATGAAGT GATGCGCTTC TTCTCTGATT GCAAGATCCA AAATGGCACA 
TCAGGTATTC GTTTCATCTA CACCAGAGAA GGCAGACCAA GTGGTGAAGC ATTTGTTGAA 
CTTGAATCTG AAGAGGAAGT GAAATTGGCT TTGAAGAAGG ACAGAGAAAC CATGGGACAC 
AGATACGTTG AAGTATTCAA GTCTAACAGT GTTGAAATGG ATTGGGTGTT GAAGCATACA 
GGTCCGAATA GCCCTGATAC TGCCAACGAT GGCTTCGTCC GGCTTAGAGG ACTCCCATTT 
GGCTGTAGCA AGGAAGAGAT TGTTCAGTTC TTTTCAGGGT TGGAAATTGT GCCAAATGGG 
ATGACACTGC CAGTGGACTT TCAGGGGCGA AGCACAGGGG AAGCCTTTGT GCAGTTTGCT 
TCACAGGAGA TAGCTGAGAA GGCCTTAAAG AAACACAAGG AAAGAATAGG GCACAGGTAC 
ATTGAGATCT TCAAGAGTAG CCGAGCTGAA GTTCGAACCC ACTATGATCC CCCTCGAAAG 
CTCATGGCTA TGCAGCGGCC AGGTCCCTAT GATAGGCCGG GGGCTGGCAG AGGGTATAAT 
AGCATTGGCA GAGGAGCTGG GTTTGAAAGG ATGAGGCGTG GTGCCTATGG TGGAGGGTAT 
GGAGGCTATG ATGACTATGG TGGCTATAAT GATGGATATG GCTTTGGGTC TGATAGATTT 
GGAAGAGACC TCAATTACTG TTTTTCAGGA ATGTCTGATC ATAGATACGG AGATGGTGGG 
TCCAGTTTCC AGAGCACCAC AGGGCACTGT GTACACATGA GGGGGTTACC TTACAGAGCC 
ACTGAGAATG ATATTTATAA TTTCTTCTCA CCTCTTAATC CCATGAGAGT ACATATTGAA 
ATTGGACCCG ATGGCAGAGT TACCGGTGAG GCAGATGTTG AATTTGCTAC TCATGAAGAT 
GCTGTGGCAG CTATGGCAAA AGACAAAGCT AATATGCAAC ACAGATATGT GGAGCTCTTC 
TTAAATTCTA CTGCAGGAAC AAGTGGGGGT GCTTACGATC ACAGCTATGT AGAACTTTTT 
TTGAATTCTA CAGCAGGGGC AAGTGGTGGC GCTTATGGTA GCCAAATGAT GGGAGGGATG 
GGCTTATCCA ACCAGTCTAG TTATGGAGGT CCTGCTAGCC AGCAGCTGAG TGGTGGTTAT 
GGAGGTGGTT ATGGTGGTCA GAGCAGTATG AGTGGATATG ACCAAGTTCT GCAGGAAAAC 
TCCAGTGACT ATCAGTCAAA CCTTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062543.1
CDS	152..1501
Translation	MMLSTEGREGFVVKVRGLPWSCSADEVMRFFSDCKIQNGTSGIRFIYTREGRPSGEAFVELESEEEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA

Target ORF information:

RefSeq Version	NM_019597.5
Organism	Homo sapiens(human)
Definition	Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019597.5

ORF Insert Sequence:

ATGATGCTGA GCACGGAAGG CAGGGAGGGG TTCGTGGTGA AGGTCAGGGG CCTACCCTGG 
TCCTGCTCAG CCGATGAAGT GATGCGCTTC TTCTCTGATT GCAAGATCCA AAATGGCACA 
TCAGGTATTC GTTTCATCTA CACCAGAGAA GGCAGACCAA GTGGTGAAGC ATTTGTTGAA 
CTTGAATCTG AAGAGGAAGT GAAATTGGCT TTGAAGAAGG ACAGAGAAAC CATGGGACAC 
AGATACGTTG AAGTATTCAA GTCTAACAGT GTTGAAATGG ATTGGGTGTT GAAGCATACA 
GGTCCGAATA GCCCTGATAC TGCCAACGAT GGCTTCGTCC GGCTTAGAGG ACTCCCATTT 
GGCTGTAGCA AGGAAGAGAT TGTTCAGTTC TTTTCAGGGT TGGAAATTGT GCCAAATGGG 
ATGACACTGC CAGTGGACTT TCAGGGGCGA AGCACAGGGG AAGCCTTTGT GCAGTTTGCT 
TCACAGGAGA TAGCTGAGAA GGCCTTAAAG AAACACAAGG AAAGAATAGG GCACAGGTAC 
ATTGAGATCT TCAAGAGTAG CCGAGCTGAA GTTCGAACCC ACTATGATCC CCCTCGAAAG 
CTCATGGCTA TGCAGCGGCC AGGTCCCTAT GATAGGCCGG GGGCTGGCAG AGGGTATAAT 
AGCATTGGCA GAGGAGCTGG GTTTGAAAGG ATGAGGCGTG GTGCCTATGG TGGAGGGTAT 
GGAGGCTATG ATGACTATGG TGGCTATAAT GATGGATATG GCTTTGGGTC TGATAGATTT 
GGAAGAGACC TCAATTACTG TTTTTCAGGA ATGTCTGATC ATAGATACGG AGATGGTGGG 
TCCAGTTTCC AGAGCACCAC AGGGCACTGT GTACACATGA GGGGGTTACC TTACAGAGCC 
ACTGAGAATG ATATTTATAA TTTCTTCTCA CCTCTTAATC CCATGAGAGT ACATATTGAA 
ATTGGACCCG ATGGCAGAGT TACCGGTGAG GCAGATGTTG AATTTGCTAC TCATGAAGAT 
GCTGTGGCAG CTATGGCAAA AGACAAAGCT AATATGCAAC ACAGATATGT GGAGCTCTTC 
TTAAATTCTA CTGCAGGAAC AAGTGGGGGT GCTTACGATC ACAGCTATGT AGAACTTTTT 
TTGAATTCTA CAGCAGGGGC AAGTGGTGGC GCTTATGGTA GCCAAATGAT GGGAGGGATG 
GGCTTATCCA ACCAGTCTAG TTATGGAGGT CCTGCTAGCC AGCAGCTGAG TGGTGGTTAT 
GGAGGTGGTT ATGGTGGTCA GAGCAGTATG AGTGGATATG ACCAAGTTCT GCAGGAAAAC 
TCCAGTGACT ATCAGTCAAA CCTTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HNRNPH2 ( NM_001032393.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001027565.1 Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10557
Clone ID Related Accession (Same CDS sequence)	NM_019597.5 , NM_001032393.2 , NM_019597.4
Accession Version	NM_001032393.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	heterogeneous nuclear ribonucleoprotein H2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA686966.1, BU167621.1, U01923.1, AL035422.12 and AA758785.1. This sequence is a reference standard in the RefSeqGene project. On Jan 5, 2011 this sequence version replaced NM_001032393.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.113742.1, SRR1803614.147482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGCTGA GCACGGAAGG CAGGGAGGGG TTCGTGGTGA AGGTCAGGGG CCTACCCTGG 
TCCTGCTCAG CCGATGAAGT GATGCGCTTC TTCTCTGATT GCAAGATCCA AAATGGCACA 
TCAGGTATTC GTTTCATCTA CACCAGAGAA GGCAGACCAA GTGGTGAAGC ATTTGTTGAA 
CTTGAATCTG AAGAGGAAGT GAAATTGGCT TTGAAGAAGG ACAGAGAAAC CATGGGACAC 
AGATACGTTG AAGTATTCAA GTCTAACAGT GTTGAAATGG ATTGGGTGTT GAAGCATACA 
GGTCCGAATA GCCCTGATAC TGCCAACGAT GGCTTCGTCC GGCTTAGAGG ACTCCCATTT 
GGCTGTAGCA AGGAAGAGAT TGTTCAGTTC TTTTCAGGGT TGGAAATTGT GCCAAATGGG 
ATGACACTGC CAGTGGACTT TCAGGGGCGA AGCACAGGGG AAGCCTTTGT GCAGTTTGCT 
TCACAGGAGA TAGCTGAGAA GGCCTTAAAG AAACACAAGG AAAGAATAGG GCACAGGTAC 
ATTGAGATCT TCAAGAGTAG CCGAGCTGAA GTTCGAACCC ACTATGATCC CCCTCGAAAG 
CTCATGGCTA TGCAGCGGCC AGGTCCCTAT GATAGGCCGG GGGCTGGCAG AGGGTATAAT 
AGCATTGGCA GAGGAGCTGG GTTTGAAAGG ATGAGGCGTG GTGCCTATGG TGGAGGGTAT 
GGAGGCTATG ATGACTATGG TGGCTATAAT GATGGATATG GCTTTGGGTC TGATAGATTT 
GGAAGAGACC TCAATTACTG TTTTTCAGGA ATGTCTGATC ATAGATACGG AGATGGTGGG 
TCCAGTTTCC AGAGCACCAC AGGGCACTGT GTACACATGA GGGGGTTACC TTACAGAGCC 
ACTGAGAATG ATATTTATAA TTTCTTCTCA CCTCTTAATC CCATGAGAGT ACATATTGAA 
ATTGGACCCG ATGGCAGAGT TACCGGTGAG GCAGATGTTG AATTTGCTAC TCATGAAGAT 
GCTGTGGCAG CTATGGCAAA AGACAAAGCT AATATGCAAC ACAGATATGT GGAGCTCTTC 
TTAAATTCTA CTGCAGGAAC AAGTGGGGGT GCTTACGATC ACAGCTATGT AGAACTTTTT 
TTGAATTCTA CAGCAGGGGC AAGTGGTGGC GCTTATGGTA GCCAAATGAT GGGAGGGATG 
GGCTTATCCA ACCAGTCTAG TTATGGAGGT CCTGCTAGCC AGCAGCTGAG TGGTGGTTAT 
GGAGGTGGTT ATGGTGGTCA GAGCAGTATG AGTGGATATG ACCAAGTTCT GCAGGAAAAC 
TCCAGTGACT ATCAGTCAAA CCTTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001027565.1
CDS	229..1578
Translation	MMLSTEGREGFVVKVRGLPWSCSADEVMRFFSDCKIQNGTSGIRFIYTREGRPSGEAFVELESEEEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA

Target ORF information:

RefSeq Version	NM_001032393.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001032393.2

ORF Insert Sequence:

ATGATGCTGA GCACGGAAGG CAGGGAGGGG TTCGTGGTGA AGGTCAGGGG CCTACCCTGG 
TCCTGCTCAG CCGATGAAGT GATGCGCTTC TTCTCTGATT GCAAGATCCA AAATGGCACA 
TCAGGTATTC GTTTCATCTA CACCAGAGAA GGCAGACCAA GTGGTGAAGC ATTTGTTGAA 
CTTGAATCTG AAGAGGAAGT GAAATTGGCT TTGAAGAAGG ACAGAGAAAC CATGGGACAC 
AGATACGTTG AAGTATTCAA GTCTAACAGT GTTGAAATGG ATTGGGTGTT GAAGCATACA 
GGTCCGAATA GCCCTGATAC TGCCAACGAT GGCTTCGTCC GGCTTAGAGG ACTCCCATTT 
GGCTGTAGCA AGGAAGAGAT TGTTCAGTTC TTTTCAGGGT TGGAAATTGT GCCAAATGGG 
ATGACACTGC CAGTGGACTT TCAGGGGCGA AGCACAGGGG AAGCCTTTGT GCAGTTTGCT 
TCACAGGAGA TAGCTGAGAA GGCCTTAAAG AAACACAAGG AAAGAATAGG GCACAGGTAC 
ATTGAGATCT TCAAGAGTAG CCGAGCTGAA GTTCGAACCC ACTATGATCC CCCTCGAAAG 
CTCATGGCTA TGCAGCGGCC AGGTCCCTAT GATAGGCCGG GGGCTGGCAG AGGGTATAAT 
AGCATTGGCA GAGGAGCTGG GTTTGAAAGG ATGAGGCGTG GTGCCTATGG TGGAGGGTAT 
GGAGGCTATG ATGACTATGG TGGCTATAAT GATGGATATG GCTTTGGGTC TGATAGATTT 
GGAAGAGACC TCAATTACTG TTTTTCAGGA ATGTCTGATC ATAGATACGG AGATGGTGGG 
TCCAGTTTCC AGAGCACCAC AGGGCACTGT GTACACATGA GGGGGTTACC TTACAGAGCC 
ACTGAGAATG ATATTTATAA TTTCTTCTCA CCTCTTAATC CCATGAGAGT ACATATTGAA 
ATTGGACCCG ATGGCAGAGT TACCGGTGAG GCAGATGTTG AATTTGCTAC TCATGAAGAT 
GCTGTGGCAG CTATGGCAAA AGACAAAGCT AATATGCAAC ACAGATATGT GGAGCTCTTC 
TTAAATTCTA CTGCAGGAAC AAGTGGGGGT GCTTACGATC ACAGCTATGT AGAACTTTTT 
TTGAATTCTA CAGCAGGGGC AAGTGGTGGC GCTTATGGTA GCCAAATGAT GGGAGGGATG 
GGCTTATCCA ACCAGTCTAG TTATGGAGGT CCTGCTAGCC AGCAGCTGAG TGGTGGTTAT 
GGAGGTGGTT ATGGTGGTCA GAGCAGTATG AGTGGATATG ACCAAGTTCT GCAGGAAAAC 
TCCAGTGACT ATCAGTCAAA CCTTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HNRNPH2 ( NM_019597.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_062543.1 Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10557
Clone ID Related Accession (Same CDS sequence)	NM_019597.5 , NM_001032393.2 , NM_019597.4
Accession Version	NM_019597.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	heterogeneous nuclear ribonucleoprotein H2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA686966.1, U01923.1, AL035422.12 and AA758785.1. On Jan 5, 2011 this sequence version replaced NM_019597.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA686966.1, SRR1803613.153650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGCTGA GCACGGAAGG CAGGGAGGGG TTCGTGGTGA AGGTCAGGGG CCTACCCTGG 
TCCTGCTCAG CCGATGAAGT GATGCGCTTC TTCTCTGATT GCAAGATCCA AAATGGCACA 
TCAGGTATTC GTTTCATCTA CACCAGAGAA GGCAGACCAA GTGGTGAAGC ATTTGTTGAA 
CTTGAATCTG AAGAGGAAGT GAAATTGGCT TTGAAGAAGG ACAGAGAAAC CATGGGACAC 
AGATACGTTG AAGTATTCAA GTCTAACAGT GTTGAAATGG ATTGGGTGTT GAAGCATACA 
GGTCCGAATA GCCCTGATAC TGCCAACGAT GGCTTCGTCC GGCTTAGAGG ACTCCCATTT 
GGCTGTAGCA AGGAAGAGAT TGTTCAGTTC TTTTCAGGGT TGGAAATTGT GCCAAATGGG 
ATGACACTGC CAGTGGACTT TCAGGGGCGA AGCACAGGGG AAGCCTTTGT GCAGTTTGCT 
TCACAGGAGA TAGCTGAGAA GGCCTTAAAG AAACACAAGG AAAGAATAGG GCACAGGTAC 
ATTGAGATCT TCAAGAGTAG CCGAGCTGAA GTTCGAACCC ACTATGATCC CCCTCGAAAG 
CTCATGGCTA TGCAGCGGCC AGGTCCCTAT GATAGGCCGG GGGCTGGCAG AGGGTATAAT 
AGCATTGGCA GAGGAGCTGG GTTTGAAAGG ATGAGGCGTG GTGCCTATGG TGGAGGGTAT 
GGAGGCTATG ATGACTATGG TGGCTATAAT GATGGATATG GCTTTGGGTC TGATAGATTT 
GGAAGAGACC TCAATTACTG TTTTTCAGGA ATGTCTGATC ATAGATACGG AGATGGTGGG 
TCCAGTTTCC AGAGCACCAC AGGGCACTGT GTACACATGA GGGGGTTACC TTACAGAGCC 
ACTGAGAATG ATATTTATAA TTTCTTCTCA CCTCTTAATC CCATGAGAGT ACATATTGAA 
ATTGGACCCG ATGGCAGAGT TACCGGTGAG GCAGATGTTG AATTTGCTAC TCATGAAGAT 
GCTGTGGCAG CTATGGCAAA AGACAAAGCT AATATGCAAC ACAGATATGT GGAGCTCTTC 
TTAAATTCTA CTGCAGGAAC AAGTGGGGGT GCTTACGATC ACAGCTATGT AGAACTTTTT 
TTGAATTCTA CAGCAGGGGC AAGTGGTGGC GCTTATGGTA GCCAAATGAT GGGAGGGATG 
GGCTTATCCA ACCAGTCTAG TTATGGAGGT CCTGCTAGCC AGCAGCTGAG TGGTGGTTAT 
GGAGGTGGTT ATGGTGGTCA GAGCAGTATG AGTGGATATG ACCAAGTTCT GCAGGAAAAC 
TCCAGTGACT ATCAGTCAAA CCTTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062543.1
CDS	241..1590
Translation	MMLSTEGREGFVVKVRGLPWSCSADEVMRFFSDCKIQNGTSGIRFIYTREGRPSGEAFVELESEEEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA

Target ORF information:

RefSeq Version	NM_019597.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019597.4

ORF Insert Sequence:

ATGATGCTGA GCACGGAAGG CAGGGAGGGG TTCGTGGTGA AGGTCAGGGG CCTACCCTGG 
TCCTGCTCAG CCGATGAAGT GATGCGCTTC TTCTCTGATT GCAAGATCCA AAATGGCACA 
TCAGGTATTC GTTTCATCTA CACCAGAGAA GGCAGACCAA GTGGTGAAGC ATTTGTTGAA 
CTTGAATCTG AAGAGGAAGT GAAATTGGCT TTGAAGAAGG ACAGAGAAAC CATGGGACAC 
AGATACGTTG AAGTATTCAA GTCTAACAGT GTTGAAATGG ATTGGGTGTT GAAGCATACA 
GGTCCGAATA GCCCTGATAC TGCCAACGAT GGCTTCGTCC GGCTTAGAGG ACTCCCATTT 
GGCTGTAGCA AGGAAGAGAT TGTTCAGTTC TTTTCAGGGT TGGAAATTGT GCCAAATGGG 
ATGACACTGC CAGTGGACTT TCAGGGGCGA AGCACAGGGG AAGCCTTTGT GCAGTTTGCT 
TCACAGGAGA TAGCTGAGAA GGCCTTAAAG AAACACAAGG AAAGAATAGG GCACAGGTAC 
ATTGAGATCT TCAAGAGTAG CCGAGCTGAA GTTCGAACCC ACTATGATCC CCCTCGAAAG 
CTCATGGCTA TGCAGCGGCC AGGTCCCTAT GATAGGCCGG GGGCTGGCAG AGGGTATAAT 
AGCATTGGCA GAGGAGCTGG GTTTGAAAGG ATGAGGCGTG GTGCCTATGG TGGAGGGTAT 
GGAGGCTATG ATGACTATGG TGGCTATAAT GATGGATATG GCTTTGGGTC TGATAGATTT 
GGAAGAGACC TCAATTACTG TTTTTCAGGA ATGTCTGATC ATAGATACGG AGATGGTGGG 
TCCAGTTTCC AGAGCACCAC AGGGCACTGT GTACACATGA GGGGGTTACC TTACAGAGCC 
ACTGAGAATG ATATTTATAA TTTCTTCTCA CCTCTTAATC CCATGAGAGT ACATATTGAA 
ATTGGACCCG ATGGCAGAGT TACCGGTGAG GCAGATGTTG AATTTGCTAC TCATGAAGAT 
GCTGTGGCAG CTATGGCAAA AGACAAAGCT AATATGCAAC ACAGATATGT GGAGCTCTTC 
TTAAATTCTA CTGCAGGAAC AAGTGGGGGT GCTTACGATC ACAGCTATGT AGAACTTTTT 
TTGAATTCTA CAGCAGGGGC AAGTGGTGGC GCTTATGGTA GCCAAATGAT GGGAGGGATG 
GGCTTATCCA ACCAGTCTAG TTATGGAGGT CCTGCTAGCC AGCAGCTGAG TGGTGGTTAT 
GGAGGTGGTT ATGGTGGTCA GAGCAGTATG AGTGGATATG ACCAAGTTCT GCAGGAAAAC 
TCCAGTGACT ATCAGTCAAA CCTTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Variants in HNRNPH2 on the X Chromosome Are Associated with a Neurodevelopmental Disorder in Females.
American journal of human genetics99(3)728-734(2016 Sep)
Bain JM,Cho MT,Telegrafi A,Wilson A,Brooks S,Botti C,Gowans G,Autullo LA,Krishnamurthy V,Willing MC,Toler TL,Ben-Zev B,Elpeleg O,Shen Y,Retterer K,Monaghan KG,Chung WK

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
PLoS genetics11(8)e1005428(2015 Aug)
Hasegawa Y,Taylor D,Ovchinnikov DA,Wolvetang EJ,de Torrent? L,Mar JC

Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.
The Journal of biological chemistry289(18)12421-34(2014 May)
Rappe U,Schlechter T,Aschoff M,Hotz-Wagenblatt A,Hofmann I

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HNRNPH2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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